LOCUS       NM_001318781            7540 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            9 (ADAMTS9), transcript variant 4, mRNA.
ACCESSION   NM_001318781 XM_005265329
VERSION     NM_001318781.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7540)
  AUTHORS   Yu,Q., Guo,K., Yang,Y., Liu,H., Huang,Y. and Li,W.
  TITLE     LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration
            under mechanical compression via ADAMTS9/fibronectin
  JOURNAL   J Periodontal Res 59 (1), 174-186 (2024)
   PUBMED   37957805
  REMARK    GeneRIF: LncRNA ADAMTS9-AS2 regulates periodontal ligament cell
            migration under mechanical compression via ADAMTS9/fibronectin.
REFERENCE   2  (bases 1 to 7540)
  AUTHORS   Shekhar,B.R., Rupani,K., Parkar,S.R., Nayak,A.S., Kumbhar,B.V.,
            Khare,S.P., Menon,S., Gawde,H. and Das,D.K.
  TITLE     Identifying novel risk conferring genes involved in glycosylation
            processes with familial schizophrenia in an Indian cohort:
            Prediction of ADAMTS9 gene variant for structural stability
  JOURNAL   Gene 872, 147443 (2023)
   PUBMED   37105505
  REMARK    GeneRIF: Identifying novel risk conferring genes involved in
            glycosylation processes with familial schizophrenia in an Indian
            cohort: Prediction of ADAMTS9 gene variant for structural
            stability.
REFERENCE   3  (bases 1 to 7540)
  AUTHORS   Nandadasa,S., Martin,D., Deshpande,G., Robert,K.L., Stack,M.S.,
            Itoh,Y. and Apte,S.S.
  TITLE     Degradomic Identification of Membrane Type 1-Matrix
            Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate
  JOURNAL   Mol Cell Proteomics 22 (6), 100566 (2023)
   PUBMED   37169079
  REMARK    GeneRIF: Degradomic Identification of Membrane Type 1-Matrix
            Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate.
REFERENCE   4  (bases 1 to 7540)
  AUTHORS   Tayman,M.A. and Koyuncu,I.
  TITLE     Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in
            periodontitis
  JOURNAL   Biotech Histochem 98 (2), 126-131 (2023)
   PUBMED   36093887
  REMARK    GeneRIF: Differential gene expression of ADAMTS-1, ADAMTS-9 and
            TIMP-3 in periodontitis.
REFERENCE   5  (bases 1 to 7540)
  AUTHORS   Li,Z., Yue,G., Zhang,T., Wu,J. and Tian,X.
  TITLE     LncRNA ADAMTS9-AS1 knockdown restricts cell proliferation and EMT
            in non-small cell lung cancer
  JOURNAL   Histol Histopathol 36 (10), 1063-1072 (2021)
   PUBMED   34085704
  REMARK    GeneRIF: LncRNA ADAMTS9-AS1 knockdown restricts cell proliferation
            and EMT in non-small cell lung cancer.
REFERENCE   6  (bases 1 to 7540)
  AUTHORS   Zeng,W., Corcoran,C., Collins-Racie,L.A., Lavallie,E.R.,
            Morris,E.A. and Flannery,C.R.
  TITLE     Glycosaminoglycan-binding properties and aggrecanase activities of
            truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and
            -18
  JOURNAL   Biochim Biophys Acta 1760 (3), 517-524 (2006)
   PUBMED   16507336
  REMARK    GeneRIF: TSR-1 domain-bearing truncated ADAMTS-9 demonstrates
            positive GAG-binding ability & displayed low aggrecanase activity.
REFERENCE   7  (bases 1 to 7540)
  AUTHORS   Cross,N.A., Chandrasekharan,S., Jokonya,N., Fowles,A., Hamdy,F.C.,
            Buttle,D.J. and Eaton,C.L.
  TITLE     The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and
            TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation
            of versican
  JOURNAL   Prostate 63 (3), 269-275 (2005)
   PUBMED   15599946
  REMARK    GeneRIF: negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15
            coupled with increases in their inhibitor, TIMP-3 may aid the
            accumulation of versican in the stromal compartment of the prostate
            in BPH and prostate cancer
REFERENCE   8  (bases 1 to 7540)
  AUTHORS   Somerville,R.P., Longpre,J.M., Jungers,K.A., Engle,J.M., Ross,M.,
            Evanko,S., Wight,T.N., Leduc,R. and Apte,S.S.
  TITLE     Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS
            subfamily related to Caenorhabditis elegans GON-1
  JOURNAL   J Biol Chem 278 (11), 9503-9513 (2003)
   PUBMED   12514189
  REMARK    GeneRIF: ancillary domains of ADAMTS-9 are required both for
            specific extracellular localization and for its versicanase and
            aggrecanase activities
REFERENCE   9  (bases 1 to 7540)
  AUTHORS   Tang,B.L.
  TITLE     ADAMTS: a novel family of extracellular matrix proteases
  JOURNAL   Int J Biochem Cell Biol 33 (1), 33-44 (2001)
   PUBMED   11167130
  REMARK    Review article
REFERENCE   10 (bases 1 to 7540)
  AUTHORS   Clark,M.E., Kelner,G.S., Turbeville,L.A., Boyer,A., Arden,K.C. and
            Maki,R.A.
  TITLE     ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family
  JOURNAL   Genomics 67 (3), 343-350 (2000)
   PUBMED   10936055
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122178.2, AF488803.1,
            BC171764.1, AC096888.2 and BC026271.2.
            
            On May 31, 2019 this sequence version replaced NM_001318781.1.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            Members of the family share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains.
            Members of the ADAMTS family have been implicated in the cleavage
            of proteoglycans, the control of organ shape during development,
            and the inhibition of angiogenesis. This gene is localized to
            chromosome 3p14.3-p14.2, an area known to be lost in hereditary
            renal tumors. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            proteolytic processing. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform 4 which is shorter than isoform 1. This isoform (4) may
            undergo proteolytic processing similar to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC171764.1, SRR18074969.1843113.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               AC122178.2         130685-130995       c
            312-321             AF488803.1         1-10
            322-6907            BC171764.1         1-6586
            6908-6908           AC096888.2         124571-124571       c
            6909-7381           BC171764.1         6588-7060
            7382-7540           BC026271.2         1513-1671
FEATURES             Location/Qualifiers
     source          1..7540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..7540
                     /gene="ADAMTS9"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 9"
                     /db_xref="GeneID:56999"
                     /db_xref="HGNC:HGNC:13202"
                     /db_xref="MIM:605421"
     exon            1..458
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..6067
                     /gene="ADAMTS9"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 9; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 9"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 9 isoform 4 precursor"
                     /protein_id="NP_001305710.1"
                     /db_xref="CCDS:CCDS82801.1"
                     /db_xref="GeneID:56999"
                     /db_xref="HGNC:HGNC:13202"
                     /db_xref="MIM:605421"
                     /translation="MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLET
                     LSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRL
                     SAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNS
                     EHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPST
                     GRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNT
                     REKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIDGPSISFNAQT
                     TLKNFCQWQHSKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSI
                     SEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKC
                     SRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMM
                     QCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSW
                     SPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDE
                     QCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTP
                     CGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNT
                     VVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAV
                     VEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSH
                     GPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVA
                     SRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGG
                     WRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKS
                     GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPW
                     GQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPET
                     RRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKE
                     ECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDC
                     SMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGS
                     QRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRL
                     VVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQR
                     NVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHV
                     GCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKV
                     VCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVS
                     CSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVG
                     VMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCKEVKRLKGASEDGEY
                     FLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDD
                     CQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCP
                     QGRFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGT
                     GLEVRVL"
     exon            459..859
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1022
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1312
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1428
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1469
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1575
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1722
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1864
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1969
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2115
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2297
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2434
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2552
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2648
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2815
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2945
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3072
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3283
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3448
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3613
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3733
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3838
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..4006
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4276
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4438
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4439..4615
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4783
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4784..4957
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            4958..5128
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5129..5323
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5324..5456
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5457..5551
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5552..5646
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5647..5780
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5781..5872
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5873..5977
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            5978..6072
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     exon            6073..7540
                     /gene="ADAMTS9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7521..7526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS9"
                     /note="hexamer: AATACA"
     polyA_site      7540
                     /gene="ADAMTS9"
                     /note="major polyA site"
ORIGIN      
        1 acagggcgcc cggcgcgcct cggagcgcaa gttcctcgcc ttctcctgcc cgctcgctgg
       61 gcattatgcg gccaagcagc cgagccccag tcctcctcct cctcctgctc ctccggctcc
      121 tcctgcggcc cgagcggctc agctctcggc aggcggcggc gttgctcagc cgagcgcaga
      181 cgggaccctc gcagcgagac ctcagcgact cctaaagtca aaagttggcg gcgggcgccg
      241 ggctccgcgc gctctccacg gccgctgcct cgcgtcgccg ccgcagccaa ggagggcagg
      301 agggaggggg gtgggggcag cggagggagg ggtgggaagc accatgcagt ttgtatcctg
      361 ggccacactg ctaacgctcc tggtgcggga cctggccgag atggggagcc cagacgccgc
      421 ggcggccgtg cgcaaggaca ggctgcaccc gaggcaagtg aaattattag agaccctgag
      481 cgaatacgaa atcgtgtctc ccatccgagt gaacgctctc ggagaaccct ttcccacgaa
      541 cgtccacttc aaaagaacgc gacggagcat taactctgcc actgacccct ggcctgcctt
      601 cgcctcctcc tcttcctcct ctacctcctc ccaggcgcat taccgcctct ctgccttcgg
      661 ccagcagttt ctatttaatc tcaccgccaa tgccggattt atcgctccac tgttcactgt
      721 caccctcctc gggacgcccg gggtgaatca gaccaagttt tattccgaag aggaagcgga
      781 actcaagcac tgtttctaca aaggctatgt caataccaac tccgagcaca cggccgtcat
      841 cagcctctgc tcaggaatgc tgggcacatt ccggtctcat gatggggatt attttattga
      901 accactacag tctatggatg aacaagaaga tgaagaggaa caaaacaaac cccacatcat
      961 ttataggcgc agcgcccccc agagagagcc ctcaacagga aggcatgcat gtgacacctc
     1021 agaacacaaa aataggcaca gtaaagacaa gaagaaaacc agagcaagaa aatggggaga
     1081 aaggattaac ctggctggtg acgtagcagc attaaacagc ggcttagcaa cagaggcatt
     1141 ttctgcttat ggtaataaga cggacaacac aagagaaaag aggacccaca gaaggacaaa
     1201 acgtttttta tcctatccac ggtttgtaga agtcttggtg gtggcagaca acagaatggt
     1261 ttcataccat ggagaaaacc ttcaacacta tattttaact ttaatgtcaa ttgatgggcc
     1321 ttccatatct tttaatgctc agacaacatt aaaaaacttt tgccagtggc agcattcgaa
     1381 gaacagtcca ggtggaatcc atcatgatac tgctgttctc ttaacaagac aggatatctg
     1441 cagagctcac gacaaatgtg ataccttagg cctggctgaa ctgggaacca tttgtgatcc
     1501 ctatagaagc tgttctatta gtgaagatag tggattgagt acagctttta cgatcgccca
     1561 tgagctgggc catgtgttta acatgcctca tgatgacaac aacaaatgta aagaagaagg
     1621 agttaagagt ccccagcatg tcatggctcc aacactgaac ttctacacca acccctggat
     1681 gtggtcaaag tgtagtcgaa aatatatcac tgagttttta gacactggtt atggcgagtg
     1741 tttgcttaac gaacctgaat ccagacccta ccctttgcct gtccaactgc caggcatcct
     1801 ttacaacgtg aataaacaat gtgaattgat ttttggacca ggttctcagg tgtgcccata
     1861 tatgatgcag tgcagacggc tctggtgcaa taacgtcaat ggagtacaca aaggctgccg
     1921 gactcagcac acaccctggg ccgatgggac ggagtgcgag cctggaaagc actgcaagta
     1981 tggattttgt gttcccaaag aaatggatgt ccccgtgaca gatggatcct ggggaagttg
     2041 gagtcccttt ggaacctgct ccagaacatg tggagggggc atcaaaacag ccattcgaga
     2101 gtgcaacaga ccagaaccaa aaaatggtgg aaaatactgt gtaggacgta gaatgaaatt
     2161 taagtcctgc aacacggagc catgtctcaa gcagaagcga gacttccgag atgaacagtg
     2221 tgctcacttt gacgggaagc attttaacat caacggtctg cttcccaatg tgcgctgggt
     2281 ccctaaatac agtggaattc tgatgaagga ccggtgcaag ttgttctgca gagtggcagg
     2341 gaacacagcc tactatcagc ttcgagacag agtgatagat ggaactcctt gtggccagga
     2401 cacaaatgat atctgtgtcc agggcctttg ccggcaagct ggatgcgatc atgttttaaa
     2461 ctcaaaagcc cggagagata aatgtggggt ttgtggtggc gataattctt catgcaaaac
     2521 agtggcagga acatttaata cagtacatta tggttacaat actgtggtcc gaattccagc
     2581 tggtgctacc aatattgatg tgcggcagca cagtttctca ggggaaacag acgatgacaa
     2641 ctacttagct ttatcaagca gtaaaggtga attcttgcta aatggaaact ttgttgtcac
     2701 aatggccaaa agggaaattc gcattgggaa tgctgtggta gagtacagtg ggtccgagac
     2761 tgccgtagaa agaattaact caacagatcg cattgagcaa gaacttttgc ttcaggtttt
     2821 gtcggtggga aagttgtaca accccgatgt acgctattct ttcaatattc caattgaaga
     2881 taaacctcag cagttttact ggaacagtca tgggccatgg caagcatgca gtaaaccctg
     2941 ccaaggggaa cggaaacgaa aacttgtttg caccagggaa tctgatcagc ttactgtttc
     3001 tgatcaaaga tgcgatcggc tgccccagcc tggacacatt actgaaccct gtggtacaga
     3061 ctgtgacctg aggtggcatg ttgccagcag gagtgaatgt agtgcccagt gtggcttggg
     3121 ttaccgcaca ttggacatct actgtgccaa atatagcagg ctggatggga agactgagaa
     3181 ggttgatgat ggtttttgca gcagccatcc caaaccaagc aaccgtgaaa aatgctcagg
     3241 ggaatgtaac acgggtggct ggcgctattc tgcctggact gaatgttcaa aaagctgtga
     3301 cggtgggacc cagaggagaa gggctatttg tgtcaatacc cgaaatgatg tactggatga
     3361 cagcaaatgc acacatcaag agaaagttac cattcagagg tgcagtgagt tcccttgtcc
     3421 acagtggaaa tctggagact ggtcagagtg cttggtcacc tgtggaaaag ggcataagca
     3481 ccgccaggtc tggtgtcagt ttggtgaaga tcgattaaat gatagaatgt gtgaccctga
     3541 gaccaagcca acatctatgc agacttgtca gcagccggaa tgtgcatcct ggcaggcggg
     3601 tccctgggga cagtgcagtg tcacttgtgg acagggatac cagctaagag cagtgaaatg
     3661 catcattggg acttatatgt cagtggtaga tgacaatgac tgtaatgcag caactagacc
     3721 aactgatacc caggactgtg aattaccatc atgtcatcct cccccagctg ccccggaaac
     3781 gaggagaagc acatacagtg caccaagaac ccagtggcga tttgggtctt ggaccccatg
     3841 ctcagccact tgtgggaaag gtacccggat gagatacgtc agctgccgag atgagaatgg
     3901 ctctgtggct gacgagagtg cctgtgctac cctgcctaga ccagtggcaa aggaagaatg
     3961 ttctgtgaca ccctgtgggc aatggaaggc cttggactgg agctcttgct ctgtgacctg
     4021 tgggcaaggt agggcaaccc ggcaagtgat gtgtgtcaac tacagtgacc acgtgatcga
     4081 tcggagtgag tgtgaccagg attatatccc agaaactgac caggactgtt ccatgtcacc
     4141 atgccctcaa aggaccccag acagtggctt agctcagcac cccttccaaa atgaggacta
     4201 tcgtccccgg agcgccagcc ccagccgcac ccatgtgctc ggtggaaacc agtggagaac
     4261 tggcccctgg ggagcatgtt ccagtacctg tgctggcgga tcccagcggc gtgttgttgt
     4321 atgtcaggat gaaaatggat acaccgcaaa cgactgtgtg gagagaataa aacctgatga
     4381 gcaaagagcc tgtgaatccg gcccttgtcc tcagtgggct tatggcaact ggggagagtg
     4441 cactaagctg tgtggtggag gcataagaac aagactggtg gtctgtcagc ggtccaacgg
     4501 tgaacggttt ccagatttga gctgtgaaat tcttgataaa cctcccgatc gtgagcagtg
     4561 taacacacat gcttgtccac acgacgctgc atggagtact ggcccttgga gctcgtgttc
     4621 tgtctcttgt ggtcgagggc ataaacaacg aaatgtttac tgcatggcaa aagatggaag
     4681 ccatttagaa agtgattact gtaagcacct ggctaagcca catgggcaca gaaagtgccg
     4741 aggaggaaga tgccccaaat ggaaagctgg cgcttggagt cagtgctctg tgtcctgtgg
     4801 ccgaggcgta cagcagaggc atgtgggctg tcagatcgga acacacaaaa tagccagaga
     4861 gaccgagtgc aacccataca ccagaccgga gtcggaacgc gactgccaag gcccacggtg
     4921 tcccctctac acttggaggg cagaggaatg gcaagaatgc accaagacct gcggcgaagg
     4981 ctccaggtac cgcaaggtgg tgtgtgtgga tgacaacaaa aacgaggtgc atggggcacg
     5041 ctgtgacgtg agcaagcggc cggtggaccg tgaaagctgt agtttgcaac cctgcgagta
     5101 tgtctggatc acaggagaat ggtcagagtg ctcagtgacc tgtggaaaag gctacaaaca
     5161 aaggcttgtc tcgtgcagcg agatttacac cgggaaggag aattatgaat acagctacca
     5221 aaccaccatc aactgcccag gcacgcagcc ccccagtgtt cacccctgtt acctgaggga
     5281 ctgccctgtc tcggccacct ggagagttgg caactggggg agctgctcag tgtcttgtgg
     5341 tgttggagtg atgcagagat ctgtgcaatg tttaaccaat gaggaccaac ccagccactt
     5401 atgccacact gatctgaagc cagaagaacg aaaaacctgc cgtaatgtct ataactgtga
     5461 gttaccccag aattgcaagg aggtaaaaag acttaaaggt gccagtgaag atggtgaata
     5521 tttcctgatg attagaggaa agcttctgaa gatattctgt gcggggatgc actctgacca
     5581 ccccaaagag tacgtgacac tggtgcatgg agactctgag aatttctccg aggtttatgg
     5641 gcacaggtta cacaacccaa cagaatgtcc ctataacggg agccggcgcg atgactgcca
     5701 atgtcggaag gattacacgg ccgctgggtt ttccagtttt cagaaaatca gaatagacct
     5761 gaccagcatg cagataatca ccactgactt acagtttgca aggacaagcg aaggacatcc
     5821 cgtccctttt gccacagccg gggattgcta cagcgctgcc aagtgcccac agggtcgttt
     5881 tagcatcaac ctttatggaa ccggcttgtc tttaactgaa tctgccagat ggatatcaca
     5941 agggaattat gctgtctctg acatcaagaa gtcgccggat ggtacccgag tcgtagggaa
     6001 atgcggtggt tactgtggaa aatgcactcc atcctctggt actggcctgg aggtgcgagt
     6061 tttatagcta aggtgctttg aagaggaagc cattatggat ggatgaagga tagtaatgca
     6121 atacctccac cttaatttgg gtgcatgtgt atgtgtgtgt gtgtttgtgt gtgacttgta
     6181 tgcttgtgtg tgtaaatgtg tgtacatata catatataca tatctacaca tacatatata
     6241 cacatatatg tgtgtatgta gatatgtaga ctatcctaat gatgtaaagt ttaatattta
     6301 tgtttgaaat tatttattgt gatgtaatat ttttgtacgt aaaatgattc tattatgact
     6361 gcctttgcat gtagtaatat gacaaagtga tccttcatta tcacggtaca ctattgttta
     6421 cttttcatct gtaaatgttt tattgttact tttttaaaat gaattttttt aaaacaatct
     6481 agccatcatc aaggtgctat aagagttgta taaaagatat ttttggcatt tctaggcaag
     6541 tatcagccaa taagtatgtt agtgatatca cagattgtac caactattaa ctatgttaaa
     6601 taagtattca gtttcatgtg atctctggga aaaaaatatg ctgccttggt gctaatattg
     6661 tatgtattta aatgatcatc cgactcagaa atataaacac ttttaatgaa agggaggaac
     6721 ggaaggacaa tttccagtgc acagaatcac ttggatgaaa taagaccagc tctttaccct
     6781 tatttttgga tatgcctttt ttggaagaga cttagacttt atccttattg ttgttagtgt
     6841 tgttaatatt cgttgcttca gcccacggtg ccttggtctc tccacaatca aatggaggat
     6901 cccccaagca gcttcattac agagtgatat tgggaaagtg agatcctctc accattttgc
     6961 caagatactc taaaatgaca tccaagttta ccagtagaaa gacacaggat gcacagaatg
     7021 ggcatgacct tcagctcacg agcacacctg gagaaattca gaaccaggtt ctgaatcatc
     7081 acgattgcct tttgcatgaa aacatcggct ggtgatgtga cttctcttca ggccatgagc
     7141 ctaacaccct gccggttttc atgcccgctg cagtaatgga cgtttgtgtg aagaaatgaa
     7201 ctgtggagta caaaatgctt tgagtctttc cgattgctca ttaattcact tttttgttac
     7261 ttctttccaa aatggaagtg ctgaagccat ggtctttctg cccctccaag ctgatgaagg
     7321 gaagcctttg ccaatggccc atggaagaca cttggtttga gaaaccctgc ccacttccaa
     7381 agaccaaaga gattaggaaa agcctggcag tattctccaa ctccaaacaa gctctagagt
     7441 gctccaggaa aagttatatt cagtatatga ataagtgtta ttctccatta ttaatgtgtt
     7501 ctgaaaatat attatgaata aatacatcac cacacccaaa
//
