LOCUS       NM_001112               6902 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens adenosine deaminase RNA specific B1 (ADARB1),
            transcript variant 1, mRNA.
ACCESSION   NM_001112
VERSION     NM_001112.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6902)
  AUTHORS   Song,Z., Ding,Q. and Yang,Y.
  TITLE     Orchestration of a blood-derived and ADARB1-centred network in
            Alzheimer's and Parkinson's disease
  JOURNAL   Cell Signal 110, 110845 (2023)
   PUBMED   37544632
  REMARK    GeneRIF: Orchestration of a blood-derived and ADARB1-centred
            network in Alzheimer's and Parkinson's disease.
REFERENCE   2  (bases 1 to 6902)
  AUTHORS   Guo,M., Chan,T.H.M., Zhou,Q., An,O., Li,Y., Song,Y., Tan,Z.H.,
            Ng,V.H.E., Peramangalam,P.S., Tan,Z.Q., Cao,X., Iwanaga,E.,
            Matsuoka,M., Ooi,M.G.M., Jen,W.Y., Koh,L.P., Chan,E., Tan,L.K.,
            Goh,Y., Wang,W., Koh,B.T.H., Chun,C.M., Fullwood,M.J., Chng,W.J.,
            Osato,M., Pulikkan,J.A., Yang,H., Chen,L. and Tenen,D.G.
  TITLE     Core-binding factor fusion downregulation of ADAR2 RNA editing
            contributes to AML leukemogenesis
  JOURNAL   Blood 141 (25), 3078-3090 (2023)
   PUBMED   36796022
  REMARK    GeneRIF: Core-binding factor fusion downregulation of ADAR2 RNA
            editing contributes to AML leukemogenesis.
REFERENCE   3  (bases 1 to 6902)
  AUTHORS   Kawahara,Y., Ito,K., Ito,M., Tsuji,S. and Kwak,S.
  TITLE     Novel splice variants of human ADAR2 mRNA: skipping of the exon
            encoding the dsRNA-binding domains, and multiple C-terminal splice
            sites
  JOURNAL   Gene 363, 193-201 (2005)
   PUBMED   16297572
REFERENCE   4  (bases 1 to 6902)
  AUTHORS   Slavov,D. and Gardiner,K.
  TITLE     Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2
            genes and transcripts: conservation and diversity in editing site
            sequence and alternative splicing patterns
  JOURNAL   Gene 299 (1-2), 83-94 (2002)
   PUBMED   12459255
REFERENCE   5  (bases 1 to 6902)
  AUTHORS   Gerber,A., O'Connell,M.A. and Keller,W.
  TITLE     Two forms of human double-stranded RNA-specific editase 1 (hRED1)
            generated by the insertion of an Alu cassette
  JOURNAL   RNA 3 (5), 453-463 (1997)
   PUBMED   9149227
REFERENCE   6  (bases 1 to 6902)
  AUTHORS   Lai,F., Chen,C.X., Carter,K.C. and Nishikura,K.
  TITLE     Editing of glutamate receptor B subunit ion channel RNAs by four
            alternatively spliced DRADA2 double-stranded RNA adenosine
            deaminases
  JOURNAL   Mol Cell Biol 17 (5), 2413-2424 (1997)
   PUBMED   9111310
REFERENCE   7  (bases 1 to 6902)
  AUTHORS   Yang,J.H., Sklar,P., Axel,R. and Maniatis,T.
  TITLE     Purification and characterization of a human RNA adenosine
            deaminase for glutamate receptor B pre-mRNA editing
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4354-4359 (1997)
   PUBMED   9113993
REFERENCE   8  (bases 1 to 6902)
  AUTHORS   Mittaz,L., Scott,H.S., Rossier,C., Seeburg,P.H., Higuchi,M. and
            Antonarakis,S.E.
  TITLE     Cloning of a human RNA editing deaminase (ADARB1) of glutamate
            receptors that maps to chromosome 21q22.3
  JOURNAL   Genomics 41 (2), 210-217 (1997)
   PUBMED   9143496
REFERENCE   9  (bases 1 to 6902)
  AUTHORS   O'Connell,M.A., Gerber,A. and Keller,W.
  TITLE     Purification of human double-stranded RNA-specific editase 1
            (hRED1) involved in editing of brain glutamate receptor B pre-mRNA
  JOURNAL   J Biol Chem 272 (1), 473-478 (1997)
   PUBMED   8995285
REFERENCE   10 (bases 1 to 6902)
  AUTHORS   Melcher,T., Maas,S., Herb,A., Sprengel,R., Seeburg,P.H. and
            Higuchi,M.
  TITLE     A mammalian RNA editing enzyme
  JOURNAL   Nature 379 (6564), 460-464 (1996)
   PUBMED   8559253
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030663.1, AB194370.1 and
            BU726292.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001112.3.
            
            Summary: This gene encodes the enzyme responsible for pre-mRNA
            editing of the glutamate receptor subunit B by site-specific
            deamination of adenosines. Studies in rat found that this enzyme
            acted on its own pre-mRNA molecules to convert an AA dinucleotide
            to an AI dinucleotide which resulted in a new splice site.
            Alternative splicing of this gene results in several transcript
            variants, some of which have been characterized by the presence or
            absence of an ALU cassette insert and a short or long C-terminal
            region. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as ADAR2a-L1 or
            DRADA2a, lacks the ALU cassette insert and contains the long
            C-terminal region, as compared to variant 2. The resulting isoform
            (1), also known as hRED1-Short, lacks an internal segment, compared
            to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB194370.1, U76420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348831.9/ ENSP00000015877.6
            RefSeq Select criteria :: based on conservation, expression
            undergoes RNA editing  :: PMID: 11717408, 12045112
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BC030663.1         12-31
            21-3818             AB194370.1         1-3798
            3819-6901           AB194370.1         3800-6882
            6902-6902           BU726292.1         21-21               c
FEATURES             Location/Qualifiers
     source          1..6902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..6902
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /note="adenosine deaminase RNA specific B1"
                     /db_xref="GeneID:104"
                     /db_xref="HGNC:HGNC:226"
                     /db_xref="MIM:601218"
     exon            1..214
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..386
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..461
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..2539
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /EC_number="3.5.4.37"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenosine deaminase, RNA-specific, B1 (homolog of rat
                     RED1); double-stranded RNA-specific editase 1; RNA editing
                     deaminase 1; RNA-editing enzyme 1; dsRNA adenosine
                     deaminase DRADA2"
                     /codon_start=1
                     /product="double-stranded RNA-specific editase 1 isoform
                     1"
                     /protein_id="NP_001103.1"
                     /db_xref="CCDS:CCDS33590.1"
                     /db_xref="GeneID:104"
                     /db_xref="HGNC:HGNC:226"
                     /db_xref="MIM:601218"
                     /translation="MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNG
                     GGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTG
                     PVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLS
                     VNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLA
                     QPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEG
                     SGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGK
                     FGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALND
                     CHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSP
                     CGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQG
                     ERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISN
                     IEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRA
                     SRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEYQAAKARLFTAFIKA
                     GLGAWVEKPTEQDQFSLTP"
     exon            462..1396
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1511
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1680
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1829
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1998
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2180
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2359
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..6902
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6880..6885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /note="hexamer: AATAAA"
     polyA_site      6902
                     /gene="ADARB1"
                     /gene_synonym="ADAR2; DRABA2; DRADA2; NEDHYMS; RED1"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgctga ggcggccgtg gcggcggcgg cggcggcggc ggcagcggcg gccaagcggc
       61 caggttggcg gccggggctc cgggccgcgc gaggccacgg ccacgccgcg ccgctgcgca
      121 caaccaacga ggcagagcgc cgcccggcgc gagactgcgg ccgaagcgtg gggcgcgcgt
      181 gcggaggacc aggcgcggcg cggctgcggc tgagagtgga gcctttcagg ctggcatgga
      241 gagcttaagg ggcaactgaa ggagacacac tggccaagcg cggagttctg cttacttcag
      301 tcctgctgag atactctctc agtccgctcg caccgaagga agctgccttg ggatcagagc
      361 agacataaag ctagaaaaat ttcaagacag aaacagtctc cgccagtcaa gaaaccctca
      421 aaagtatttt gccatggata tagaagatga agaaaacatg agttccagca gcactgatgt
      481 gaaggaaaac cgcaatctgg acaacgtgtc ccccaaggat ggcagcacac ctgggcctgg
      541 cgagggctct cagctctcca atgggggtgg tggtggcccc ggcagaaagc ggcccctgga
      601 ggagggcagc aatggccact ccaagtaccg cctgaagaaa aggaggaaaa caccagggcc
      661 cgtcctcccc aagaacgccc tgatgcagct gaatgagatc aagcctggtt tgcagtacac
      721 actcctgtcc cagactgggc ccgtgcacgc gcctttgttt gtcatgtctg tggaggtgaa
      781 tggccaggtt tttgagggct ctggtcccac aaagaaaaag gcaaaactcc atgctgctga
      841 gaaggccttg aggtctttcg ttcagtttcc taatgcctct gaggcccacc tggccatggg
      901 gaggaccctg tctgtcaaca cggacttcac atctgaccag gccgacttcc ctgacacgct
      961 cttcaatggt tttgaaactc ctgacaaggc ggagcctccc ttttacgtgg gctccaatgg
     1021 ggatgactcc ttcagttcca gcggggacct cagcttgtct gcttccccgg tgcctgccag
     1081 cctagcccag cctcctctcc ctgtcttacc accattccca cccccgagtg ggaagaatcc
     1141 cgtgatgatc ttgaacgaac tgcgcccagg actcaagtat gacttcctct ccgagagcgg
     1201 ggagagccat gccaagagct tcgtcatgtc tgtggtcgtg gatggtcagt tctttgaagg
     1261 ctcggggaga aacaagaagc ttgccaaggc ccgggctgcg cagtctgccc tggccgccat
     1321 ttttaacttg cacttggatc agacgccatc tcgccagcct attcccagtg agggtcttca
     1381 gctgcattta ccgcaggttt tagctgacgc tgtctcacgc ctggtcctgg gtaagtttgg
     1441 tgacctgacc gacaacttct cctcccctca cgctcgcaga aaagtgctgg ctggagtcgt
     1501 catgacaaca ggcacagatg ttaaagatgc caaggtgata agtgtttcta caggaacaaa
     1561 atgtattaat ggtgaataca tgagtgatcg tggccttgca ttaaatgact gccatgcaga
     1621 aataatatct cggagatcct tgctcagatt tctttataca caacttgagc tttacttaaa
     1681 taacaaagat gatcaaaaaa gatccatctt tcagaaatca gagcgagggg ggtttaggct
     1741 gaaggagaat gtccagtttc atctgtacat cagcacctct ccctgtggag atgccagaat
     1801 cttctcacca catgagccaa tcctggaaga accagcagat agacacccaa atcgtaaagc
     1861 aagaggacag ctacggacca aaatagagtc tggtgagggg acgattccag tgcgctccaa
     1921 tgcgagcatc caaacgtggg acggggtgct gcaaggggag cggctgctca ccatgtcctg
     1981 cagtgacaag attgcacgct ggaacgtggt gggcatccag ggatccctgc tcagcatttt
     2041 cgtggagccc atttacttct cgagcatcat cctgggcagc ctttaccacg gggaccacct
     2101 ttccagggcc atgtaccagc ggatctccaa catagaggac ctgccacctc tctacaccct
     2161 caacaagcct ttgctcagtg gcatcagcaa tgcagaagca cggcagccag ggaaggcccc
     2221 caacttcagt gtcaactgga cggtaggcga ctccgctatt gaggtcatca acgccacgac
     2281 tgggaaggat gagctgggcc gcgcgtcccg cctgtgtaag cacgcgttgt actgtcgctg
     2341 gatgcgtgtg cacggcaagg ttccctccca cttactacgc tccaagatta ccaagcccaa
     2401 cgtgtaccat gagtccaagc tggcggcaaa ggagtaccag gccgccaagg cgcgtctgtt
     2461 cacagccttc atcaaggcgg ggctgggggc ctgggtggag aagcccaccg agcaggacca
     2521 gttctcactc acgccctgac ccgggcagac atgatggggg gtgcaggggg ctgtgggcat
     2581 ccagcgtcat cctccagaac ctcacatctg aactgggggc aggtgcatac cttggggagg
     2641 gagtaggggg acacggggga ccaccaggtg tccacggttg tccccagcat ctcacatcag
     2701 acctggggca ggtgcgcagt gtggggaggg gatggggtgc gtcagggccc agcatcgccg
     2761 cctggcatct ctctgccgca gcatttcccc ttctgaaccg tccagtgact gctttcaatc
     2821 tcggtttacg tttagaaatt gagttctact gagtagggct tccttaagtt taggaaaata
     2881 gaaattactt tgtgtgaaat tcttgaataa ataatttatt cagagctagg aatgtggttt
     2941 ataaaatagg aagtaattgt gtcaggtcac ttttatgcca cattatttta attgcaaaaa
     3001 agcatctata tatggaggag ggtgggaaaa tagaggtagg aaatagtagc ctaaaggaaa
     3061 tcgccacacg tctgtctaaa cttaggtctc ttttctccgt aggtacctcc ctgggtagtt
     3121 ccacacacta ggttgtaaca gtctctccct gaggagcaga ctcccagcat ggtgtagcgt
     3181 ggccctgtca tgcacatggg gtcccgcagc agtgactgtg tgtcctgcag aggcgtgacc
     3241 caggcccctg tagccctcag cctcctctag aagcttctgt actccttgta ggatcagatc
     3301 atggaaaact tttctcagtt tacttctaag taatcacaga taatacatgg ccagtaatcc
     3361 caggctggcc attcattcag gttttttaaa ggatatttaa cttttatgga ctagaaggaa
     3421 tcacgagggc tactgcacaa tacatggcct aagttccctc tgttccttcc tctgaatcga
     3481 atggatgtgg gtgaccgccc gaaggccttc acaggatgga agtagaatga tttcagtaga
     3541 tactcattct tggaaaatgc catagtttta aattattgtt tccagcttta tcaaagacat
     3601 gtttgaaaaa taaaaagcat ccaagtgaga gctggtgaga ccacgtgctg ctggcgtagt
     3661 gtaggccaga cattgacagt cctgacggga gctcagggct gcccagcgcc cagcgtgcac
     3721 gggacggccc cacgacagag ggagtcagcc cgggaggtca ggagcgcggc gggcgagggc
     3781 cctgtgtgga ccacctccac caagctcaga gatttgcacc aggtgccttg ttgcctccgc
     3841 tcaggatgaa agaggagctg agagaagtgc tctgcctgcc agtgcagtgc ccagctccaa
     3901 ggctctagag ggtgttcagg tgggtctcct ggggccatgg ggagagattg gtgcagacct
     3961 taccccacag catacacctg ccacagcgaa atccagggtg ttggcacctg tgtgtccgtg
     4021 atgagcctag gaaaccagag caggggcaga ggggcgtcat cctcccaccg gacgctggga
     4081 gctcagaccc caaaactgaa acaccgtggc ttcggcgggg ggtgtgcctc ctgatgtcag
     4141 gagccccatc cacgtgtgtc cacacagatc tcgtcgcagc acggcaggaa ggggtgctgc
     4201 ttagggctca ttgttgggga catgaccggg ttcagcggct agaacatctg ccccacagca
     4261 gcctcctcct ccaccgaaga gggtagttgt ctccctgaag cagtcacagc aggcgtctct
     4321 gccgctccgt caccacagtg gggttttgtt caggcagatc gcgctggggt tctgcacctg
     4381 cagaaggaga ggggtctgtt gtcgctggct ttcccccaag caggctcttg cacactctag
     4441 aaaaaacacc ttgtaagtct gtgcattttt attgtcttga taaattgtat ttttttctaa
     4501 tggggattgg gagatggact tcgtttttaa aaatatgtgg attttggtta ccaagtttag
     4561 tgttaatata ttccatatac atacaaaact acccggtatg tctggctttt cccttctgtc
     4621 aggtaatagc taaagtcagc atgattgctc cctgtaccac cccaaataag tgagtgcctc
     4681 accttgtggg gcctgagcag ctaccttgag accatgtgag gtggcacctt tccggggtgg
     4741 actcgtgcgg ccttgaggac aggcacaggg caccctatcc caagccgtcc aggcaggagg
     4801 aaggcagcca aggcaactgg gttctgggag ccctgggtgg ggcagctgtg gggaggaact
     4861 gggttcgggg agccctgggc ggggcggctg ttggggggaa ctgggttcgg ggtgccctgg
     4921 gcagggggct actggggggc ggctgtgagg aggagttggg ttcagggagc cctgggcggg
     4981 gtggctgtca gggggaactg ggttccggga gccctgggcc ggggcagggg gcggctgtag
     5041 gaaggaactg gtttcgggga gccctgggcg gggcggctgt ggggaggaag gtgacgtgca
     5101 ggggaccaga ggctctgcac tgctcctagg acagctcatc tgtaatcaga aaaaaaataa
     5161 acaaaataca gaacgctgac tcctccgtga gacagatcgg ggaccttagc actttaatcc
     5221 ctcccttctg agcgctcggt gtgcactttt agactatagc tgtttcattg acgtgtcact
     5281 ctccatccag tgtccttgat gtggctttta gagacttagc agaaaattcg acacaagcag
     5341 gaacttgatt ttttaagaaa aaatattaca ttttgaggac attttgacaa gtaggggaag
     5401 agagggcttc tgttgttttg ttttgttttg ttttgttaac taaacctgaa gtattaattc
     5461 cacaaagaca ctgtccctca ggaccactca ggtacagctc tgccagggac agagtcctgc
     5521 tagtgggagg tctcaggtgg ggcggtgtgt tctgtgccat gaggcagcga caggtccaga
     5581 tggatgtcgt caccaccttc ctcagctctc atcacctggt cgtacgccag gcccacctct
     5641 tcccagcaag ggacgccaaa gaactgcagt ttttattctg agtcttaatt taacttttca
     5701 tcatcttttc ctattttgga gaattttttg taattaaaag caattatttt aaaatgtgca
     5761 agccagtatc tcacaaggca tggatttctg tggaatttat ttttattcaa ataaccatat
     5821 ttatctccag gctgtggaat cgccactttc tttgtgaaga cagtgtctct ccttgtaatc
     5881 tcacacaggt acactgagga ggggacggct ccgtcttcac attgtgcaca gatctgagga
     5941 tgggattagc gaagctgtgg agactgcaca tccggacctg cccatgtctc aaaacaaaca
     6001 catgtacagt ggctcttttt ccttctcaaa cactttaccc cagaagcagg tggtctgccc
     6061 caggcataaa gaaggaaaat tggccatctt tcccacctct aaattctgta aaattataga
     6121 cttgctcaaa agattccttt ttatcatccc cacgctgtgt aagtggaaag ggcattgtgt
     6181 tccgtgtgtg tccagtttac agcgtctctg ccccctagcg tgttttgtga caatctccct
     6241 gggtgaggag tgggtgcacc cagccccgag gccagtggtt gctcggggcc ttccgtgtga
     6301 gttctagtgt tcacttgatg ccggggaata gaattagaga aaactctgac ctgccgggtt
     6361 ccagggactg gtggaggtgg atggcaggtc cgactcgacc atgacttagt tgtaagggtg
     6421 tgtcggcttt ttcagtctca tgtgaaaatc ctcctgtctc tggcagcact gtctgcactt
     6481 tcttgtttac tgtttgaagg gacgagtacc aagccacaag aacacttctt ttggccacag
     6541 cataagctga tggtatgtaa ggaaccgatg ggccattaaa catgaactga acggttaaaa
     6601 gcacagtcta tggaacgcta atggagtcag cccctaaagc tgtttgcttt ttcaggcttt
     6661 ggattacatg cttttaattt gattttagaa tctggacact ttctatgaat gtaattcggc
     6721 tgagaaacat gttgctgaga tgcaatcctc agtgttctct gtatgtaaat ctgtgtatac
     6781 accacacgtt acaactgcat gagcttcctc tcgcacaaga ccagctggaa ctgagcatga
     6841 gacgctgtca aatacagaca aaggatttga gatgttctca ataaaaagaa aatgtttcac
     6901 ta
//
