LOCUS       NM_207517               7299 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ADAMTS like 3 (ADAMTSL3), transcript variant 1, mRNA.
ACCESSION   NM_207517
VERSION     NM_207517.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7299)
  AUTHORS   Zhou,X., Li,R., Jing,R., Zuo,B. and Zheng,Q.
  TITLE     Genome-wide CRISPR knockout screens identify ADAMTSL3 and PTEN
            genes as suppressors of HCC proliferation and metastasis,
            respectively
  JOURNAL   J Cancer Res Clin Oncol 146 (6), 1509-1521 (2020)
   PUBMED   32266537
  REMARK    GeneRIF: knocking out either the ADAMTSL3 or PTEN genes promoted
            either the proliferation or metastasis of hepatocellular carcinoma
            cells, respectively
REFERENCE   2  (bases 1 to 7299)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7299)
  AUTHORS   Jambaljav,B., Tanaka,D., Nagashima,K., Harashima,S.I., Harada,N.,
            Harada,T., Fujiwara,Y., Wang,Y., Liu,Y., Tabara,Y., Matsuda,F.,
            Koizumi,A. and Inagaki,N.
  TITLE     Whole-exome sequencing in a Japanese family with highly aggregated
            diabetes identifies a candidate susceptibility mutation in ADAMTSL3
  JOURNAL   Diabetes Res Clin Pract 135, 143-149 (2018)
   PUBMED   29162515
  REMARK    GeneRIF: A137T in ADAMTSL3 may be a susceptibility mutation for
            diabetes.
REFERENCE   4  (bases 1 to 7299)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   5  (bases 1 to 7299)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 7299)
  AUTHORS   Weedon,M.N., Lango,H., Lindgren,C.M., Wallace,C., Evans,D.M.,
            Mangino,M., Freathy,R.M., Perry,J.R., Stevens,S., Hall,A.S.,
            Samani,N.J., Shields,B., Prokopenko,I., Farrall,M., Dominiczak,A.,
            Johnson,T., Bergmann,S., Beckmann,J.S., Vollenweider,P.,
            Waterworth,D.M., Mooser,V., Palmer,C.N., Morris,A.D.,
            Ouwehand,W.H., Zhao,J.H., Li,S., Loos,R.J., Barroso,I.,
            Deloukas,P., Sandhu,M.S., Wheeler,E., Soranzo,N., Inouye,M.,
            Wareham,N.J., Caulfield,M., Munroe,P.B., Hattersley,A.T.,
            McCarthy,M.I. and Frayling,T.M.
  CONSRTM   Diabetes Genetics Initiative; Wellcome Trust Case Control
            Consortium; Cambridge GEM Consortium
  TITLE     Genome-wide association analysis identifies 20 loci that influence
            adult height
  JOURNAL   Nat Genet 40 (5), 575-583 (2008)
   PUBMED   18391952
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 7299)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   8  (bases 1 to 7299)
  AUTHORS   Lettre,G., Jackson,A.U., Gieger,C., Schumacher,F.R., Berndt,S.I.,
            Sanna,S., Eyheramendy,S., Voight,B.F., Butler,J.L., Guiducci,C.,
            Illig,T., Hackett,R., Heid,I.M., Jacobs,K.B., Lyssenko,V., Uda,M.,
            Boehnke,M., Chanock,S.J., Groop,L.C., Hu,F.B., Isomaa,B., Kraft,P.,
            Peltonen,L., Salomaa,V., Schlessinger,D., Hunter,D.J., Hayes,R.B.,
            Abecasis,G.R., Wichmann,H.E., Mohlke,K.L. and Hirschhorn,J.N.
  CONSRTM   Diabetes Genetics Initiative; FUSION; KORA; Prostate, Lung
            Colorectal and Ovarian Cancer Screening Trial; Nurses' Health
            Study; SardiNIA
  TITLE     Identification of ten loci associated with height highlights new
            biological pathways in human growth
  JOURNAL   Nat Genet 40 (5), 584-591 (2008)
   PUBMED   18391950
REFERENCE   9  (bases 1 to 7299)
  AUTHORS   Koo,B.H., Hurskainen,T., Mielke,K., Aung,P.P., Casey,G.,
            Autio-Harmainen,H. and Apte,S.S.
  TITLE     ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors,
            is widely expressed in normal and malignant epithelial cells,
            vascular endothelial cells and other cell types, and its mRNA is
            reduced in colon cancer
  JOURNAL   Int J Cancer 121 (8), 1710-1716 (2007)
   PUBMED   17597111
  REMARK    GeneRIF: ADAMTSL3 is expressed in numerous tissues, suggesting a
            broader regulatory role than in colorectal epithelium alone, and
            that colorectal cancer has both structural mutations as well as
            decreased expression of ADAMTSL3.
REFERENCE   10 (bases 1 to 7299)
  AUTHORS   Hall,N.G., Klenotic,P., Anand-Apte,B. and Apte,S.S.
  TITLE     ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix
            related to the ADAMTS family of metalloproteases
  JOURNAL   Matrix Biol 22 (6), 501-510 (2003)
   PUBMED   14667842
  REMARK    GeneRIF: Highest expression of ADAMTSL3 was found in liver, kidney,
            heart and skeletal muscle.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF237652.1, BC128389.1, AC116157.4 and AC027807.6.
            
            On Nov 23, 2018 this sequence version replaced NM_207517.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286744.10/ ENSP00000286744.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-980               AF237652.1         38-1017
            981-1054            BC128389.1         1016-1089
            1055-1055           AC116157.4         46492-46492         c
            1056-1932           BC128389.1         1091-1967
            1933-2168           AC116157.4         3987-4222           c
            2169-3096           BC128389.1         2204-3131
            3097-3144           AC027807.6         103928-103975       c
            3145-4762           BC128389.1         3180-4797
            4763-4763           AC027807.6         61157-61157         c
            4764-6884           BC128389.1         4799-6919
            6885-7299           AC027807.6         46671-47085         c
FEATURES             Location/Qualifiers
     source          1..7299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..7299
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /note="ADAMTS like 3"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
     exon            1..154
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            155..256
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..5263
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; a disintegrin-like and metalloprotease domain
                     with thrombospondin type I motifs-like 3; punctin-2;
                     ADAMTS-like protein 3"
                     /codon_start=1
                     /product="ADAMTS-like protein 3 isoform a precursor"
                     /protein_id="NP_997400.2"
                     /db_xref="CCDS:CCDS10326.1"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
                     /translation="MASWTSPWWVLIGMVFMHSPLPQTTAEKSPGAYFLPEFALSPQG
                     SFLEDTTGEQFLTYRYDDQTSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRC
                     LTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAP
                     CALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCG
                     VCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQG
                     SKGEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFF
                     FYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPK
                     LKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESM
                     HGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINH
                     RGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEP
                     TFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEA
                     CDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVND
                     SLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPP
                     EECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNL
                     SDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRI
                     PLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRI
                     NLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGSLKIHGL
                     AAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEANSLGVTW
                     HKMRQMWNNKNDLYLDDDHISNQPFLRALLGHCSNSAGSTNSWELKNKQFEAAVKQGA
                     YSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRGIQEETP
                     PAAQLRGETGSVSQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYI
                     TKRTEVINILCDLITPSEATYTWTKDGTLLQPSVKIILDGTGKIQIQNPTRKEQGIYE
                     CSVANHLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIR
                     CPVKGVPQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLENEGTYVCIATNALGKAVA
                     TSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEPGNWSHC
                     SATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQ
                     CSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNR
                     CPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCT
                     AACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMF
                     VKHLNLCSLDRYKQRCCQSCQEG"
     exon            257..376
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            377..504
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..550
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..787
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            788..914
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..989
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1147
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1259
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1398
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1449
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1654
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1802
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1887
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2174
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2304
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2497
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2677
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2831
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3903
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4031
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4032..4160
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4343
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4460
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4461..4644
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4645..4843
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4844..4941
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4942..5156
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5157..7299
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7261..7266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /note="hexamer: AATAAA"
     polyA_site      7299
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgccgc gggctggagg ccggcgtcgg ggaaggtcct ggtgccggat tccgcacgag
       61 gtgttgacgg gcggcttctg ccaacttctc cccagcgcgc gccgagcccg cgcggccccg
      121 gggctgcacg tcccagatac ttctgcggcg caaggctaca actgagaccc ggaggagact
      181 agaccccatg gcttcctgga cgagcccctg gtgggtgctg atagggatgg tcttcatgca
      241 ctctcccctc ccgcagacca cagctgagaa atctcctgga gcctatttcc ttcccgagtt
      301 tgcactttct cctcagggaa gttttctgga agacacaaca ggggagcagt tcctcactta
      361 tcgctatgat gaccagacct caagaaacac tcgttcagat gaagacaaag atggcaactg
      421 ggatgcttgg ggcgactgga gtgactgctc ccggacctgt gggggaggag catcatattc
      481 tctgcggaga tgtttgactg gaaggaattg tgaagggcag aacattcggt acaagacatg
      541 cagcaatcat gactgccctc cagatgcaga agatttcaga gcccagcagt gctcagccta
      601 caatgatgtc cagtatcagg ggcattacta tgaatggctt ccacgatata atgatcctgc
      661 tgccccgtgt gcactcaagt gtcatgcaca aggacaaaac ttggtggtgg agctggcacc
      721 taaggtactg gatggaactc gttgcaacac ggactccttg gacatgtgta tcagtggcat
      781 ctgtcaggca gtgggctgcg atcggcaact gggaagcaat gccaaggagg acaactgtgg
      841 agtctgtgcc ggcgatggct ccacctgcag gcttgtacgg ggacaatcaa agtcacacgt
      901 ttctcctgaa aaaagagaag aaaatgtaat tgctgttcct ttgggaagtc gaagtgtgag
      961 aattacagtg aaaggacctg cccacctctt tattgaatca aaaacacttc aaggaagcaa
     1021 aggagaacac agctttaaca gccccggcgt ctttctcgta gaaaacacaa cagtggaatt
     1081 tcagaggggc tccgagaggc aaacttttaa gattccagga cctctgatgg ctgatttcat
     1141 cttcaagacc aggtacactg cagccaaaga cagcgtggtt cagttcttct tttaccagcc
     1201 catcagtcat cagtggagac aaactgactt ctttccctgc actgtgacgt gtggaggagg
     1261 ttatcagctc aattctgctg aatgtgtgga tatccgcttg aagagggtag ttcctgacca
     1321 ttattgtcac tactaccctg aaaatgtaaa accaaaacca aaactgaagg aatgcagcat
     1381 ggatccctgc ccatcaagtg atggatttaa agagataatg ccctatgacc acttccaacc
     1441 tcttcctcgc tgggaacata atccttggac tgcatgttcc gtgtcctgtg gaggagggat
     1501 tcagagacgg agctttgtgt gtgtagagga atccatgcat ggagagatat tgcaggtgga
     1561 agaatggaag tgcatgtacg cacccaaacc caaggttatg caaacttgta atctgtttga
     1621 ttgccccaag tggattgcca tggagtggtc tcagtgcaca gtgacttgtg gccgagggtt
     1681 acggtaccgg gttgttctgt gtattaacca ccgcggagag catgttgggg gctgcaatcc
     1741 acaactgaag ttacacatca aagaagaatg tgtcattccc atcccgtgtt ataaaccaaa
     1801 agaaaaaagt ccagtggaag caaaattgcc ttggctgaaa caagcacaag aactagaaga
     1861 gaccagaata gcaacagaag aaccaacgtt cattccagaa ccctggtcag cctgcagtac
     1921 cacgtgtggg ccgggtgtgc aggtccgtga ggtgaagtgc cgtgtgctcc tcacattcac
     1981 gcagactgag actgagctgc ccgaggaaga gtgtgaaggc cccaagctgc ccaccgaacg
     2041 gccctgcctc ctggaagcat gtgatgagag cccggcctcc cgagagctag acatccctct
     2101 ccctgaggac agtgagacga cttacgactg ggagtacgct gggttcaccc cttgcacagc
     2161 aacatgcgtg ggaggccatc aagaagccat agcagtgtgc ttacatatcc agacccagca
     2221 gacagtcaat gacagcttgt gtgatatggt ccaccgtcct ccagccatga gccaggcctg
     2281 taacacagag ccctgtcccc ccaggtggca tgtgggctct tgggggccct gctcagctac
     2341 ctgtggagtt ggaattcaga cccgagatgt gtactgcctg cacccagggg agacccctgc
     2401 ccctcctgag gagtgccgag atgaaaagcc ccatgcttta caagcatgca atcagtttga
     2461 ctgccctcct ggctggcaca ttgaagaatg gcagcagtgt tccaggactt gtggcggggg
     2521 aactcagaac agaagagtca cctgtcggca gctgctaacg gatggcagct ttttgaatct
     2581 ctcagatgaa ttgtgccaag gacccaaggc atcgtctcac aagtcctgtg ccaggacaga
     2641 ctgtcctcca catttagctg tgggagactg gtcgaagtgt tctgtcagtt gtggtgttgg
     2701 aatccagaga agaaagcagg tgtgtcaaag gctggcagcc aaaggtcggc gcatccccct
     2761 cagtgagatg atgtgcaggg atctaccagg gctccctctt gtaagatctt gccagatgcc
     2821 tgagtgcagt aaaatcaaat cagagatgaa gacaaaactt ggtgagcagg gtccgcagat
     2881 cctcagtgtc cagagagtct acattcagac aagggaagag aagcgtatta acctgaccat
     2941 tggtagcaga gcctatttgc tgcccaacac atccgtgatt attaagtgcc ccgtgcgacg
     3001 attccagaaa tctctgatcc agtgggagaa ggatggccgt tgcctgcaga actccaaacg
     3061 gcttggcatc accaagtcag gctcactaaa aatccatggt cttgctgccc ccgacatcgg
     3121 cgtgtaccgg tgcattgcag gctctgcaca ggaaacagtt gtgctcaagc tcattggtac
     3181 tgacaaccgg ctcatcgcac gcccagccct cagggagcct atgagggaat atcctgggat
     3241 ggaccacagc gaagccaata gtttgggagt cacatggcac aaaatgaggc aaatgtggaa
     3301 taacaaaaat gacctttatc tggatgatga ccacattagt aaccagcctt tcttgagagc
     3361 tctgttaggc cactgcagca attctgcagg aagcaccaac tcctgggagt tgaagaataa
     3421 gcagtttgaa gcagcagtta aacaaggagc atatagcatg gatacagccc agtttgatga
     3481 gctgataaga aacatgagtc agctcatgga aaccggagag gtcagcgatg atcttgcgtc
     3541 ccagctgata tatcagctgg tggccgaatt agccaaggca cagccaacac acatgcagtg
     3601 gcggggcatc caggaagaga cacctcctgc tgctcagctc agaggggaaa cagggagtgt
     3661 gtcccaaagc tcgcatgcaa aaaactcagg caagctgaca ttcaagccga aaggacctgt
     3721 tctcatgagg caaagccaac ctccctcaat ttcatttaat aaaacaataa attccaggat
     3781 tggaaataca gtatacatta caaaaaggac agaggtcatc aatatactgt gtgaccttat
     3841 tacccccagt gaggccacat atacatggac caaggatgga accttgttac agccctcagt
     3901 aaaaataatt ttggatggaa ctgggaagat acagatacag aatcctacaa ggaaagaaca
     3961 aggcatatat gaatgttctg tagctaatca tcttggttca gatgtggaaa gttcttctgt
     4021 gctgtatgca gaggcacctg tcatcttgtc tgttgaaaga aatatcacca aaccagagca
     4081 caaccatctg tctgttgtgg ttggaggcat cgtggaggca gcccttggag caaacgtgac
     4141 aatccgatgt cctgtaaaag gtgtccctca gcctaatata acttggttga agagaggagg
     4201 atctctgagt ggcaatgttt ccttgctttt caatggatcc ctgttgttgc agaatgtttc
     4261 ccttgaaaat gaaggaacct acgtctgcat agccaccaat gctcttggaa aggcagtggc
     4321 aacatctgta ctccacttgc tggaacgaag atggccagag agtagaatcg tatttctgca
     4381 aggacataaa aagtacattc tccaggcaac caacactaga accaacagca atgacccaac
     4441 aggagaaccc ccgcctcaag agcctttttg ggagcctggt aactggtcac attgttctgc
     4501 cacctgtggt catttgggag cccgcattca gagaccccag tgtgtgatgg ccaatgggca
     4561 ggaagtgagt gaggccctgt gtgatcacct ccagaagcca ctggctgggt ttgagccctg
     4621 taacatccgg gactgcccag cgaggtggtt cacaagtgtg tggtcacagt gctctgtgtc
     4681 ttgcggtgaa ggataccaca gtcggcaggt gacgtgcaag cggacaaaag ccaatggaac
     4741 tgtgcaggtg gtgtctccaa gagcatgtgc ccctaaagac cggcctctgg gaagaaaacc
     4801 atgttttggt catccatgtg ttcagtggga accagggaac cggtgtcctg gacgttgcat
     4861 gggccgtgct gtgaggatgc agcagcgtca cacagcttgt caacacaaca gctctgactc
     4921 caactgtgat gacagaaaga gacccacctt aagaaggaac tgcacatcag gggcctgtga
     4981 tgtgtgttgg cacacaggcc cttggaagcc ctgtacagca gcctgtggca ggggtttcca
     5041 gtctcggaaa gtcgactgta tccacacaag gagttgcaaa cctgtggcca agagacactg
     5101 tgtacagaaa aagaaaccaa tttcctggcg gcactgtctt gggccctcct gtgatagaga
     5161 ctgcacagac acaactcact actgtatgtt tgtaaaacat cttaatttgt gttctctaga
     5221 ccgctacaaa caaaggtgct gccagtcatg tcaagaggga taaacctttg gaggggtcat
     5281 gatgctgctg tgaagataaa agtagaatat aaaagctctt ttccccatgt cgctgattca
     5341 aaaacatgta tttcttaaaa gactagattc tatggatcaa acagaggttg atgcaaaaac
     5401 accactgtta aggtgtaaag tgaaattttc caatggtagt tttatattcc aattttttaa
     5461 aatgatgtat tcaaggatga acaaaatact atagcatgca tgccactgca cttgggacct
     5521 catcatgtca gttgaatcga gaaatcacca agattatgag tgcatcctca cgtgctgcct
     5581 ctttcctgtg atatgtagac tagcacagag tggtacatcc taaaaacttg ggaaacacag
     5641 caacccatga cttcctcttc tctcaagttg caggttttca acagttttat aaggtatttg
     5701 cattttagaa gctctggcca gtagttgtta agatgttggc attaatggca ttttcataga
     5761 tccttggttt agtctgtgaa aaagaaacca tctctctgga taggctgtca cactgactga
     5821 cctaagggtt catggaagca tggcatcttg tccttgcttt tagaacaccc atggaagaaa
     5881 acacagagta gatattgctg tcatttatac aactacagaa atttatctat gacctaatga
     5941 ggcatctcgg aagtcaaaga agagggaaag ttaacctttt ctactgattt cgtagtatat
     6001 tcagagcttt cttttaagag ctgtgaatga aactttttct aagcactatt ctattgcaca
     6061 caaacagaaa accaaagcct tattagacct aatttatgca taaagtagta ttcctgagaa
     6121 ctttattttg gaaaatttat aagaaagtaa tccaaataag aaacacgata gttgaaaata
     6181 atttttatag taaataattg ttttgggctg atttttcagt aaatccaaag tgacttaggt
     6241 tagaagttac actaaggacc aggggttgga atcagaattt agtttaagat ttgaggaaaa
     6301 gggtaagggt tagtttcagt tttaggatta gagctagaat tgggttaggt gagaaagaaa
     6361 gttaaggtta aggctagagt tgtctttaag ggttagggtt aggaccaggt taggtcaggg
     6421 ttggattggg tttagattgg ggccagtgct ggtgttagtg atagtgtcag gatggaggtt
     6481 aggtttggag taagcgttgt tgctgaagtg agttcaggct agcattaaat tgtaagttct
     6541 gaagctgatt tggttatggg gtctttcccc tgtatactac cagttgtgtc tttagatggc
     6601 acacaagtcc aaataagtgg tcatacttct ttattcaggg tctcagctgc ctgtacacct
     6661 gctgcctaca tcttcttggc aacaaagtta cctgccacag gctctgctga gcctagttcc
     6721 tggtcagtaa taactgaaca gtgcattttg gctttggatg tgtctgtgga caagcttgct
     6781 gagtttctct accatattct gagcacacgg tctcttttgt tctaacttca gcttcactga
     6841 cactgggttg agcactactg tatgtggagg gtttggtgat tgggaatgga tgggggacag
     6901 tgaggaggac acaccagccc attagttgtt aatcatcaat cacatctgat tgttgaaggt
     6961 tattaaatta aaagaaagat catttgtaac atactctttg tatatattta ttatatgaaa
     7021 ggtgcaatat tttattttgt acagtatgta ataaagacat gggacatata tttttcttat
     7081 taacaaaatt tcatattaaa ttgcttcact ttgtatttaa agttaaaagt tactattttt
     7141 catttgctat tgtactttca ttgttgtcat tcaattgaca ttcctgtgta ctgtatttta
     7201 ctactgtttt tataacatga gagttaatgt ttctgtttca tgatccttat gtaattcaga
     7261 aataaattta ctttgattat tcagtggcat ccttataaa
//
