LOCUS       XM_047433672            4790 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ADAM metallopeptidase with thrombospondin
            type 1 motif 18 (ADAMTS18), transcript variant X1, mRNA.
ACCESSION   XM_047433672
VERSION     XM_047433672.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000016.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
     gene            1..4790
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 18; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 24 ESTs, 48 long SRA
                     reads, and 100% coverage of the annotated genomic feature
                     by RNAseq alignments, including 4 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:170692"
                     /db_xref="HGNC:HGNC:17110"
                     /db_xref="MIM:607512"
     CDS             26..2962
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 18 isoform X1"
                     /protein_id="XP_047289628.1"
                     /db_xref="GeneID:170692"
                     /db_xref="HGNC:HGNC:17110"
                     /db_xref="MIM:607512"
                     /translation="MNSSSRHYLSFWPRNTTTAPLRVTILTYCTKGQQRRRSSGTVAT
                     PALAGIILVTPQVTFPMHLRVERQSITIEGCKSSIFVDDARNVYAPKPPTEDTYLRFD
                     EYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDG
                     TIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLT
                     GFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG
                     EGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKY
                     PDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGT
                     VCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ
                     YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEED
                     RCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDAC
                     GVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQ
                     KYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGI
                     AWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSF
                     CSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAV
                     LHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPE
                     SQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECTVTCGGGVQTRSVHCVQQGRPS
                     SSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCK
                     SCTRKI"
ORIGIN      
        1 tcaggtttaa taaggacacg aaaaaatgaa ttcctcatct cgccattacc tcagcttctg
       61 gcccaggaac acaactacag ctcccctgcg ggtcaccatc ctcacgtact gtacaaaagg
      121 acagcagagg agaagatcca gcggtaccgt ggctaccccg gctctggccg gaattatcct
      181 ggttactccc caagtcacat tccccatgca tctcagagtc gagagacaga gtatcaccat
      241 cgaaggttgc aaaagcagca tttttgtgga cgacgcaaga aatgtatatg ctcccaagcc
      301 tcccacagag gacacctatc taaggtttga tgaatatggg agctctgggc gacccagaag
      361 atcagctgga aaatcacaaa agggcctcaa tgtggaaacc ctcgtggtgg cagacaagaa
      421 aatggtggaa aagcatggca agggaaatgt caccacatac attctcacag taatgaacat
      481 ggtttctggc ctatttaaag atgggactat tggaagtgac ataaacgtgg ttgtggtgag
      541 cctaattctt ctggaacaag aacctggagg attattgatc aaccatcatg cagaccagtc
      601 tctgaatagt ttttgtcaat ggcagtctgc cctcattgga aagaatggca agagacatga
      661 tcatgccatc ttactaacag gatttgatat ttgttcttgg aagaatgaac catgtgacac
      721 tctagggttt gcccccatca gtggaatgtg ctctaagtac cgaagttgta ccatcaatga
      781 ggacacagga cttggccttg ccttcaccat cgctcatgag tcagggcaca actttggtat
      841 gattcacgat ggagaaggga atccctgcag aaaggctgaa ggcaatatca tgtctcccac
      901 actgaccgga aacaatggag tgttttcatg gtcttcctgc agccgccagt atctcaagaa
      961 attcctcagc acacctcagg cggggtgtct agtggatgag cccaagcaag caggacagta
     1021 taaatatccg gacaaactac caggacagat ttatgatgct gacacacagt gtaaatggca
     1081 atttggagca aaagccaagt tatgcagcct tggttttgtg aaggatattt gcaaatcact
     1141 ttggtgccac cgagtaggcc acaggtgtga gaccaagttt atgcccgcag cagaagggac
     1201 cgtttgtggc ttgagtatgt ggtgtcggca aggccagtgc gtaaagtttg gggagctcgg
     1261 gccccggccc atccacggcc agtggtccgc ctggtcgaag tggtcagaat gttcccggac
     1321 atgtggtgga ggagtcaagt tccaggagag acactgcaat aaccccaagc ctcagtatgg
     1381 tggcttattc tgtccaggtt ctagccgtat ttatcagctg tgcaatatta acccttgcaa
     1441 tgaaaatagc ttggattttc gggctcaaca gtgtgcagaa tataacagca aacctttccg
     1501 tggatggttc taccagtgga aaccctatac aaaagtggaa gaggaagatc gatgcaaact
     1561 gtactgcaag gctgagaact ttgaattttt ttttgcaatg tccggcaaag tgaaagatgg
     1621 aactccctgc tccccaaaca aaaatgatgt ttgtattgac ggggtttgtg aactagtggg
     1681 atgtgatcat gaactaggct ctaaagcagt ttcagatgct tgtggcgttt gcaaaggtga
     1741 taattcaact tgcaagtttt ataaaggcct gtacctcaac cagcataaag caaatgaata
     1801 ttatccggtg gtcctcattc cagctggcgc ccgaagcatc gaaatccagg agctgcaggt
     1861 ttcctccagt tacctcgcag ttcgaagcct cagtcaaaag tattacctca ccgggggctg
     1921 gagcatcgac tggcctgggg agttcccctt cgctgggacc acgtttgaat accagcgctc
     1981 tttcaaccgc ccggaacgtc tgtacgcgcc agggcccaca aatgagacgc tggtctttga
     2041 aattctgatg caaggcaaaa atccagggat agcttggaag tatgcacttc ccaaggtcat
     2101 gaatggaact ccaccagcca caaaaagacc tgcctatacc tggagtatcg tgcagtcaga
     2161 gtgctccgtc tcctgtggtg gaggttacat aaatgtaaag gccatttgct tgcgagatca
     2221 aaatactcaa gtcaattcct cattctgcag tgcaaaaacc aagccagtaa ctgagcccaa
     2281 aatctgcaac gctttctcct gcccggctta ctggatgcca ggtgaatgga gtacatgcag
     2341 caaggcctgt gctggaggcc agcagagccg aaagatccag tgtgtgcaaa agaagccctt
     2401 ccaaaaggag gaagcagtgt tgcattctct ctgtccagtg agcacaccca ctcaggtcca
     2461 agcctgcaac agccatgcct gccctccaca atggagcctt ggaccctggt ctcagtgttc
     2521 caagacctgt ggacgagggg tgaggaagcg tgaactcctc tgcaagggct ctgccgcaga
     2581 aaccctcccc gagagccagt gtaccagtct ccccagacct gagctgcagg agggctgtgt
     2641 gcttggacga tgccccaaga acagccggct acagtgggtc gcttcttcgt ggagcgagtg
     2701 cacagtcacc tgtgggggag gggtccagac ccggtcagtc cactgtgttc agcaaggccg
     2761 gccttcctca agttgtctgc tccatcagaa acctccggtg ctacgagcct gtaatacaaa
     2821 cttctgtcca gctcctgaaa agagagagga tccatcctgc gtagatttct tcaactggtg
     2881 tcacctagtt cctcagcatg gtgtctgcaa ccacaagttt tacggaaaac aatgctgcaa
     2941 gtcatgcaca aggaagatct gatcttggtg tcctccccag caccttaggg ccaggggctt
     3001 acctttcaac ctctagagag accagctgcc tttgagacca ggagctgagc accgagaacc
     3061 atctgtgagc tgccgctgtg atgaaggagc ctgctctgag gaacagacag gttgccagta
     3121 ggcttctagc tcaattccct gaagcacgtg gtactctgaa gcacttgaaa atgggaagcg
     3181 atgacaaatc tgactttaaa aaaaatcttt gatttgcact gttatatgca agaagtggtg
     3241 aatcacactg agatacgtcg atttggggag agaccccctt ttgaacttca aagggttcaa
     3301 gggcaaagac atctgtttta aaaaggtcct ttatgacttc aggtcaaaga ctgagactca
     3361 gaactttcaa atctggatgg aataccttgc ctaactgttg cgtggagttc acagttcgac
     3421 taaccctgtg aacacccaag ccaggagttc tatgagaagc caaatggtgc tcgcaattgt
     3481 gcttgctgct ggactggcaa gcttcatgtt atgtttattt ggtgtgcgtg tgtctttatt
     3541 attttgtgta aactatattc tgcttataga gagtctctga gactaaaatt gacaacttga
     3601 aaagtattcc aaggaatatt atgaaaatag ggcaacatgg actgtttaag atctccatgt
     3661 aattgaaatt catgcaagga aacaactcat agaaaagata aatatggatg cccttcacat
     3721 gttatcaacc tcgtaacttt tggtgcttgc tgaatcagtc catgaaaagc tacagcccgc
     3781 tctttgggaa tgctacatac ccatttctgg tatttaaaaa atatctagga ggagctaaat
     3841 gacaaaacac agcagtgttt tgagggagaa aggaccatca tttataatgc tctgtacata
     3901 ctaccagagc tgcttggaaa attaaaggcc acttgtggct ttttcctacc aactgatacg
     3961 tttaaatttg ccctaggatt gagctaacag caaaaaaaaa aaaaaaaaaa agagagaaag
     4021 aaaggagtaa acagtggtaa taaaaaaatc catctgtctt cttgctatgt taatattaat
     4081 aaatcataat atgacaagac cctcactgaa taagagtatt ttcagtcatc agaagccagc
     4141 tgttggtagg cattaatgag tttaaaattg ttctcaattg aaaaaacatc acactatttt
     4201 gccaaaacca aagtaattat aatactgtgt cctcctgtaa ttttttgaga agtggttata
     4261 aagggcatat ttacataaat tctactttat tcctcaactt ctttgatgaa tgtaacccaa
     4321 ttttacttct ttaaaaagtc tcaattcaag ctggattagc cagctcagca taatcaacta
     4381 gacagtggtt tgttaaattt agcagcatac ttcgttccca ttctaattaa agtcatgagt
     4441 tcttgaatcc cagagaaata atgcttagga acttctctca atctgcttgg cttggcctag
     4501 agaagtggcc attttatcaa caggaaaaaa aaaaattttc tctactacaa ccccgttgcc
     4561 ttctgaaaaa cagcaagtta tttctttata taattatcat tttattattt tatggaaaat
     4621 taatttatta attaatagcc tattatgtgt tctcacttgc ttctctaagt aatattttga
     4681 gataaaatgt tgaataaaac catggattat agagaaaagt caaaatatat gtgtaatatt
     4741 taattatttt ataagtttta taataaagta ttccatttct ttatctttga
//
