LOCUS       NM_018404               2669 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ArfGAP with dual PH domains 2 (ADAP2), transcript
            variant 2, mRNA.
ACCESSION   NM_018404
VERSION     NM_018404.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Qiang,Y., Wang,X., Ding,J., Wang,Z., Li,B., Ji,H., Zhang,X.,
            Yang,Y., Liu,K., Zhang,L., Ma,S., Zhao,D. and Lu,G.
  TITLE     Elevated Expression of ADAP2 is Associated With Aggressive Behavior
            of Human Clear-Cell Renal Cell Carcinoma and Poor Patient Survival
  JOURNAL   Clin Genitourin Cancer 21 (2), e78-e91 (2023)
   PUBMED   36127253
  REMARK    GeneRIF: Elevated Expression of ADAP2 is Associated With Aggressive
            Behavior of Human Clear-Cell Renal Cell Carcinoma and Poor Patient
            Survival.
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Bist,P., Kim,S.S., Pulloor,N.K., McCaffrey,K., Nair,S.K., Liu,Y.,
            Lin,R. and Krishnan,M.N.
  TITLE     ArfGAP Domain-Containing Protein 2 (ADAP2) Integrates Upstream and
            Downstream Modules of RIG-I Signaling and Facilitates Type I
            Interferon Production
  JOURNAL   Mol Cell Biol 37 (6), e00537-16 (2017)
   PUBMED   27956705
  REMARK    GeneRIF: ArfGAP domain-containing protein 2 (ADAP2) is identified
            as a key novel scaffolding protein that integrates different
            modules of the RIG-I pathway, located at distinct subcellular
            locations, and mediates cellular antiviral type I interferon
            production.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2669)
  AUTHORS   Shu,Q., Lennemann,N.J., Sarkar,S.N., Sadovsky,Y. and Coyne,C.B.
  TITLE     ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus
            Entry
  JOURNAL   PLoS Pathog 11 (9), e1005150 (2015)
   PUBMED   26372645
  REMARK    GeneRIF: Data suggest ADAP2 (an interferon-beta stimulated gene)
            disrupts pathogenic internalization of some RNA viruses/virions
            (dengue, vesicular stomatitis) by altering ADP ribosylation factor
            6-mediated processes including up-regulation of pinocytosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2669)
  AUTHORS   Zuccotti,P., Cartelli,D., Stroppi,M., Pandini,V., Venturin,M.,
            Aliverti,A., Battaglioli,E., Cappelletti,G. and Riva,P.
  TITLE     Centaurin-alpha interacts with beta-tubulin and stabilizes
            microtubules
  JOURNAL   PLoS One 7 (12), e52867 (2012)
   PUBMED   23285209
  REMARK    GeneRIF: Centaurin-alpha interacts with beta-tubulin and stabilizes
            microtubules.
REFERENCE   5  (bases 1 to 2669)
  AUTHORS   Fenner,B.J., Scannell,M. and Prehn,J.H.
  TITLE     Expanding the substantial interactome of NEMO using protein
            microarrays
  JOURNAL   PLoS One 5 (1), e8799 (2010)
   PUBMED   20098747
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2669)
  AUTHORS   Venturin,M., Bentivegna,A., Moroni,R., Larizza,L. and Riva,P.
  TITLE     Evidence by expression analysis of candidate genes for congenital
            heart defects in the NF1 microdeletion interval
  JOURNAL   Ann Hum Genet 69 (Pt 5), 508-516 (2005)
   PUBMED   16138909
REFERENCE   7  (bases 1 to 2669)
  AUTHORS   Hanck,T., Stricker,R., Sedehizade,F. and Reiser,G.
  TITLE     Identification of gene structure and subcellular localization of
            human centaurin alpha 2, and p42IP4, a family of two highly
            homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter
            proteins
  JOURNAL   J Neurochem 88 (2), 326-336 (2004)
   PUBMED   14690521
  REMARK    GeneRIF: The human gene for centaurin alpha 2 is located on
            chromosome 17, position 17q11.2, near the neurofibromatosis 1 (NF1)
            locus and concentrated at the plasma membrane.
REFERENCE   8  (bases 1 to 2669)
  AUTHORS   Whitley,P., Gibbard,A.M., Koumanov,F., Oldfield,S., Kilgour,E.E.,
            Prestwich,G.D. and Holman,G.D.
  TITLE     Identification of centaurin-alpha2: a phosphatidylinositide-binding
            protein present in fat, heart and skeletal muscle
  JOURNAL   Eur J Cell Biol 81 (4), 222-230 (2002)
   PUBMED   12018390
REFERENCE   9  (bases 1 to 2669)
  AUTHORS   Jenne,D.E., Tinschert,S., Stegmann,E., Reimann,H., Nurnberg,P.,
            Horn,D., Naumann,I., Buske,A. and Thiel,G.
  TITLE     A common set of at least 11 functional genes is lost in the
            majority of NF1 patients with gross deletions
  JOURNAL   Genomics 66 (1), 93-97 (2000)
   PUBMED   10843809
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ272195.1, BC033758.1 and
            AC138207.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018404.2.
            
            Summary: The protein encoded by this gene binds beta-tubulin and
            increases the stability of microtubules. The encoded protein can
            also translocate to the cell membrane and bind phosphatidylinositol
            3,4,5-trisphosphate (PtdInsP3) and inositol
            1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a
            GTPase-activating protein for ADP ribosylation factor 6 and may be
            able to block the entry of some RNA viruses. [provided by RefSeq,
            Oct 2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.213282.1, AJ272195.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330889.8/ ENSP00000329468.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1660              AJ272195.1         31-1690
            1661-1907           BC033758.1         1684-1930
            1908-2540           AJ272195.1         1938-2570
            2541-2669           AC138207.3         161066-161194       c
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..2669
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /note="ArfGAP with dual PH domains 2"
                     /db_xref="GeneID:55803"
                     /db_xref="HGNC:HGNC:16487"
                     /db_xref="MIM:608635"
     exon            1..164
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1216
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /note="isoform 2 is encoded by transcript variant 2;
                     centaurin-alpha 2 protein; arf-GAP with dual PH
                     domain-containing protein 2; centaurin beta"
                     /codon_start=1
                     /product="arf-GAP with dual PH domain-containing protein 2
                     isoform 2"
                     /protein_id="NP_060874.1"
                     /db_xref="CCDS:CCDS11261.1"
                     /db_xref="GeneID:55803"
                     /db_xref="HGNC:HGNC:16487"
                     /db_xref="MIM:608635"
                     /translation="MGDRERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFI
                     CLNCCGVHRNFPDISRVKSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQA
                     NDCLVLKEQWIRAKYERREFMADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLARE
                     GLLKYFTKEQGKSPKAVISIKDLNATFQTEKIGHPHGLQITYRRDGHTRNLFVYHESG
                     KEIVDWFNALRAARLQYLKMAFPELPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKR
                     WFALDCHERRLLYYKNPLDAFEQGQVFLGNKEQGYEAYEDLPKGIRGNRWKAGLTIVT
                     PERRFVLTCPSEKEQQEWLESLRGVLSSPLTPLNRLTASTESGRSSR"
     exon            165..295
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     exon            296..387
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     exon            388..467
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     exon            468..580
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     exon            581..727
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     exon            728..811
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     exon            812..874
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     exon            875..952
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1181
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..2669
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2516..2521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /note="hexamer: AATAAA"
     polyA_site      2544
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /note="major polyA site"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
                     /note="hexamer: GATAAA"
     polyA_site      2669
                     /gene="ADAP2"
                     /gene_synonym="cent-b; CENTA2; HSA272195"
ORIGIN      
        1 gtccctctcc acctgccggg cggagcgcac gggccatggg ctgagccccg ctgagcccgc
       61 cgggccggcc atgggcgatc gcgagcgcaa caagaagcgg ctgctggagc tgctgcgggc
      121 gccggacaca ggcaacgcgc actgcgccga ctgcggggcg gcagatcccg actgggcctc
      181 ttacaagctg gggatcttca tctgtctcaa ctgctgcggc gtccaccgta acttccctga
      241 catcagcaga gttaaatctg tgcgacttga cttctgggac gacagtattg tggagtttat
      301 gatccacaat ggaaacctcc gtgtgaaggc caagttcgaa gccagagtcc cagctttcta
      361 ctacatcccc caggccaacg actgcctggt cttaaaggaa caatggattc gagctaagta
      421 tgagagacgg gaatttatgg ctgatgggga aaccatctcg ctcccaggta accgagaagg
      481 attcctgtgg aagcgaggaa gggacaactc acagtttctg agaaggaagt ttgtacttct
      541 ggcaagagaa ggcctcctga agtacttcac aaaggaacag ggtaaaagcc ccaaagctgt
      601 catcagcatt aaggacttga atgccacctt ccagacagag aagatagggc acccccatgg
      661 gctgcagatc acctacagga gagatggcca caccaggaac ctgtttgtgt atcatgaaag
      721 tgggaaggag atagtggact ggttcaatgc cctccgtgca gcccgtctgc agtacctaaa
      781 aatggccttt cctgaactcc cagagtctga gctcgtgcca ttcctcacca ggaactacct
      841 caaacaaggc ttcatggaaa agactgggcc aaagcagaaa gaacctttca agaaaaggtg
      901 gttcgccctg gattgccatg agcggaggct gctctattac aagaacccac tggatgcctt
      961 cgagcagggc caggtttttc ttgggaacaa ggagcaggga tatgaagcct acgaagacct
     1021 gcccaagggc atccgaggaa atcgctggaa agccggactc accattgtca ccccagagcg
     1081 gagatttgtc ctcacttgcc ccagtgagaa ggaacagcag gaatggctgg aaagtttgcg
     1141 gggtgtcctg tccagcccct tgacgcccct caaccggctt actgcatcaa cagagagtgg
     1201 ccgcagcagc aggtgaccca ttaactgagg aactggctgc cactgaacac ctggaactcc
     1261 ttgtgggaag aagtttgcac ctcggccctg gctgcccacc atcagtgccc cgcagtcagc
     1321 agccattcct ggcagtgaac tctgccagga ctgaagctgt ggctttatcc atcagctccc
     1381 tgggccttcc ccgcaaccca cctcggggat ctgaggatct ggtgcataga tgaacatcta
     1441 tcccctcctc ccccatacac acctaggctt gaaatgccct acaggcccag aactttctca
     1501 catctgaaat ggaggcattg caatgaaaag gcacccacag catcatgcaa gtggcatctt
     1561 gtaaaaaaaa aaaaaaagtt taatctgaat ctaaccatga ggaaataatc agacaaatcc
     1621 acattagggg cattctgcta aacatctgac ccagactctt caaaaatgaa gagtgaaaga
     1681 taaagtagtc aatggccggg cgcagtgaga ttgcgccatt gcattccagc ctgggtgaca
     1741 gagcgagact ccgtatcaga aagaaaaaga ggaactgaat gaaatctcag atggctgaaa
     1801 tgttagagaa acagagcacc aagtcccctg ctctgtgact cgttgttcct ttcctctgtc
     1861 ttcaagcacc acgcagaaat acactggatg ttctctcttt gcttcaatgg agacccaagg
     1921 agctgggagg tctcttaaga gactctctga ttctccgtgg ctgggtgtga tggctcatgc
     1981 ccataatccc agccctttgg gaagctgagg caggaggatt gagaccagga gttcgagaag
     2041 agcctgggca acatagtgag accccatctc tacaaagaaa aaaaaattag ctggacatgg
     2101 taatgaatgc ctgtagtccc agctactccg gacactgatg tgagaggatc acttgagcca
     2161 gggaggtcat ggctacagtg acccctcatt gcaccacttt acttagcctg ggtgacagag
     2221 tgagacccta tctcaaaaaa aaaaaaaatc tatgcattgt atgggacttt cctttggatc
     2281 ccccaatcaa aggataagca atgcgtaagc ctgtgtcctt cctgaagctt ctcgactgcc
     2341 cagataggga ggtgagtcct ctctatctcc tctggctctg gaagcacctt gaaaatgtgc
     2401 attttcaagg acacttgctg ggttgtgcat taagggccag tttacttgtc tgcctctttg
     2461 accacctgtg aactctgttg ggtgtactct gctaagttct ggggatgagg aaattaataa
     2521 aggtacagtc ttgccttcaa ggaacttatg gtctagagga gaagaacgag aagtatagat
     2581 aggcagtaac aaagctactt gaagaggcca actgggattc taagggtggg aaagaacaga
     2641 cacaagagat aaagtcctaa tgaaatgga
//
