LOCUS       NM_133638               5201 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            19 (ADAMTS19), mRNA.
ACCESSION   NM_133638
VERSION     NM_133638.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5201)
  AUTHORS   Jiang,Y., Yu,X., Zhao,Y., Huang,J., Li,T., Chen,H., Zhou,J.,
            Huang,Z. and Yang,Z.
  TITLE     ADAMTS19 Suppresses Cell Migration and Invasion by Targeting
            S100A16 via the NF-kappaB Pathway in Human Gastric Cancer
  JOURNAL   Biomolecules 11 (4), 561 (2021)
   PUBMED   33921267
  REMARK    GeneRIF: ADAMTS19 Suppresses Cell Migration and Invasion by
            Targeting S100A16 via the NF-kappaB Pathway in Human Gastric
            Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5201)
  AUTHORS   Massadeh,S., Alhashem,A., van de Laar,I.M.B.H., Alhabshan,F.,
            Ordonez,N., Alawbathani,S., Khan,S., Kabbani,M.S., Chaikhouni,F.,
            Sheereen,A., Almohammed,I., Alghamdi,B., Frohn-Mulder,I., Ahmad,S.,
            Beetz,C., Bauer,P., Wessels,M.W., Alaamery,M. and
            Bertoli-Avella,A.M.
  TITLE     ADAMTS19-associated heart valve defects: Novel genetic variants
            consolidating a recognizable cardiac phenotype
  JOURNAL   Clin Genet 98 (1), 56-63 (2020)
   PUBMED   32323311
  REMARK    GeneRIF: ADAMTS19-associated heart valve defects: Novel genetic
            variants consolidating a recognizable cardiac phenotype.
REFERENCE   3  (bases 1 to 5201)
  AUTHORS   Wunnemann,F., Ta-Shma,A., Preuss,C., Leclerc,S., van Vliet,P.P.,
            Oneglia,A., Thibeault,M., Nordquist,E., Lincoln,J.,
            Scharfenberg,F., Becker-Pauly,C., Hofmann,P., Hoff,K., Audain,E.,
            Kramer,H.H., Makalowski,W., Nir,A., Gerety,S.S., Hurles,M.,
            Comes,J., Fournier,A., Osinska,H., Robins,J., Puceat,M.,
            Elpeleg,O., Hitz,M.P. and Andelfinger,G.
  CONSRTM   MIBAVA Leducq Consortium principal investigators
  TITLE     Loss of ADAMTS19 causes progressive non-syndromic heart valve
            disease
  JOURNAL   Nat Genet 52 (1), 40-47 (2020)
   PUBMED   31844321
  REMARK    GeneRIF: Mutations in ADAMTS19 lead to progressive heart valve
            disease.
REFERENCE   4  (bases 1 to 5201)
  AUTHORS   Pekcan,M.K., Sarikaya,E., Tokmak,A., Alisik,M., Alkan,A.,
            Ozaksit,G. and Erel,O.
  TITLE     ADAMTS-3, -13, -16, and -19 levels in patients with habitual
            abortion
  JOURNAL   Kaohsiung J Med Sci 33 (1), 30-35 (2017)
   PUBMED   28088271
  REMARK    GeneRIF: The pregnancy loss rate does not appear to be affected by
            both ADAMTS-13 and ADAMTS-19.
REFERENCE   5  (bases 1 to 5201)
  AUTHORS   Pyun,J.A., Kim,S. and Kwack,K.
  TITLE     Epistasis between polymorphisms in ACVR2B and ADAMTS19 is
            associated with premature ovarian failure
  JOURNAL   Menopause 22 (2), 212-216 (2015)
   PUBMED   25051287
  REMARK    GeneRIF: We found that the AAAAA, AGGAG, and AGGGA haplotypes in
            ACVR2B were associated with susceptibility to Premature Ovarian
            Failure when they also had at least one CATAG haplotype in
            ADAMTS19.
REFERENCE   6  (bases 1 to 5201)
  AUTHORS   Pyun,J.A., Kim,S., Cha,D.H. and Kwack,K.
  TITLE     Epistasis between IGF2R and ADAMTS19 polymorphisms associates with
            premature ovarian failure
  JOURNAL   Hum Reprod 28 (11), 3146-3154 (2013)
   PUBMED   24014609
  REMARK    GeneRIF: Synergistic interactions were detected between SNPs,
            including a non-synonymous SNP, and diplotypes within IGF2R and
            ADAMTS19 which may contribute to POF.
REFERENCE   7  (bases 1 to 5201)
  AUTHORS   Kurose,K., Hiratsuka,K., Ishiwata,K., Nishikawa,J., Nonen,S.,
            Azuma,J., Kato,M., Wakeno,M., Okugawa,G., Kinoshita,T.,
            Kurosawa,T., Hasegawa,R. and Saito,Y.
  TITLE     Genome-wide association study of SSRI/SNRI-induced sexual
            dysfunction in a Japanese cohort with major depression
  JOURNAL   Psychiatry Res 198 (3), 424-429 (2012)
   PUBMED   22445761
REFERENCE   8  (bases 1 to 5201)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   9  (bases 1 to 5201)
  AUTHORS   Knauff,E.A., Franke,L., van Es,M.A., van den Berg,L.H., van der
            Schouw,Y.T., Laven,J.S., Lambalk,C.B., Hoek,A., Goverde,A.J.,
            Christin-Maitre,S., Hsueh,A.J., Wijmenga,C. and Fauser,B.C.
  CONSRTM   Dutch POF Consortium
  TITLE     Genome-wide association study in premature ovarian failure patients
            suggests ADAMTS19 as a possible candidate gene
  JOURNAL   Hum Reprod 24 (9), 2372-2378 (2009)
   PUBMED   19508998
  REMARK    GeneRIF: Although limited by sample size, this proof-of-principle
            study's findings reveal ADAMTS19 as a possible candidate gene for
            premature ovarian failure and thus a larger follow-up study is
            warranted.
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 5201)
  AUTHORS   Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and
            Lopez-Otin,C.
  TITLE     Cloning, expression analysis, and structural characterization of
            seven novel human ADAMTSs, a family of metalloproteinases with
            disintegrin and thrombospondin-1 domains
  JOURNAL   Gene 283 (1-2), 49-62 (2002)
   PUBMED   11867212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106781.2, AC008425.6,
            AC129713.1, AC008528.6 and AC008591.6.
            
            On Jan 22, 2020 this sequence version replaced NM_133638.5.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motif) protein family.
            Members of the family share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            protein encoded by this gene has high sequence similarity to the
            protein encoded by ADAMTS16, another family member. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ311904.1, ERR4368410.539109.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2155974
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274487.9/ ENSP00000274487.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC106781.2         140423-140607
            186-841             AC106781.2         141227-141882
            842-1007            AC008425.6         56539-56704
            1008-1180           AC008425.6         73746-73918
            1181-1264           AC008425.6         75210-75293
            1265-1422           AC008425.6         75982-76139
            1423-1466           AC008425.6         99326-99369
            1467-1572           AC129713.1         19816-19921         c
            1573-1713           AC008528.6         16135-16275
            1714-1864           AC008528.6         17715-17865
            1865-1966           AC008528.6         37376-37477
            1967-2097           AC008528.6         43282-43412
            2098-2270           AC008528.6         44315-44487
            2271-2398           AC008528.6         49823-49950
            2399-2519           AC008528.6         54134-54254
            2520-2600           AC008528.6         61016-61096
            2601-2758           AC008591.6         180563-180720       c
            2759-2912           AC008591.6         176211-176364       c
            2913-3048           AC008591.6         165629-165764       c
            3049-3253           AC008591.6         158892-159096       c
            3254-3406           AC008591.6         156093-156245       c
            3407-3584           AC008591.6         125375-125552       c
            3585-5201           AC008591.6         121801-123417       c
FEATURES             Location/Qualifiers
     source          1..5201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.3"
     gene            1..5201
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 19"
                     /db_xref="GeneID:171019"
                     /db_xref="HGNC:HGNC:17111"
                     /db_xref="MIM:607513"
     exon            1..185
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3736
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 19"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 19"
                     /protein_id="NP_598377.4"
                     /db_xref="CCDS:CCDS4146.2"
                     /db_xref="GeneID:171019"
                     /db_xref="HGNC:HGNC:17111"
                     /db_xref="MIM:607513"
                     /translation="MGKNREMRLTHICCCCLLYQLGFLSNGIVSELQFAPDREEWEVV
                     FPALWRREPVDPAGGSGGSADPGWVRGVGGGGSARAQAAGSSREVRSVAPVPLEEPVE
                     GRSESRLRPPPPSEGEEDEELESQELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPP
                     AQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQP
                     PAPPDAGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITGHPH
                     RVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIE
                     TVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPE
                     LYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHK
                     DEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADG
                     LHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPG
                     MTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGK
                     WCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQ
                     YRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQ
                     PILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKII
                     KGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGA
                     FNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQ
                     SSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEP
                     QIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPK
                     PASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDC
                     EDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHL
                     QPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDF
                     YAQKLQQKS"
     exon            186..841
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1007
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1180
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1264
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1422
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1466
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1572
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1713
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1864
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1966
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2097
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2270
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2398
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2519
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2600
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2758
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2912
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3048
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3253
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3406
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3584
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..5201
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4830..4835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /note="hexamer: AATAAA"
     polyA_site      4849
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /note="major polyA site"
     regulatory      5179..5184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
                     /note="hexamer: AATAAA"
     polyA_site      5201
                     /gene="ADAMTS19"
                     /gene_synonym="CVDP2"
ORIGIN      
        1 ggcctcctag cgctccgggg aggccgctgc gccccggagt ggatcgcgct ggaggcgtgc
       61 gccgggcgag aagccgcggc cgcgggagcg cagtatgggg aagaaccgcg agatgcgcct
      121 gactcacatc tgctgctgct gcctccttta ccagctgggg ttcctgtcga atgggatcgt
      181 ttcagagctg cagttcgccc ccgaccgcga ggagtgggaa gtcgtgtttc ctgcgctctg
      241 gcgccgggag ccggtggacc cggctggcgg cagcgggggc agcgcggacc cgggctgggt
      301 gcgcggcgtt gggggcggcg gaagcgcccg ggcgcaggct gccggcagct cacgcgaggt
      361 gcgctctgtg gctccggtgc ctttggagga gcccgtggag ggccgatcag agtcccggct
      421 ccggcccccg ccgccgtcgg agggtgagga ggacgaggag ctcgagtcgc aggagctgcc
      481 gcggggatcc agcggggctg ccgccttgtc cccgggcgcc ccggcctcgt ggcagccgcc
      541 gcctcccccg cagccgcccc cgtccccgcc cccggcccag catgccgagc cggatggcga
      601 cgaagtgttg ctgcggatcc cggccttctc tcgggacctg tacctgctgc tccggagaga
      661 cggccgcttc ctggcgccgc gcttcgcagt ggaacagcgg ccaaatcccg gccccggccc
      721 cacgggggca gcatccgccc cgcaacctcc cgcgccacca gacgcaggct gcttctacac
      781 cggagctgtg ctgcggcacc ctggctcgct ggcttctttc agcacctgtg gaggtggcct
      841 gatgggattt atacagctca atgaggactt catatttatt gagccactca atgatacaat
      901 ggccataaca ggtcacccac accgtgtata taggcagaaa aggtccatgg aggaaaaggt
      961 cacagagaag tcagctcttc acagtcatta ctgtggtatc atttcagata aaggaagacc
     1021 taggtctaga aaaatagcag aaagtggaag agggaaacga tattcataca aattacctca
     1081 agaatacaac atagagactg tagtggttgc agacccagca atggtttcct atcatggagc
     1141 agatgcagcc aggagattca ttctaaccat cttaaatatg gtatttaacc ttttccaaca
     1201 caagagtctg agtgtgcagg tcaatcttcg tgtgataaag cttattctgc tccatgaaac
     1261 tccaccagaa ctatatattg ggcatcatgg agaaaaaatg ctagagagtt tttgtaagtg
     1321 gcaacatgaa gaatttggca aaaagaatga tatacattta gagatgtcaa caaactgggg
     1381 ggaagacatg acttcagtgg atgcagctat acttataaca aggaaagatt tctgtgtgca
     1441 caaagatgaa ccatgtgata ctgttggtat agcttacttg agtggaatgt gtagtgaaaa
     1501 gagaaaatgt attattgctg aagacaatgg cttgaatctt gcttttacaa ttgctcatga
     1561 aatgggtcac aacatgggca ttaaccatga caatgaccac ccatcgtgtg ctgatggtct
     1621 tcatatcatg tctggtgaat ggattaaagg acagaatctt ggtgacgttt catggtctcg
     1681 atgtagcaag gaagatttgg aaagatttct caggtcaaag gccagtaact gcttgctaca
     1741 aacaaatccg cagagtgtca attctgtgat ggttccctcc aagctgccag ggatgacata
     1801 cactgctgat gaacaatgcc agatcctttt tgggccattg gcttcttttt gtcaggagat
     1861 gcagcatgtt atttgcacag gattatggtg caaggtagaa ggtgagaaag aatgcagaac
     1921 caagctagac ccaccaatgg atggaactga ctgtgacctt ggtaagtggt gtaaggctgg
     1981 agaatgtacc agcaggacct cagcacctga acatctggcc ggagagtgga gcctgtggag
     2041 tccttgtagc cgaacctgca gtgctgggat cagcagtcga gagcgcaaat gtcctgggct
     2101 agattctgaa gcaagggatt gtaatggtcc cagaaaacaa tacagaatat gtgagaatcc
     2161 accttgtcct gcaggtttgc ctggattcag agactggcaa tgtcaggctt atagtgttag
     2221 aacttcctcc ccaaagcata tacttcagtg gcaagctgtc ctggatgaag aaaaaccatg
     2281 tgccttgttt tgctctcctg ttggaaaaga acagcctatt cttctatcag aaaaagtgat
     2341 ggatggaact tcttgtggct atcagggatt agatatctgt gcaaatggca ggtgccagaa
     2401 agttggctgt gatggtttat tagggtctct tgcaagagaa gatcattgtg gtgtatgcaa
     2461 tggcaatgga aaatcatgca agatcattaa aggggatttt aatcacacca gaggagcagg
     2521 ttatgtagaa gtgctggtga tacctgctgg agcaagaaga atcaaagttg tggaggaaaa
     2581 gccggcacat agctatttag ctctccgaga tgctggcaaa cagtctatta atagtgactg
     2641 gaagattgaa cactctggag ccttcaattt ggctggaact accgttcatt atgtaagacg
     2701 aggcctctgg gagaagatct ctgccaaagg tcctactaca gcacctttac atcttctggt
     2761 gctcctgttt caggatcaga attatggtct tcactatgaa tacactatcc catcagaccc
     2821 tcttccagaa aaccagagct ctaaagcacc tgagcccctc ttcatgtgga cacacacaag
     2881 ctgggaagat tgcgatgcca cttgtggagg aggagaaagg aagacaacag tgtcctgcac
     2941 aaaaatcatg agcaaaaata tcagcattgt ggacaatgag aaatgcaaat acttaaccaa
     3001 gccagagcca cagattcgaa agtgcaatga gcaaccatgt caaacaaggt ggatgatgac
     3061 agaatggacc ccttgttcac gaacttgtgg aaaaggaatg cagagcagac aagtggcctg
     3121 tacccaacaa ctgagcaatg gaacactgat tagagcccga gagagggact gcattgggcc
     3181 caagcccgcc tctgcccagc gctgtgaggg ccaggactgc atgaccgtgt gggaggcggg
     3241 agtgtggtct gagtgttcag tcaagtgtgg caaaggcata cgtcatcgga ccgttagatg
     3301 taccaaccca agaaagaagt gtgtcctctc taccagaccc agggaggctg aagactgtga
     3361 ggattattca aaatgctatg tgtggcgaat gggtgactgg tctaagtgct caattacctg
     3421 tggcaaagga atgcagtccc gtgtaatcca atgcatgcat aagatcacag gaagacatgg
     3481 aaatgaatgt ttttcctcag aaaaacctgc agcatacagg ccatgccatc ttcaaccctg
     3541 caatgagaaa attaatgtaa ataccataac atcacccaga ctggctgctc tgactttcaa
     3601 gtgcctggga gatcagtggc cagtgtactg ccgagtgata cgtgaaaaga acctatgtca
     3661 ggacatgcgg tggtatcagc gctgctgtga aacatgcagg gacttctatg cccaaaagct
     3721 gcagcagaag agttgacctc tagcaggctg gctggatcac agctcttggc aattacatta
     3781 tttataaaca cacacactag catgtttttc agaccaaata ttatcagatt acatataatt
     3841 taatcaaatt aatttatttt tttgcctgcc aaacatccaa tgtggtgctt gttttggtta
     3901 cacaaacatt ttgatttata ctatatggct tcataaataa ttttatatga atgaattagt
     3961 tggatccagt aatataataa aaagaaaaag gaaaaaaata gatcattata cttaaaacaa
     4021 gttttcgttg tttgttaggg ctatctctaa ggtgctactc tctccccacc aataacattg
     4081 aattatccag aatgtatact gacttagcat aatagtttag gtgtatatga agagaaacta
     4141 tttttgtttt ttggtgtcct gctgcagaat tagcccattt tctgtcacct gcaggagatg
     4201 tgtaaacata atgaacctca tgctgttgaa caggttttta gagaatgtat tatgaatttg
     4261 gttcagattt atagacatcc ataggaaaaa ttctgctgta attataacct tattttgata
     4321 tggaaaagaa aagtcaaaat agagactttg atcatgttca tgaacatgta cttgaacaca
     4381 agtattgtaa caatgaaaca ctgtaatgat ttacactgaa tcacaattgc actgttgata
     4441 tagtgtagag aaatcgttag aaatggtgac atcttacaaa aaatgtgtat tattttaaca
     4501 tgttatcact agattttagc tttttttaaa tatttttaac aaagaaaaca ttgatccacc
     4561 catttccctg tatcttttta gcagatttat taaagagtat agtacttagc ctcacgaatc
     4621 ataattagaa aatttactag tatttctcag ccttttccct aggaacaagg aaaaacagaa
     4681 agcatataat acggtggtcg tttcattgtg tttttcttcc ttttaaaaat taaaaagttt
     4741 tacaattatg tgaaacgttc aaaagccagc ttaaaatttt tcttgtgaga aaatattata
     4801 catgattcac atgatttctt agatttttca ataaaatatg taaaacttcc cactgagaga
     4861 caattcttca tagacttgtc acatatccac atgtctgatg aacaaaggta ctgtctactt
     4921 ttgttctgga gtatcttcta gaggatgttt atagagtgaa ctgccttgga agatagtatg
     4981 tctcttggga gcaaagggca aacatacttc tcattataaa agtttcaggt tccctaaaat
     5041 tggggtttct ttactataag acaatccaat gtatgttctg aggtcacctg gctctcttca
     5101 tgtcaccctt tgggaaatgg ggctcaacga gccagtacag gaaaagctga ttccctggct
     5161 actactatcg ctgtgagtaa taaagtcctt tgtgtctaat g
//
