LOCUS       NM_182920               7624 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            9 (ADAMTS9), transcript variant 1, mRNA.
ACCESSION   NM_182920
VERSION     NM_182920.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7624)
  AUTHORS   Yu,Q., Guo,K., Yang,Y., Liu,H., Huang,Y. and Li,W.
  TITLE     LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration
            under mechanical compression via ADAMTS9/fibronectin
  JOURNAL   J Periodontal Res 59 (1), 174-186 (2024)
   PUBMED   37957805
  REMARK    GeneRIF: LncRNA ADAMTS9-AS2 regulates periodontal ligament cell
            migration under mechanical compression via ADAMTS9/fibronectin.
REFERENCE   2  (bases 1 to 7624)
  AUTHORS   Shekhar,B.R., Rupani,K., Parkar,S.R., Nayak,A.S., Kumbhar,B.V.,
            Khare,S.P., Menon,S., Gawde,H. and Das,D.K.
  TITLE     Identifying novel risk conferring genes involved in glycosylation
            processes with familial schizophrenia in an Indian cohort:
            Prediction of ADAMTS9 gene variant for structural stability
  JOURNAL   Gene 872, 147443 (2023)
   PUBMED   37105505
  REMARK    GeneRIF: Identifying novel risk conferring genes involved in
            glycosylation processes with familial schizophrenia in an Indian
            cohort: Prediction of ADAMTS9 gene variant for structural
            stability.
REFERENCE   3  (bases 1 to 7624)
  AUTHORS   Nandadasa,S., Martin,D., Deshpande,G., Robert,K.L., Stack,M.S.,
            Itoh,Y. and Apte,S.S.
  TITLE     Degradomic Identification of Membrane Type 1-Matrix
            Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate
  JOURNAL   Mol Cell Proteomics 22 (6), 100566 (2023)
   PUBMED   37169079
  REMARK    GeneRIF: Degradomic Identification of Membrane Type 1-Matrix
            Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate.
REFERENCE   4  (bases 1 to 7624)
  AUTHORS   Tayman,M.A. and Koyuncu,I.
  TITLE     Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in
            periodontitis
  JOURNAL   Biotech Histochem 98 (2), 126-131 (2023)
   PUBMED   36093887
  REMARK    GeneRIF: Differential gene expression of ADAMTS-1, ADAMTS-9 and
            TIMP-3 in periodontitis.
REFERENCE   5  (bases 1 to 7624)
  AUTHORS   Li,Z., Yue,G., Zhang,T., Wu,J. and Tian,X.
  TITLE     LncRNA ADAMTS9-AS1 knockdown restricts cell proliferation and EMT
            in non-small cell lung cancer
  JOURNAL   Histol Histopathol 36 (10), 1063-1072 (2021)
   PUBMED   34085704
  REMARK    GeneRIF: LncRNA ADAMTS9-AS1 knockdown restricts cell proliferation
            and EMT in non-small cell lung cancer.
REFERENCE   6  (bases 1 to 7624)
  AUTHORS   Zeng,W., Corcoran,C., Collins-Racie,L.A., Lavallie,E.R.,
            Morris,E.A. and Flannery,C.R.
  TITLE     Glycosaminoglycan-binding properties and aggrecanase activities of
            truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and
            -18
  JOURNAL   Biochim Biophys Acta 1760 (3), 517-524 (2006)
   PUBMED   16507336
  REMARK    GeneRIF: TSR-1 domain-bearing truncated ADAMTS-9 demonstrates
            positive GAG-binding ability & displayed low aggrecanase activity.
REFERENCE   7  (bases 1 to 7624)
  AUTHORS   Cross,N.A., Chandrasekharan,S., Jokonya,N., Fowles,A., Hamdy,F.C.,
            Buttle,D.J. and Eaton,C.L.
  TITLE     The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and
            TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation
            of versican
  JOURNAL   Prostate 63 (3), 269-275 (2005)
   PUBMED   15599946
  REMARK    GeneRIF: negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15
            coupled with increases in their inhibitor, TIMP-3 may aid the
            accumulation of versican in the stromal compartment of the prostate
            in BPH and prostate cancer
REFERENCE   8  (bases 1 to 7624)
  AUTHORS   Somerville,R.P., Longpre,J.M., Jungers,K.A., Engle,J.M., Ross,M.,
            Evanko,S., Wight,T.N., Leduc,R. and Apte,S.S.
  TITLE     Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS
            subfamily related to Caenorhabditis elegans GON-1
  JOURNAL   J Biol Chem 278 (11), 9503-9513 (2003)
   PUBMED   12514189
  REMARK    GeneRIF: ancillary domains of ADAMTS-9 are required both for
            specific extracellular localization and for its versicanase and
            aggrecanase activities
REFERENCE   9  (bases 1 to 7624)
  AUTHORS   Tang,B.L.
  TITLE     ADAMTS: a novel family of extracellular matrix proteases
  JOURNAL   Int J Biochem Cell Biol 33 (1), 33-44 (2001)
   PUBMED   11167130
  REMARK    Review article
REFERENCE   10 (bases 1 to 7624)
  AUTHORS   Clark,M.E., Kelner,G.S., Turbeville,L.A., Boyer,A., Arden,K.C. and
            Maki,R.A.
  TITLE     ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family
  JOURNAL   Genomics 67 (3), 343-350 (2000)
   PUBMED   10936055
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122178.2, BC036770.1,
            AB037733.1, BX482310.1, AF488803.1, CD103111.1 and BC026271.2.
            
            On Nov 23, 2018 this sequence version replaced NM_182920.1.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            Members of the family share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains.
            Members of the ADAMTS family have been implicated in the cleavage
            of proteoglycans, the control of organ shape during development,
            and the inhibition of angiogenesis. This gene is localized to
            chromosome 3p14.3-p14.2, an area known to be lost in hereditary
            renal tumors. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            proteolytic processing. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130578.1, AF488803.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000498707.5/ ENSP00000418735.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               AC122178.2         130685-130995       c
            312-1806            BC036770.1         302-1796
            1807-5212           AB037733.1         991-4396
            5213-5503           BX482310.1         210-500
            5504-6304           AF488803.1         5193-5993
            6305-6794           CD103111.1         247-736
            6795-7624           BC026271.2         842-1671
FEATURES             Location/Qualifiers
     source          1..7624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..7624
                     /gene="ADAMTS9"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 9"
                     /db_xref="GeneID:56999"
                     /db_xref="HGNC:HGNC:13202"
                     /db_xref="MIM:605421"
     exon            1..458
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..6151
                     /gene="ADAMTS9"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 9; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 9"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 9 isoform 1 preproprotein"
                     /protein_id="NP_891550.1"
                     /db_xref="CCDS:CCDS2903.1"
                     /db_xref="GeneID:56999"
                     /db_xref="HGNC:HGNC:13202"
                     /db_xref="MIM:605421"
                     /translation="MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLET
                     LSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRL
                     SAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNS
                     EHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPST
                     GRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNT
                     REKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIG
                     NLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQD
                     ICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKC
                     KEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPV
                     QLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTEC
                     EPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGG
                     KYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILM
                     KDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRD
                     KCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLAL
                     SSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSV
                     GKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVS
                     DQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKT
                     EKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRND
                     VLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLND
                     RMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDN
                     DCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRM
                     RYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQ
                     VMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSAS
                     PSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRAC
                     ESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNT
                     HACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCR
                     GGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGP
                     RCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQ
                     PCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVH
                     PCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKT
                     CRNVYNCELPQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHG
                     DSENFSEVYGHRLHNPTECPYNGSRRDDCQCRKDYTAAGFSSFQKIRIDLTSMQIITT
                     DLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWISQGNYAVS
                     DIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRVL"
     exon            459..859
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1022
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1312
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1396
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1512
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1553
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1659
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1806
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1948
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2053
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2199
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2381
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2518
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2636
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2732
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2899
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3029
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3156
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3367
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3532
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3697
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3817
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..3922
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3923..4090
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4091..4360
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4522
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4523..4699
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4700..4867
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4868..5041
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5042..5212
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5213..5407
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5540
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5541..5635
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5636..5730
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5731..5864
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5865..5956
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5957..6061
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            6062..6156
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            6157..7624
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7605..7610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS9"
                     /note="hexamer: AATACA"
     polyA_site      7624
                     /gene="ADAMTS9"
                     /note="major polyA site"
ORIGIN      
        1 acagggcgcc cggcgcgcct cggagcgcaa gttcctcgcc ttctcctgcc cgctcgctgg
       61 gcattatgcg gccaagcagc cgagccccag tcctcctcct cctcctgctc ctccggctcc
      121 tcctgcggcc cgagcggctc agctctcggc aggcggcggc gttgctcagc cgagcgcaga
      181 cgggaccctc gcagcgagac ctcagcgact cctaaagtca aaagttggcg gcgggcgccg
      241 ggctccgcgc gctctccacg gccgctgcct cgcgtcgccg ccgcagccaa ggagggcagg
      301 agggaggggg gtgggggcag cggagggagg ggtgggaagc accatgcagt ttgtatcctg
      361 ggccacactg ctaacgctcc tggtgcggga cctggccgag atggggagcc cagacgccgc
      421 ggcggccgtg cgcaaggaca ggctgcaccc gaggcaagtg aaattattag agaccctgag
      481 cgaatacgaa atcgtgtctc ccatccgagt gaacgctctc ggagaaccct ttcccacgaa
      541 cgtccacttc aaaagaacgc gacggagcat taactctgcc actgacccct ggcctgcctt
      601 cgcctcctcc tcttcctcct ctacctcctc ccaggcgcat taccgcctct ctgccttcgg
      661 ccagcagttt ctatttaatc tcaccgccaa tgccggattt atcgctccac tgttcactgt
      721 caccctcctc gggacgcccg gggtgaatca gaccaagttt tattccgaag aggaagcgga
      781 actcaagcac tgtttctaca aaggctatgt caataccaac tccgagcaca cggccgtcat
      841 cagcctctgc tcaggaatgc tgggcacatt ccggtctcat gatggggatt attttattga
      901 accactacag tctatggatg aacaagaaga tgaagaggaa caaaacaaac cccacatcat
      961 ttataggcgc agcgcccccc agagagagcc ctcaacagga aggcatgcat gtgacacctc
     1021 agaacacaaa aataggcaca gtaaagacaa gaagaaaacc agagcaagaa aatggggaga
     1081 aaggattaac ctggctggtg acgtagcagc attaaacagc ggcttagcaa cagaggcatt
     1141 ttctgcttat ggtaataaga cggacaacac aagagaaaag aggacccaca gaaggacaaa
     1201 acgtttttta tcctatccac ggtttgtaga agtcttggtg gtggcagaca acagaatggt
     1261 ttcataccat ggagaaaacc ttcaacacta tattttaact ttaatgtcaa ttgtagcctc
     1321 tatctataaa gacccaagta ttggaaattt aattaatatt gttattgtga acttaattgt
     1381 gattcataat gaacaggatg ggccttccat atcttttaat gctcagacaa cattaaaaaa
     1441 cttttgccag tggcagcatt cgaagaacag tccaggtgga atccatcatg atactgctgt
     1501 tctcttaaca agacaggata tctgcagagc tcacgacaaa tgtgatacct taggcctggc
     1561 tgaactggga accatttgtg atccctatag aagctgttct attagtgaag atagtggatt
     1621 gagtacagct tttacgatcg cccatgagct gggccatgtg tttaacatgc ctcatgatga
     1681 caacaacaaa tgtaaagaag aaggagttaa gagtccccag catgtcatgg ctccaacact
     1741 gaacttctac accaacccct ggatgtggtc aaagtgtagt cgaaaatata tcactgagtt
     1801 tttagacact ggttatggcg agtgtttgct taacgaacct gaatccagac cctacccttt
     1861 gcctgtccaa ctgccaggca tcctttacaa cgtgaataaa caatgtgaat tgatttttgg
     1921 accaggttct caggtgtgcc catatatgat gcagtgcaga cggctctggt gcaataacgt
     1981 caatggagta cacaaaggct gccggactca gcacacaccc tgggccgatg ggacggagtg
     2041 cgagcctgga aagcactgca agtatggatt ttgtgttccc aaagaaatgg atgtccccgt
     2101 gacagatgga tcctggggaa gttggagtcc ctttggaacc tgctccagaa catgtggagg
     2161 gggcatcaaa acagccattc gagagtgcaa cagaccagaa ccaaaaaatg gtggaaaata
     2221 ctgtgtagga cgtagaatga aatttaagtc ctgcaacacg gagccatgtc tcaagcagaa
     2281 gcgagacttc cgagatgaac agtgtgctca ctttgacggg aagcatttta acatcaacgg
     2341 tctgcttccc aatgtgcgct gggtccctaa atacagtgga attctgatga aggaccggtg
     2401 caagttgttc tgcagagtgg cagggaacac agcctactat cagcttcgag acagagtgat
     2461 agatggaact ccttgtggcc aggacacaaa tgatatctgt gtccagggcc tttgccggca
     2521 agctggatgc gatcatgttt taaactcaaa agcccggaga gataaatgtg gggtttgtgg
     2581 tggcgataat tcttcatgca aaacagtggc aggaacattt aatacagtac attatggtta
     2641 caatactgtg gtccgaattc cagctggtgc taccaatatt gatgtgcggc agcacagttt
     2701 ctcaggggaa acagacgatg acaactactt agctttatca agcagtaaag gtgaattctt
     2761 gctaaatgga aactttgttg tcacaatggc caaaagggaa attcgcattg ggaatgctgt
     2821 ggtagagtac agtgggtccg agactgccgt agaaagaatt aactcaacag atcgcattga
     2881 gcaagaactt ttgcttcagg ttttgtcggt gggaaagttg tacaaccccg atgtacgcta
     2941 ttctttcaat attccaattg aagataaacc tcagcagttt tactggaaca gtcatgggcc
     3001 atggcaagca tgcagtaaac cctgccaagg ggaacggaaa cgaaaacttg tttgcaccag
     3061 ggaatctgat cagcttactg tttctgatca aagatgcgat cggctgcccc agcctggaca
     3121 cattactgaa ccctgtggta cagactgtga cctgaggtgg catgttgcca gcaggagtga
     3181 atgtagtgcc cagtgtggct tgggttaccg cacattggac atctactgtg ccaaatatag
     3241 caggctggat gggaagactg agaaggttga tgatggtttt tgcagcagcc atcccaaacc
     3301 aagcaaccgt gaaaaatgct caggggaatg taacacgggt ggctggcgct attctgcctg
     3361 gactgaatgt tcaaaaagct gtgacggtgg gacccagagg agaagggcta tttgtgtcaa
     3421 tacccgaaat gatgtactgg atgacagcaa atgcacacat caagagaaag ttaccattca
     3481 gaggtgcagt gagttccctt gtccacagtg gaaatctgga gactggtcag agtgcttggt
     3541 cacctgtgga aaagggcata agcaccgcca ggtctggtgt cagtttggtg aagatcgatt
     3601 aaatgataga atgtgtgacc ctgagaccaa gccaacatct atgcagactt gtcagcagcc
     3661 ggaatgtgca tcctggcagg cgggtccctg gggacagtgc agtgtcactt gtggacaggg
     3721 ataccagcta agagcagtga aatgcatcat tgggacttat atgtcagtgg tagatgacaa
     3781 tgactgtaat gcagcaacta gaccaactga tacccaggac tgtgaattac catcatgtca
     3841 tcctccccca gctgccccgg aaacgaggag aagcacatac agtgcaccaa gaacccagtg
     3901 gcgatttggg tcttggaccc catgctcagc cacttgtggg aaaggtaccc ggatgagata
     3961 cgtcagctgc cgagatgaga atggctctgt ggctgacgag agtgcctgtg ctaccctgcc
     4021 tagaccagtg gcaaaggaag aatgttctgt gacaccctgt gggcaatgga aggccttgga
     4081 ctggagctct tgctctgtga cctgtgggca aggtagggca acccggcaag tgatgtgtgt
     4141 caactacagt gaccacgtga tcgatcggag tgagtgtgac caggattata tcccagaaac
     4201 tgaccaggac tgttccatgt caccatgccc tcaaaggacc ccagacagtg gcttagctca
     4261 gcaccccttc caaaatgagg actatcgtcc ccggagcgcc agccccagcc gcacccatgt
     4321 gctcggtgga aaccagtgga gaactggccc ctggggagca tgttccagta cctgtgctgg
     4381 cggatcccag cggcgtgttg ttgtatgtca ggatgaaaat ggatacaccg caaacgactg
     4441 tgtggagaga ataaaacctg atgagcaaag agcctgtgaa tccggccctt gtcctcagtg
     4501 ggcttatggc aactggggag agtgcactaa gctgtgtggt ggaggcataa gaacaagact
     4561 ggtggtctgt cagcggtcca acggtgaacg gtttccagat ttgagctgtg aaattcttga
     4621 taaacctccc gatcgtgagc agtgtaacac acatgcttgt ccacacgacg ctgcatggag
     4681 tactggccct tggagctcgt gttctgtctc ttgtggtcga gggcataaac aacgaaatgt
     4741 ttactgcatg gcaaaagatg gaagccattt agaaagtgat tactgtaagc acctggctaa
     4801 gccacatggg cacagaaagt gccgaggagg aagatgcccc aaatggaaag ctggcgcttg
     4861 gagtcagtgc tctgtgtcct gtggccgagg cgtacagcag aggcatgtgg gctgtcagat
     4921 cggaacacac aaaatagcca gagagaccga gtgcaaccca tacaccagac cggagtcgga
     4981 acgcgactgc caaggcccac ggtgtcccct ctacacttgg agggcagagg aatggcaaga
     5041 atgcaccaag acctgcggcg aaggctccag gtaccgcaag gtggtgtgtg tggatgacaa
     5101 caaaaacgag gtgcatgggg cacgctgtga cgtgagcaag cggccggtgg accgtgaaag
     5161 ctgtagtttg caaccctgcg agtatgtctg gatcacagga gaatggtcag agtgctcagt
     5221 gacctgtgga aaaggctaca aacaaaggct tgtctcgtgc agcgagattt acaccgggaa
     5281 ggagaattat gaatacagct accaaaccac catcaactgc ccaggcacgc agccccccag
     5341 tgttcacccc tgttacctga gggactgccc tgtctcggcc acctggagag ttggcaactg
     5401 ggggagctgc tcagtgtctt gtggtgttgg agtgatgcag agatctgtgc aatgtttaac
     5461 caatgaggac caacccagcc acttatgcca cactgatctg aagccagaag aacgaaaaac
     5521 ctgccgtaat gtctataact gtgagttacc ccagaattgc aaggaggtaa aaagacttaa
     5581 aggtgccagt gaagatggtg aatatttcct gatgattaga ggaaagcttc tgaagatatt
     5641 ctgtgcgggg atgcactctg accaccccaa agagtacgtg acactggtgc atggagactc
     5701 tgagaatttc tccgaggttt atgggcacag gttacacaac ccaacagaat gtccctataa
     5761 cgggagccgg cgcgatgact gccaatgtcg gaaggattac acggccgctg ggttttccag
     5821 ttttcagaaa atcagaatag acctgaccag catgcagata atcaccactg acttacagtt
     5881 tgcaaggaca agcgaaggac atcccgtccc ttttgccaca gccggggatt gctacagcgc
     5941 tgccaagtgc ccacagggtc gttttagcat caacctttat ggaaccggct tgtctttaac
     6001 tgaatctgcc agatggatat cacaagggaa ttatgctgtc tctgacatca agaagtcgcc
     6061 ggatggtacc cgagtcgtag ggaaatgcgg tggttactgt ggaaaatgca ctccatcctc
     6121 tggtactggc ctggaggtgc gagttttata gctaaggtgc tttgaagagg aagccattat
     6181 ggatggatga aggatagtaa tgcaatacct ccaccttaat ttgggtgcat gtgtatgtgt
     6241 gtgtgtgttt gtgtgtgact tgtatgcttg tgtgtgtaaa tgtgtgtaca tatacatata
     6301 tacatatcta cacatacata tatacacata tatgtgtgta tgtagatatg tagactatcc
     6361 taatgatgta aagtttaata tttatgtttg aaattattta ttgtgatgta atatttttgt
     6421 acgtaaaatg attctattat gactgccttt gcatgtagta atatgacaaa gtgatccttc
     6481 attatcacgg tacactattg tttacttttc atctgtaaat gttttattgt tactttttta
     6541 aaatgaattt ttttaaaaca atctagccat catcaaggtg ctataagagt tgtataaaag
     6601 atatttttgg catttctagg caagtatcag ccaataagta tgttagtgat atcacagatt
     6661 gtaccaacta ttaactatgt taaataagta ttcagtttca tgtgatctct gggaaaaaaa
     6721 tatgctgcct tggtgctaat attgtatgta tttaaatgat catccgactc agaaatataa
     6781 acacttttaa tgaaagggag gaacggaagg acaatttcca gtgcacagaa tcacttggat
     6841 gaaataagac cagctcttta cccttatttt tggatatgcc ttttttggaa gagacttaga
     6901 ctttatcctt attgttgtta gtgttgttaa tattcgttgc ttcagcccac ggtgccttgg
     6961 tctctccaca atcaaatgga ggatccccca agcagcttca ttacagagtg atattgggaa
     7021 agtgagatcc tctcaccatt ttgccaagat actctaaaat gacatccaag tttaccagta
     7081 gaaagacaca ggatgcacag aatgggcatg accttcagct cacgagcaca cctggagaaa
     7141 ttcagaacca ggttctgaat catcacgatt gccttttgca tgaaaacatc ggctggtgat
     7201 gtgacttctc ttcaggccat gagcctaaca ccctgccggt tttcatgccc gctgcagtaa
     7261 tggacgtttg tgtgaagaaa tgaactgtgg agtacaaaat gctttgagtc tttccgattg
     7321 ctcattaatt cacttttttg ttacttcttt ccaaaatgga agtgctgaag ccatggtctt
     7381 tctgcccctc caagctgatg aagggaagcc tttgccaatg gcccatggaa gacacttggt
     7441 ttgagaaacc ctgcccactt ccaaagacca aagagattag gaaaagcctg gcagtattct
     7501 ccaactccaa acaagctcta gagtgctcca ggaaaagtta tattcagtat atgaataagt
     7561 gttattctcc attattaatg tgttctgaaa atatattatg aataaataca tcaccacacc
     7621 caaa
//
