LOCUS       NM_014244               6783 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            2 (ADAMTS2), transcript variant 1, mRNA.
ACCESSION   NM_014244
VERSION     NM_014244.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6783)
  AUTHORS   Carter,E.P., Yoneten,K.K., Gavara,N., Tyler,E.J., Gauthier,V.,
            Murray,E.R., Ten Dijke,P., Cameron,A.J., Pearce,O. and Grose,R.P.
  TITLE     Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast
            differentiation and function
  JOURNAL   J Pathol 262 (1), 90-104 (2024)
   PUBMED   37929635
  REMARK    GeneRIF: Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast
            differentiation and function.
REFERENCE   2  (bases 1 to 6783)
  AUTHORS   Earley,E.J., Kelly,S., Fang,F., Alencar,C.S., Rodrigues,D.O.W.,
            Soares Cruz,D.T., Flanagan,J.M., Ware,R.E., Zhang,X., Gordeuk,V.,
            Gladwin,M., Zhang,Y., Nouraie,M., Nekhai,S., Sabino,E., Custer,B.,
            Dinardo,C. and Page,G.P.
  CONSRTM   International Component of the NHLBI Recipient Epidemiology and
            Donor Evaluation Study (REDS-III) and the NHLBI Trans-Omics for
            Precision Medicine (TOPMed) Consortium
  TITLE     Genome-wide association study of early ischaemic stroke risk in
            Brazilian individuals with sickle cell disease implicates ADAMTS2
            and CDK18 and uncovers novel loci
  JOURNAL   Br J Haematol 201 (2), 343-352 (2023)
   PUBMED   36602125
  REMARK    GeneRIF: Genome-wide association study of early ischaemic stroke
            risk in Brazilian individuals with sickle cell disease implicates
            ADAMTS2 and CDK18 and uncovers novel loci.
REFERENCE   3  (bases 1 to 6783)
  AUTHORS   Zhang,Y., Li,J., Ji,Y., Cheng,Y. and Fu,X.
  TITLE     Mutations in the TBX15-ADAMTS2 pathway associate with a novel soft
            palate dysplasia
  JOURNAL   Hum Mutat 43 (12), 2102-2115 (2022)
   PUBMED   36124393
  REMARK    GeneRIF: Mutations in the TBX15-ADAMTS2 pathway associate with a
            novel soft palate dysplasia.
REFERENCE   4  (bases 1 to 6783)
  AUTHORS   Witten,A., Ruhle,F., de Witt,M., Barysenka,A., Stach,M., Junker,R.,
            Nowak-Gottl,U. and Stoll,M.
  TITLE     ADAMTS12, a new candidate gene for pediatric stroke
  JOURNAL   PLoS One 15 (8), e0237928 (2020)
   PUBMED   32817637
  REMARK    GeneRIF: ADAMTS12, a new candidate gene for pediatric stroke.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6783)
  AUTHORS   Bekhouche,M. and Colige,A.
  TITLE     The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology
  JOURNAL   Matrix Biol 44-46, 46-53 (2015)
   PUBMED   25863161
  REMARK    GeneRIF: Data indicate that ADAMTS2 and 3 cleave the
            amino-propeptide of fibrillar collagens and regulate blood vessels
            homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads
            to the dermatosparactic type of Ehlers-Danlos syndrome. [review]
            Review article
REFERENCE   6  (bases 1 to 6783)
  AUTHORS   Colige,A., Ruggiero,F., Vandenberghe,I., Dubail,J., Kesteloot,F.,
            Van Beeumen,J., Beschin,A., Brys,L., Lapiere,C.M. and Nusgens,B.
  TITLE     Domains and maturation processes that regulate the activity of
            ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of
            fibrillar procollagens types I-III and V
  JOURNAL   J Biol Chem 280 (41), 34397-34408 (2005)
   PUBMED   16046392
  REMARK    GeneRIF: Determination of the processing, activity and cleavage
            specificity of the bovine ADAMTS2 protein.
REFERENCE   7  (bases 1 to 6783)
  AUTHORS   Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
REFERENCE   8  (bases 1 to 6783)
  AUTHORS   Colige,A., Sieron,A.L., Li,S.W., Schwarze,U., Petty,E.,
            Wertelecki,W., Wilcox,W., Krakow,D., Cohn,D.H., Reardon,W.,
            Byers,P.H., Lapiere,C.M., Prockop,D.J. and Nusgens,B.V.
  TITLE     Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis
            are caused by mutations in the procollagen I N-proteinase gene
  JOURNAL   Am J Hum Genet 65 (2), 308-317 (1999)
   PUBMED   10417273
REFERENCE   9  (bases 1 to 6783)
  AUTHORS   Tang,B.L. and Hong,W.
  TITLE     ADAMTS: a novel family of proteases with an ADAM protease domain
            and thrombospondin 1 repeats
  JOURNAL   FEBS Lett 445 (2-3), 223-225 (1999)
   PUBMED   10094461
  REMARK    Review article
REFERENCE   10 (bases 1 to 6783)
  AUTHORS   Reardon,W., Winter,R.M., Smith,L.T., Lake,B.D., Rossiter,M. and
            Baraitser,M.
  TITLE     The natural history of human dermatosparaxis (Ehlers-Danlos
            syndrome type VIIC)
  JOURNAL   Clin Dysmorphol 4 (1), 1-11 (1995)
   PUBMED   7735500
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109479.3, DA928965.1,
            AJ003125.1, AC008544.7, AC010216.8 and CA445758.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014244.4.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            Members of the family share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature procollagen N-proteinase. This proteinase excises the
            N-propeptide of the fibrillar procollagens types I-III and type V.
            Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a
            recessively inherited connective-tissue disorder. Alternative
            splicing results in multiple transcript variants, at least one of
            which encodes an isoform that is proteolytically processed.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ003125.1, DRR138522.934417.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251582.12/ ENSP00000251582.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC109479.3         72538-72568
            32-133              DA928965.1         2-103
            134-918             AJ003125.1         1-785
            919-919             AC008544.7         143676-143676
            920-2160            AJ003125.1         787-2027
            2161-2161           AC010216.8         49261-49261
            2162-2664           AJ003125.1         2029-2531
            2665-2665           AC010216.8         57183-57183
            2666-3134           AJ003125.1         2533-3001
            3135-3135           AC010216.8         62497-62497
            3136-3398           AJ003125.1         3003-3265
            3399-6556           AC010216.8         70990-74147
            6557-6783           CA445758.1         21-247              c
FEATURES             Location/Qualifiers
     source          1..6783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..6783
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 2"
                     /db_xref="GeneID:9509"
                     /db_xref="HGNC:HGNC:218"
                     /db_xref="MIM:604539"
     exon            1..272
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            273..667
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            668..821
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1024
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1108
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1265
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1371
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1515
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1648
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1762
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1908
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2084
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2218
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2342
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2423
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2590
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2750
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2883
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3091
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3221
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3311
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..6783
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3768..3773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /note="hexamer: AATAAA"
     polyA_site      3787
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
     regulatory      6750..6755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /note="hexamer: ATTAAA"
     polyA_site      6783
                     /gene="ADAMTS2"
                     /gene_synonym="ADAM-TS2; ADAMTS-2; ADAMTS-3; EDSDERMS;
                     NPI; PC I-NP; PCI-NP; PCINP; PCPNI; PNPI"
                     /note="major polyA site"
ORIGIN      
        1 gcctcctccg ccccgcgccc tgcggtgctg cagctgcggg cggctccagc tgcccccaga
       61 tgtgggctgg gcggctcgcg gggaactttc gcgccggctg cgagtgcggg gccccggctg
      121 cagtccggct gccatggatc cgccggcggg agccgctcgc cgcctgctct gccccgcgct
      181 gctgctgctg ctgctgctgc tgccgccgcc gctcctgccg ccgccgccgc cgcccgcgaa
      241 cgccaggctc gccgccgccg ccgacccccc aggcgggccc ctggggcacg gagcggagcg
      301 catcctggcg gtgcccgtgc gcactgacgc ccagggccgc ttggtgtccc acgtggtgtc
      361 ggcagctacg tccagagcag gggtacgagc ccgcagggcc gccccggtcc ggaccccgag
      421 cttccccgga ggcaacgagg aggagcctgg cagtcacctc ttctacaatg tcacggtctt
      481 tggccgagac ctgcacctgc ggctgcggcc caacgcccgc ctcgtggcgc ccggggccac
      541 tatggagtgg cagggcgaga agggcaccac ccgcgtggag cccctgctcg ggagctgtct
      601 ctacgtcgga gacgtggccg gcctagccga agcctcctct gtggcgctca gcaactgcga
      661 tgggctggct ggtctgatcc ggatggagga ggaggagttc ttcatcgaac ccttggagaa
      721 ggggctggcg gcgcaggagg ctgagcaagg ccgtgtgcat gtggtgtatc gccggccacc
      781 cacgtcccct cctctcgggg ggccacaggc cctggacaca ggggcctccc tggacagcct
      841 ggacagcctc agccgcgccc tgggcgtcct agaggagcac gccaacagct cgaggcggag
      901 ggcacgcagg catgctgcgg acgatgacta caacatcgag gtcctgctgg gcgtggatga
      961 ctctgtggtg cagttccacg ggaaggagca cgtacagaag tacctgctga cactcatgaa
     1021 cattgtcaat gaaatctacc atgacgagtc cttgggtgcc cacatcaacg tggtcctggt
     1081 gcggatcatc ctcctgagct atggaaagtc catgagcctc atcgagatcg ggaacccctc
     1141 tcagagcctg gagaatgtct gccgctgggc ctacctccag cagaagccag acacgggcca
     1201 cgatgaatac cacgatcacg ccatcttcct cacacggcag gactttgggc cttccggcat
     1261 gcaaggctat gctcctgtca ccggcatgtg ccatccggtc cgcagctgca ccctgaacca
     1321 tgaggacggc ttctcctcag cgtttgtggt ggcccatgag actggccacg tgctgggcat
     1381 ggagcacgac gggcagggca accgctgtgg cgacgaggtg cggctgggca gcatcatggc
     1441 gcccctggtg caggccgcct tccaccgctt ccactggtcc cgctgcagcc agcaggagct
     1501 gagccgctac ctgcactcct atgactgcct gctggatgac cccttcgccc acgactggcc
     1561 ggcgctgccc cagctcccgg gactgcacta ctccatgaac gagcaatgcc gctttgactt
     1621 cggcctgggc tacatgatgt gcacggcgtt ccggaccttt gacccctgca agcagctgtg
     1681 gtgcagccat cctgacaacc cctacttttg caagaccaag aaggggcccc ccttggacgg
     1741 gactatgtgt gcacctggca agcattgttt taaaggacac tgcatctggc tgacacctga
     1801 catcctcaaa cgggacggca gctggggcgc ttggagtccg tttggctcct gctcacgtac
     1861 ctgtggcacg ggcgtgaagt tcaggacccg ccagtgtgac aacccacacc cggccaacgg
     1921 gggccgcacc tgctcgggcc ttgcctacga cttccagctc tgcagccgcc aggactgccc
     1981 cgactccctg gctgacttcc gcgaggagca gtgccgccag tgggacctgt acttcgagca
     2041 cggcgacgcc cagcaccact ggctgcccca cgagcaccgg gatgccaagg agagatgcca
     2101 cctgtactgc gagtccaggg agaccgggga ggtggtgtcc atgaagcgca tggtgcatga
     2161 cgggacgcgc tgctcctaca aggacgcctt cagcctctgt gtgcgcgggg actgcaggaa
     2221 ggtgggctgt gacggtgtga tcggctccag caagcaggaa gacaagtgtg gcgtgtgcgg
     2281 aggggacaac agccactgca aagtggtcaa gggcacgttc acacggtcac ccaagaagca
     2341 tggttacatc aagatgtttg agatccctgc aggagccaga cacctgctca ttcaggaggt
     2401 agacgccacc agccaccatc tggccgtcaa gaacctggag acaggcaagt tcatcttaaa
     2461 tgaagagaat gacgtggatg ccagttccaa aaccttcatt gccatgggcg tggagtggga
     2521 gtacagagac gaggacggcc gggagacgct gcagaccatg ggccccctcc acggcaccat
     2581 caccgttctg gtcatcccgg tgggagacac ccgggtctca ctgacgtaca aatacatgat
     2641 ccatgaggac tcactgaatg tcgacgacaa caacgtcctg gaagaggact ctgtggtcta
     2701 cgagtgggcc ctgaagaagt ggtctccgtg ctccaagccc tgtggcggag ggtcccagtt
     2761 caccaagtat ggctgccgcc ggaggctgga ccacaagatg gtacaccgtg gcttctgtgc
     2821 cgccctctcg aagcccaaag ccatccgcag agcgtgcaac ccacaggaat gctcccagcc
     2881 agtgtgggtc acaggcgaat gggagccatg tagccagacc tgtgggcgga caggcatgca
     2941 ggtgcgctcc gtgcgctgca ttcagccgct acacgacaac accacccgct ccgtgcacgc
     3001 caagcactgc aatgacgccc ggcccgagag ccgccgggcc tgcagccgcg agctctgccc
     3061 tggtcgttgg cgagccgggc cctggtccca gtgctcagta acctgtggca acggcaccca
     3121 ggagcggcca gtgctctgcc gcaccgcgga cgacagcttc ggcatctgcc aggaggagcg
     3181 tcctgagaca gcgaggacct gcaggcttgg cccctgtccc cgaaacatct cagatccctc
     3241 caagaagagc tacgtagttc agtggctgtc ccgcccggac cccgactcgc ccatccggaa
     3301 gatctcgtca aagggccact gccaaggcga caagtcaata ttctgtagga tggaagtctt
     3361 gtcccgctat tgctccatcc caggctacaa caagctgtgc tgcaagtcct gtaacctgta
     3421 caacaacctc accaacgtgg agggcaggat agagccaccg cctgggaagc acaacgacat
     3481 tgacgtgttc atgcctaccc tcccagtgcc cactgtagcc atggaggtgc ggccatcacc
     3541 aagcaccccc ctggaggtcc ctctcaatgc ctccagcacc aatgccacag aggatcaccc
     3601 agaaaccaat gccgtagatg aaccctacaa aatccatggc ctggaagatg aagtccagcc
     3661 acccaaccta atccctcgac gaccgagccc ctatgaaaag accagaaacc aaagaatcca
     3721 agagctcatt gatgagatgc ggaagaaaga gatgctcgga aagttctaat aaaatggaaa
     3781 gatagcatcc ctagcatttt tttcttgctt atagagatat tccatgggat agcaaatcct
     3841 gtgtcatgga gatgaagtca aaattcctga ttccaaaagg ttttgagaaa acaaagaggg
     3901 ggaatgacgt aagaaagata ggcatgagca tgtggtaact aggttagcac gtgtgcttcc
     3961 cagcccagga gcgaccaaat actgtggtgg cgtcaggtgt gcagtggaga ggaatataga
     4021 ggctgtatgg cctccctcag tgagggcagg gcaagaggga tcactctgag agaacaaaaa
     4081 taggccccaa gttgctaagc agtgattggg aaccttcctt tccttggcgg agatgcatga
     4141 cattccctac cgatccccag acacagcctg tgggactctt aggagaaatg gtgatttact
     4201 gaataactga cccgttgccg agatgagtac aatgaagtgg aggtgatgaa ctcaaatcgt
     4261 cttccagggc caggcggctg accggggtga gcgtagtggc ccgctgggga ccatggccgc
     4321 cctgacagcc acacccacct ggagctgact tggttctggc tgttgctgcc actgtgaaat
     4381 ctgtatctct ctccatctct gctctactat ccccggcctt gccagacagt gttctttttc
     4441 ggaagaagtc tagatttttg catgaaaaaa actcaatctt taaaggtcga ctcagaacat
     4501 tttaaggagg cctccacttg gtctgatgca gtcttgctaa ttaagaacta aaggccttct
     4561 gaccttcttg gtgctcatgc tgtacggcat ctgaatgtct cgaccgagtc tgagccgtgc
     4621 agctgtcctc cacctgcgaa agtaatgaga atcctatcac gggacataag gataggtcta
     4681 aacagggtcc atgccaagaa aacagtgggg tgctctccca ggcctctccc ctgtccacta
     4741 accctggcct tgccggctgc cttccaggct ctgggggaag agctcctgca ttcttccctg
     4801 gccaccttgg ctccagggct ccccagagag cctcttccct ccccaagtac ctgagaaaga
     4861 tgagagaggc acgtgctctg ctgggaaggt ccagtgagcg gttcaagggc ctggaatctc
     4921 cctacggcca agtctaaggg ttctgggatt ctgggctttg tgggctttgc ttgcttgctg
     4981 ggaatgggct ttccctgtcc cgccctgccc cacctcgcct ctgtctctca gaagctccag
     5041 aacccagcag tgacctgcaa aatgtggcct ctgatggggg cttagggtgg gagatgggga
     5101 gagcctacat tgtcttttgc tccttgaaaa ctttaatagc tcctattttc cagagaatgg
     5161 tgctttgtga gcaacatgcg agtaagagag aaataggagg aagggggagt aggggcggat
     5221 gggagaagag tggctcattt ttacctctca ctgccttgac attttgtgaa cgtgaagctt
     5281 aaactttctg ggcttacaag acccaggggc acgtcagctc cttagatggg ctcagcctga
     5341 cacataattc ttaaaccttt cctgtttaag aaacttctag aggctgtgta ctctcaccaa
     5401 tcctcttcga gaatttgttc atgtgtattt ccccattata tggatgaggc tcaggataac
     5461 agcatagtgg ctaccttcta ctgagttttg aggtgctaat aagtatgttt gtctgaggct
     5521 gcacatgtgg gtggctctgt gtgtatgatc caagggacaa aatgacgatg taggaaccag
     5581 caagaacgga atctgggctg atgcttcagt ctccacctgg gtgatggcta gcctcccgcc
     5641 ctccaccacc gcatcccaca cgtgctgcgc actgtccccg tgtctcctgg agaaccaaac
     5701 tggagaaaac ctttctgagt atctctcata gtaccccttc cttaagaaga tgtggtttag
     5761 agcatgtgtg caatcctgcc tctgtaatta ggaaacggag cccgaggctt tccattgttg
     5821 gttgaaccca ggacagctgg tgctattcac aggctgaaga actgggcagt tcttacttgg
     5881 gtctgtccta ggatgtggag gaagttcagg actaacgcta ggcagagagt atgactcggt
     5941 ttacccagcc taggggcctc tggatgggaa cactccattc caagatctca gcagagcagg
     6001 gcttcctggc ttgaggctgg aagcctttgg gaagaggccc agctgggaca ttccctgggc
     6061 acctgtcttc cgctgaaggg agcaaggtgc cctctgggac tgacagccat gaccctctgt
     6121 gccatcctca atccttgagc catatatcaa gagtcctcta gagccggatg gtcctcaaaa
     6181 gtctgtccaa ggaatgccaa cgttcaccgg gctctgagaa acgacgcaaa tctctgagct
     6241 ggggaccact tggagaaccg gcttagtaac agtcctgatc ttcgcaagcc agcttcttct
     6301 gcatctgagg ggctcctggc gcccagagga ggcagacaga tgtcttctag ctgagtttct
     6361 aaccgcatga tgagactcag accttccgct gcactagaaa atctgcaaca gtgtccctga
     6421 gtcacttctc cttagtgggc agactcgtgt tagatttgtg gaacccagct ctctgattta
     6481 ctccttttgg aaaacccatg gaatttcatg tataaggctt tcatttgtat tttaaggttt
     6541 ttctgtttgt tttgagtata tacatggtgc tcaatagcaa catcttagca gatgaagcag
     6601 tttatgattc cactccctcc tgtatgacag gtagccacta tactgaatca aggtgctgaa
     6661 ctcaaatcac aaaattctgg cttaccgata caacaaccaa tacatctttg ttctgtaatg
     6721 taaaatttga ctccttactt ttataactta ttaaagttaa aatgtctgtg tttttgcaaa
     6781 tca
//
