LOCUS       NM_007037               3628 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            8 (ADAMTS8), mRNA.
ACCESSION   NM_007037
VERSION     NM_007037.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3628)
  AUTHORS   Ma,F., Liu,H., Xia,T., Zhang,Z., Ma,S., Hao,Y., Shen,J., Jiang,Y.
            and Li,N.
  TITLE     HSFAS mediates fibroblast proliferation, migration,
            trans-differentiation and apoptosis in hypertrophic scars via
            interacting with ADAMTS8
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (3), 440-451 (2024)
   PUBMED   38006215
  REMARK    GeneRIF: HSFAS mediates fibroblast proliferation, migration,
            trans-differentiation and apoptosis in hypertrophic scars via
            interacting with ADAMTS8.
REFERENCE   2  (bases 1 to 3628)
  AUTHORS   Zhang,Q., Kanyomse,Q., Luo,C., Mo,Q., Zhao,X., Wang,L., Peng,W. and
            Ren,G.
  TITLE     The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor
            in Breast Cancer
  JOURNAL   Cancer Invest 41 (2), 119-132 (2023)
   PUBMED   36346393
  REMARK    GeneRIF: The Prognostic Value of ADAMTS8 and Its Role as a Tumor
            Suppressor in Breast Cancer.
REFERENCE   3  (bases 1 to 3628)
  AUTHORS   Zhou,B., Liu,Y., Ma,G., Wang,X., Chang,B., Lu,H. and Feng,X.
  TITLE     ADAMTS8 inhibits glioma development in vitro and in vivo
  JOURNAL   Folia Neuropathol 61 (2), 144-152 (2023)
   PUBMED   37587889
  REMARK    GeneRIF: ADAMTS8 inhibits glioma development in vitro and in vivo.
REFERENCE   4  (bases 1 to 3628)
  AUTHORS   Zhang,Y., Hu,K., Qu,Z., Xie,Z. and Tian,F.
  TITLE     ADAMTS8 inhibited lung cancer progression through suppressing VEGFA
  JOURNAL   Biochem Biophys Res Commun 598, 1-8 (2022)
   PUBMED   35149432
  REMARK    GeneRIF: ADAMTS8 inhibited lung cancer progression through
            suppressing VEGFA.
REFERENCE   5  (bases 1 to 3628)
  AUTHORS   Santamaria,S., Martin,D.R., Dong,X., Yamamoto,K., Apte,S.S. and
            Ahnstrom,J.
  TITLE     Post-translational regulation and proteolytic activity of the
            metalloproteinase ADAMTS8
  JOURNAL   J Biol Chem 297 (5), 101323 (2021)
   PUBMED   34687701
  REMARK    GeneRIF: Post-translational regulation and proteolytic activity of
            the metalloproteinase ADAMTS8.
REFERENCE   6  (bases 1 to 3628)
  AUTHORS   Porter,S., Span,P.N., Sweep,F.C., Tjan-Heijnen,V.C.,
            Pennington,C.J., Pedersen,T.X., Johnsen,M., Lund,L.R., Romer,J. and
            Edwards,D.R.
  TITLE     ADAMTS8 and ADAMTS15 expression predicts survival in human breast
            carcinoma
  JOURNAL   Int J Cancer 118 (5), 1241-1247 (2006)
   PUBMED   16152618
  REMARK    GeneRIF: ADAMTS8 and ADAMTS15 have emerged as novel predictors of
            survival in patients with breast carcinoma
REFERENCE   7  (bases 1 to 3628)
  AUTHORS   Dunn,J.R., Panutsopulos,D., Shaw,M.W., Heighway,J., Dormer,R.,
            Salmo,E.N., Watson,S.G., Field,J.K. and Liloglou,T.
  TITLE     METH-2 silencing and promoter hypermethylation in NSCLC
  JOURNAL   Br J Cancer 91 (6), 1149-1154 (2004)
   PUBMED   15328519
  REMARK    GeneRIF: Downdownregulation of METH-2 expression in primary NSCLC,
            often associated with promoter hypermethylation, is a frequent
            event, which may be related to the development of the disease.
REFERENCE   8  (bases 1 to 3628)
  AUTHORS   Collins-Racie,L.A., Flannery,C.R., Zeng,W., Corcoran,C.,
            Annis-Freeman,B., Agostino,M.J., Arai,M., DiBlasio-Smith,E.,
            Dorner,A.J., Georgiadis,K.E., Jin,M., Tan,X.Y., Morris,E.A. and
            LaVallie,E.R.
  TITLE     ADAMTS-8 exhibits aggrecanase activity and is expressed in human
            articular cartilage
  JOURNAL   Matrix Biol 23 (4), 219-230 (2004)
   PUBMED   15296936
  REMARK    GeneRIF: Ability of ADAMTS-8 to cleave aggrecan at
            aggrecanase-susceptible Glu373-Ala374 peptide bond. Presence of
            ADAMTS-8 mRNA transcripts in normal and osteoarthritic human
            cartilage. (ADAMTS-8)
REFERENCE   9  (bases 1 to 3628)
  AUTHORS   Georgiadis,K.E., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on
            mouse chromosome 9 and human chromosome 11
  JOURNAL   Genomics 62 (2), 312-315 (1999)
   PUBMED   10610729
REFERENCE   10 (bases 1 to 3628)
  AUTHORS   Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S.,
            Lombardo,M. and Iruela-Arispe,M.L.
  TITLE     METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a
            new family of proteins with angio-inhibitory activity
  JOURNAL   J Biol Chem 274 (33), 23349-23357 (1999)
   PUBMED   10438512
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF060153.1, BX424609.2,
            AP002986.2 and BC089435.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007037.5.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            Members of the family share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature enzyme. This enzyme contains two C-terminal TS motifs, and
            disrupts angiogenesis in vivo. A number of disorders have been
            mapped in the vicinity of this gene, most notably lung neoplasms.
            Reduced expression of this gene has been observed in multiple human
            cancers and this gene has been proposed as a potential tumor
            suppressor. [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF060153.1, SRR14038196.2400245.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257359.7/ ENSP00000257359.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AF060153.1         385-575
            192-547             BX424609.2         133-488
            548-609             AP002986.2         113142-113203       c
            610-3628            BC089435.1         374-3392
FEATURES             Location/Qualifiers
     source          1..3628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..3628
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 8"
                     /db_xref="GeneID:11095"
                     /db_xref="HGNC:HGNC:224"
                     /db_xref="MIM:605175"
     exon            1..1043
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..2993
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 8; METH-2; METH-8;
                     ADAMTS-8"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 8 preproprotein"
                     /protein_id="NP_008968.4"
                     /db_xref="CCDS:CCDS41732.1"
                     /db_xref="GeneID:11095"
                     /db_xref="HGNC:HGNC:224"
                     /db_xref="MIM:605175"
                     /translation="MLPAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPT
                     RLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFF
                     SGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARP
                     LPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEA
                     RFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDE
                     KWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGV
                     ADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVM
                     APLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQ
                     QCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCS
                     EGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCL
                     GRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCK
                     LFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVC
                     GGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADG
                     QYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVF
                     PPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRT
                     VECRDPSGQASATCNKALKPEDAKPCESQLCPL"
     exon            1044..1283
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1419
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1587
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1889
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2073
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2246
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2422
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..3628
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3606..3611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /note="hexamer: ACTAAA"
     polyA_site      3628
                     /gene="ADAMTS8"
                     /gene_synonym="ADAM-TS8; METH2"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcttccc ggggtgggga ggaggcagga ggcggctgcg cggggctggc gcgggcaggg
       61 gcggaggacg ggcgcacgcg ggccggggcc agctgctcgc gctcggctcg ggggcggcgg
      121 cgcgggagga gcgggctgcg ccagccagag gggccgccgg gggagcgctc ccgccgccgg
      181 gccccgcggg ccgagtcggc cttgcacccg attgattccg cttttcctgg agagagcggc
      241 cgggccgcgc tcgggccgcc agcacctgcc cgcgcctggc gggcttcttc cctctcctgc
      301 gcgcagccac cgccgcagcc cccatgctcc ccgcccccgc cgccccccgg tggcctccgc
      361 tcctgctgct gctgctgctg ctgctgccgc tggcccgcgg cgccccggcc cggcccgcag
      421 ccggggggca ggcctcggag ctggtggtgc ccacgcggtt gcccggcagc gcgggcgagc
      481 tcgcgctcca cctgtccgcc ttcggcaagg gcttcgtgct gcgcctggcg cccgacgaca
      541 gcttcctagc gcccgagttc aagatcgagc gcctcggggg ctccggccgg gcgaccgggg
      601 gcgagcgggg gctgcgcggc tgcttcttct ccggcaccgt gaatggggag cccgagtcgc
      661 tggcggcggt cagcctgtgc cgcgggctga gcggctcctt cctgctggac ggcgaggagt
      721 tcaccatcca gccgcagggc gcggggggct ccctggctca gccgcaccgc ctgcagcgct
      781 ggggtcccgc cggagcccgc cccctcccgc gaggacccga gtgggaggtg gagacgggag
      841 agggtcagag gcaggagaga ggagaccacc aggaggacag cgaggaggag agccaagaag
      901 aggaggcaga aggcgctagc gagccgccac cgcccctggg ggccacgagt aggaccaagc
      961 ggtttgtgtc tgaggcgcgc ttcgtggaga cgctgctggt ggccgatgcg tccatggctg
     1021 ccttctacgg ggccgacctg cagaaccaca tcctgacgtt aatgtctgtg gcagcccgaa
     1081 tctacaagca ccccagcatc aagaattcca tcaacctgat ggtggtaaaa gtgctgatcg
     1141 tagaagatga aaaatggggc ccagaggtgt ccgacaatgg ggggcttaca ctgcgtaact
     1201 tctgcaactg gcagcggcgt ttcaaccagc ccagcgaccg ccacccagag cactacgaca
     1261 cggccatcct gctcaccaga cagaacttct gtgggcagga ggggctgtgt gacaccctgg
     1321 gtgtggcaga catcgggacc atttgtgacc ccaacaaaag ctgctccgtg atcgaggatg
     1381 aggggctcca ggcggcccac accctggccc atgaactagg gcacgtcctc agcatgcccc
     1441 acgacgactc caagccctgc acacggctct tcgggcccat gggcaagcac cacgtgatgg
     1501 caccgctgtt cgtccacctg aaccagacgc tgccctggtc cccctgcagc gccatgtatc
     1561 tcacagagct tctggacggc gggcacggag actgtctcct ggatgcccct gctgcggccc
     1621 tgcccctccc cacaggcctc ccgggccgca tggccctgta ccagctggac cagcagtgca
     1681 ggcagatctt tgggccggat ttccgccact gccccaacac ctctgctcag gacgtctgcg
     1741 cccagctttg gtgccacact gatggggctg agcccctgtg ccacacgaag aatggcagcc
     1801 tgccctgggc tgacggcacg ccgtgcgggc ctgggcacct ctgctcagaa ggcagctgtc
     1861 tacctgagga ggaagtggag aggcccaagc ccgtggcaga tggaggctgg gcaccgtggg
     1921 gaccctgggg agaatgttct cggacctgtg gaggaggagt acagttttca caccgtgagt
     1981 gcaaggaccc cgagcctcag aatggaggaa gatactgcct gggtcggaga gccaagtacc
     2041 agtcatgcca cacggaggaa tgcccccctg acgggaaaag cttcagggag cagcagtgtg
     2101 agaagtataa tgcctacaat tacactgaca tggacgggaa tctcctgcag tgggtcccca
     2161 agtatgctgg ggtgtccccc cgggaccgct gcaagttgtt ctgccgagcc cgggggagga
     2221 gcgagttcaa agtgttcgag gccaaggtga ttgatggcac cctgtgtggg ccagaaacac
     2281 tggccatctg tgtccgtggc cagtgtgtca aggccggctg tgaccatgtg gtggactcgc
     2341 ctcggaagct ggacaaatgc ggggtgtgtg ggggcaaagg caactcctgc aggaaggtct
     2401 ccgggtccct cacccccacc aattatggct acaatgacat tgtcaccatc ccagctggtg
     2461 ccactaatat tgacgtgaag cagcggagcc acccgggtgt gcagaacgat gggaactacc
     2521 tggcgctgaa gacggctgat gggcagtacc tgctcaacgg caacctggcc atctctgcca
     2581 tagagcagga catcttggtg aaggggacca tcctgaagta cagcggctcc atcgccaccc
     2641 tggagcgcct gcagagcttc cggcccttgc cagagcctct gacagtgcag ctcctgacag
     2701 tccctggcga ggtcttcccc ccaaaagtca aatacacctt ctttgttcct aatgacgtgg
     2761 actttagcat gcagagcagc aaagagagag caaccaccaa catcatccag ccgctgctcc
     2821 acgcacagtg ggtgctgggg gactggtctg agtgctctag cacctgcggg gccggctggc
     2881 agaggcgaac tgtagagtgc agggacccct ccggccaggc ctctgccacc tgcaacaagg
     2941 ctctgaaacc cgaggatgcc aagccctgcg aaagccagct gtgccccctg tgattcaggg
     3001 gggcaggggc cagtcttgtg ctcctggaca tgcggtactg aggtgcagac aagggtctcc
     3061 actgtggtga ctgggtccct tggccatatc aaggcagcac ggcccaccca ggcctcccat
     3121 tgccgcaacc cctccagtac tgcacaaatt cctaaggggg aagaggagag ggtatggggc
     3181 ggcagaccct atcatcaact gtccagtgga ctggaccttg ctcgggttca agtagagggc
     3241 ataggttaaa aggtaaaagt gcacttattg actcagacag gacactcagc gtcagtctgt
     3301 ttgcaaagga ctagcaaact taaatgaaaa aaaaaattct atctggtttc cccgataaat
     3361 aatctacctc acaggggaaa aaattagtac aagagaggcg tggggcaggg agtcaatggt
     3421 gaatgtcaaa gcaggctcca aagctggacc ccaagctgtc ttcaagaatg accacgactg
     3481 tcttcagtgt taaaatccat cacctaaagg gccgcagcgt cgcagggttt ggagagccac
     3541 atgttctcag gctgccacct gcaggggtgg atccatttca agtatttatg caaatgtgtc
     3601 tctgaactaa agtgtgatct tatgccaa
//
