LOCUS       NM_025003               6358 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            20 (ADAMTS20), mRNA.
ACCESSION   NM_025003 NM_001077205
VERSION     NM_025003.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6358)
  AUTHORS   Nandadasa,S., Martin,D., Deshpande,G., Robert,K.L., Stack,M.S.,
            Itoh,Y. and Apte,S.S.
  TITLE     Degradomic Identification of Membrane Type 1-Matrix
            Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate
  JOURNAL   Mol Cell Proteomics 22 (6), 100566 (2023)
   PUBMED   37169079
  REMARK    GeneRIF: Degradomic Identification of Membrane Type 1-Matrix
            Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate.
REFERENCE   2  (bases 1 to 6358)
  AUTHORS   Nandadasa,S., Kraft,C.M., Wang,L.W., O'Donnell,A., Patel,R.,
            Gee,H.Y., Grobe,K., Cox,T.C., Hildebrandt,F. and Apte,S.S.
  TITLE     Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical
            role in ciliary vesicle growth during ciliogenesis
  JOURNAL   Nat Commun 10 (1), 953 (2019)
   PUBMED   30814516
  REMARK    GeneRIF: CRISPR-Cas9 inactivation of ADAMTS9 impaired ciliogenesis
            in RPE-1 cells, which was restored by catalytically active ADAMTS9
            or ADAMTS20 acting in trans, but not by their proteolytically
            inactive mutants.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6358)
  AUTHORS   Wolf,Z.T., Brand,H.A., Shaffer,J.R., Leslie,E.J., Arzi,B.,
            Willet,C.E., Cox,T.C., McHenry,T., Narayan,N., Feingold,E.,
            Wang,X., Sliskovic,S., Karmi,N., Safra,N., Sanchez,C.,
            Deleyiannis,F.W., Murray,J.C., Wade,C.M., Marazita,M.L. and
            Bannasch,D.L.
  TITLE     Genome-wide association studies in dogs and humans identify
            ADAMTS20 as a risk variant for cleft lip and palate
  JOURNAL   PLoS Genet 11 (3), e1005059 (2015)
   PUBMED   25798845
  REMARK    GeneRIF: In summary, this study provides genetic evidence for a
            role of ADAMTS20 in CL/P development in dogs and as a candidate
            gene for CL/P development in humans.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6358)
  AUTHORS   Lambert,J.C., Ibrahim-Verbaas,C.A., Harold,D., Naj,A.C., Sims,R.,
            Bellenguez,C., DeStafano,A.L., Bis,J.C., Beecham,G.W.,
            Grenier-Boley,B., Russo,G., Thorton-Wells,T.A., Jones,N.,
            Smith,A.V., Chouraki,V., Thomas,C., Ikram,M.A., Zelenika,D.,
            Vardarajan,B.N., Kamatani,Y., Lin,C.F., Gerrish,A., Schmidt,H.,
            Kunkle,B., Dunstan,M.L., Ruiz,A., Bihoreau,M.T., Choi,S.H.,
            Reitz,C., Pasquier,F., Cruchaga,C., Craig,D., Amin,N., Berr,C.,
            Lopez,O.L., De Jager,P.L., Deramecourt,V., Johnston,J.A., Evans,D.,
            Lovestone,S., Letenneur,L., Moron,F.J., Rubinsztein,D.C.,
            Eiriksdottir,G., Sleegers,K., Goate,A.M., Fievet,N.,
            Huentelman,M.W., Gill,M., Brown,K., Kamboh,M.I., Keller,L.,
            Barberger-Gateau,P., McGuiness,B., Larson,E.B., Green,R.,
            Myers,A.J., Dufouil,C., Todd,S., Wallon,D., Love,S., Rogaeva,E.,
            Gallacher,J., St George-Hyslop,P., Clarimon,J., Lleo,A., Bayer,A.,
            Tsuang,D.W., Yu,L., Tsolaki,M., Bossu,P., Spalletta,G., Proitsi,P.,
            Collinge,J., Sorbi,S., Sanchez-Garcia,F., Fox,N.C., Hardy,J., Deniz
            Naranjo,M.C., Bosco,P., Clarke,R., Brayne,C., Galimberti,D.,
            Mancuso,M., Matthews,F., Moebus,S., Mecocci,P., Del Zompo,M.,
            Maier,W., Hampel,H., Pilotto,A., Bullido,M., Panza,F., Caffarra,P.,
            Nacmias,B., Gilbert,J.R., Mayhaus,M., Lannefelt,L., Hakonarson,H.,
            Pichler,S., Carrasquillo,M.M., Ingelsson,M., Beekly,D., Alvarez,V.,
            Zou,F., Valladares,O., Younkin,S.G., Coto,E., Hamilton-Nelson,K.L.,
            Gu,W., Razquin,C., Pastor,P., Mateo,I., Owen,M.J., Faber,K.M.,
            Jonsson,P.V., Combarros,O., O'Donovan,M.C., Cantwell,L.B.,
            Soininen,H., Blacker,D., Mead,S., Mosley,T.H. Jr., Bennett,D.A.,
            Harris,T.B., Fratiglioni,L., Holmes,C., de Bruijn,R.F.,
            Passmore,P., Montine,T.J., Bettens,K., Rotter,J.I., Brice,A.,
            Morgan,K., Foroud,T.M., Kukull,W.A., Hannequin,D., Powell,J.F.,
            Nalls,M.A., Ritchie,K., Lunetta,K.L., Kauwe,J.S., Boerwinkle,E.,
            Riemenschneider,M., Boada,M., Hiltuenen,M., Martin,E.R.,
            Schmidt,R., Rujescu,D., Wang,L.S., Dartigues,J.F., Mayeux,R.,
            Tzourio,C., Hofman,A., Nothen,M.M., Graff,C., Psaty,B.M., Jones,L.,
            Haines,J.L., Holmans,P.A., Lathrop,M., Pericak-Vance,M.A.,
            Launer,L.J., Farrer,L.A., van Duijn,C.M., Van Broeckhoven,C.,
            Moskvina,V., Seshadri,S., Williams,J., Schellenberg,G.D. and
            Amouyel,P.
  CONSRTM   European Alzheimer's Disease Initiative (EADI); Genetic and
            Environmental Risk in Alzheimer's Disease; Alzheimer's Disease
            Genetic Consortium; Cohorts for Heart and Aging Research in Genomic
            Epidemiology
  TITLE     Meta-analysis of 74,046 individuals identifies 11 new
            susceptibility loci for Alzheimer's disease
  JOURNAL   Nat Genet 45 (12), 1452-1458 (2013)
   PUBMED   24162737
REFERENCE   5  (bases 1 to 6358)
  AUTHORS   McCormack,M., Urban,T.J., Shianna,K.V., Walley,N., Pandolfo,M.,
            Depondt,C., Chaila,E., O'Conner,G.D., Kasperaviciute,D.,
            Radtke,R.A., Heinzen,E.L., Sisodiya,S.M., Delanty,N. and
            Cavalleri,G.L.
  TITLE     Genome-wide mapping for clinically relevant predictors of
            lamotrigine- and phenytoin-induced hypersensitivity reactions
  JOURNAL   Pharmacogenomics 13 (4), 399-405 (2012)
   PUBMED   22379998
REFERENCE   6  (bases 1 to 6358)
  AUTHORS   Barallobre-Barreiro,J., Didangelos,A., Schoendube,F.A., Drozdov,I.,
            Yin,X., Fernandez-Caggiano,M., Willeit,P., Puntmann,V.O.,
            Aldama-Lopez,G., Shah,A.M., Domenech,N. and Mayr,M.
  TITLE     Proteomics analysis of cardiac extracellular matrix remodeling in a
            porcine model of ischemia/reperfusion injury
  JOURNAL   Circulation 125 (6), 789-802 (2012)
   PUBMED   22261194
REFERENCE   7  (bases 1 to 6358)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 6358)
  AUTHORS   Edwards,M., Bigham,A., Tan,J., Li,S., Gozdzik,A., Ross,K., Jin,L.
            and Parra,E.J.
  TITLE     Association of the OCA2 polymorphism His615Arg with melanin content
            in east Asian populations: further evidence of convergent evolution
            of skin pigmentation
  JOURNAL   PLoS Genet 6 (3), e1000867 (2010)
   PUBMED   20221248
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6358)
  AUTHORS   Llamazares,M., Cal,S., Quesada,V. and Lopez-Otin,C.
  TITLE     Identification and characterization of ADAMTS-20 defines a novel
            subfamily of metalloproteinases-disintegrins with multiple
            thrombospondin-1 repeats and a unique GON domain
  JOURNAL   J Biol Chem 278 (15), 13382-13389 (2003)
   PUBMED   12562771
  REMARK    GeneRIF: This protein is identified and characterized and its
            relation to other disintegrins and thrombospondin 1 repeats is
            examined.
            Erratum:[J Biol Chem. 2018 Jul 27;293(30):11785. doi:
            10.1074/jbc.AAC118.004702.. PMID: 30054291]
REFERENCE   10 (bases 1 to 6358)
  AUTHORS   Somerville,R.P., Longpre,J.M., Jungers,K.A., Engle,J.M., Ross,M.,
            Evanko,S., Wight,T.N., Leduc,R. and Apte,S.S.
  TITLE     Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS
            subfamily related to Caenorhabditis elegans GON-1
  JOURNAL   J Biol Chem 278 (11), 9503-9513 (2003)
   PUBMED   12514189
  REMARK    GeneRIF: ADAMTS-9 and ADAMTS-20 have an identical modular
            structure, are distinct in possessing 15 thrombospondin type I
            repeats and a unique C-terminal domain, and have a similar gene
            structure
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090525.8, AF488804.1,
            AJ515153.3, AC120104.4 and CN292892.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_025003.4.
            
            Summary: The protein encoded by this gene is a member of the ADAMTS
            family of zinc-dependent proteases. The encoded protein has a
            signal peptide that is cleaved to release the mature peptide, which
            is secreted and found in the extracellular matrix. This protein may
            be involved in tissue remodeling. [provided by RefSeq, Sep 2011].
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2153307 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389420.8/ ENSP00000374071.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               AC090525.8         44127-44408         c
            283-1196            AF488804.1         1-914
            1197-1359           AJ515153.3         915-1077
            1360-1393           AF488804.1         1078-1111
            1394-1577           AJ515153.3         1112-1295
            1578-1649           AC120104.4         43745-43816
            1650-3003           AF488804.1         1368-2721
            3004-4224           AJ515153.3         2716-3936
            4225-4261           AF488804.1         3946-3982
            4262-5594           AJ515153.3         3974-5306
            5595-6015           AF488804.1         5316-5736
            6016-6358           CN292892.1         365-707
FEATURES             Location/Qualifiers
     source          1..6358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..6358
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 20"
                     /db_xref="GeneID:80070"
                     /db_xref="HGNC:HGNC:17178"
                     /db_xref="MIM:611681"
     exon            1..373
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..6015
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 20"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 20 preproprotein"
                     /protein_id="NP_079279.3"
                     /db_xref="CCDS:CCDS31778.2"
                     /db_xref="GeneID:80070"
                     /db_xref="HGNC:HGNC:17178"
                     /db_xref="MIM:611681"
                     /translation="MWVAKWLTGLLYHLSLFITRSWEVDFHPRQEALVRTLTSYEVVI
                     PERVNEFGEVFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFLAA
                     GYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNG
                     EYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPFHTY
                     SNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHG
                     SNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFC
                     SWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFINEE
                     KGLISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKY
                     VTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINICMH
                     LWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYS
                     SCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSD
                     FNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTE
                     THDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYGYNVVVKI
                     PAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEY
                     SGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFTWDPYGPW
                     EGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKS
                     ECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHY
                     SEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAASEW
                     SECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPC
                     TTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLP
                     TVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDC
                     FTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAA
                     CPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSC
                     SGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGI
                     KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKG
                     RKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQ
                     QRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDS
                     HQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQ
                     RITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSV
                     TCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTCKEIQVKNHIRK
                     DGDYYLNIKGRIIKIYCADMYLENPKEYLTLVQGEENFSEVYGFRLKNPYQCPFNGSR
                     REDCECDNGHLAAGYTVFSKIRIDLTSMQIKTTDLLFSKTIFGNAVPFATAGDCYSAF
                     RCPQGQFSINLSGTGMKISSTAKWLTQGSYTSVSIRRSEDGTRFFGKCGGYCGKCLPH
                     MTTGLPIQVI"
     exon            374..735
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..895
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1149
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1233
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1358
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1399
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1505
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1649
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1791
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1896
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2042
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2224
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2361
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2479
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2572
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2745
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2875
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3002
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3213
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3378
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3543
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3663
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3771
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..3936
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3937..4227
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4389
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4390..4566
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4567..4734
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4735..4908
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4909..5079
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5080..5277
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5278..5407
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5502
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5503..5594
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5595..5728
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5729..5820
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5821..5925
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5926..6358
                     /gene="ADAMTS20"
                     /gene_synonym="ADAM-TS20; ADAMTS-20; GON-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttccccgc gccgagctga acctgagcag agagtttctg agggcagcgc gggcgcagga
       61 aggggggtga ggctgcagtg cgatgaagca gcggctcagc gagcggagac aggcggtgtg
      121 gctggaccag ccggcccagg gcccgcgctg ctgttcccta ggctgctgag gcgcggagag
      181 cggcgggcga gagggaggag agggatcgga gcgcgaggga agccggcttg gctgccggcg
      241 gctctggtgg gcctccccga tcggggtccc cagggtggaa ccatgtgggt ggccaagtgg
      301 ctgactgggc tgctctacca tctctcgctc ttcatcacca ggtcttggga agttgacttc
      361 caccccaggc aagaagccct ggtgaggaca ctgacctcct acgaagtagt gatccccgag
      421 cgggtcaatg agtttggaga agtgttccct cagagccacc acttcagccg gcagaaacgc
      481 agctccgagg cgctggaacc catgccgttc cgaacccact atcgcttcac tgcctacggg
      541 cagctcttcc agctgaacct gaccgccgat gcatcctttc tggccgccgg ctacaccgag
      601 gtgcacttgg gaaccccgga gcgcggggcc tgggagagcg acgcagggcc ctcggacctg
      661 cgccactgct tctaccgcgg ccaggtcaac tcacaggagg attacaaggc cgtcgtcagc
      721 ttatgcggag gcctgacggg aacatttaaa ggacagaacg gtgaatattt cttagaacct
      781 ataatgaagg cagatgggaa tgaatatgaa gatggtcaca acaagccaca tcttatatac
      841 agacaagact taaataactc ttttctgcag actctgaagt attgcagtgt gtcagaaagt
      901 caaataaagg aaaccagttt accctttcat acctacagca acatgaatga agatcttaat
      961 gtaatgaaag aaagagtttt aggacacaca tcaaaaaatg taccattgaa agatgaaaga
     1021 agacattcca ggaaaaaacg tcttatatca tatccaagat acattgaaat tatggttaca
     1081 gctgatgcta aagtggtttc tgctcatgga tcgaatttgc aaaactatat actgactcta
     1141 atgtcaattg ttgcaacaat ctacaaagat ccaagtattg gaaatttgat acacatagta
     1201 gtggtaaaat tagttatgat tcaccgtgag gaggaaggac cagtcattaa ttttgatggt
     1261 gctaccacat taaagaactt ttgttcatgg caacaaactc agaatgacct tgatgatgtt
     1321 cacccttccc accatgacac tgctgttctt atcactaggg aagacatttg ttcatctaaa
     1381 gagaaatgta acatgttagg tttatcatat ttaggtacca tatgtgatcc tttacaaagc
     1441 tgctttatta atgaagaaaa aggactcatt tctgctttta ctatagccca tgagcttggg
     1501 cacacacttg gtgttcaaca tgatgataat cctagatgta aagaaatgaa agttacaaag
     1561 tatcatgtaa tggcccctgc tttaagtttt cacatgagtc cttggagctg gtcaaactgt
     1621 agtcggaaat atgttactga attcctagat actggttacg gggaatgtct tcttgacaaa
     1681 ccagatgaag aaatatataa tctgccttca gaacttcctg gatcacgata tgatggaaac
     1741 aagcagtgtg agcttgcgtt tggtcctggg tcacaaatgt gtccccatat aaatatatgc
     1801 atgcatctgt ggtgcacaag cacagaaaag cttcacaaag gctgtttcac tcaacacgtg
     1861 ccaccagcag atggaacaga ctgcggtcct ggaatgcatt gccgtcatgg gctatgtgta
     1921 aacaaagaaa cggaaacacg tcctgtaaat ggtgaatggg gaccatggga accttacagt
     1981 tcttgttcaa gaacatgtgg aggcggaatc gaaagtgcaa ccaggcgctg taatcgtcct
     2041 gagccaagaa acggaggaaa ttactgtgtg ggccgcagga tgaaatttcg atcatgtaat
     2101 actgattcat gtccaaaagg cacacaagac tttcgagaga agcagtgctc tgattttaat
     2161 ggtaaacatt tggacatcag tggcattccc tctaatgtga ggtggcttcc aagatacagt
     2221 ggcattggca caaaggatcg ttgtaaactc tattgtcagg ttgctggaac caattatttc
     2281 tacctattga aggatatggt tgaagatggt actccttgtg gaactgaaac tcatgacatc
     2341 tgtgttcaag gccagtgtat ggcagctggt tgtgatcacg tgttaaactc cagtgccaag
     2401 atagacaaat gtggagtgtg tggtggggac aactcttcat gcaagacaat aacaggtgtc
     2461 ttcaacagtt ctcattatgg ttataatgtt gttgtaaaga ttcccgcagg agcaacaaac
     2521 gttgacattc gtcagtacag ctattctgga caaccagatg acagttacct tgcattatct
     2581 gacgctgaag ggaattttct tttcaatgga aattttcttc taagtacgtc aaaaaaagaa
     2641 atcaatgtgc aaggaacaag aactgttatt gaatacagtg gatcaaataa cgcagttgaa
     2701 agaattaata gtactaatcg acaagagaaa gaacttattt tgcaggtgtt gtgtgtgggt
     2761 aatttataca accctgatgt acattattcc ttcaatatcc ctttggaaga gaggagtgac
     2821 atgttcacat gggaccccta tggaccatgg gaaggctgta ccaaaatgtg tcaaggtctt
     2881 cagcgaagaa acataacttg catacataag agtgatcata gtgttgtgtc tgataaagaa
     2941 tgtgaccact tgccacttcc atcatttgtt actcaaagtt gcaatacaga ctgtgaacta
     3001 aggtggcatg ttattggcaa aagtgaatgt tcatcccaat gtggtcaagg atatagaacc
     3061 ttggacatcc attgcatgaa gtattccatt catgaaggac agactgttca agttgatgac
     3121 cactactgtg gtgaccagct taaacctcct acccaagaac tatgccatgg taactgtgtc
     3181 ttcacaagat ggcattattc agaatggtct cagtgttcca ggagttgtgg aggaggggaa
     3241 aggtctcgag aatcttattg tatgaataac tttggccatc gtcttgctga caatgaatgc
     3301 caagaactgt cccgagtgac gagagagaat tgcaatgaat tttcctgtcc cagttgggct
     3361 gctagtgaat ggagcgagtg ccttgttaca tgtggtaaag gaacaaagca gcggcaggta
     3421 tggtgtcagc tgaatgtaga tcacttgagt gatggcttct gtaattcaag taccaaacct
     3481 gaatctctga gtccatgtga acttcataca tgtgcttcct ggcaagtagg accatggggt
     3541 ccttgcacaa ccacatgtgg acatgggtat cagatgcgag atgttaaatg tgtcaatgag
     3601 ctagctagtg cagtgttaga ggacacagaa tgccatgaag ctagtcgccc cagtgacaga
     3661 cagagctgtg tacttacacc ttgctcattt atttctaaac ttgagaccgc tttattacca
     3721 actgttctca taaaaaagat ggcacaatgg cgacatggtt cttggacccc atgctccgta
     3781 tcttgtggaa gaggtactca agcccgctat gtaagctgtc gtgatgctct tgatagaata
     3841 gcagatgaat catattgtgc ccacttaccc cgacctgctg aaatatggga ctgttttacc
     3901 ccttgtggag agtggcaagc aggggattgg tcaccctgtt cagcttcctg tggccatgga
     3961 aaaacaactc gacaagtttt atgcatgaac taccatcagc caattgatga gaattactgt
     4021 gatcctgaag ttcgcccttt gatggaacag gaatgtagcc tggcagcctg ccctcctgca
     4081 cacagccact ttcctagttc ccctgtgcag ccaagctatt atctaagcac gaatttgcca
     4141 ttaactcaaa aacttgaaga taatgaaaat caggtggtcc atccatcagt cagaggaaac
     4201 cagtggagaa ccggaccatg gggatcatgc tccagcagtt gttctggagg tcttcagcat
     4261 agggctgtgg tctgccagga tgaaaatgga caaagtgcta gttactgcga tgcagcctcc
     4321 aagcctccag agttacagca atgtggtcca gggccttgtc cacagtggaa ctacggaaat
     4381 tggggagaat gttcacaaac atgtggagga ggaataaaat caagacttgt aatatgtcaa
     4441 tttcccaatg gccaaatatt agaagatcac aactgtgaaa ttgtaaacaa gccacctagc
     4501 gtaatacagt gtcatatgca tgcttgccct gctgatgtgt catggcatca ggaaccatgg
     4561 acatcgtgct cagcttcttg tggtaaaggt agaaagtacc gtgaagtgtt ttgcattgac
     4621 caattccaaa ggaaattaga agacacaaat tgcagtcaag tacagaaacc tccaactcac
     4681 aaagcctgta gatctgtcag atgcccttca tggaaagcca atagctggaa tgagtgctct
     4741 gtgacctgtg gctctggagt tcagcagagg gatgtatact gcagactgaa aggtgttggt
     4801 caggtggttg aagaaatgtg tgatcagtcc acccgacctt gttctcagag gcgatgttgg
     4861 agtcaggact gtgtgcagca caaggggatg gaaagaggga ggctgaattg ttcaacatca
     4921 tgtgagagaa aagattcaca tcaacgaatg gagtgcacag ataaccaaat cagacaagtg
     4981 aatgaaatag tctataattc ttcaaccata tctcttacat ccaagaattg caggaaccct
     5041 ccttgcaatt acattgtggt aacagcagac tcatcacagt gtgcaaacaa ctgtggattt
     5101 agttacagac aaaggattac atattgcacc gagatcccat ctactaagaa acataagctc
     5161 catcgacttc ggcctatagt ttatcaagaa tgccctgtgg tgccttcctc tcaggtttac
     5221 caatgcatta acagctgttt gcatttggcc acttggaaag ttggaaaatg gagcaagtgc
     5281 tcagtgactt gtggaattgg gataatgaag agacaagtga aatgcattac caaacatggt
     5341 ttgtccagtg acttatgttt aaaccattta aaaccaggtg ctcaaaagaa atgttatgcc
     5401 aatgactgta aatcatttac cacctgcaaa gaaattcaag tgaaaaacca cattagaaag
     5461 gatggtgact attaccttaa cattaaggga agaataataa agatttattg tgcagacatg
     5521 tacttggaga accctaagga atatttaaca ctggtccaag gtgaagaaaa cttttctgaa
     5581 gtgtatggct ttagactaaa aaatccatat caatgtcctt ttaatgggag tagaagggaa
     5641 gactgtgaat gtgacaatgg acacttagct gctggataca ctgttttcag caaaataaga
     5701 attgatctca cttccatgca aattaaaact acggaccttc ttttttccaa aacaatattt
     5761 ggaaatgcag ttccatttgc cacagctgga gattgctaca gtgctttcag atgcccacag
     5821 ggacagttta gcattaattt gtcaggaact gggatgaaga tatccagcac agcaaagtgg
     5881 ctcactcagg ggagttatac ctctgtcagc atacgaagat cagaggatgg aactagattt
     5941 ttcggcaaat gtggagggta ctgtggaaag tgtcttcctc acatgactac tggtctccca
     6001 attcaagtca tatgaacatt tagaaggggg aagtatgccc taaagagggg atattctctg
     6061 gaatattcaa ataactggtg ctcatttctt tatatctccc ttcccgagat ttccatgtcc
     6121 aatatgtctc tgcctttttt tcagggtgct catcagggat tcaaatcact gcttaataag
     6181 gtctataaaa gaaatttaag agctatctta atttatttta tatctaatca ggatattttt
     6241 taaagaacat aataatttat aatagagaat accaggattg aatgaattat accaagacag
     6301 tgttgctctt aacatcttgg cctggaccac acttatttta tacctataaa cacacatg
//
