LOCUS       NM_014694               3875 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens ADAMTS like 2 (ADAMTSL2), transcript variant 1, mRNA.
ACCESSION   NM_014694 XM_003403574 XM_003403826 XM_003403827
VERSION     NM_014694.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3875)
  AUTHORS   Taye,N., Singh,M., Baldock,C. and Hubmacher,D.
  TITLE     Secreted ADAMTS-like 2 promotes myoblast differentiation by
            potentiating WNT signaling
  JOURNAL   Matrix Biol 120, 24-42 (2023)
   PUBMED   37187448
  REMARK    GeneRIF: Secreted ADAMTS-like 2 promotes myoblast differentiation
            by potentiating WNT signaling.
REFERENCE   2  (bases 1 to 3875)
  AUTHORS   Batkovskyte,D., McKenzie,F., Taylan,F., Simsek-Kiper,P.O.,
            Nikkel,S.M., Ohashi,H., Stevenson,R.E., Ha,T., Cavalcanti,D.P.,
            Miyahara,H., Skinner,S.A., Aguirre,M.A., Akcoren,Z., Utine,G.E.,
            Chiu,T., Shimizu,K., Hammarsjo,A., Boduroglu,K., Moore,H.W.,
            Louie,R.J., Arts,P., Merrihew,A.N., Babic,M., Jackson,M.R.,
            Papadogiannakis,N., Lindstrand,A., Nordgren,A., Barnett,C.P.,
            Scott,H.S., Chagin,A.S., Nishimura,G. and Grigelioniene,G.
  TITLE     Al-Gazali Skeletal Dysplasia Constitutes the Lethal End of
            ADAMTSL2-Related Disorders
  JOURNAL   J Bone Miner Res 38 (5), 692-706 (2023)
   PUBMED   36896612
  REMARK    GeneRIF: Al-Gazali Skeletal Dysplasia Constitutes the Lethal End of
            ADAMTSL2-Related Disorders.
REFERENCE   3  (bases 1 to 3875)
  AUTHORS   Podgorska,D., Ciesla,M., Majdan,M., Podgorski,R. and Kolarz,B.
  TITLE     The relationship of ADAMTSL2 and LRPAP1 gene methylation level with
            rheumatoid arthritis activity
  JOURNAL   Clin Exp Rheumatol 40 (11), 2052-2059 (2022)
   PUBMED   34936547
  REMARK    GeneRIF: The relationship of ADAMTSL2 and LRPAP1 gene methylation
            level with rheumatoid arthritis activity.
REFERENCE   4  (bases 1 to 3875)
  AUTHORS   Liu,B., Zhao,S., Liu,L., Du,H., Zhao,H., Wang,S., Niu,Y., Li,X.,
            Qiu,G., Wu,Z., Zhang,T.J. and Wu,N.
  CONSRTM   Deciphering disorders Involving Scoliosis COmorbidities (DISCO)
            study group
  TITLE     Aberrant interaction between mutated ADAMTSL2 and LTBP4 is
            associated with adolescent idiopathic scoliosis
  JOURNAL   Gene 814, 146126 (2022)
   PUBMED   34958866
  REMARK    GeneRIF: Aberrant interaction between mutated ADAMTSL2 and LTBP4 is
            associated with adolescent idiopathic scoliosis.
REFERENCE   5  (bases 1 to 3875)
  AUTHORS   Ben-Salem,S., Hertecant,J., Al-Shamsi,A.M., Ali,B.R. and
            Al-Gazali,L.
  TITLE     Novel mutations in ADAMTSL2 gene underlying geleophysic dysplasia
            in families from United Arab Emirates
  JOURNAL   Birth Defects Res A Clin Mol Teratol 97 (12), 764-769 (2013)
   PUBMED   24014090
  REMARK    GeneRIF: Two novel homozygous missense mutations in the ADAMTSL2
            gene underlie geleophysic dysplasia in two consanguineous families
            from the United Arab Emirates.
REFERENCE   6  (bases 1 to 3875)
  AUTHORS   Allali,S., Le Goff,C., Pressac-Diebold,I., Pfennig,G., Mahaut,C.,
            Dagoneau,N., Alanay,Y., Brady,A.F., Crow,Y.J., Devriendt,K.,
            Drouin-Garraud,V., Flori,E., Genevieve,D., Hennekam,R.C., Hurst,J.,
            Krakow,D., Le Merrer,M., Lichtenbelt,K.D., Lynch,S.A., Lyonnet,S.,
            MacDermot,K., Mansour,S., Megarbane,A., Santos,H.G., Splitt,M.,
            Superti-Furga,A., Unger,S., Williams,D., Munnich,A. and
            Cormier-Daire,V.
  TITLE     Molecular screening of ADAMTSL2 gene in 33 patients reveals the
            genetic heterogeneity of geleophysic dysplasia
  JOURNAL   J Med Genet 48 (6), 417-421 (2011)
   PUBMED   21415077
  REMARK    GeneRIF: Molecular screening of ADAMTSL2 gene in 33 patients
            reveals the genetic heterogeneity of geleophysic dysplasia.
REFERENCE   7  (bases 1 to 3875)
  AUTHORS   Le Goff,C., Morice-Picard,F., Dagoneau,N., Wang,L.W., Perrot,C.,
            Crow,Y.J., Bauer,F., Flori,E., Prost-Squarcioni,C., Krakow,D.,
            Ge,G., Greenspan,D.S., Bonnet,D., Le Merrer,M., Munnich,A.,
            Apte,S.S. and Cormier-Daire,V.
  TITLE     ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for
            ADAMTS-like proteins in TGF-beta bioavailability regulation
  JOURNAL   Nat Genet 40 (9), 1119-1123 (2008)
   PUBMED   18677313
  REMARK    GeneRIF: These data suggest that ADAMTSL2 mutations may lead to a
            dysregulation of TGF-beta signaling and may be the underlying
            mechanism of geleophysic dysplasia.
REFERENCE   8  (bases 1 to 3875)
  AUTHORS   Koo,B.H., Le Goff,C., Jungers,K.A., Vasanji,A., O'Flaherty,J.,
            Weyman,C.M. and Apte,S.S.
  TITLE     ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely
            expressed during mouse embryogenesis and is regulated during
            skeletal myogenesis
  JOURNAL   Matrix Biol 26 (6), 431-441 (2007)
   PUBMED   17509843
REFERENCE   9  (bases 1 to 3875)
  AUTHORS   Hall,N.G., Klenotic,P., Anand-Apte,B. and Apte,S.S.
  TITLE     ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix
            related to the ADAMTS family of metalloproteases
  JOURNAL   Matrix Biol 22 (6), 501-510 (2003)
   PUBMED   14667842
REFERENCE   10 (bases 1 to 3875)
  AUTHORS   Marzin,P. and Cormier-Daire,V.
  TITLE     Geleophysic Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX324209.11, BC050544.1 and
            BX629352.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 29, 2018 this sequence version replaced NM_014694.3.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) and ADAMTS-like
            protein family. Members of the family share several distinct
            protein modules, including a propeptide region, a metalloproteinase
            domain, a disintegrin-like domain, and a thrombospondin type 1 (TS)
            motif. Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            protein encoded by this gene lacks the protease domain, and is
            therefore of a member of the the ADAMTS-like protein subfamily. It
            is a secreted glycoprotein that binds the cell surface and
            extracellular matrix; it also interacts with latent transforming
            growth factor beta binding protein 1. Mutations in this gene have
            been associated with geleophysic dysplasia. [provided by RefSeq,
            Feb 2009].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1175528.1, BC050544.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000651351.2/
                                                ENSP00000498961.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               BX324209.11        32634-32782
            150-1134            BC050544.1         1-985
            1135-1228           BX324209.11        44975-45068
            1229-2672           BC050544.1         1080-2523
            2673-2682           BX629352.5         2994-3003
            2683-3374           BC050544.1         2534-3225
            3375-3381           BX629352.5         8541-8547
            3382-3875           BC050544.1         3233-3726
FEATURES             Location/Qualifiers
     source          1..3875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..3875
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /note="ADAMTS like 2"
                     /db_xref="GeneID:9719"
                     /db_xref="HGNC:HGNC:14631"
                     /db_xref="MIM:612277"
     exon            1..214
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..454
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..3220
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /note="ADAMTS-like protein 2"
                     /codon_start=1
                     /product="ADAMTS-like protein 2 precursor"
                     /protein_id="NP_055509.2"
                     /db_xref="CCDS:CCDS6976.1"
                     /db_xref="GeneID:9719"
                     /db_xref="HGNC:HGNC:14631"
                     /db_xref="MIM:612277"
                     /translation="MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTD
                     ATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRV
                     QECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQ
                     LMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG
                     NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKN
                     FNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPP
                     HESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQASSERLGLDNRLFGHPGLD
                     MELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFASQ
                     EFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPY
                     LLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMY
                     RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP
                     RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRN
                     PACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQ
                     WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHW
                     LAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK
                     WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDD
                     SCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS"
     exon            455..597
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..673
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..776
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..922
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1046
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1127
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1303
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1640
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..2013
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2111
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2238
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2452
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2608
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2779
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2956
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3101
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3875
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3849..3854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /note="hexamer: AATAAA"
     polyA_site      3875
                     /gene="ADAMTSL2"
                     /gene_synonym="ADAMTSL-2; GPHYSD1"
                     /note="major polyA site"
ORIGIN      
        1 actgggctgc gcccctcccg ggaaccccct ctcttggatg ctctttgaag tgggagaggg
       61 aggcggcgcg ggggaggagg ggaaggggag agggaggccg ggccgcagcc tctgcactca
      121 cgccgccccc gcacgcacag cgcacctggc gccgtctgcc ctccgcagcg ctcgcccctt
      181 tctctgggag gacaacctgc tgacccgaag ccagggtctg ccagacaacc acgaccaact
      241 agtcccagat aaccttgagg cctgggcact ggctgggccc cgagggctct tcccaaagcg
      301 taccctggtc atctggaaga ggatcggagc tggcctggtg gtgacagtgg ccttgcttcc
      361 taggatggat ggcagatggc aatgttcctg ctgggcctgg ttcctgctgg ttctggcagt
      421 tgtagctggg gacacagtgt caaccgggtc cacggacaac agcccaacat ccaatagcct
      481 ggaggggggc accgacgcca cggccttctg gtggggggag tggaccaagt ggacggcgtg
      541 ttcccgcagt tgcgggggtg gggtgacatc ccaggagcgg cactgcctgc agcagaggag
      601 gaagtccgtc ccgggccccg ggaacaggac ctgcacgggc acgtccaagc ggtaccagct
      661 ctgcagagtg caggagtgtc cgccggacgg gaggagcttc cgcgaggagc agtgcgtctc
      721 cttcaactcc cacgtgtaca acgggcggac gcaccagtgg aagcctctgt acccggatga
      781 ctatgtccac atctccagca aaccgtgtga cctgcactgt accaccgtgg acggccagcg
      841 gcagctcatg gtccccgccc gcgacggcac atcctgcaag ctcactgacc tgcgaggggt
      901 ttgcgtgtct ggaaaatgtg agcccatcgg ctgtgacggg gtgcttttct ccacccacac
      961 actggacaag tgtggcatct gccaggggga cggtagcagc tgcacccacg tgacgggcaa
     1021 ctatcgcaag gggaatgccc accttggtta ctctctggtg acccacatcc cggctggtgc
     1081 ccgagacatc cagattgtag agaggaagaa gtccgctgac gtgctagctc ttgcagacga
     1141 agctggctac tacttcttca acggcaacta caaggtggac agccccaaga acttcaacat
     1201 cgcaggcacg gtggtcaagt acaggcggcc catggatgtc tatgagaccg gaatcgagta
     1261 catcgtggca caggggccca ccaaccaggg cctgaatgtc atggtgtgga accagaacgg
     1321 caaaagcccc tccatcacct tcgagtacac gctgctgcag ccgccacacg agagccgccc
     1381 ccagcccatc tactatggct tctccgagag cgctgagagc cagggcctgg acggggccgg
     1441 gctgatgggc ttcgtcccgc acaacggctc cctctacggc caggcctcct cagagcggct
     1501 gggcctggac aaccggctgt tcggccaccc gggcctggac atggagctgg gccccagcca
     1561 gggccaggag accaacgagg tgtgcgagca ggccggcggc ggggcctgcg aggggccccc
     1621 caggggcaag ggcttccgag accgcaacgt cacggggact cctctcaccg gggacaagga
     1681 tgacgaagag gttgacaccc acttcgcctc ccaggagttc ttctcggcta acgccatctc
     1741 tgaccagctg ctgggcgcag gctctgactt gaaggacttc accctcaatg agactgtgaa
     1801 cagcatcttt gcacagggcg ccccaaggag ctccctggcc gagagcttct tcgtggatta
     1861 tgaggagaac gagggggctg gcccttacct gctcaacggg tcctacctgg agctgagcag
     1921 cgacagggtt gccaacagct cctccgaggc cccattcccc aacgttagca ccagcctgct
     1981 cacctcggcc gggaacagga ctcacaaggc caggaccagg cccaaggcgc gcaagcaagg
     2041 cgtgagtccc gcggacatgt accggtggaa gctctcgtcc cacgagccct gcagtgccac
     2101 ctgcaccaca ggggtcatgt ctgcgtacgc catgtgtgtc cgctatgatg gcgtcgaggt
     2161 ggatgacagc tactgtgacg ccctgacccg tcccgagcct gtccacgagt tctgcgctgg
     2221 gagggagtgc cagcccaggt gggagacgag cagctggagc gagtgttcgc gcacctgcgg
     2281 agagggctac cagttccgcg tcgtgcgctg ctggaagatg ctctcgcccg gcttcgacag
     2341 ctccgtgtac agcgacctgt gcgaggcagc cgaggccgtg cggcccgagg aacgcaagac
     2401 ctgccggaac cccgcctgcg ggccccagtg ggagatgtcg gagtggtccg agtgcactgc
     2461 caagtgtggg gagcgcagtg tggtgaccag ggacatccgc tgctcggagg atgagaagct
     2521 gtgtgacccc aacaccaggc ctgtagggga gaagaactgc acgggcccgc cctgtgaccg
     2581 gcagtggacc gtctccgact ggggaccgtg cagtggaagc tgcgggcaag gccgcaccat
     2641 caggcacgtg tactgcaaga ccagcgacgg acgggtagta cctgagtccc agtgccagat
     2701 ggagaccaag cctctggcca tccacccctg tggggacaaa aactgtcccg cccactggct
     2761 ggcccaggac tgggagcggt gcaacaccac ctgcgggcgc ggggtcaaga agcggctggt
     2821 gctctgcatg gagctggcca acgggaagcc gcagacgcgc agtggccccg agtgcgggct
     2881 cgccaagaag cctcccgagg agagcacgtg tttcgagagg ccctgcttca agtggtacac
     2941 cagcccctgg tcagagtgca ccaagacctg cggggtgggc gtgaggatgc gagacgtcaa
     3001 gtgctaccag gggaccgaca tcgtccgtgg ttgcgatccg ttggtgaagc ccgttggcag
     3061 acaggcctgt gatctgcagc cctgccccac ggagccccca gatgacagct gccaggacca
     3121 gccaggcacc aactgtgccc tggccatcaa agtgaacctc tgcgggcact ggtactacag
     3181 caaggcgtgc tgccgctcct gcaggccccc ccactcctag gcccggcagc tgcagcccct
     3241 tccagatgaa gaccaagcgc ccctcctggg gctgctgcag cttctggggc ctccacagac
     3301 ccccctcctg cggggcacgc tggcctaaga gacgtggcac tgagcctcgg ctgtcgagag
     3361 gggacttccc acggcccgtg gacctttgtg ctcctggggc agagcctccg gcacccagtg
     3421 gcctccccca gacagagcca cccctgccgt gggaacctgt ccgtgttcct gcgtggatcc
     3481 tgtgtttgtg gctcccactc cccagccccc cagcagcccc cagccgaggg gcccagggcc
     3541 cacagccagc ggtggaggtg tcttgctccg ggcccgtagc ccacgccctc tctgggtggc
     3601 agggccttct gaaggaaact tgcaggcgag cccaacgtgg tggggggcct tcctccctca
     3661 gaggccatgg ggtgagaggg gctcaggcag ccaaggaggc ccaggcgtgc tccctcttat
     3721 ggagcccctc ccatggagct ctcttcccgc cgcactttct accccgggca gaggcgcttg
     3781 cccacgggac gtttggggat ggacctcggc ccccgcccct gcagtcagcg tcagtgctca
     3841 tctacgttaa taaagtggtc ctatttatgg cggca
//
