LOCUS       NM_001111               6610 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens adenosine deaminase RNA specific (ADAR), transcript
            variant 1, mRNA.
ACCESSION   NM_001111
VERSION     NM_001111.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6610)
  AUTHORS   Baker,A.R. and Slack,F.J.
  TITLE     ADAR1 and its implications in cancer development and treatment
  JOURNAL   Trends Genet 38 (8), 821-830 (2022)
   PUBMED   35459560
  REMARK    GeneRIF: ADAR1 and its implications in cancer development and
            treatment.
            Review article
REFERENCE   2  (bases 1 to 6610)
  AUTHORS   Song,B., Shiromoto,Y., Minakuchi,M. and Nishikura,K.
  TITLE     The role of RNA editing enzyme ADAR1 in human disease
  JOURNAL   Wiley Interdiscip Rev RNA 13 (1), e1665 (2022)
   PUBMED   34105255
  REMARK    Review article
REFERENCE   3  (bases 1 to 6610)
  AUTHORS   Herbert,A.
  TITLE     ADAR and Immune Silencing in Cancer
  JOURNAL   Trends Cancer 5 (5), 272-282 (2019)
   PUBMED   31174840
  REMARK    Review article
REFERENCE   4  (bases 1 to 6610)
  AUTHORS   Nishikura,K.
  TITLE     Functions and regulation of RNA editing by ADAR deaminases
  JOURNAL   Annu Rev Biochem 79, 321-349 (2010)
   PUBMED   20192758
  REMARK    Review article
REFERENCE   5  (bases 1 to 6610)
  AUTHORS   Poulsen,H., Nilsson,J., Damgaard,C.K., Egebjerg,J. and Kjems,J.
  TITLE     CRM1 mediates the export of ADAR1 through a nuclear export signal
            within the Z-DNA binding domain
  JOURNAL   Mol Cell Biol 21 (22), 7862-7871 (2001)
   PUBMED   11604520
REFERENCE   6  (bases 1 to 6610)
  AUTHORS   George,C.X. and Samuel,C.E.
  TITLE     Human RNA-specific adenosine deaminase ADAR1 transcripts possess
            alternative exon 1 structures that initiate from different
            promoters, one constitutively active and the other interferon
            inducible
  JOURNAL   Proc Natl Acad Sci U S A 96 (8), 4621-4626 (1999)
   PUBMED   10200312
REFERENCE   7  (bases 1 to 6610)
  AUTHORS   Liu,Y., George,C.X., Patterson,J.B. and Samuel,C.E.
  TITLE     Functionally distinct double-stranded RNA-binding domains
            associated with alternative splice site variants of the
            interferon-inducible double-stranded RNA-specific adenosine
            deaminase
  JOURNAL   J Biol Chem 272 (7), 4419-4428 (1997)
   PUBMED   9020165
REFERENCE   8  (bases 1 to 6610)
  AUTHORS   Wang,Y., Zeng,Y., Murray,J.M. and Nishikura,K.
  TITLE     Genomic organization and chromosomal location of the human dsRNA
            adenosine deaminase gene: the enzyme for glutamate-activated ion
            channel RNA editing
  JOURNAL   J Mol Biol 254 (2), 184-195 (1995)
   PUBMED   7490742
REFERENCE   9  (bases 1 to 6610)
  AUTHORS   Patterson,J.B. and Samuel,C.E.
  TITLE     Expression and regulation by interferon of a
            double-stranded-RNA-specific adenosine deaminase from human cells:
            evidence for two forms of the deaminase
  JOURNAL   Mol Cell Biol 15 (10), 5376-5388 (1995)
   PUBMED   7565688
REFERENCE   10 (bases 1 to 6610)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
REFERENCE   11 (bases 1 to 6610)
  AUTHORS   Crow,Y.J.
  TITLE     Aicardi-Goutieres Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301648
REFERENCE   12 (bases 1 to 6610)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK304153.1, AA449679.1,
            AL606500.8, U10439.1, AL592078.10 and AI309328.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2018 this sequence version replaced NM_001111.4.
            
            Summary: This gene encodes the enzyme responsible for RNA editing
            by site-specific deamination of adenosines. This enzyme
            destabilizes double-stranded RNA through conversion of adenosine to
            inosine. Mutations in this gene have been associated with
            dyschromatosis symmetrica hereditaria. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes isoform (a, also
            referred to as ADAR-a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10439.1, U18121.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368474.9/ ENSP00000357459.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AK304153.1         17-273
            258-418             AA449679.1         105-265
            419-478             AL606500.8         15706-15765         c
            479-3971            U10439.1           453-3945
            3972-5804           U10439.1           3947-5779
            5805-5805           AL592078.10        3783-3783
            5806-6598           U10439.1           5780-6572
            6599-6610           AI309328.1         13-24               c
FEATURES             Location/Qualifiers
     source          1..6610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..6610
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /note="adenosine deaminase RNA specific"
                     /db_xref="GeneID:103"
                     /db_xref="HGNC:HGNC:225"
                     /db_xref="MIM:146920"
     exon            1..195
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3861
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /EC_number="3.5.4.37"
                     /note="isoform a is encoded by transcript variant 1;
                     interferon-induced protein 4; interferon-inducible protein
                     4; dsRNA adenosine deaminase; adenosine deaminase acting
                     on RNA 1-A; 136 kDa double-stranded RNA-binding protein;
                     dsRNA adeonosine deaminase"
                     /codon_start=1
                     /product="double-stranded RNA-specific adenosine deaminase
                     isoform a"
                     /protein_id="NP_001102.3"
                     /db_xref="CCDS:CCDS1071.1"
                     /db_xref="GeneID:103"
                     /db_xref="HGNC:HGNC:225"
                     /db_xref="MIM:146920"
                     /translation="MNPRQGYSLSGYYTHPFQGYEHRQLRYQQPGPGSSPSSFLLKQI
                     EFLKGQLPEAPVIGKQTPSLPPSLPGLRPRFPVLLASSTRGRQVDIRGVPRGVHLRSQ
                     GLQRGFQHPSPRGRSLPQRGVDCLSSHFQELSIYQDQEQRILKFLEELGEGKATTAHD
                     LSGKLGTPKKEINRVLYSLAKKGKLQKEAGTPPLWKIAVSTQAWNQHSGVVRPDGHSQ
                     GAPNSDPSLEPEDRNSTSVSEDLLEPFIAVSAQAWNQHSGVVRPDSHSQGSPNSDPGL
                     EPEDSNSTSALEDPLEFLDMAEIKEKICDYLFNVSDSSALNLAKNIGLTKARDINAVL
                     IDMERQGDVYRQGTTPPIWHLTDKKRERMQIKRNTNSVPETAPAAIPETKRNAEFLTC
                     NIPTSNASNNMVTTEKVENGQEPVIKLENRQEARPEPARLKPPVHYNGPSKAGYVDFE
                     NGQWATDDIPDDLNSIRAAPGEFRAIMEMPSFYSHGLPRCSPYKKLTECQLKNPISGL
                     LEYAQFASQTCEFNMIEQSGPPHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAMKAM
                     TILLEEAKAKDSGKSEESSHYSTEKESEKTAESQTPTPSATSFFSGKSPVTTLLECMH
                     KLGNSCEFRLLSKEGPAHEPKFQYCVAVGAQTFPSVSAPSKKVAKQMAAEEAMKALHG
                     EATNSMASDNQPEGMISESLDNLESMMPNKVRKIGELVRYLNTNPVGGLLEYARSHGF
                     AAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQEAADAALRVLIGENEK
                     AERMGFTEVTPVTGASLRRTMLLLSRSPEAQPKTLPLTGSTFHDQIAMLSHRCFNTLT
                     NSFQPSLLGRKILAAIIMKKDSEDMGVVVSLGTGNRCVKGDSLSLKGETVNDCHAEII
                     SRRGFIRFLYSELMKYNSQTAKDSIFEPAKGGEKLQIKKTVSFHLYISTAPCGDGALF
                     DKSCSDRAMESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGER
                     LRTMSCSDKILRWNVLGLQGALLTHFLQPIYLKSVTLGYLFSQGHLTRAICCRVTRDG
                     SAFEDGLRHPFIVNHPKVGRVSIYDSKRQSGKTKETSVNWCLADGYDLEILDGTRGTV
                     DGPRNELSRVSKKNIFLLFKKLCSFRYRRDLLRLSYGEAKKAARDYETAKNYFKKGLK
                     DMGYGNWISKPQEEKNFYLCPV"
     exon            196..1781
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1965
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2114
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2259
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2450
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2676
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2848
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2942
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3065
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3199
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3382
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3495
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3623
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..6610
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6576..6581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /note="hexamer: AATAAA"
     regulatory      6587..6592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /note="hexamer: AACAAG"
     polyA_site      6606
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
                     /note="major polyA site"
     polyA_site      6610
                     /gene="ADAR"
                     /gene_synonym="ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1;
                     IFI-4; IFI4; K88DSRBP; P136"
ORIGIN      
        1 gaaccggagc catcttgggc ccggcgcgca gacccgcgga gtttcccgtg ccgacgcccc
       61 ggggccactt ccagtgcgga gtagcggagg cgtgggggcc tcgaggggct ggcgcggccc
      121 agcggtcggg ccagggtcgt gccgccggcg ggtcgggccg ggcaatgcct cgcgggcgca
      181 atgaatccgc ggcaggggta ttccctcagc ggatactaca cccatccatt tcaaggctat
      241 gagcacagac agctcaggta ccagcagcct gggccaggat cttcccccag tagtttcctg
      301 cttaagcaaa tagaatttct caaggggcag ctcccagaag caccggtgat tggaaagcag
      361 acaccgtcac tgccaccttc cctcccagga ctccggccaa ggtttccagt actacttgcc
      421 tccagtacca gaggcaggca agtggacatc aggggtgtcc ccaggggcgt gcatctcaga
      481 agtcaggggc tccagagagg gttccagcat ccttcaccac gtggcaggag tctgccacag
      541 agaggtgttg attgcctttc ctcacatttc caggaactga gtatctacca agatcaggaa
      601 caaaggatct taaagttcct ggaagagctt ggggaaggga aggccaccac agcacatgat
      661 ctgtctggga aacttgggac tccgaagaaa gaaatcaatc gagttttata ctccctggca
      721 aagaagggca agctacagaa agaggcagga acaccccctt tgtggaaaat cgcggtctcc
      781 actcaggctt ggaaccagca cagcggagtg gtaagaccag acggtcatag ccaaggagcc
      841 ccaaactcag acccgagttt ggaaccggaa gacagaaact ccacatctgt ctcagaagat
      901 cttcttgagc cttttattgc agtctcagct caggcttgga accagcacag cggagtggta
      961 agaccagaca gtcatagcca aggatcccca aactcagacc caggtttgga acctgaagac
     1021 agcaactcca catctgcctt ggaagatcct cttgagtttt tagacatggc cgagatcaag
     1081 gagaaaatct gcgactatct cttcaatgtg tctgactcct ctgccctgaa tttggctaaa
     1141 aatattggcc ttaccaaggc ccgagatata aatgctgtgc taattgacat ggaaaggcag
     1201 ggggatgtct atagacaagg gacaacccct cccatatggc atttgacaga caagaagcga
     1261 gagaggatgc aaatcaagag aaatacgaac agtgttcctg aaaccgctcc agctgcaatc
     1321 cctgagacca aaagaaacgc agagttcctc acctgtaata tacccacatc aaatgcctca
     1381 aataacatgg taaccacaga aaaagtggag aatgggcagg aacctgtcat aaagttagaa
     1441 aacaggcaag aggccagacc agaaccagca agactgaaac cacctgttca ttacaatggc
     1501 ccctcaaaag cagggtatgt tgactttgaa aatggccagt gggccacaga tgacatccca
     1561 gatgacttga atagtatccg cgcagcacca ggtgagtttc gagccatcat ggagatgccc
     1621 tccttctaca gtcatggctt gccacggtgt tcaccctaca agaaactgac agagtgccag
     1681 ctgaagaacc ccatcagcgg gctgttagaa tatgcccagt tcgctagtca aacctgtgag
     1741 ttcaacatga tagagcagag tggaccaccc catgaacctc gatttaaatt ccaggttgtc
     1801 atcaatggcc gagagtttcc cccagctgaa gctggaagca agaaagtggc caagcaggat
     1861 gcagctatga aagccatgac aattctgcta gaggaagcca aagccaagga cagtggaaaa
     1921 tcagaagaat catcccacta ttccacagag aaagaatcag agaagactgc agagtcccag
     1981 acccccaccc cttcagccac atccttcttt tctgggaaga gccccgtcac cacactgctt
     2041 gagtgtatgc acaaattggg gaactcctgc gaattccgtc tcctgtccaa agaaggccct
     2101 gcccatgaac ccaagttcca atactgtgtt gcagtgggag cccaaacttt ccccagtgtg
     2161 agtgctccca gcaagaaagt ggcaaagcag atggccgcag aggaagccat gaaggccctg
     2221 catggggagg cgaccaactc catggcttct gataaccagc ctgaaggtat gatctcagag
     2281 tcacttgata acttggaatc catgatgccc aacaaggtca ggaagattgg cgagctcgtg
     2341 agatacctga acaccaaccc tgtgggtggc cttttggagt acgcccgctc ccatggcttt
     2401 gctgctgaat tcaagttggt cgaccagtcc ggacctcctc acgagcccaa gttcgtttac
     2461 caagcaaaag ttgggggtcg ctggttccca gccgtctgcg cacacagcaa gaagcaaggc
     2521 aagcaggaag cagcagatgc ggctctccgt gtcttgattg gggagaacga gaaggcagaa
     2581 cgcatgggtt tcacagaggt aaccccagtg acaggggcca gtctcagaag aactatgctc
     2641 ctcctctcaa ggtccccaga agcacagcca aagacactcc ctctcactgg cagcaccttc
     2701 catgaccaga tagccatgct gagccaccgg tgcttcaaca ctctgactaa cagcttccag
     2761 ccctccttgc tcggccgcaa gattctggcc gccatcatta tgaaaaaaga ctctgaggac
     2821 atgggtgtcg tcgtcagctt gggaacaggg aatcgctgtg tgaaaggaga ttctctcagc
     2881 ctaaaaggag aaactgtcaa tgactgccat gcagaaataa tctcccggag aggcttcatc
     2941 aggtttctct acagtgagtt aatgaaatac aactcccaga ctgcgaagga tagtatattt
     3001 gaacctgcta agggaggaga aaagctccaa ataaaaaaga ctgtgtcatt ccatctgtat
     3061 atcagcactg ctccgtgtgg agatggcgcc ctctttgaca agtcctgcag cgaccgtgct
     3121 atggaaagca cagaatcccg ccactaccct gtcttcgaga atcccaaaca aggaaagctc
     3181 cgcaccaagg tggagaacgg agaaggcaca atccctgtgg aatccagtga cattgtgcct
     3241 acgtgggatg gcattcggct cggggagaga ctccgtacca tgtcctgtag tgacaaaatc
     3301 ctacgctgga acgtgctggg cctgcaaggg gcactgttga cccacttcct gcagcccatt
     3361 tatctcaaat ctgtcacatt gggttacctt ttcagccaag ggcatctgac ccgtgctatt
     3421 tgctgtcgtg tgacaagaga tgggagtgca tttgaggatg gactacgaca tccctttatt
     3481 gtcaaccacc ccaaggttgg cagagtcagc atatatgatt ccaaaaggca atccgggaag
     3541 actaaggaga caagcgtcaa ctggtgtctg gctgatggct atgacctgga gatcctggac
     3601 ggtaccagag gcactgtgga tgggccacgg aatgaattgt cccgggtctc caaaaagaac
     3661 atttttcttc tatttaagaa gctctgctcc ttccgttacc gcagggatct actgagactc
     3721 tcctatggtg aggccaagaa agctgcccgt gactacgaga cggccaagaa ctacttcaaa
     3781 aaaggcctga aggatatggg ctatgggaac tggattagca aaccccagga ggaaaagaac
     3841 ttttatctct gcccagtata gtatgctcca gtgacagatg gattagggtg tgtcatacta
     3901 gggtgtgaga gaggtaggtc gtagcattcc tcatcacatg gtcaggggat ttttttttct
     3961 cctttttttt tctttttaag ccataattgg tgatactgaa aactttgggt tcccatttat
     4021 cctgctttct ttgggattgc taggcaaggt ctggccaggc cccccttttt tcccccaagt
     4081 gaagaggcag aaacctaaga agttatcttt tctttctacc caaagcatac atagtcactg
     4141 agcacctgcg gtccatttcc tcttaaaagt tttgttttga tttgtttcca tttcctttcc
     4201 ctttgtgttt gctacactga cctcttgcgg tcttgattag gtttcagtca actctggatc
     4261 atgtcaggga ctgataattt catttgtgga ttacgcagac ccctctactt cccctctttc
     4321 ccttctgaga ttctttcctt gtgatctgaa tgtctccttt tccccctcag agggcaaaga
     4381 ggtgaacata aaggatttgg tgaaacattt gtaagggtag gagttgaaaa ctgcagttcc
     4441 cagtgccacg gaagtgtgat tggagcctgc agataatgcc cagccatcct cccatcctgc
     4501 actttagcca gctgcagggc gggcaaggca aggaaagctg cttccctgga agtgtatcac
     4561 tttctccggc agctgggaag tctagaacca gccagactgg gttaagggag ctgctcaagc
     4621 aatagcagag gtttcacccg gcaggatgac acagaccact tcccagggag cacgggcatg
     4681 ccttggaata ttgccaagct tccagctgcc tcttctccta aagcattcct aggaatattt
     4741 tccccgccaa tgctgggcgt acaccctagc caacgggaca aatcctagag ggtataaaat
     4801 catctctgct cagataatca tgacttagca agaataaggg caaaaaatcc tgttggctta
     4861 acgtcactgt tccacccggt gtaatatctc tcatgacagt gacaccaagg gaagttgact
     4921 aagtcacatg taaattagga gtgttttaaa gaatgccata gatgttgatt cttaactgct
     4981 acagataacc tgtaattgag cagatttaaa attcaggcat acttttccat ttatccaagt
     5041 gctttcattt ttccagatgg cttcagaagt aggctcgtgg gcagggcgca gacctgatct
     5101 ttatagggtt gacatagaaa gcagtagttg tgggtgaaag ggcaggttgt cttcaaactc
     5161 tgtgaggtag aatcctttgt ctatacctcc atgaacattg actcgtgtgt tcagagcctt
     5221 tggcctctct gtggagtctg gctctctggc tcctgtgcat tctttgaata gtcactcgta
     5281 aaaactgtca gtgcttgaaa ctgtttcctt tactcatgtt gaagggactt tgttggcttt
     5341 tagagtgttg gtcatgactc caagagcaga gcagggaaga gcccaagcat agacttggtg
     5401 ccgtggtgat ggctgcagtc cagttttgtg atgctgcttt tacgtgtccc tcgataacag
     5461 tcagctagac acactcagga ggactactga ggctctgcga ccttcaggag ctgagcctgc
     5521 ctctctcctt tagatgacag accttcatct gggaacgtgc tgagccagca ccctcagatg
     5581 atttccctcc aaactgctga ctaggtcatc ctctgtctgg tagagacatt cacatctttg
     5641 cttttattct atgctctctg tacttttgac caaaaattga ccaaagtaag aaaatgcaag
     5701 ttctaaaaat agactaagga tgcctttgca gaacaccaaa gcatcccaag gaactggtag
     5761 ggaagtggcg cctgtctcct ggagtggaag aggcctgctc cctggctctg ggtctgctgg
     5821 gggcacagta aatcagtctt ggcacccaca tccagggcag agaggtctgt ggttctcagc
     5881 atcagaaggc agcgcagccc ctctcctctt caggctacag ggttgtcacc tgctgagtcc
     5941 tcaggttgtt tggcctctct ggtccatctt gggcattagg ttctccagca gagctctggc
     6001 cagctgcctc ttctttaact gggaacacag gctctcacaa gatcagaacc cccactcacc
     6061 cccaagatct tatctagcaa gcctgtagta ttcagtttct gttgtaggaa gagagcgagg
     6121 catccctgaa ttccacgcat ctgctggaaa cgagccgtgt cagatcgcac atccctgcgc
     6181 ccccatgccc ctctgagtca cacaggacag aggaggcaga gcttctgccc actgttatct
     6241 tcactttctt tgtccagtct tttgttttta ataagcagtg accctcccta ctcttctttt
     6301 taatgatttt tgtagttgat ttgtctgaac tgtggctact gtgcattcct tgaataatca
     6361 cttgtaaaaa ttgtcagtgc ttgaagctgt ttcctttact cacattgaag ggacttcgtt
     6421 ggttttttgg agtcttggtt gtgactccaa gagcagagtg aggaagaccc ccaagcatag
     6481 actcgggtac tgtgatgatg gctgcagtcc agttttatga ttctgctttt atgtgtccct
     6541 tgataacagt gacttaacaa tatacattcc tcataaataa aaaaaaaaca agaatctgaa
     6601 ttcttagaaa
//
