LOCUS       NM_199355               5833 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            18 (ADAMTS18), transcript variant 1, mRNA.
ACCESSION   NM_199355
VERSION     NM_199355.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5833)
  AUTHORS   Liu,X.Y., Tao,Y.F., Mao,Y.K., Chen,Z.J., Wang,Y., Hong,Y.F. and
            Fan,N.
  TITLE     [A family with developmental glaucoma and microcornea due to novel
            ADAMTS18 gene mutations]
  JOURNAL   Zhonghua Yan Ke Za Zhi 60 (1), 78-83 (2024)
   PUBMED   38199772
  REMARK    GeneRIF: [A family with developmental glaucoma and microcornea due
            to novel ADAMTS18 gene mutations].
REFERENCE   2  (bases 1 to 5833)
  AUTHORS   Nie,J. and Zhang,W.
  TITLE     Secreted protease ADAMTS18 in development and disease
  JOURNAL   Gene 858, 147169 (2023)
   PUBMED   36632911
  REMARK    GeneRIF: Secreted protease ADAMTS18 in development and disease.
            Review article
REFERENCE   3  (bases 1 to 5833)
  AUTHORS   Mushimiyimana,I., Niskanen,H., Beter,M., Laakkonen,J.P.,
            Kaikkonen,M.U., Yla-Herttuala,S. and Laham-Karam,N.
  TITLE     Characterization of a functional endothelial super-enhancer that
            regulates ADAMTS18 and angiogenesis
  JOURNAL   Nucleic Acids Res 49 (14), 8078-8096 (2021)
   PUBMED   34320216
  REMARK    GeneRIF: Characterization of a functional endothelial
            super-enhancer that regulates ADAMTS18 and angiogenesis.
REFERENCE   4  (bases 1 to 5833)
  AUTHORS   Xu,B., Peng,Y.J., Ma,B.L. and Cheng,S.D.
  TITLE     Aberrant methylation of the 16q23.1 tumor suppressor gene ADAMTS18
            promotes tumorigenesis and progression of clear cell renal cell
            carcinoma
  JOURNAL   Genes Genomics 43 (2), 123-131 (2021)
   PUBMED   33469885
  REMARK    GeneRIF: Aberrant methylation of the 16q23.1 tumor suppressor gene
            ADAMTS18 promotes tumorigenesis and progression of clear cell renal
            cell carcinoma.
REFERENCE   5  (bases 1 to 5833)
  AUTHORS   Ataca,D., Aouad,P., Constantin,C., Laszlo,C., Beleut,M.,
            Shamseddin,M., Rajaram,R.D., Jeitziner,R., Mead,T.J., Caikovski,M.,
            Bucher,P., Ambrosini,G., Apte,S.S. and Brisken,C.
  TITLE     The secreted protease Adamts18 links hormone action to activation
            of the mammary stem cell niche
  JOURNAL   Nat Commun 11 (1), 1571 (2020)
   PUBMED   32218432
  REMARK    GeneRIF: Adamts18 links luminal hormone receptor signaling to
            basement membrane remodeling and stem cell activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5833)
  AUTHORS   Li,Z., Nardi,M.A., Li,Y.S., Zhang,W., Pan,R., Dang,S., Yee,H.,
            Quartermain,D., Jonas,S. and Karpatkin,S.
  TITLE     C-terminal ADAMTS-18 fragment induces oxidative platelet
            fragmentation, dissolves platelet aggregates, and protects against
            carotid artery occlusion and cerebral stroke
  JOURNAL   Blood 113 (24), 6051-6060 (2009)
   PUBMED   19218546
REFERENCE   7  (bases 1 to 5833)
  AUTHORS   Nordgard,S.H., Johansen,F.E., Alnaes,G.I., Bucher,E., Syvanen,A.C.,
            Naume,B., Borresen-Dale,A.L. and Kristensen,V.N.
  TITLE     Genome-wide analysis identifies 16q deletion associated with
            survival, molecular subtypes, mRNA expression, and germline
            haplotypes in breast cancer patients
  JOURNAL   Genes Chromosomes Cancer 47 (8), 680-696 (2008)
   PUBMED   18398821
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5833)
  AUTHORS   Jin,H., Wang,X., Ying,J., Wong,A.H., Li,H., Lee,K.Y.,
            Srivastava,G., Chan,A.T., Yeo,W., Ma,B.B., Putti,T.C., Lung,M.L.,
            Shen,Z.Y., Xu,L.Y., Langford,C. and Tao,Q.
  TITLE     Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor
            suppressor frequently silenced in esophageal, nasopharyngeal and
            multiple other carcinomas
  JOURNAL   Oncogene 26 (53), 7490-7498 (2007)
   PUBMED   17546048
  REMARK    GeneRIF: Functional epigenetics show ADAMTS18 to be a novel
            functional tumor suppressor, being frequently inactivated
            epigenetically in multiple carcinomas.
REFERENCE   9  (bases 1 to 5833)
  AUTHORS   Zeng,W., Corcoran,C., Collins-Racie,L.A., Lavallie,E.R.,
            Morris,E.A. and Flannery,C.R.
  TITLE     Glycosaminoglycan-binding properties and aggrecanase activities of
            truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and
            -18
  JOURNAL   Biochim Biophys Acta 1760 (3), 517-524 (2006)
   PUBMED   16507336
  REMARK    GeneRIF: comparison of the effects of C-terminal truncation on the
            GAG-binding properties and aggrecanase activity of ADAMTS-5
            relative to three other ADAMTS family members, ADAMTS-9, ADAMTS-16
            and ADAMTS-18
REFERENCE   10 (bases 1 to 5833)
  AUTHORS   Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and
            Lopez-Otin,C.
  TITLE     Cloning, expression analysis, and structural characterization of
            seven novel human ADAMTSs, a family of metalloproteinases with
            disintegrin and thrombospondin-1 domains
  JOURNAL   Gene 283 (1-2), 49-62 (2002)
   PUBMED   11867212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC063283.1, AK131403.1,
            AC010548.10, AJ311903.1, AY172951.1, AC009139.8 and BM684970.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_199355.3.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            ADAMTS family members share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature protein, which may regulate hemostatic balance and function
            as a tumor suppressor. Mutations in this gene may be associated
            with microcornea, myopic chorioretinal atrophy, and telecanthus
            (MMCAT) and cone-rod dystrophy in human patients. [provided by
            RefSeq, May 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063283.1, SRR1660803.101284.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282849.10/ ENSP00000282849.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-909               BC063283.1         81-989
            910-1280            AK131403.1         497-867
            1281-1679           BC063283.1         1361-1759
            1680-1680           AC010548.10        76804-76804
            1681-2214           BC063283.1         1761-2294
            2215-2424           AK131403.1         1802-2011
            2425-3174           AJ311903.1         2165-2914
            3175-4811           BC063283.1         3255-4891
            4812-5034           AY172951.1         1970-2192
            5035-5288           AC009139.8         137513-137766       c
            5289-5833           BM684970.1         18-562              c
FEATURES             Location/Qualifiers
     source          1..5833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..5833
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 18"
                     /db_xref="GeneID:170692"
                     /db_xref="HGNC:HGNC:17110"
                     /db_xref="MIM:607512"
     exon            1..429
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..4005
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 18; a
                     disintegrin-like and metalloprotease (reprolysin type)
                     with thrombospondin type 1 motif, 21; a disintegrin and
                     metalloproteinase with thrombospondin motifs 18;
                     disintegrin and metalloprotease-like protein"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 18 isoform 1 preproprotein"
                     /protein_id="NP_955387.1"
                     /db_xref="CCDS:CCDS10926.1"
                     /db_xref="GeneID:170692"
                     /db_xref="HGNC:HGNC:17110"
                     /db_xref="MIM:607512"
                     /translation="MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAA
                     ALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFS
                     AFGQELHLELKPSAILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVS
                     TCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYP
                     GSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEY
                     GSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTI
                     GSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGF
                     DICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEG
                     NPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPD
                     KLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVC
                     GLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYG
                     GLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRC
                     KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGV
                     CKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKY
                     YLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAW
                     KYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCS
                     AKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLH
                     SLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQ
                     CTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKL
                     ITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTR
                     SVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVC
                     NHKFYGKQCCKSCTRKI"
     exon            430..517
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            518..834
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1117
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1311
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1395
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1555
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1661
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1799
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1953
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2049
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2198
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2371
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2502
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2626
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2871
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3013
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3140
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3345
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3528
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3741
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3742..3889
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..5833
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5749..5754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /note="hexamer: ATTATA"
     polyA_site      5768
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /note="major polyA site"
     regulatory      5805..5810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
                     /note="hexamer: AATAAA"
     polyA_site      5833
                     /gene="ADAMTS18"
                     /gene_synonym="ADAMTS21; KNO2; MMCAT"
ORIGIN      
        1 agacgctcac accgacacag acagacgcac agacgggcgg gcagacaccg acagtctccc
       61 aaccgtttgc gctccagtcc cggcccaggg agccccccgt accctctggg gtgccgcaaa
      121 ctgcagctcg gcaggcccgc gccgggagaa gggagggcgc gcaggcggcc ggaggagggg
      181 aggtcccagc gcgcccccgc tgcgatgtga acggcggcgg ctctcacctg gagccgcacc
      241 tggggcgccg agctccgggg ccgcggaaag aatgcgcgcc gcccgtgcgc tccgcctgcc
      301 gcgtctggcc acccgcagcc gccgcgtccg cacctgacca tggagtgcgc cctcctgctc
      361 gcgtgtgcct tcccggctgc gggttcgggc ccgccgaggg gcctggcggg actggggcgc
      421 gtggccaagg cgctccagct gtgctgcctc tgctgtgcgt cggtcgccgc ggccttagcc
      481 agtgacagca gcagcggcgc cagcggatta aatgatgatt acgtctttgt cacgccagta
      541 gaagtagact cagccgggtc atatatttca cacgacattt tgcacaacgg caggaaaaag
      601 cgatcggcgc agaatgccag aagctccctg cactaccgat tttcagcatt tggacaggaa
      661 ctgcacttag aacttaagcc ctcggcgatt ttgagcagtc actttattgt ccaggtactt
      721 ggaaaagatg gtgcttcaga gactcagaaa cccgaggtgc agcaatgctt ctatcaggga
      781 tttatcagaa atgacagctc ctcctctgtc gctgtgtcta cgtgtgctgg cttgtcaggt
      841 ttaataagga cacgaaaaaa tgaattcctc atctcgccat tacctcagct tctggcccag
      901 gaacacaact acagctcccc tgcgggtcac catcctcacg tactgtacaa aaggacagca
      961 gaggagaaga tccagcggta ccgtggctac cccggctctg gccggaatta tcctggttac
     1021 tccccaagtc acattcccca tgcatctcag agtcgagaga cagagtatca ccatcgaagg
     1081 ttgcaaaagc agcatttttg tggacgacgc aagaaatatg ctcccaagcc tcccacagag
     1141 gacacctatc taaggtttga tgaatatggg agctctgggc gacccagaag atcagctgga
     1201 aaatcacaaa agggcctcaa tgtggaaacc ctcgtggtgg cagacaagaa aatggtggaa
     1261 aagcatggca agggaaatgt caccacatac attctcacag taatgaacat ggtttctggc
     1321 ctatttaaag atgggactat tggaagtgac ataaacgtgg ttgtggtgag cctaattctt
     1381 ctggaacaag aacctggagg attattgatc aaccatcatg cagaccagtc tctgaatagt
     1441 ttttgtcaat ggcagtctgc cctcattgga aagaatggca agagacatga tcatgccatc
     1501 ttactaacag gatttgatat ttgttcttgg aagaatgaac catgtgacac tctagggttt
     1561 gcccccatca gtggaatgtg ctctaagtac cgaagttgta ccatcaatga ggacacagga
     1621 cttggccttg ccttcaccat cgctcatgag tcagggcaca actttggtat gattcacgat
     1681 ggagaaggga atccctgcag aaaggctgaa ggcaatatca tgtctcccac actgaccgga
     1741 aacaatggag tgttttcatg gtcttcctgc agccgccagt atctcaagaa attcctcagc
     1801 acacctcagg cggggtgtct agtggatgag cccaagcaag caggacagta taaatatccg
     1861 gacaaactac caggacagat ttatgatgct gacacacagt gtaaatggca atttggagca
     1921 aaagccaagt tatgcagcct tggttttgtg aaggatattt gcaaatcact ttggtgccac
     1981 cgagtaggcc acaggtgtga gaccaagttt atgcccgcag cagaagggac cgtttgtggc
     2041 ttgagtatgt ggtgtcggca aggccagtgc gtaaagtttg gggagctcgg gccccggccc
     2101 atccacggcc agtggtccgc ctggtcgaag tggtcagaat gttcccggac atgtggtgga
     2161 ggagtcaagt tccaggagag acactgcaat aaccccaagc ctcagtatgg tggcttattc
     2221 tgtccaggtt ctagccgtat ttatcagctg tgcaatatta acccttgcaa tgaaaatagc
     2281 ttggattttc gggctcaaca gtgtgcagaa tataacagca aacctttccg tggatggttc
     2341 taccagtgga aaccctatac aaaagtggaa gaggaagatc gatgcaaact gtactgcaag
     2401 gctgagaact ttgaattttt ttttgcaatg tccggcaaag tgaaagatgg aactccctgc
     2461 tccccaaaca aaaatgatgt ttgtattgac ggggtttgtg aactagtggg atgtgatcat
     2521 gaactaggct ctaaagcagt ttcagatgct tgtggcgttt gcaaaggtga taattcaact
     2581 tgcaagtttt ataaaggcct gtacctcaac cagcataaag caaatgaata ttatccggtg
     2641 gtcctcattc cagctggcgc ccgaagcatc gaaatccagg agctgcaggt ttcctccagt
     2701 tacctcgcag ttcgaagcct cagtcaaaag tattacctca ccgggggctg gagcatcgac
     2761 tggcctgggg agttcccctt cgctgggacc acgtttgaat accagcgctc tttcaaccgc
     2821 ccggaacgtc tgtacgcgcc agggcccaca aatgagacgc tggtctttga aattctgatg
     2881 caaggcaaaa atccagggat agcttggaag tatgcacttc ccaaggtcat gaatggaact
     2941 ccaccagcca caaaaagacc tgcctatacc tggagtatcg tgcagtcaga gtgctccgtc
     3001 tcctgtggtg gaggttacat aaatgtaaag gccatttgct tgcgagatca aaatactcaa
     3061 gtcaattcct cattctgcag tgcaaaaacc aagccagtaa ctgagcccaa aatctgcaac
     3121 gctttctcct gcccggctta ctggatgcca ggtgaatgga gtacatgcag caaggcctgt
     3181 gctggaggcc agcagagccg aaagatccag tgtgtgcaaa agaagccctt ccaaaaggag
     3241 gaagcagtgt tgcattctct ctgtccagtg agcacaccca ctcaggtcca agcctgcaac
     3301 agccatgcct gccctccaca atggagcctt ggaccctggt ctcagtgttc caagacctgt
     3361 ggacgagggg tgaggaagcg tgaactcctc tgcaagggct ctgccgcaga aaccctcccc
     3421 gagagccagt gtaccagtct ccccagacct gagctgcagg agggctgtgt gcttggacga
     3481 tgccccaaga acagccggct acagtgggtc gcttcttcgt ggagcgagtg ttctgcaacc
     3541 tgtggtttgg gtgtgaggaa gagggagatg aagtgcagcg agaagggctt ccagggaaag
     3601 ctgataactt tcccagagcg aagatgccgt aatattaaga aaccaaatct ggacttggaa
     3661 gagacctgca accgacgggc ttgcccagcc catccagtgt acaacatggt agctggatgg
     3721 tattcattgc cgtggcagca gtgcacagtc acctgtgggg gaggggtcca gacccggtca
     3781 gtccactgtg ttcagcaagg ccggccttcc tcaagttgtc tgctccatca gaaacctccg
     3841 gtgctacgag cctgtaatac aaacttctgt ccagctcctg aaaagagaga ggatccatcc
     3901 tgcgtagatt tcttcaactg gtgtcaccta gttcctcagc atggtgtctg caaccacaag
     3961 ttttacggaa aacaatgctg caagtcatgc acaaggaaga tctgatcttg gtgtcctccc
     4021 cagcacctta gggccagggg cttacctttc aacctctaga gagaccagct gcctttgaga
     4081 ccaggagctg agcaccgaga accatctgtg agctgccgct gtgatgaagg agcctgctct
     4141 gaggaacaga caggttgcca gtaggcttct agctcaattc cctgaagcac gtggtactct
     4201 gaagcacttg aaaatgggaa gcgatgacaa atctgacttt aaaaaaaatc tttgatttgc
     4261 actgttatat gcaagaagtg gtgaatcaca ctgagatacg tcgatttggg gagagacccc
     4321 cttttgaact tcaaagggtt caagggcaaa gacatctgtt ttaaaaaggt cctttatgac
     4381 ttcaggtcaa agactgagac tcagaacttt caaatctgga tggaatacct tgcctaactg
     4441 ttgcgtggag ttcacagttc gactaaccct gtgaacaccc aagccaggag ttctatgaga
     4501 agccaaatgg tgctcgcaat tgtgcttgct gctggactgg caagcttcat gttatgttta
     4561 tttggtgtgc gtgtgtcttt attattttgt gtaaactata ttctgcttat agagagtctc
     4621 tgagactaaa attgacaact tgaaaagtat tccaaggaat attatgaaaa tagggcaaca
     4681 tggactgttt aagatctcca tgtaattgaa attcatgcaa ggaaacaact catagaaaag
     4741 ataaatatgg atgcccttca catgttatca acctcgtaac ttttggtgct tgctgaatca
     4801 gtccatgaaa agctacagcc cgctctttgg gaatgctaca tacccatttc tggtatttaa
     4861 aaaatatcta ggaggagcta aatgacaaaa cacagcagtg ttttgaggga gaaaggacca
     4921 tcatttataa tgctctgtac atactaccag agctgcttgg aaaattaaag gccacttgtg
     4981 gctttttcct accaactgat acgtttaaat ttgccctagg attgagctaa cagcaaaaaa
     5041 aaaaaaaaaa aaaagagaga aagaaaggag taaacagtgg taataaaaaa atccatctgt
     5101 cttcttgcta tgttaatatt aataaatcat aatatgacaa gaccctcact gaataagagt
     5161 attttcagtc atcagaagcc agctgttggt aggcattaat gagtttaaaa ttgttctcaa
     5221 ttgaaaaaac atcacactat tttgccaaaa ccaaagtaat tataatactg tgtcctcctg
     5281 taattttttg agaagtggtt ataaagggca tatttacata aattctactt tattcctcaa
     5341 cttctttgat gaatgtaacc caattttact tctttaaaaa gtctcaattc aagctggatt
     5401 agccagctca gcataatcaa ctagacagtg gtttgttaaa tttagcagca tacttcgttc
     5461 ccattctaat taaagtcatg agttcttgaa tcccagagaa ataatgctta ggaacttctc
     5521 tcaatctgct tggcttggcc tagagaagtg gccattttat caacaggaaa aaaaaaaatt
     5581 ttctctacta caaccccgtt gccttctgaa aaacagcaag ttatttcttt atataattat
     5641 cattttatta ttttatggaa aattaattta ttaattaata gcctattatg tgttctcact
     5701 tgcttctcta agtaatattt tgagataaaa tgttgaataa aaccatggat tatagagaaa
     5761 agtcaaaata tatgtgtaat atttaattat tttataagtt ttataataaa gtattccatt
     5821 tctttatctt tga
//
