LOCUS       NM_006869               2349 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens ArfGAP with dual PH domains 1 (ADAP1), transcript
            variant 1, mRNA.
ACCESSION   NM_006869
VERSION     NM_006869.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Suzuki,K., Okawa,Y., Akter,S., Ito,H. and Shiba,Y.
  TITLE     Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate
            incorporation of CD63 in multivesicular bodies
  JOURNAL   Biol Open 13 (5) (2024)
   PUBMED   38682696
  REMARK    GeneRIF: Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate
            incorporation of CD63 in multivesicular bodies.
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Liu,Z., Liu,R., Gao,H., Jung,S., Gao,X., Sun,R., Liu,X., Kim,Y.,
            Lee,H.S., Kawai,Y., Nagasaki,M., Umeno,J., Tokunaga,K.,
            Kinouchi,Y., Masamune,A., Shi,W., Shen,C., Guo,Z., Yuan,K., Zhu,S.,
            Li,D., Liu,J., Ge,T., Cho,J., Daly,M.J., McGovern,D.P.B., Ye,B.D.,
            Song,K., Kakuta,Y., Li,M. and Huang,H.
  CONSRTM   FinnGen; International Inflammatory Bowel Disease Genetics
            Consortium; Chinese Inflammatory Bowel Disease Genetics Consortium
  TITLE     Genetic architecture of the inflammatory bowel diseases across East
            Asian and European ancestries
  JOURNAL   Nat Genet 55 (5), 796-806 (2023)
   PUBMED   37156999
  REMARK    GeneRIF: Genetic architecture of the inflammatory bowel diseases
            across East Asian and European ancestries.
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Talebi,A., Shahidsales,S., Aliakbarian,M., Pezeshki Rad,M. and
            Kerachian,M.A.
  TITLE     Oncogenic fusion transcript analysis identified ADAP1-NOC4L,
            potentially associated with metastatic colorectal cancer
  JOURNAL   Cancer Med 12 (1), 525-540 (2023)
   PUBMED   35702822
  REMARK    GeneRIF: Oncogenic fusion transcript analysis identified
            ADAP1-NOC4L, potentially associated with metastatic colorectal
            cancer.
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Ramirez,N.P., Lee,J., Zheng,Y., Li,L., Dennis,B., Chen,D.,
            Challa,A., Planelles,V., Westover,K.D., Alto,N.M. and D'Orso,I.
  TITLE     ADAP1 promotes latent HIV-1 reactivation by selectively tuning
            KRAS-ERK-AP-1 T cell signaling-transcriptional axis
  JOURNAL   Nat Commun 13 (1), 1109 (2022)
   PUBMED   35232997
  REMARK    GeneRIF: ADAP1 promotes latent HIV-1 reactivation by selectively
            tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Duellberg,C., Auer,A., Canigova,N., Loibl,K. and Loose,M.
  TITLE     In vitro reconstitution reveals phosphoinositides as cargo-release
            factors and activators of the ARF6 GAP ADAP1
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33443153
  REMARK    GeneRIF: In vitro reconstitution reveals phosphoinositides as
            cargo-release factors and activators of the ARF6 GAP ADAP1.
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Whitley,P., Gibbard,A.M., Koumanov,F., Oldfield,S., Kilgour,E.E.,
            Prestwich,G.D. and Holman,G.D.
  TITLE     Identification of centaurin-alpha2: a phosphatidylinositide-binding
            protein present in fat, heart and skeletal muscle
  JOURNAL   Eur J Cell Biol 81 (4), 222-230 (2002)
   PUBMED   12018390
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Sedehizade,F., Hanck,T., Stricker,R., Horstmayer,A., Bernstein,H.G.
            and Reiser,G.
  TITLE     Cellular expression and subcellular localization of the human
            Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in
            neuronal cells
  JOURNAL   Brain Res Mol Brain Res 99 (1), 1-11 (2002)
   PUBMED   11869802
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Dubois,T., Kerai,P., Zemlickova,E., Howell,S., Jackson,T.R.,
            Venkateswarlu,K., Cullen,P.J., Theibert,A.B., Larose,L., Roach,P.J.
            and Aitken,A.
  TITLE     Casein kinase I associates with members of the centaurin-alpha
            family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins
  JOURNAL   J Biol Chem 276 (22), 18757-18764 (2001)
   PUBMED   11278595
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Venkateswarlu,K. and Cullen,P.J.
  TITLE     Molecular cloning and functional characterization of a human
            homologue of centaurin-alpha
  JOURNAL   Biochem Biophys Res Commun 262 (1), 237-244 (1999)
   PUBMED   10448098
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Venkateswarlu,K., Oatey,P.B., Tavare,J.M., Jackson,T.R. and
            Cullen,P.J.
  TITLE     Identification of centaurin-alpha1 as a potential in vivo
            phosphatidylinositol 3,4,5-trisphosphate-binding protein that is
            functionally homologous to the yeast ADP-ribosylation factor (ARF)
            GTPase-activating protein, Gcs1
  JOURNAL   Biochem J 340 (Pt 2) (Pt 2), 359-363 (1999)
   PUBMED   10333475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073957.7.
            
            On Nov 23, 2018 this sequence version replaced NM_006869.3.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.31505.1, AB097049.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265846.10/ ENSP00000265846.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AC073957.7         75456-75740         c
            286-416             AC073957.7         56435-56565         c
            417-508             AC073957.7         47613-47704         c
            509-591             AC073957.7         41029-41111         c
            592-704             AC073957.7         26121-26233         c
            705-851             AC073957.7         25187-25333         c
            852-935             AC073957.7         21594-21677         c
            936-998             AC073957.7         21163-21225         c
            999-1070            AC073957.7         20480-20551         c
            1071-1299           AC073957.7         20094-20322         c
            1300-2349           AC073957.7         18961-20010         c
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..2349
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /note="ArfGAP with dual PH domains 1"
                     /db_xref="GeneID:11033"
                     /db_xref="HGNC:HGNC:16486"
                     /db_xref="MIM:608114"
     exon            1..285
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1328
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centaurin-alpha; arf-GAP with dual PH domain-containing
                     protein 1; cnt-a1; centaurin-alpha-1; putative
                     MAPK-activating protein PM25"
                     /codon_start=1
                     /product="arf-GAP with dual PH domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_006860.2"
                     /db_xref="CCDS:CCDS5318.1"
                     /db_xref="GeneID:11033"
                     /db_xref="HGNC:HGNC:16486"
                     /db_xref="MIM:608114"
                     /translation="MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSC
                     SGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQ
                     LLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGAL
                     KYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEI
                     VDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFT
                     MDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKF
                     LFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP"
     exon            286..416
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            417..508
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            509..591
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            592..704
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            705..851
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            852..935
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            936..998
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1070
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1299
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..2349
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /note="hexamer: AATAAA"
     polyA_site      2349
                     /gene="ADAP1"
                     /gene_synonym="CENTA1; GCS1L; p42IP4"
                     /note="major polyA site"
ORIGIN      
        1 actcgctcag cgaccgcggc ggagacacga gcggcggcgg cggagcccag agggcggcgg
       61 gaatgcggaa ccggcgcgcg ggctgaggcc gcccgggatg gcgcaggggc ggcggcggcg
      121 ggcggcctgc gcggggccct agcgagccgg gctgacgctc ccggccccgg ccccggcatc
      181 ggcatcgcgg gcgcatcgcg gccatggcca aggagcggcg cagggcggtc ctggagctgc
      241 tgcagcggcc ggggaacgcg cgctgcgcgg actgcggcgc cccggatccc gactgggcct
      301 cctacactct gggcgtcttc atctgcctga gctgctcggg aatccaccgg aatatccccc
      361 aggtcagcaa ggtgaagtcc gtccgcctgg acgcctggga ggaggcccaa gtggagttca
      421 tggcctccca cgggaacgac gccgcgagag ccaggtttga gtccaaagta ccctccttct
      481 actaccggcc cacgccctcc gactgccagc tccttcgaga gcagtggatc cgggccaagt
      541 acgagcgaca ggagttcatc tacccggaga agcaggagcc ctactcggca gggtaccgtg
      601 agggttttct ctggaagcgt ggccgggaca acgggcagtt tttgagccgg aagtttgtgc
      661 tgacagaacg agagggtgct ctgaagtatt tcaacagaaa tgatgccaag gagcccaagg
      721 ccgtgatgaa gatcgagcac ctgaacgcca ccttccagcc ggccaagatc ggccaccccc
      781 acggcctgca ggtcacctac ctgaaggaca acagcacccg taacatcttc atctaccatg
      841 aggacgggaa ggagattgtg gactggttca atgcactccg agctgctcgc ttccactacc
      901 tgcaggtggc attcccaggg gccggcgacg cagatctggt gccaaagctc tccaggaact
      961 acctgaagga aggctacatg gagaagacgg ggcccaagca aacggaaggc ttccggaagc
     1021 gctggttcac catggatgac cgcaggctca tgtacttcaa agaccccctg gacgccttcg
     1081 cccgagggga agtcttcatt ggcagcaagg agagtggcta cacggtgctg catgggttcc
     1141 cgccgtccac ccagggccac cactggccac atggcatcac catcgtcacg cccgaccgca
     1201 agtttctgtt tgcctgcgag acggagtccg accagaggga gtgggtggcg gccttccaga
     1261 aggcggtgga caggcccatg ctgccccagg agtacgcagt ggaggcgcac ttcaagcata
     1321 aaccttagcg agtgcggctg gaggaccacg gacattggac tcactgtggc tggacggagg
     1381 ggacccgtgg atgggggggc tctggcgtcc tgaggccacc tggccccacc tgctcctcag
     1441 ggcagcccgg cgcggccagg tagggcccga gcttcagctt ccaggatgct tctctggaac
     1501 ctcaaggcag gcagcccagg ccctgggcct gatctctaac cccgtcatgc tgctgctgac
     1561 cacacccagc caacctgccc ctccctgacc cggggccccc tttcctccag ggcccagtct
     1621 ggctcccgag ctcagacaca gcccccagga gccgcccacc acggctgtgg gaacttccag
     1681 gcctcagcgc agagccctgc ttggggccag cacggtgggc agctgccggc cgctggggac
     1741 tgggccctgc tcgcatgccg ccccgccctc cccccacctc cacgactatt tattgagcgc
     1801 ctgttgtgtg tcacggggct atgagggccg tggggtgttt gggtggatta tccacacagg
     1861 tcccggcccc tgcccgggct ggagttgcca cagcctgtgc tcctggtcct cacctggagg
     1921 ggccagcagg ctgccgtccc accacacgtg gcctctgcgc ccagcacggt gctcgccgac
     1981 agtggtgtct gaacccttgg ggacgagggc ctgggccgcg gtgaggccac cagaggcagg
     2041 agtggccctg ggggtcccgg gcactgtcgc gcttgctgca ggcggcccag ccgtgtattt
     2101 atttttcacc tatctccttc ctgtcaaggc aggccgggct ccagggctcc ccttgcgtgg
     2161 ggcatgtagg tgggggaggc gtctgcaggt cacctggggg gcccagccct ctcccagcct
     2221 tgcctggctg agctgtgttc caggggagcc ctggacaagc cctcataggc agggaggggg
     2281 tttccgaggc caggcatccg ccgccccgtg tcgcatcctg gaataaaatg tggctctggc
     2341 atggttcca
//
