LOCUS       NM_197941               7309 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            6 (ADAMTS6), transcript variant 1, mRNA.
ACCESSION   NM_197941 NM_014273 XM_293904
VERSION     NM_197941.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7309)
  AUTHORS   Han,P., Jiang,F. and Zhang,L.
  TITLE     The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to
            lumbar disc herniation in Chinese Han population
  JOURNAL   Eur Spine J 32 (4), 1106-1114 (2023)
   PUBMED   36810712
  REMARK    GeneRIF: The role of ADAMTS6 and ADAMTS17 polymorphisms in
            susceptibility to lumbar disc herniation in Chinese Han population.
REFERENCE   2  (bases 1 to 7309)
  AUTHORS   Zhu,Y.Z., Liu,Y., Liao,X.W. and Luo,S.S.
  TITLE     Identified a disintegrin and metalloproteinase with thrombospondin
            motifs 6 serve as a novel gastric cancer prognostic biomarker by
            bioinformatics analysis
  JOURNAL   Biosci Rep 41 (4) (2021)
   PUBMED   33851708
  REMARK    GeneRIF: Identified a disintegrin and metalloproteinase with
            thrombospondin motifs 6 serve as a novel gastric cancer prognostic
            biomarker by bioinformatics analysis.
REFERENCE   3  (bases 1 to 7309)
  AUTHORS   Prins,B.P., Mead,T.J., Brody,J.A., Sveinbjornsson,G., Ntalla,I.,
            Bihlmeyer,N.A., van den Berg,M., Bork-Jensen,J., Cappellani,S., Van
            Duijvenboden,S., Klena,N.T., Gabriel,G.C., Liu,X., Gulec,C.,
            Grarup,N., Haessler,J., Hall,L.M., Iorio,A., Isaacs,A., Li-Gao,R.,
            Lin,H., Liu,C.T., Lyytikainen,L.P., Marten,J., Mei,H.,
            Muller-Nurasyid,M., Orini,M., Padmanabhan,S., Radmanesh,F.,
            Ramirez,J., Robino,A., Schwartz,M., van Setten,J., Smith,A.V.,
            Verweij,N., Warren,H.R., Weiss,S., Alonso,A., Arnar,D.O.,
            Bots,M.L., de Boer,R.A., Dominiczak,A.F., Eijgelsheim,M.,
            Ellinor,P.T., Guo,X., Felix,S.B., Harris,T.B., Hayward,C.,
            Heckbert,S.R., Huang,P.L., Jukema,J.W., Kahonen,M., Kors,J.A.,
            Lambiase,P.D., Launer,L.J., Li,M., Linneberg,A., Nelson,C.P.,
            Pedersen,O., Perez,M., Peters,A., Polasek,O., Psaty,B.M.,
            Raitakari,O.T., Rice,K.M., Rotter,J.I., Sinner,M.F., Soliman,E.Z.,
            Spector,T.D., Strauch,K., Thorsteinsdottir,U., Tinker,A.,
            Trompet,S., Uitterlinden,A., Vaartjes,I., van der Meer,P.,
            Volker,U., Volzke,H., Waldenberger,M., Wilson,J.G., Xie,Z.,
            Asselbergs,F.W., Dorr,M., van Duijn,C.M., Gasparini,P.,
            Gudbjartsson,D.F., Gudnason,V., Hansen,T., Kaab,S., Kanters,J.K.,
            Kooperberg,C., Lehtimaki,T., Lin,H.J., Lubitz,S.A.,
            Mook-Kanamori,D.O., Conti,F.J., Newton-Cheh,C.H., Rosand,J.,
            Rudan,I., Samani,N.J., Sinagra,G., Smith,B.H., Holm,H.,
            Stricker,B.H., Ulivi,S., Sotoodehnia,N., Apte,S.S., van der
            Harst,P., Stefansson,K., Munroe,P.B., Arking,D.E., Lo,C.W. and
            Jamshidi,Y.
  TITLE     Exome-chip meta-analysis identifies novel loci associated with
            cardiac conduction, including ADAMTS6
  JOURNAL   Genome Biol 19 (1), 87 (2018)
   PUBMED   30012220
  REMARK    GeneRIF: Exome-chip meta-analysis identifies novel loci associated
            with cardiac conduction, including ADAMTS6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7309)
  AUTHORS   Liu,L., Yang,Z., Ni,W. and Xuan,Y.
  TITLE     ADAMTS-6 is a predictor of poor prognosis in patients with
            esophageal squamous cell carcinoma
  JOURNAL   Exp Mol Pathol 104 (2), 134-139 (2018)
   PUBMED   29475036
  REMARK    GeneRIF: High ADAMTS-6 expression is a marker of poor prognosis in
            patients with esophageal squamous cell carcinoma.
REFERENCE   5  (bases 1 to 7309)
  AUTHORS   Kelwick,R., Desanlis,I., Wheeler,G.N. and Edwards,D.R.
  TITLE     The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin
            motifs) family
  JOURNAL   Genome Biol 16 (1), 113 (2015)
   PUBMED   26025392
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7309)
  AUTHORS   Bevitt,D.J., Li,Z., Lindrop,J.L., Barker,M.D., Clarke,M.P. and
            McKie,N.
  TITLE     Analysis of full length ADAMTS6 transcript reveals alternative
            splicing and a role for the 5' untranslated region in translational
            control
  JOURNAL   Gene 359, 99-110 (2005)
   PUBMED   16129570
  REMARK    GeneRIF: Study shows that the ADAMTS6 transcript contains unusually
            large untranslated regions (UTRs) at both the 5' and 3'end, and the
            5'UTR contains 11 AUG codons upstream of the predicted ADAMTS6
            start codon.
REFERENCE   7  (bases 1 to 7309)
  AUTHORS   Tang,B.L.
  TITLE     ADAMTS: a novel family of extracellular matrix proteases
  JOURNAL   Int J Biochem Cell Biol 33 (1), 33-44 (2001)
   PUBMED   11167130
  REMARK    Review article
REFERENCE   8  (bases 1 to 7309)
  AUTHORS   Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
REFERENCE   9  (bases 1 to 7309)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   10 (bases 1 to 7309)
  AUTHORS   Adams,M.D., Soares,M.B., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     Rapid cDNA sequencing (expressed sequence tags) from a
            directionally cloned human infant brain cDNA library
  JOURNAL   Nat Genet 4 (4), 373-380 (1993)
   PUBMED   8401585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY692422.1, AY692424.1,
            AY692426.1 and AY692423.1.
            
            On Nov 22, 2018 this sequence version replaced NM_197941.3.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            Members of the family share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature enzyme. Expression of this gene may be regulated by the
            cytokine TNF-alpha. [provided by RefSeq, Mar 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY692424.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381055.8/ ENSP00000370443.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-860               AY692422.1         1-860
            861-1303            AY692424.1         819-1261
            1304-1542           AY692426.1         465-703
            1543-2133           AY692424.1         1501-2091
            2134-2551           AY692426.1         1300-1717
            2552-6380           AY692424.1         2510-6338
            6381-7309           AY692423.1         2984-3912
FEATURES             Location/Qualifiers
     source          1..7309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..7309
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 6"
                     /db_xref="GeneID:11174"
                     /db_xref="HGNC:HGNC:222"
                     /db_xref="MIM:605008"
     exon            1..578
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            579..954
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             858..4211
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 6; a disintegrin
                     and metalloproteinase with thrombospondin motifs 6"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 6 preproprotein"
                     /protein_id="NP_922932.2"
                     /db_xref="CCDS:CCDS3983.2"
                     /db_xref="GeneID:11174"
                     /db_xref="HGNC:HGNC:222"
                     /db_xref="MIM:605008"
                     /translation="MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQL
                     TIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTL
                     NTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIAT
                     EDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKP
                     WWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYIL
                     SVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILS
                     HQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINED
                     IGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRD
                     YITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCR
                     ELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSL
                     WGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQC
                     ADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDI
                     CINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPR
                     GSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPES
                     LEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATC
                     AGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKT
                     CDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECT
                     PKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQC
                     SAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNK
                     VAYCPLVLKFKFCSRAYFRQMCCKTCQGH"
     exon            955..1319
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1488
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1700
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1784
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1930
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..1974
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2080
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2227
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2369
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2477
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2623
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2687
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2790
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2924
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3048
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3129
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3293
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3432
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3562
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3563..3767
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3944
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3945..4101
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..7309
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7284..7289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /note="hexamer: AATAAA"
     polyA_site      7309
                     /gene="ADAMTS6"
                     /gene_synonym="ADAM-TS 6; ADAM-TS6; ADAMTS-6"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgctct gcctccgagg aaaagctgcc aaaattttct cctgctgcaa ttcaagttgg
       61 ctgggggccg gtagtgagat ctagggctac ttcaacaaaa ctttgctgcc cttcctgctc
      121 ctcttgtctt cttttctcct gatacctttt gatgctctgc acatgttatt tgcatagcaa
      181 aggcactaag ctttccagga agagagggca ccacttccac ccccaataag tcttttttcc
      241 cgtcttttct ttcttttcct ttcctttttt ggggggtggg gagggagaga aagggggttt
      301 gcaaaggcag catctcagag tgatagccta gatgtattga aggcatctct tattctgcca
      361 aatcggaaag tcagttctct aaagcccggg ttagccagac catagggttt tattctggct
      421 gcagaataac tggctggtgt ggctttgcaa aggggggcaa aaaataaaaa aataaaaaaa
      481 attaaaaaaa gttagagagg agagggagta cgtgagtcgt ccagtgcaat ctctattgtc
      541 tgaaacttac tttttatcag aatttgaaga tgaaaacggt taaaaaatgg ccatacttta
      601 gtaactaatc agcctaatgc tttgcttatg aaaactttta ccatcattat ttttttcatt
      661 ttggattgag aaaatgaatc cagatataga agaaagtgca ggatgttgga taaaagtggc
      721 tcttaaacag tggaacatcc aataactaat ttgcaagaag ttttaaagaa ataaaattgt
      781 tatgcttcga ttttggtatg gtattgactc tttagcacat aggtagccct caaaaaaatc
      841 atccagtttt ctaaattatg gaaattttgt ggaagacgtt gacctggatt ttgagcctca
      901 tcatggcttc atcggaattt catagtgacc acaggctttc atacagttct caagaggaat
      961 tcctgactta tcttgaacac taccagctaa ctattccaat aagggttgat caaaatggag
     1021 catttctcag ctttactgtg aaaaatgata aacactcaag gagaagacgg agtatggacc
     1081 ctattgatcc acagcaggca gtatctaagt tattttttaa actttcagcc tatggcaagc
     1141 actttcatct aaacttgact ctcaacacag attttgtgtc caaacatttt acagtagaat
     1201 attgggggaa agatggaccc cagtggaaac atgatttttt agacaactgt cattacacag
     1261 gatatttgca agatcaacgt agtacaacta aagtggcttt aagcaactgt gttgggttgc
     1321 atggtgttat tgctacagaa gatgaagagt attttatcga acctttaaag aataccacag
     1381 aggattccaa gcattttagt tatgaaaatg gccaccctca tgttatttac aaaaagtctg
     1441 cccttcaaca acgacatctg tatgatcact ctcattgtgg ggtttcggat ttcacaagaa
     1501 gtggcaaacc ttggtggctg aatgacacat ccactgtttc ttattcacta ccaattaaca
     1561 acacacatat ccaccacaga cagaagagat cagtgagcat tgaacggttt gtggagacat
     1621 tggtagtggc agacaaaatg atggtgggct accatggccg caaagacatt gaacattaca
     1681 ttttgagtgt gatgaatatt gttgccaaac tttaccgtga ttccagccta ggaaacgttg
     1741 tgaatattat agtggcccgc ttaattgttc tcacagaaga tcagccaaac ttggagataa
     1801 accaccatgc agacaagtcc ctcgatagct tctgtaaatg gcagaaatcc attctctccc
     1861 accaaagtga tggaaacacc attccagaaa atgggattgc ccaccacgat aatgcagttc
     1921 ttattactag atatgatatc tgcacttata aaaataagcc ctgtggaaca ctgggcttgg
     1981 cctctgtggc tggaatgtgt gagcctgaaa ggagctgcag cattaatgaa gacattggcc
     2041 tgggttcagc ttttaccatt gcacatgaga ttggtcacaa ttttggtatg aaccatgatg
     2101 gaattggaaa ttcttgtggg acgaaaggtc atgaagcagc aaaacttatg gcagctcaca
     2161 ttactgcgaa taccaatcct ttttcctggt ctgcttgcag tcgagactac atcaccagct
     2221 ttctagattc aggccgtggt acttgccttg ataatgagcc tcccaagcgt gactttcttt
     2281 atccagctgt ggccccaggt caggtgtatg atgctgatga gcaatgtcgt ttccagtatg
     2341 gagcaacctc ccgccaatgt aaatatgggg aagtgtgtag agagctctgg tgtctcagca
     2401 aaagcaaccg ctgtgtcacc aacagtattc cagcagctga ggggacactg tgtcaaactg
     2461 ggaatattga aaaagggtgg tgttatcagg gagattgtgt tccttttggc acttggcccc
     2521 agagcataga tgggggctgg ggtccctggt cactatgggg agagtgcagc aggacctgcg
     2581 ggggaggcgt ctcctcatcc ctaagacact gtgacagtcc agcaccttca ggaggtggaa
     2641 aatattgcct tggggaaagg aaacggtatc gctcctgtaa cacagatcca tgccctttgg
     2701 gttcccgaga ttttcgagag aaacagtgtg cagactttga caatatgcct ttccgaggaa
     2761 agtattataa ctggaaaccc tatactggag gtggggtaaa accttgtgca ttaaactgct
     2821 tggctgaagg ttataatttc tacactgaac gtgctcctgc ggtgatcgat gggacccagt
     2881 gcaatgcgga ttcactggat atctgcatca atggagaatg caagcacgta ggctgtgata
     2941 atattttggg atctgatgct agggaagata gatgtcgagt ctgtggaggg gacggaagca
     3001 catgtgatgc cattgaaggg ttcttcaatg attcactgcc caggggaggc tacatggaag
     3061 tggtgcagat accaagaggc tctgttcaca ttgaagttag agaagttgcc atgtcaaaga
     3121 actatattgc tttaaaatct gaaggagatg attactatat taatggtgcc tggactattg
     3181 actggcctag gaaatttgat gttgctggga cagcttttca ttacaagaga ccaactgatg
     3241 aaccagaatc cttggaagct ctaggtccta cctcagaaaa tctcatcgtc atggttctgc
     3301 ttcaagaaca gaatttggga attaggtata agttcaatgt tcccatcact cgaactggca
     3361 gtggagataa tgaagttggc tttacatgga atcatcagcc ttggtcagaa tgctcagcta
     3421 cttgtgctgg aggtgtccaa agacaggagg tggtctgtaa aaggttggat gacaactcca
     3481 ttgtccagaa caattactgt gatcctgaca gtaagccacc tgaaaatcaa agagcctgca
     3541 acactgagcc ctgcccacct gagtggttca ttggggattg gttggaatgc agcaagactt
     3601 gtgatggtgg gatgcgcaca agggcagtgc tctgcatcag gaagatcgga ccttctgagg
     3661 aggagacgct ggactacagt ggttgtttaa cacaccggcc tgtcgaaaaa gagccctgca
     3721 acaaccagtc atgtccacca cagtgggtgg ctttggactg gtctgagtgt actccaaaat
     3781 gtggtccagg attcaagcat cggattgttc tgtgcaagag cagtgacctt tctaagacat
     3841 tcccagctgc acaatgtcca gaggaaagca aacctcctgt ccgcatccgc tgcagtttgg
     3901 gccgctgccc tcctcctcgc tgggtcacag gagactgggg ccagtgttct gctcagtgtg
     3961 gccttggaca gcagatgaga actgtgcagt gtctctccta caccggacag gcatctagtg
     4021 actgtctaga aactgttcgg cctccatcaa tgcagcagtg tgaaagcaaa tgtgacagta
     4081 cccccatttc taatactgaa gagtgcaaag atgtgaataa agtggcttat tgcccactgg
     4141 tgctgaagtt caagttctgc agtcgagcat acttcagaca gatgtgttgt aagacctgcc
     4201 aaggacactg acccacagaa agccagagag agtgccttgt catttcatca tggaaatgca
     4261 tccatcaaag agagccaccc agaggaagag gattgatgtc cttgcaaatg cattaccctg
     4321 tggaaaacgt aaccactggt cagccctagc tgacaaaatt tcaatattat tttagcttct
     4381 gtgaagtggg atttattgat ccaaagtgct ggacacggta ttaggaggga atgccagatt
     4441 ggagagatcc aaacaacaca gggagacttg cttactgtgg agcgtttgtg ttctttcgag
     4501 taaatccaat agcctgttta cctccttgga ccattaagat aatttttatt atggacttag
     4561 caatgacact gaatccattt gtatttaaaa ctgtttaaaa tgtagctgtt atgacttggt
     4621 caactatgga agtgaagaag gttcagaatt cttaagtcat agcttaaaaa tatttactgt
     4681 actttatctc actacaacag caccacaatt taaattataa aacgggcttt gaactataat
     4741 ttaaggagca attataaatc aaaagtaatg aaagtttgta ttatttttct tcattccact
     4801 taatttcctt aggaataatc ccctggttct gaacactgct gtgagccata tataaaacta
     4861 tattaaactg aacaataatg aggggcatag tttaaagcag tgcatcagtt actgcagctg
     4921 tgcaagtcta taaactcagt gctgaaagac tgtggccaac ttgccattgt gcaagtaaag
     4981 ctgagatttc cattaaaact ttaagagaaa aacatttcaa tttcatgcag aaaccagacc
     5041 tggggtatgg tacagaccaa aggaccaggc cctttgctgc caccacacag gatgccttag
     5101 ttcttatttg agtccctcca actcacttgt gtttacatcc tccccagcca cagcacggct
     5161 tctgcccttt ggattgctgc acgtgtgttg agcttactga gatgatacca tgcaaaagat
     5221 agactggctc ggtaaccagg cagacccttt tgcagtttgt tgacaattac gatgagttcc
     5281 agatgtccct tctttgatat ggtagaaggg catttattta tatgagagca aatgtgtgtg
     5341 tgtgtttgcg ggcgctttta agtgtgtgga tagatgagtg tgcttgcaca taatgtgcta
     5401 tttctgtgag ttttaaagta ggcaagggat aataaccaaa gaagaaaatt tcatgaagac
     5461 tagacatcat aaagcataat tttaatagtc actcaaccaa gtatttttta ttttttatgg
     5521 atactctgaa tggcaattaa atgtgaaacc cagtttcttg ggcaagtcaa attctggaat
     5581 cacatccacc taaattaaaa tgactagctc gtattttccc catcttcaag tttcacatcc
     5641 tggtcatcaa aagactcgac agcaagactt agaatgaaaa agggtacttg tttatattaa
     5701 tattttttac ttgaacacgt gtagcttgca gcaggttctt gatgaatgtg ctttgtgtcc
     5761 aaaatgcctc cccattgtac acaggtgtac accatgcatg caccaacacc taaaactcaa
     5821 aactaaatgg ctattttgta aggttaatac tttcagttaa acagcatgtt tgacttgatt
     5881 ccatcatggt gctcttaaat tacatgtcag tgcatcacat atatcatgat ctaatgcaga
     5941 tgactaggct ttttccaaaa ggaagacaga ccctcagaca ccaaaagcca atctaaacaa
     6001 ctcccaggtt tgctgtggac aatcagcatg gaatgttttc tgcactctca gtcatgacca
     6061 tctgtatctt gttacctgct ttctctctca acaccacagt tctcaaccct gagccttcca
     6121 gagagagcta ttgatgatac aagaggaatc accagggccc ggatctaaga tgcccttaga
     6181 agaccagccc aagtgccgtc ttagccattc agtgaagggc aaacagccca tgggtagtat
     6241 ggcccgagca ctgaattccc ttgcgccttt tcaaagaaca gttaacttgg tgctaatgtg
     6301 ccctggtgaa ataaataaaa gatgggcagt ttctgtggca ttttaggcat aggtttgcaa
     6361 tccagatctg attttctcca acataaatat cagctcatgt tcttatttca aaaagatttc
     6421 ttattaccga ctaaaagcta ttttttacct cacctggaaa ctaccattgt gagggccatc
     6481 ccccaggcac tgcacagcac cttggctgat gctggaagag gagggcagtc agtgtcactt
     6541 ctgggatgtg ccccagcact gagaacaaaa tgcaggcatc ccccggggca gcatcagagt
     6601 gcctttctag agggagccac gcacagaatg taacaggatg aaacagtttc aagtaagcct
     6661 tgaattgaaa cctgagtagg ttaaaacaat tctatttcat agcacatcac aatactgctg
     6721 ctactctgta gccaccccca tggctacatg atgccctatt cctaaataat aacaatagca
     6781 ttgtcagtgg aggctgggcc accatggcag accttccaaa agtagtgagc tacatagact
     6841 acttagggaa ccccagggaa actggtaccc tacacctggg agcagtatct gccactggga
     6901 taaagtccta ctaaaaaagg aacggtaaat gtaccctaat gattaaaccc cgtgagatac
     6961 atatgatttc caaatagtcc atttcattag gaactttttt gtttgaatga atgtcacata
     7021 ggtatcctca gtaacacaga acgaaattac ctttgtatta ttgtgattag ttgttgctta
     7081 ttattttata ctcagtaata atgtggtaca ctgttaattt ttttgctttt gtaaattata
     7141 ttctaattta ttgccatgtt tcctaacact tgtcctacat tcattctcct gcttgtaatg
     7201 aaaatgaaaa aatcattgta acacttgatg gagtgaaatt ccacgccagg cacagaattt
     7261 ttttgacata gataatttag taaaataaaa attcagctta taataatga
//
