LOCUS       NM_019032               4212 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ADAMTS like 4 (ADAMTSL4), transcript variant 1, mRNA.
ACCESSION   NM_019032
VERSION     NM_019032.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4212)
  AUTHORS   Chen,T., Liu,Y., Zhao,Y., Wang,M., Song,L. and Jiang,Y.
  TITLE     Mutations in ADAMTSL4 cause a unique form of autosomal-recessive
            congenital ectopia lentis
  JOURNAL   Exp Eye Res 248, 110090 (2024)
   PUBMED   39278391
  REMARK    GeneRIF: Mutations in ADAMTSL4 cause a unique form of
            autosomal-recessive congenital ectopia lentis.
REFERENCE   2  (bases 1 to 4212)
  AUTHORS   Guo,D., Yang,F., Zhou,Y., Zhang,X., Cao,Q., Jin,G. and Zheng,D.
  TITLE     Novel ADAMTSL4 gene mutations in Chinese patients with isolated
            ectopia lentis
  JOURNAL   Br J Ophthalmol 107 (6), 774-779 (2023)
   PUBMED   35042684
  REMARK    GeneRIF: Novel ADAMTSL4 gene mutations in Chinese patients with
            isolated ectopia lentis.
REFERENCE   3  (bases 1 to 4212)
  AUTHORS   Chen,Z.X., Jia,W.N., Sun,Y., Chen,T.H., Zhao,Z.N., Lan,L.N.,
            Liu,Y., Song,L.H. and Jiang,Y.X.
  TITLE     Biallelic ADAMTSL4 variants in a Chinese cohort of congenital
            ectopia lentis: Implications for genotype-phenotype relationships
  JOURNAL   Hum Mutat 43 (12), 2141-2152 (2022)
   PUBMED   36208099
  REMARK    GeneRIF: Biallelic ADAMTSL4 variants in a Chinese cohort of
            congenital ectopia lentis: Implications for genotype-phenotype
            relationships.
REFERENCE   4  (bases 1 to 4212)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4212)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4212)
  AUTHORS   Ahram,D., Sato,T.S., Kohilan,A., Tayeh,M., Chen,S., Leal,S.,
            Al-Salem,M. and El-Shanti,H.
  TITLE     A homozygous mutation in ADAMTSL4 causes autosomal-recessive
            isolated ectopia lentis
  JOURNAL   Am J Hum Genet 84 (2), 274-278 (2009)
   PUBMED   19200529
  REMARK    GeneRIF: Mutations in ADAMTSL4 are responsible for
            autosomal-recessive simple ectopia lentis and this proteins
            affectsthe development of the zonular fibers.
REFERENCE   7  (bases 1 to 4212)
  AUTHORS   Liu,J., Guo,Q., Chen,B., Yu,Y., Lu,H. and Li,Y.Y.
  TITLE     Cathepsin B and its interacting proteins, bikunin and TSRC1,
            correlate with TNF-induced apoptosis of ovarian cancer cells OV-90
  JOURNAL   FEBS Lett 580 (1), 245-250 (2006)
   PUBMED   16364318
REFERENCE   8  (bases 1 to 4212)
  AUTHORS   Buchner,D.A. and Meisler,M.H.
  TITLE     TSRC1, a widely expressed gene containing seven thrombospondin type
            I repeats
  JOURNAL   Gene 307, 23-30 (2003)
   PUBMED   12706885
REFERENCE   9  (bases 1 to 4212)
  AUTHORS   Adams,J.C. and Tucker,R.P.
  TITLE     The thrombospondin type 1 repeat (TSR) superfamily: diverse
            proteins with related roles in neuronal development
  JOURNAL   Dev Dyn 218 (2), 280-299 (2000)
   PUBMED   10842357
  REMARK    Review article
REFERENCE   10 (bases 1 to 4212)
  AUTHORS   Rodahl,E., Mellgren,A.E.C., Boonstra,N.E. and Knappskog,P.M.
  TITLE     ADAMTSL4-Related Eye Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22338190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356356.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 21, 2020 this sequence version replaced NM_019032.5.
            
            Summary: This gene is a member of ADAMTS (a disintegrin and
            metalloproteinase with thrombospondin motifs)-like gene family and
            encodes a protein with seven thrombospondin type 1 repeats. The
            thrombospondin type 1 repeat domain is found in many proteins with
            diverse biological functions including cellular adhesion,
            angiogenesis, and patterning of the developing nervous system.
            Alternate transcriptional splice variants, encoding different
            isoforms, have been characterized. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2024349.1,
                                           DRR138518.288376.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271643.9/ ENSP00000271643.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AL356356.17        76670-76761
            93-166              AL356356.17        77084-77157
            167-270             AL356356.17        79467-79570
            271-328             AL356356.17        79805-79862
            329-684             AL356356.17        80160-80515
            685-1381            AL356356.17        80688-81384
            1382-1484           AL356356.17        81627-81729
            1485-1621           AL356356.17        82691-82827
            1622-1826           AL356356.17        83424-83628
            1827-1999           AL356356.17        83883-84055
            2000-2111           AL356356.17        84201-84312
            2112-2297           AL356356.17        84412-84597
            2298-2427           AL356356.17        84756-84885
            2428-2632           AL356356.17        85207-85411
            2633-2809           AL356356.17        85735-85911
            2810-3013           AL356356.17        86224-86427
            3014-3193           AL356356.17        86549-86728
            3194-3338           AL356356.17        87023-87167
            3339-4212           AL356356.17        87322-88195
FEATURES             Location/Qualifiers
     source          1..4212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..4212
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /note="ADAMTS like 4"
                     /db_xref="GeneID:54507"
                     /db_xref="HGNC:HGNC:19706"
                     /db_xref="MIM:610113"
     exon            1..92
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..166
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..270
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..3475
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ADAMTS-like protein 4; thrombospondin
                     repeat-containing protein 1"
                     /codon_start=1
                     /product="ADAMTS-like protein 4 isoform 1 precursor"
                     /protein_id="NP_061905.2"
                     /db_xref="CCDS:CCDS955.1"
                     /db_xref="GeneID:54507"
                     /db_xref="HGNC:HGNC:19706"
                     /db_xref="MIM:610113"
                     /translation="MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPE
                     GVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGP
                     RPQTSPETLPLYRTQSRGRGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYG
                     RVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTE
                     LSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFR
                     ASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQH
                     PGAWLPLLSNGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCA
                     AFNSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDI
                     CVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPA
                     GALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGK
                     GESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILR
                     VEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGK
                     GVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCG
                     PGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVR
                     CGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSA
                     ECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRW
                     YTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQD
                     RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPD
                     DQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLERSPQDPS"
     exon            271..328
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..684
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1381
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1484
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1621
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1826
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1999
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2111
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2297
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2427
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2632
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2809
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..3013
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3193
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3338
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..4212
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4189..4194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /note="hexamer: ATTAAA"
     polyA_site      4212
                     /gene="ADAMTSL4"
                     /gene_synonym="ADAMTSL-4; ECTOL2; TSRC1"
                     /note="major polyA site"
ORIGIN      
        1 aggggcccca gtggccgccg cggagcgagg ttgcctggag agagcgcctg ggcgcagaag
       61 ggttaacggg ccaccggggg ctcgcagagc aggagggtgc tctcggacgg tgtgtccccc
      121 actgcactcc tgaacttgga ggacagggtc gccgcgaggg acgcagagag caccctccac
      181 gcccagatgc ctgcgtagtt tttgtgacca gtccgctcct gcctccccct ggggcagtag
      241 agggggagcg atggagaact ggactggcag gccctggctg tatctgctgc tgcttctgtc
      301 cctccctcag ctctgcttgg atcaggaggt gttgtccgga cactctcttc agacacctac
      361 agaggagggc cagggccccg aaggtgtctg gggaccttgg gtccagtggg cctcttgctc
      421 ccagccctgc ggggtggggg tgcagcgcag gagccggaca tgtcagctcc ctacagtgca
      481 gctccacccg agtctgcccc tccctccccg gcccccaaga catccagaag ccctcctccc
      541 ccggggccag ggtcccagac cccagacttc tccagaaacc ctccccttgt acaggacaca
      601 gtctcgggga aggggtggcc cacttcgagg tcccgcttcc cacctaggga gagaggagac
      661 ccaggagatt cgagcggcca ggaggtcccg gcttcgagac cccatcaagc caggaatgtt
      721 cggttatggg agagtgccct ttgcattgcc actgcaccgg aaccgcaggc accctcggag
      781 cccacccaga tctgagctgt ccctgatctc ttctagaggg gaagaggcta ttccgtcccc
      841 tactccaaga gcagagccat tctccgcaaa cggcagcccc caaactgagc tccctcccac
      901 agaactgtct gtccacaccc catcccccca agcagaacct ctaagccctg aaactgctca
      961 gacagaggtg gcccccagaa ccaggcctgc ccccctacgg catcacccca gagcccaggc
     1021 ctctggcaca gagcccccct cacccacgca ctccttagga gaaggtggct tcttccgtgc
     1081 atcccctcag ccacgaaggc caagttccca gggttgggcc agtccccagg tagcagggag
     1141 acgccctgat ccttttcctt cggtccctcg gggccgaggc cagcagggcc aagggccttg
     1201 gggaacgggg gggactcctc acgggccccg cctggagcct gaccctcagc acccgggcgc
     1261 ctggctgccc ctgctgagca acggccccca tgccagctcc ctctggagcc tctttgctcc
     1321 cagtagccct attccaagat gttctgggga gagtgaacag ctaagagcct gcagccaagc
     1381 gccctgcccc cctgagcagc cagacccccg ggccctgcag tgcgcagcct ttaactccca
     1441 ggaattcatg ggccagctgt atcagtggga gcccttcact gaagtccagg gctcccagcg
     1501 ctgtgaactg aactgccggc cccgtggctt ccgcttctat gtccgtcaca ctgaaaaggt
     1561 ccaggatggg accctgtgtc agcctggagc ccctgacatc tgtgtggctg gacgctgtct
     1621 gagccccggc tgtgatggga tccttggctc tggcaggcgt cctgatggct gtggagtctg
     1681 tgggggtgat gattctacct gtcgccttgt ttcggggaac ctcactgacc gagggggccc
     1741 cctgggctat cagaagatct tgtggattcc agcgggagcc ttgcggctcc agattgccca
     1801 gctccggcct agctccaact acctggcact tcgtggccct gggggccggt ccatcatcaa
     1861 tgggaactgg gctgtggatc cccctgggtc ctacagggcc ggcgggaccg tctttcgata
     1921 taaccgtcct cccagggagg agggcaaagg ggagagtctg tcggctgaag gccccaccac
     1981 ccagcctgtg gatgtctata tgatctttca ggaggaaaac ccaggcgttt tttatcagta
     2041 tgtcatctct tcacctcctc caatccttga gaaccccacc ccagagcccc ctgtccccca
     2101 gcttcagccg gagattctga gggtggagcc cccacttgct ccggcacccc gcccagcccg
     2161 gaccccaggc accctccagc gtcaggtgcg gatcccccag atgcccgccc cgccccatcc
     2221 caggacaccc ctggggtctc cagctgcgta ctggaaacga gtgggacact ctgcatgctc
     2281 agcgtcctgc gggaaaggtg tctggcgccc cattttcctc tgcatctccc gtgagtcggg
     2341 agaggaactg gatgaacgca gctgtgccgc gggtgccagg cccccagcct cccctgaacc
     2401 ctgccacggc accccatgcc ccccatactg ggaggctggc gagtggacat cctgcagccg
     2461 ctcctgtggc cccggcaccc agcaccgcca gctgcagtgc cggcaggaat ttgggggggg
     2521 tggctcctcg gtgcccccgg agcgctgtgg acatctcccc cggcccaaca tcacccagtc
     2581 ttgccagctg cgcctctgtg gccattggga agttggctct ccttggagcc agtgctccgt
     2641 gcggtgcggc cggggccaga gaagccggca ggttcgctgt gttgggaaca atggtgatga
     2701 agtgagcgag caggagtgtg cgtcaggccc cccgcagccc cccagcagag aggcctgtga
     2761 catggggccc tgtactactg cctggttcca cagcgactgg agctccaagt gctcagccga
     2821 gtgtgggacg ggaatccagc ggcgctctgt ggtctgcctt gggagtgggg cagccctcgg
     2881 gccaggccag ggggaagcag gagcaggaac tgggcagagc tgtccaacag gaagccggcc
     2941 ccctgacatg cgcgcctgca gcctggggcc ctgtgagaga acttggcgct ggtacacagg
     3001 gccctggggt gagtgctcct ccgaatgtgg ctctggcaca cagcgtagag acatcatctg
     3061 tgtatccaaa ctggggacgg agttcaacgt gacttctccg agcaactgtt ctcacctccc
     3121 caggccccct gccctgcagc cctgtcaagg gcaggcctgc caggaccgat ggttttccac
     3181 gccctggagc ccatgttctc gctcctgcca agggggaacg cagacacggg aggtccagtg
     3241 cctgagcacc aaccagaccc tcagcacccg atgccctcct caactgcggc cctccaggaa
     3301 gcgcccctgt aacagccaac cctgcagcca gcgccctgat gatcaatgca aggacagctc
     3361 tccacattgc cccctggtgg tacaggcccg gctctgcgtc tacccctact acacagccac
     3421 ctgttgccgc tcttgcgcac atgtcctgga gcggtctccc caggatccct cctgaaaggg
     3481 gtccggggca ccttcacggt tttctgtgcc accatcggtc acccattgat cggcccactc
     3541 tgaaccccct ggctctccag cctgtcccag tctcagcagg gatgtcctcc aggtgacaga
     3601 gggtggcaag gtgactgaca caaagtgact ttcagggctg tggtcaggcc catgtggtgg
     3661 tgtgatgggt gtgtgcacat atgcctcagg tgtgcttttg ggactgcatg gatatgtgtg
     3721 tgctcaaacg tgtatcactt ttcaaaaaga ggttacacag actgagaagg acaagacctg
     3781 tttccttgag actttcctag gtggaaagga aagcaagtct gcagttcctt gctaatctga
     3841 gctacttaga gtgtggtctc cccaccaact ccagttttgt gccctaagcc tcatttctca
     3901 tgttcagacc tcacatcttc taagccgccc tgtgtctctg accccttctc atttgcctag
     3961 tatctctgcc cctgcctccc taattagcta gggctggggt cagccactgc caatcctgcc
     4021 ttactcagga aggcaggagg aaagagactg cctctccaga gcaaggccca gctgggcaga
     4081 gggtgaaaaa gagaaatgtg agcatccgct cccccaccac cccgcccagc ccctagcccc
     4141 actccctgcc tcctgaaatg gttcccaccc agaactaatt tattttttat taaagatggt
     4201 catgacaaat ga
//
