LOCUS       NM_014272               5520 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            7 (ADAMTS7), mRNA.
ACCESSION   NM_014272 XM_350991
VERSION     NM_014272.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5520)
  AUTHORS   Ding,J.Y., Yan,X., Zhang,R.J., Zhang,H.Q., Kang,L., Jia,C.Y.,
            Thorne,R.F., Liu,X.Y. and Shen,C.L.
  TITLE     Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc
            degeneration
  JOURNAL   Eur J Med Res 29 (1), 196 (2024)
   PUBMED   38528617
  REMARK    GeneRIF: Diagnostic value of serum COMP and ADAMTS7 for
            intervertebral disc degeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5520)
  AUTHORS   Iwanicka,J., Balcerzyk-Matic,A., Iwanicki,T., Mizia-Stec,K.,
            Banka,P., Filipecki,A., Gawron,K., Jarosz,A., Nowak,T., Krauze,J.
            and Niemiec,P.
  TITLE     The Association of ADAMTS7 Gene Polymorphisms with the Risk of
            Coronary Artery Disease Occurrence and Cardiovascular Survival in
            the Polish Population: A Case-Control and a Prospective Cohort
            Study
  JOURNAL   Int J Mol Sci 25 (4), 2274 (2024)
   PUBMED   38396951
  REMARK    GeneRIF: The Association of ADAMTS7 Gene Polymorphisms with the
            Risk of Coronary Artery Disease Occurrence and Cardiovascular
            Survival in the Polish Population: A Case-Control and a Prospective
            Cohort Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5520)
  AUTHORS   Sharifi,M.A., Wierer,M., Dang,T.A., Milic,J., Moggio,A., Sachs,N.,
            von Scheidt,M., Hinterdobler,J., Muller,P., Werner,J., Stiller,B.,
            Aherrahrou,Z., Erdmann,J., Zaliani,A., Graettinger,M.,
            Reinshagen,J., Gul,S., Gribbon,P., Maegdefessel,L., Bernhagen,J.,
            Sager,H.B., Mann,M., Schunkert,H. and Kessler,T.
  TITLE     ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation
            of TIMP-1
  JOURNAL   Circ Res 133 (8), 674-686 (2023)
   PUBMED   37675562
  REMARK    GeneRIF: ADAMTS-7 Modulates Atherosclerotic Plaque Formation by
            Degradation of TIMP-1.
REFERENCE   4  (bases 1 to 5520)
  AUTHORS   Gong,Z., Huang,J., Wang,D., Yang,S., Ma,Z., Fu,Y., Ma,Q. and
            Kong,W.
  TITLE     ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and
            dissection in mice
  JOURNAL   J Mol Med (Berl) 101 (3), 237-248 (2023)
   PUBMED   36662289
  REMARK    GeneRIF: ADAMTS-7 deficiency attenuates thoracic aortic aneurysm
            and dissection in mice.
REFERENCE   5  (bases 1 to 5520)
  AUTHORS   Li,L., Wang,S., Wang,M., Liu,G., Yang,Z. and Wang,L.
  TITLE     miR-654-5p Suppresses Migration and Proliferation of Vascular
            Smooth Muscle Cells by Targeting ADAMTS-7
  JOURNAL   Cells Tissues Organs 212 (4), 285-292 (2023)
   PUBMED   35462367
  REMARK    GeneRIF: miR-654-5p Suppresses Migration and Proliferation of
            Vascular Smooth Muscle Cells by Targeting ADAMTS-7.
REFERENCE   6  (bases 1 to 5520)
  AUTHORS   Bai,X.H., Wang,D.W., Kong,L., Zhang,Y., Luan,Y., Kobayashi,T.,
            Kronenberg,H.M., Yu,X.P. and Liu,C.J.
  TITLE     ADAMTS-7, a direct target of PTHrP, adversely regulates
            endochondral bone growth by associating with and inactivating GEP
            growth factor
  JOURNAL   Mol Cell Biol 29 (15), 4201-4219 (2009)
   PUBMED   19487464
  REMARK    GeneRIF: Findings demonstrate that ADAMTS-7, a direct target of
            PTHrP signaling, negatively regulates endochondral bone formation
            by associating with and inactivating GEP chondrogenic growth
            factor.
REFERENCE   7  (bases 1 to 5520)
  AUTHORS   Luan,Y., Kong,L., Howell,D.R., Ilalov,K., Fajardo,M., Bai,X.H., Di
            Cesare,P.E., Goldring,M.B., Abramson,S.B. and Liu,C.J.
  TITLE     Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage
            oligomeric matrix protein by alpha-2-macroglobulin
  JOURNAL   Osteoarthritis Cartilage 16 (11), 1413-1420 (2008)
   PUBMED   18485748
REFERENCE   8  (bases 1 to 5520)
  AUTHORS   Liu,C.J., Kong,W., Ilalov,K., Yu,S., Xu,K., Prazak,L., Fajardo,M.,
            Sehgal,B. and Di Cesare,P.E.
  TITLE     ADAMTS-7: a metalloproteinase that directly binds to and degrades
            cartilage oligomeric matrix protein
  JOURNAL   FASEB J 20 (7), 988-990 (2006)
   PUBMED   16585064
  REMARK    GeneRIF: ADAMTS-7 is the first metalloproteinase found to bind
            directly to and degrade COMP
REFERENCE   9  (bases 1 to 5520)
  AUTHORS   Tang,B.L.
  TITLE     ADAMTS: a novel family of extracellular matrix proteases
  JOURNAL   Int J Biochem Cell Biol 33 (1), 33-44 (2001)
   PUBMED   11167130
  REMARK    Review article
REFERENCE   10 (bases 1 to 5520)
  AUTHORS   Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022748.10, HY169258.1,
            AY327122.1, BC061631.1 and AL110226.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014272.4.
            
            Summary: The protein encoded by this gene is a member of the ADAMTS
            (a disintegrin and metalloproteinase with thrombospondin motifs)
            family. Members of this family share several distinct protein
            modules, including a propeptide region, a metalloproteinase domain,
            a disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature enzyme. This enzyme contains two C-terminal TS motifs and
            may regulate vascular smooth muscle cell (VSMC) migration.
            Mutations in this gene may be associated with susceptibility to
            coronary artery disease. [provided by RefSeq, Feb 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061631.1, AY327122.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388820.5/ ENSP00000373472.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC022748.10        5318-5318
            2-499               HY169258.1         1-498
            500-700             AY327122.1         266-466
            701-866             BC061631.1         680-845
            867-1711            AY327122.1         633-1477
            1712-2762           BC061631.1         1691-2741
            2763-3103           AY327122.1         2529-2869
            3104-4510           AC022748.10        49731-51137
            4511-5393           BC061631.1         4490-5372
            5394-5520           AL110226.1         2787-2913
FEATURES             Location/Qualifiers
     source          1..5520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..5520
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 7"
                     /db_xref="GeneID:11173"
                     /db_xref="HGNC:HGNC:223"
                     /db_xref="MIM:605009"
     exon            1..344
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..5305
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /EC_number="3.4.24.-"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 7; a disintegrin
                     and metalloproteinase with thrombospondin motifs 7;
                     COMPase; a disintegrin and metalloprotease with
                     thrombospondin motifs-7 preproprotein"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 preproprotein"
                     /protein_id="NP_055087.2"
                     /db_xref="CCDS:CCDS32303.1"
                     /db_xref="GeneID:11173"
                     /db_xref="HGNC:HGNC:223"
                     /db_xref="MIM:605009"
                     /translation="MPGGPSPRSPAPLLRPLLLLLCALAPGAPGPAPGRATEGRAALD
                     IVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLL
                     APGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSN
                     EDYFIEPLDSAPARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRER
                     WEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAG
                     LFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLH
                     HDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGH
                     SFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDD
                     PPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWCSVGTTCHSKLD
                     AAVDGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCT
                     QPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPVVN
                     DVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGA
                     MEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALR
                     SEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTKEPVWIQLLFQES
                     NPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPV
                     DEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLD
                     EQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTND
                     TGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAPRP
                     SPASSPKPGTMGNAIEEEAPELDLPGPVFVDDFYYDYNFINFHEDLSYGPSEEPDLDL
                     AGTGDRTPPPHSHPAAPSTGSPVPATEPPAAKEEGVLGPWSPSPWPSQAGRSPPPPSE
                     QTPGNPLINFLPEEDTPIGAPDLGLPSLSWPRVSTDGLQTPATPESQNDFPVGKDSQS
                     QLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAELWT
                     GGTVAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTP
                     GPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALNPGPKGQPESLSPEVPLSSRLLSTPA
                     WDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPV
                     RCSSGRDEDCAPAGRPQPARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRD
                     LRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGL
                     CEEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQ
                     CGHEAWPESSRPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSC
                     SPPSHGAPSRGHQRVARR"
     exon            345..700
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            701..866
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1063
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1147
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1272
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1422
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1566
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1711
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1804
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1950
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2120
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2254
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2375
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2620
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2762
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2889
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3103
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..4510
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4663
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4664..4837
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..4984
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4985..5147
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     exon            5148..5520
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5495..5500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /note="hexamer: CATAAA"
     polyA_site      5520
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /note="major polyA site"
ORIGIN      
        1 ctttctttct ttctctcctt ctagctctct tgtcttttct ttgcctctgc agcggccaag
       61 ggggcgggcc ctgcagcctt tgttgcccgc ggaccgagcg cagccgaacg gagtcggggc
      121 cgggtcgccg ggagctgcac gccggccggg catgtcctga gccggacctg ggaccaggca
      181 gcgaccggac gggacggacg agagcgtgcg cgcggggtca cccggcggcc gcccggttcc
      241 tgccatgccc ggcggcccca gtccccgcag ccccgcgcct ttgctgcgcc ccctcctcct
      301 gctcctctgc gctctggctc ccggcgcccc cggacccgca ccaggacgtg caaccgaggg
      361 ccgggcggca ctggacatcg tgcacccggt tcgagtcgac gcggggggct ccttcctgtc
      421 ctacgagctg tggccccgcg cactgcgcaa gcgggatgta tctgtgcgcc gagacgcgcc
      481 cgccttctac gagctacaat accgcgggcg cgagctgcgc ttcaacctga ccgccaatca
      541 gcacctgctg gcgcccggct ttgtgagcga gacgcggcgg cgcggcggcc tgggccgcgc
      601 gcacatccgg gcccacaccc cggcctgcca cctgcttggc gaggtgcagg accctgagct
      661 cgagggtggc ctggcggcca tcagcgcctg cgacggcctg aaaggtgtgt tccagctctc
      721 caacgaggac tacttcattg agcccctgga cagtgccccg gcccggcctg gccacgccca
      781 gccccatgtg gtgtacaagc gtcaggcccc ggagaggctg gcacagcggg gtgattccag
      841 tgctccaagc acctgtggag tgcaagtgta cccagagctg gagtctcgac gggagcgttg
      901 ggagcagcgg cagcagtggc ggcggccacg gctgaggcgt ctacaccagc ggtcggtcag
      961 caaagagaag tgggtggaga ccctggtagt agctgatgcc aaaatggtgg agtaccacgg
     1021 acagccgcag gttgagagct atgtgctgac catcatgaac atggtggctg gcctgtttca
     1081 tgaccccagc attgggaacc ccatccacat caccattgtg cgcctggtcc tgctggaaga
     1141 tgaggaggag gacctaaaga tcacgcacca tgcagacaac accctgaaga gcttctgcaa
     1201 gtggcagaaa agcatcaaca tgaaggggga tgcccatccc ctgcaccatg acactgccat
     1261 cctgctcacc agaaaggacc tgtgtgcagc catgaaccgg ccctgtgaga ccctgggact
     1321 gtcccatgtg gcgggcatgt gccagccgca ccgcagctgc agcatcaacg aggacacggg
     1381 cctgccgctg gccttcactg tagcccacga gctcgggcac agttttggca ttcagcatga
     1441 cggaagcggc aatgactgtg agcccgttgg gaaacgacct ttcatcatgt ctccacagct
     1501 cctgtacgac gccgctcccc tcacctggtc ccgctgcagc cgccagtata tcaccaggtt
     1561 ccttgaccgt gggtggggcc tgtgcctgga cgaccctcct gccaaggaca ttatcgactt
     1621 cccctcggtg ccacctggcg tcctctatga tgtaagccac cagtgccgcc tccagtacgg
     1681 ggcctactct gccttctgcg aggacatgga taatgtctgc cacacactct ggtgctctgt
     1741 ggggaccacc tgtcactcca agctggatgc agctgtggac ggcacccggt gtggggagaa
     1801 taagtggtgt ctcagtgggg agtgcgtacc cgtgggcttc cggcccgagg ccgtggatgg
     1861 tggctggtct ggctggagcg cctggtccat ctgctcacgg agctgtggca tgggcgtaca
     1921 gagcgccgag cggcagtgca cgcagcctac gcccaaatac aaaggcagat actgtgtggg
     1981 tgagcgcaag cgcttccgcc tctgcaacct gcaggcctgc cctgctggcc gcccctcctt
     2041 ccgccacgtc cagtgcagcc actttgacgc tatgctctac aagggccagc tgcacacatg
     2101 ggtgcccgtg gtcaatgacg tgaacccctg cgagctgcac tgccggcccg cgaatgagta
     2161 ctttgccgag aagctgcggg acgccgtggt cgatggcacc ccctgctacc aggtccgagc
     2221 cagccgggac ctctgcatca acggcatctg taagaacgtg ggctgtgact tcgagattga
     2281 ctccggtgct atggaggacc gctgtggtgt gtgccacggc aacggctcca cctgccacac
     2341 cgtgagcggg accttcgagg aggccgaggg cctggggtat gtggatgtgg ggctgatccc
     2401 agcgggcgca cgcgagatcc gcatccaaga ggttgccgag gctgccaact tcctggcact
     2461 gcggagcgag gacccggaga agtacttcct caatggtggc tggaccatcc agtggaacgg
     2521 ggactaccag gtggcaggga ccaccttcac atacgcacgc aggggcaact gggagaacct
     2581 cacgtccccg ggtcccacca aggagcctgt ctggatccag ctgctgttcc aggagagcaa
     2641 ccctggggtg cactacgagt acaccatcca cagggaggca ggtggccacg acgaggtccc
     2701 gccgcccgtg ttctcctggc attatgggcc ctggaccaag tgcacagtca cctgcggcag
     2761 aggtgtgcag aggcagaatg tgtactgctt ggagcggcag gcagggcccg tggacgagga
     2821 gcactgtgac cccctgggcc ggcctgatga ccaacagagg aagtgcagcg agcagccctg
     2881 ccctgccagg tggtgggcag gtgagtggca gctgtgctcc agctcctgcg ggcctggggg
     2941 cctctcccgc cgggccgtgc tctgcatccg cagcgtgggg ctggatgagc agagcgccct
     3001 ggagccaccc gcctgtgaac accttccccg gccccctact gaaacccctt gcaaccgcca
     3061 tgtaccctgt ccggccacct gggctgtggg gaactggtct cagtgctcag tgacatgtgg
     3121 ggagggcact cagcgccgaa atgtcctctg caccaatgac accggtgtcc cctgtgacga
     3181 ggcccagcag ccagccagcg aagtcacctg ctctctgcca ctctgtcggt ggcccctggg
     3241 cacactgggc cctgaaggct caggcagcgg ctcctccagc cacgagctct tcaacgaggc
     3301 tgacttcatc ccgcaccacc tggccccacg cccttcaccc gcctcatcac ccaagccagg
     3361 caccatgggc aacgccattg aggaggaggc tccagagctg gacctgccgg ggcccgtgtt
     3421 tgtggacgac ttctactacg actacaattt catcaatttc cacgaggatc tgtcctacgg
     3481 gccctctgag gagcccgatc tagacctggc ggggacaggg gaccggacac ccccaccaca
     3541 cagccatcct gctgcgccct ccacgggtag ccccgtgcct gccacagagc ctcctgcagc
     3601 caaggaggag ggggtactgg gaccttggtc cccgagccct tggcctagcc aggccggccg
     3661 ctccccaccc ccaccctcag agcagacccc tgggaaccct ttgatcaatt tcctgcctga
     3721 ggaagacacc cccatagggg ccccagatct tgggctcccc agcctgtcct ggcccagggt
     3781 ttccactgat ggcctgcaga cacctgccac ccctgagagc caaaatgatt tcccagttgg
     3841 caaggacagc cagagccagc tgccccctcc atggcgggac aggaccaatg aggttttcaa
     3901 ggatgatgag gaacccaagg gccgaggagc accccacctg cccccgagac ccagctccac
     3961 gctgccccct ttgtcccctg ttggcagcac ccactcctct cctagtcctg acgtggcgga
     4021 gctgtggaca ggaggcacag tggcctggga gccagctctg gagggtggcc tggggcctgt
     4081 ggacagtgaa ctgtggccca ctgttggggt ggcttctctc cttcctcctc ccatagcccc
     4141 tctgccagag atgaaggtca gggacagttc cctggagccg gggactccct ccttcccaac
     4201 cccaggacca ggctcatggg acctgcagac tgtggcagtg tgggggacct tcctccccac
     4261 aaccctgact ggcctcgggc acatgcctga gcctgccctg aacccaggac ccaagggtca
     4321 gcctgagtcc ctcagccctg aggtgcccct gagctctagg ctgctgtcca caccagcttg
     4381 ggacagcccc gccaacagcc acagagtccc tgagacccag ccgctggctc ccagcctggc
     4441 tgaagcgggg ccccccgcgg acccgttggt tgtcaggaac gccggctggc aagcgggaaa
     4501 ctggagcgag tgctctacca cctgtggcct gggtgcggtc tggaggccgg tgcgctgtag
     4561 ctccggccgg gatgaggact gcgcccccgc tggccggccc cagcctgccc gccgctgcca
     4621 cctgcggccc tgtgccacct ggcactcagg caactggagt aagtgctccc gcagctgcgg
     4681 cggaggttcc tcagtgcggg acgtgcagtg tgtggacaca cgggacctcc ggccactgcg
     4741 gcccttccat tgtcagcccg ggcctgccaa gccgcctgcg caccggccct gcggggccca
     4801 gccctgcctc agctggtaca catcttcctg gagggagtgc tccgaggcct gtggcggtgg
     4861 tgagcagcag cgtctagtga cctgcccgga gccaggcctc tgcgaggagg cgctgagacc
     4921 caacaccacc cggccctgca acacccaccc ctgcacgcag tgggtggtgg ggccctgggg
     4981 ccagtgctca ggcccctgtg gtggtggtgt ccagcggcgc ctggtcaagt gtgtcaacac
     5041 ccagacaggg ctgcccgagg aagacagtga ccagtgtggc cacgaggcct ggcctgagag
     5101 ctcccggccg tgtggcaccg aggattgtga gcccgtcgag cctccccgct gtgagcggga
     5161 ccgcctgtcc ttcgggttct gcgagacgct gcgcctactg ggccgctgcc agctgcccac
     5221 catccgcacc cagtgctgcc gctcgtgctc tccgcccagc cacggcgccc cctcccgagg
     5281 ccatcagcgg gttgcccgcc gctgactgcg ccaggatgca cagaccgacc gacagacctc
     5341 agtgcccacc acgggctgtg gcggagctcc cgccccctgc gccctaatgg tgctaacccc
     5401 ctctcactac ccagcagcag gctggggacc tcctccccct caaaaaaggt atttttttat
     5461 tctaacagtt tgtgtaacat ttattatgat tttacataaa tgagcatcta ccattccaaa
//
