LOCUS       NM_001040272            7771 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ADAMTS like 1 (ADAMTSL1), transcript variant 4, mRNA.
ACCESSION   NM_001040272
VERSION     NM_001040272.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7771)
  AUTHORS   Kantaputra,P.N., Pruksametanan,A., Phondee,N., Hutsadaloi,A.,
            Intachai,W., Kawasaki,K., Ohazama,A., Ngamphiw,C., Tongsima,S.,
            Ketudat Cairns,J.R. and Tripuwabhrut,P.
  TITLE     ADAMTSL1 and mandibular prognathism
  JOURNAL   Clin Genet 95 (4), 507-515 (2019)
   PUBMED   30714143
  REMARK    GeneRIF: This explains why the patients with ADAMTSL1 mutations had
            abnormal mandibles but normal long bones. This is the first report
            that mutations in ADAMTSL1 are responsible for the pathogenesis of
            mandibular prognathism.
REFERENCE   2  (bases 1 to 7771)
  AUTHORS   Kadalayil,L., Khan,S., Nevanlinna,H., Fasching,P.A., Couch,F.J.,
            Hopper,J.L., Liu,J., Maishman,T., Durcan,L., Gerty,S.,
            Blomqvist,C., Rack,B., Janni,W., Collins,A., Eccles,D. and
            Tapper,W.
  TITLE     Germline variation in ADAMTSL1 is associated with prognosis
            following breast cancer treatment in young women
  JOURNAL   Nat Commun 8 (1), 1632 (2017)
   PUBMED   29158497
  REMARK    GeneRIF: ADAMTSL1 are associated with breast cancer prognosis and
            may involve an interaction with AREG expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7771)
  AUTHORS   Hendee,K., Wang,L.W., Reis,L.M., Rice,G.M., Apte,S.S. and
            Semina,E.V.
  TITLE     Identification and functional analysis of an ADAMTSL1 variant
            associated with a complex phenotype including congenital glaucoma,
            craniofacial, and other systemic features in a three-generation
            human pedigree
  JOURNAL   Hum Mutat 38 (11), 1485-1490 (2017)
   PUBMED   28722276
  REMARK    GeneRIF: These data imply a multisystem role for ADAMTSL1 and
            present the first disease-associated variant affecting a
            C-mannosylation motif.
REFERENCE   4  (bases 1 to 7771)
  AUTHORS   Singh,A., Babyak,M.A., Nolan,D.K., Brummett,B.H., Jiang,R.,
            Siegler,I.C., Kraus,W.E., Shah,S.H., Williams,R.B. and Hauser,E.R.
  TITLE     Gene by stress genome-wide interaction analysis and path analysis
            identify EBF1 as a cardiovascular and metabolic risk gene
  JOURNAL   Eur J Hum Genet 23 (6), 854-862 (2015)
   PUBMED   25271088
REFERENCE   5  (bases 1 to 7771)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
REFERENCE   6  (bases 1 to 7771)
  AUTHORS   Wang,L.W., Leonhard-Melief,C., Haltiwanger,R.S. and Apte,S.S.
  TITLE     Post-translational modification of thrombospondin type-1 repeats in
            ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan
  JOURNAL   J Biol Chem 284 (44), 30004-30015 (2009)
   PUBMED   19671700
  REMARK    GeneRIF: thrombospondin type-1 repeats from punctin-1 carries
            C-mannosylation in close proximity to O-linked fucose
REFERENCE   7  (bases 1 to 7771)
  AUTHORS   Wang,L.W., Dlugosz,M., Somerville,R.P., Raed,M., Haltiwanger,R.S.
            and Apte,S.S.
  TITLE     O-fucosylation of thrombospondin type 1 repeats in
            ADAMTS-like-1/punctin-1 regulates secretion: implications for the
            ADAMTS superfamily
  JOURNAL   J Biol Chem 282 (23), 17024-17031 (2007)
   PUBMED   17395588
  REMARK    GeneRIF: data define a critical role for N-glycosylation and
            O-fucosylation in the biosynthesis of punctin-1
REFERENCE   8  (bases 1 to 7771)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   9  (bases 1 to 7771)
  AUTHORS   Hall,N.G., Klenotic,P., Anand-Apte,B. and Apte,S.S.
  TITLE     ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix
            related to the ADAMTS family of metalloproteases
  JOURNAL   Matrix Biol 22 (6), 501-510 (2003)
   PUBMED   14667842
REFERENCE   10 (bases 1 to 7771)
  AUTHORS   Hirohata,S., Wang,L.W., Miyagi,M., Yan,L., Seldin,M.F., Keene,D.R.,
            Crabb,J.W. and Apte,S.S.
  TITLE     Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular
            matrix
  JOURNAL   J Biol Chem 277 (14), 12182-12189 (2002)
   PUBMED   11805097
  REMARK    GeneRIF: Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in
            extracellular matrix
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA598045.1, CX758410.1, AF251058.1, DA549329.1, AL591423.7,
            AI750970.1, BX640951.1, BC100790.2, AL158150.14 and BU626040.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001040272.5.
            
            Summary: This gene encodes a secreted protein and member of the
            ADAMTS (a disintegrin and metalloproteinase with thrombospondin
            motif) family. This protein lacks the metalloproteinase and
            disintegrin-like domains, which are typical of the ADAMTS family,
            but contains other ADAMTS domains, including the thrombospondin
            type 1 motif. This protein may have important functions in the
            extracellular matrix. Alternative splicing results in multiple
            transcript variants encoding distinct proteins. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) encodes the longer isoform
            (4).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968189,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380548.9/ ENSP00000369921.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DA598045.1         48-76
            30-731              CX758410.1         1-702
            732-2086            AF251058.1         15-1369
            2087-2257           DA549329.1         413-583
            2258-2297           AL591423.7         1324-1363
            2298-2477           AL591423.7         18457-18636
            2478-2631           AL591423.7         23598-23751
            2632-3589           AL591423.7         24636-25593
            3590-4001           AI750970.1         8-419
            4002-4305           BX640951.1         207-510
            4306-5430           BC100790.2         426-1550
            5431-7109           AL158150.14        105293-106971
            7110-7771           BU626040.1         16-677              c
FEATURES             Location/Qualifiers
     source          1..7771
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.2-p22.1"
     gene            1..7771
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /note="ADAMTS like 1"
                     /db_xref="GeneID:92949"
                     /db_xref="HGNC:HGNC:14632"
                     /db_xref="MIM:609198"
     exon            1..143
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..5369
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; ADAM-TS related protein 1; ADAMTS-like protein
                     1; punctin-1"
                     /codon_start=1
                     /product="ADAMTS-like protein 1 isoform 4 precursor"
                     /protein_id="NP_001035362.3"
                     /db_xref="CCDS:CCDS47954.1"
                     /db_xref="GeneID:92949"
                     /db_xref="HGNC:HGNC:14632"
                     /db_xref="MIM:609198"
                     /translation="MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSE
                     CSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHH
                     GQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIV
                     GCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLV
                     LKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFI
                     VKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA
                     DQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSC
                     GGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTV
                     TCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWF
                     KQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDE
                     CEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCG
                     GGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTC
                     GVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPC
                     SRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWT
                     ECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCARPGRPS
                     TKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCPARRVRKPLITWEKD
                     GQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKLIGGNRKLVARPL
                     SPRSEEEVLAGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSRYDDLVSRLLE
                     QGGWPGELLASWEAQDSAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDDILGNLSQQ
                     PEELRDLYSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKHVSGFSSSLR
                     TSSTGDAGGGSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLLHCEA
                     IGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDSVS
                     IAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEVTW
                     FRNKSKLGSPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLILDPPQVPT
                     QLEDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHPVPNITWFHGGQP
                     IVTATGLTHHILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVD
                     RLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVT
                     SWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEW
                     AFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSV
                     HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCE
                     NMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGKA"
     exon            144..271
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            272..317
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            318..554
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            555..681
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            682..756
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            757..914
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1026
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1165
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1216
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1421
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1569
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1654
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1956
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2086
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2297
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2477
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2631
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..3757
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3885
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..4014
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4194
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4329
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4542
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4543..4723
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4724..4931
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4932..5041
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            5042..5262
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            5263..7771
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7751..7756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /note="hexamer: AATACA"
     polyA_site      7771
                     /gene="ADAMTSL1"
                     /gene_synonym="ADAMTSL-1; ADAMTSR1; C9orf94; PUNCTIN"
                     /note="major polyA site"
ORIGIN      
        1 agtactggat gtgacagcag gcagaggagc acttagcagc ttattcagtg tccgattctg
       61 attccggcaa ggatccaagc atggaatgct gccgtcgggc aactcctggc acactgctcc
      121 tctttctggc tttcctgctc ctgagttcca ggaccgcacg ctccgaggag gaccgggacg
      181 gcctatggga tgcctggggc ccatggagtg aatgctcacg cacctgcggg ggtggggcct
      241 cctactctct gaggcgctgc ctgagcagca agagctgtga aggaagaaat atccgataca
      301 gaacatgcag taatgtggac tgcccaccag aagcaggtga tttccgagct cagcaatgct
      361 cagctcataa tgatgtcaag caccatggcc agttttatga atggcttcct gtgtctaatg
      421 accctgacaa cccatgttca ctcaagtgcc aagccaaagg aacaaccctg gttgttgaac
      481 tagcacctaa ggtcttagat ggtacgcgtt gctatacaga atctttggat atgtgcatca
      541 gtggtttatg ccaaattgtt ggctgcgatc accagctggg aagcaccgtc aaggaagata
      601 actgtggggt ctgcaacgga gatgggtcca cctgccggct ggtccgaggg cagtataaat
      661 cccagctctc cgcaaccaaa tcggatgata ctgtggttgc aattccctat ggaagtagac
      721 atattcgcct tgtcttaaaa ggtcctgatc acttatatct ggaaaccaaa accctccagg
      781 ggactaaagg tgaaaacagt ctcagctcca caggaacttt ccttgtggac aattctagtg
      841 tggacttcca gaaatttcca gacaaagaga tactgagaat ggctggacca ctcacagcag
      901 atttcattgt caagattcgt aactcgggct ccgctgacag tacagtccag ttcatcttct
      961 atcaacccat catccaccga tggagggaga cggatttctt tccttgctca gcaacctgtg
     1021 gaggaggtta tcagctgaca tcggctgagt gctacgatct gaggagcaac cgtgtggttg
     1081 ctgaccaata ctgtcactat tacccagaga acatcaaacc caaacccaag cttcaggagt
     1141 gcaacttgga tccttgtcca gccagtgacg gatacaagca gatcatgcct tatgacctct
     1201 accatcccct tcctcggtgg gaggccaccc catggaccgc gtgctcctcc tcgtgtgggg
     1261 ggggcatcca gagccgggca gtttcctgtg tggaggagga catccagggg catgtcactt
     1321 cagtggaaga gtggaaatgc atgtacaccc ctaagatgcc catcgcgcag ccctgcaaca
     1381 tttttgactg ccctaaatgg ctggcacagg agtggtctcc gtgcacagtg acatgtggcc
     1441 agggcctcag ataccgtgtg gtcctctgca tcgaccatcg aggaatgcac acaggaggct
     1501 gtagcccaaa aacaaagccc cacataaaag aggaatgcat cgtacccact ccctgctata
     1561 aacccaaaga gaaacttcca gtcgaggcca agttgccatg gttcaaacaa gctcaagagc
     1621 tagaagaagg agctgctgtg tcagaggagc cctcgttcat cccagaggcc tggtcggcct
     1681 gcacagtcac ctgtggtgtg gggacccagg tgcgaatagt caggtgccag gtgctcctgt
     1741 ctttctctca gtccgtggct gacctgccta ttgacgagtg tgaagggccc aagccagcat
     1801 cccagcgtgc ctgttatgca ggcccatgca gcggggaaat tcctgagttc aacccagacg
     1861 agacagatgg gctctttggt ggcctgcagg atttcgacga gctgtatgac tgggagtatg
     1921 aggggttcac caagtgctcc gagtcctgtg gaggaggtgt ccaggaggct gtggtgagct
     1981 gcttgaacaa acagactcgg gagcctgctg aggagaacct gtgcgtgacc agccgccggc
     2041 ccccacagct cctgaagtcc tgcaatttgg atccctgccc agcaaggtgg gaaattggca
     2101 agtggagtcc atgtagtctc acatgtgggg tcggcctaca gaccagagac gtcttctgca
     2161 gccacctgct ttccagagag atgaatgaaa cagtcatcct ggctgatgag ctgtgtcgcc
     2221 agcccaagcc cagcacggtg caagcttgta accgctttaa ttgcccccca gcctggtacc
     2281 ctgcacagtg gcagccgtgt tccagaacgt gtggcggggg tgttcagaaa cgtgaggttc
     2341 tttgcaagca gcgcatggct gatggcagct tcctggagct tcctgagacc ttctgttcag
     2401 cttcaaaacc tgcctgccag caagcatgca agaaagatga ctgtcccagc gagtggcttc
     2461 tctcagactg gacagagtgt tccacaagct gcggggaagg cacccagact cgaagcgcca
     2521 tttgccgaaa gatgctgaaa accggcctct caacggttgt caattccacc ctgtgcccgc
     2581 ccctgccttt ctcttcctcc atcaggccct gtatgctggc aacctgtgca aggcccgggc
     2641 ggccatccac gaagcacagc ccgcacatcg cggccgccag gaaggtctac atacagactc
     2701 gcaggcagag gaagctgcac ttcgtggtgg ggggcttcgc ctacctgctc cccaagacgg
     2761 cggtggtgct gcgctgcccg gcgcgcaggg tccgcaagcc cctcatcacc tgggagaagg
     2821 acggccagca cctcatcagc tcgacgcacg tcacggtggc ccccttcggc tatctcaaga
     2881 tccaccgcct caagccctcg gatgcaggcg tctacacctg ctcagcgggc ccggcccggg
     2941 agcactttgt gattaagctc atcggaggca accgcaagct cgtggcccgg cccttgagcc
     3001 cgagaagtga ggaagaggtg cttgcgggga ggaagggcgg cccgaaggag gccctgcaga
     3061 cccacaaaca ccagaacggg atcttctcca acggcagcaa ggcggagaag cggggcctgg
     3121 ccgccaaccc ggggagccgc tacgacgacc tcgtctcccg gctgctggag cagggcggct
     3181 ggcccggaga gctgctggcc tcgtgggagg cgcaggactc tgcggaaagg aacacgacct
     3241 cggaggagga cccgggtgca gagcaagtgc tcctgcacct gcccttcacc atggtgaccg
     3301 agcagcggcg cctggacgac atcctgggga acctctccca gcagcccgag gagctgcgcg
     3361 acctctacag caagcacctg gtggcccagc tggcccagga gatcttccgc agccacctgg
     3421 agcaccagga cacgctcctg aagccctcgg agcgcaggac ttccccagtg actctctcgc
     3481 ctcataaaca cgtgtctggc ttcagcagct ccctgcggac ctcctccacc ggggacgccg
     3541 ggggaggctc tcgaaggcca caccgcaagc ccaccatcct gcgcaagatc tcagcggccc
     3601 agcagctctc agcctcggag gtggtcaccc acctggggca gacggtggcc ctggccagcg
     3661 ggacactgag tgttcttctg cactgtgagg ccatcggcca cccaaggcct accatcagct
     3721 gggccaggaa tggagaagaa gttcagttca gtgacaggat tcttctacag ccagatgatt
     3781 ccttacagat cttggcacca gtggaagcag atgtgggttt ctacacttgc aatgccacca
     3841 atgccttggg atacgactct gtctccattg ccgtcacatt agcaggaaag ccactagtga
     3901 aaacgtcacg aatgacagtg atcaacacgg agaagcctgc agtcacagtc gatataggaa
     3961 gcaccatcaa aacagtgcag ggagtgaatg tgacaatcaa ctgccaggtt gcaggagtgc
     4021 ctgaagctga agtcacttgg ttcaggaata aaagcaaact gggctccccg caccatctgc
     4081 acgaaggctc cttgctgctc acaaacgtgt cctcctcgga tcagggcctg tactcctgca
     4141 gggcggccaa tcttcatgga gagctgactg agagcaccca gctgctgatc ctagatcccc
     4201 cccaagtccc cacacagttg gaagacatca gggccttgct cgctgccact ggaccgaacc
     4261 ttccttcagt gctgacgtct cctctgggaa cacagctggt cctggatcct gggaattctg
     4321 ctctccttgg ctgccccatc aaaggtcacc ctgtccctaa tatcacctgg tttcatggtg
     4381 gtcagccaat tgtcactgcc acaggactga cgcatcacat cttggcagct ggacagatcc
     4441 ttcaagttgc aaaccttagc ggtgggtctc aaggggaatt cagctgcctt gctcagaatg
     4501 aggcaggggt gctcatgcag aaggcatctt tagtgatcca agattactgg tggtctgtgg
     4561 acagactggc aacctgctca gcctcctgtg gtaaccgggg ggttcagcag ccccgcttga
     4621 ggtgcctgct gaacagcacg gaggtcaacc ctgcccactg cgcagggaag gttcgccctg
     4681 cggtgcagcc catcgcgtgc aaccggagag actgcccttc tcggtggatg gtgacctcct
     4741 ggtctgcctg tacccggagc tgtgggggag gtgtccagac ccgcagggtg acctgtcaaa
     4801 agctgaaagc ctctgggatc tccacccctg tgtccaatga catgtgcacc caggtcgcca
     4861 agcggcctgt ggacacccag gcctgtaacc agcagctgtg tgtggagtgg gccttctcca
     4921 gctggggcca gtgcaatggg ccttgcatcg ggcctcacct agctgtgcaa cacagacaag
     4981 tcttctgcca gacacgggat ggcatcacct taccatcaga gcagtgcagt gctcttccga
     5041 ggcctgtgag cacccagaac tgctggtcag aggcctgcag tgtacactgg agagtcagcc
     5101 tgtggaccct gtgcacagct acctgtggca actacggctt ccagtcccgg cgtgtggagt
     5161 gtgtgcatgc ccgcaccaac aaggcagtgc ctgagcacct gtgctcctgg gggccccggc
     5221 ctgccaactg gcagcgctgc aacatcaccc catgtgaaaa catggagtgc agagacacca
     5281 ccaggtactg cgagaaggtg aaacagctga aactctgcca actcagccag tttaaatctc
     5341 gctgctgtgg aacttgtggc aaagcgtgaa gatagggtgt ggggaaaaac tctaccctgg
     5401 ccacacgaag gactcacgca accacctcgg acagaaccta agctttcttc attttattta
     5461 tttatttccc cctccccact ccacacacac ccttccaacc tcctccacct ccaccttcaa
     5521 gcataaggac gtccgcgtgt tttctctttc agttagctgg aggacaggat gttgggaaag
     5581 gaaaggacag atgtctaaag gaggttgcag agcaggccag gcagacagtg ggggctccct
     5641 tgaagagctt cctccctccc aaacctgggt ctcaaagacc tagaaagagg caggcacagc
     5701 ccctgcggac agcagggagc cagaaggttt gtagcctatt ggtgcaaaca ttggacaaat
     5761 tcctgtgtct ttcctagaag cgcactatca caaacacagg agtgttttgc tcctttgtct
     5821 cctcttcccc atctatgtcc ctttagtcac agttaggaca aatggggagg ggacaccatg
     5881 ctgaggcaga aactagccca gaactcactc agttcttcta gtgggtgagt gcagagagag
     5941 aagaactcag atcaccagta gggagaggta aaaaagcaaa caaagcaggc tctaaggcac
     6001 acaacattgc agaaaatgag gaagggaggg gagggaaggg acagaagcaa aaaggagcct
     6061 gtggtgttcc ccagtggggc agggtgagca ggggcttcca ggctgcatga ggctcatgga
     6121 ccagctctga tcccatgcat gtgcgcatgc tcagagccct gctgcccaca acagagcact
     6181 gcgctgcgtg ggagtcccca cttcccaagc tatcagagtc aacgtcctgc ctgtgcagct
     6241 gcagcaaagc cagtgagagg tgggtctcgc catgcagtaa ggccaccctg gcacctcttt
     6301 atctaaatcc gaagtcccct agccccgcac taactaactg ctgctgtggg ccagggccat
     6361 tttgagcatg aatggcccag gttttttgcc ttctaggacc tttgctgctc caccgaaggg
     6421 ccagggacta tggttaactt atcaacatca acccattaac tagtcactgt gccagagagt
     6481 atctgtcagg ctgtcaggtt gtagcaacct cttcattcca gagctggccc agggaccggg
     6541 gtgggacaat gggtttatgc gtgtccacag tacaccctcc ctctcccagc ctccacccca
     6601 gggtctgcag gtcctccggc atgtagtatt tatctagcaa ggcggggtgg tggaggcagc
     6661 accctggcaa agcagctcac acactgcagc cacactcatc agctgtggtg aggcggctgg
     6721 agcaaagtca aagtcatgca gcaaaatgaa aactctggga ctcttcggca aaatcctcat
     6781 taagccgagc agctttggcc aagtaatttt tgcctccttc cctcgcgtgg cctgagttta
     6841 ggagcaaggg tggccagagt cccttaccca cagataagcc tcccctcatg aaatgccact
     6901 caccccgggc taccattgac atcagggctg catttccagc cagcctggaa gtaaaatttg
     6961 agaggaagac aatattaatc tgtgtcccca cctagtgagc tgtggacagg tttaagttgg
     7021 gtctccttct tcttcaccac aaaaacaggc tctaagaaat catgttacta aaaaatcagt
     7081 gtaaagtctg tttaaaataa aaaagaatgt tttctatgtc tgtatatctt ttgtgaatat
     7141 ttattaggat ttcttattaa aaaagtgcaa tattaataat tgtacattgt catccagaaa
     7201 caaaactatt ggggggactt tattaactaa cttcctgcag ttgtgttcct gtaaactcag
     7261 tagtgattat tatatttttc ctatttttaa tagaacctgg tgtttaactc tggatccatt
     7321 cactgtacag gatgtgttgt aaaaactaac atgggatgct gaggcagtaa gagggaattc
     7381 atttgtggca taatagttat gcatggaatg ataaagacag acaaattcca tactactact
     7441 aatgtggtta attatttcta gttcgatagt gattgaaaat cagtggtcac tatttacatt
     7501 tcctaaagag caagcatcct ccagctccat gttgggttgg agcagttggc agtgggtctc
     7561 agtgagctgg cagaacctag gtttgggtgg gaagcagaat gctcgttgca tgaaatgaat
     7621 gtacatttaa tgtttgttct gtgaattgca actcagcagc accacaagac aatgaaggct
     7681 gctggctaat gtggaaggag gcactttctc ctctaaaaca caaaactgta tttgtatttt
     7741 ttgtacagat aatacagctt atttatttaa a
//
