LOCUS       NM_139057               6329 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            17 (ADAMTS17), mRNA.
ACCESSION   NM_139057
VERSION     NM_139057.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6329)
  AUTHORS   Guo,D., Liu,L., Yang,F., Young,C.A., Zheng,D. and Jin,G.
  TITLE     Characteristics and genotype-phenotype correlations in ADAMTS17
            mutation-related Weill-Marchesani syndrome
  JOURNAL   Exp Eye Res 234, 109606 (2023)
   PUBMED   37506754
  REMARK    GeneRIF: Characteristics and genotype-phenotype correlations in
            ADAMTS17 mutation-related Weill-Marchesani syndrome.
REFERENCE   2  (bases 1 to 6329)
  AUTHORS   Han,P., Jiang,F. and Zhang,L.
  TITLE     The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to
            lumbar disc herniation in Chinese Han population
  JOURNAL   Eur Spine J 32 (4), 1106-1114 (2023)
   PUBMED   36810712
  REMARK    GeneRIF: The role of ADAMTS6 and ADAMTS17 polymorphisms in
            susceptibility to lumbar disc herniation in Chinese Han population.
REFERENCE   3  (bases 1 to 6329)
  AUTHORS   Taniguchi,Y., Akune,T., Nishida,N., Omori,G., Ha,K., Ueno,K.,
            Saito,T., Oichi,T., Koike,A., Mabuchi,A., Oka,H., Muraki,S.,
            Oshima,Y., Kawaguchi,H., Nakamura,K., Tokunaga,K., Tanaka,S. and
            Yoshimura,N.
  TITLE     A common variant rs2054564 in ADAMST17 is associated with
            susceptibility to lumbar spondylosis
  JOURNAL   Sci Rep 13 (1), 4900 (2023)
   PUBMED   36966180
  REMARK    GeneRIF: A common variant rs2054564 in ADAMST17 is associated with
            susceptibility to lumbar spondylosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6329)
  AUTHORS   Evans,D.R., Green,J.S., Fahiminiya,S., Majewski,J., Fernandez,B.A.,
            Deardorff,M.A., Johnson,G.J., Whelan,J.H., Hubmacher,D., Apte,S.S.
            and Woods,M.O.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     A novel pathogenic missense ADAMTS17 variant that impairs secretion
            causes Weill-Marchesani Syndrome with variably dysmorphic hand
            features
  JOURNAL   Sci Rep 10 (1), 10827 (2020)
   PUBMED   32616716
  REMARK    GeneRIF: A novel pathogenic missense ADAMTS17 variant that impairs
            secretion causes Weill-Marchesani Syndrome with variably dysmorphic
            hand features.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6329)
  AUTHORS   Karoulias,S.Z., Beyens,A., Balic,Z., Symoens,S., Vandersteen,A.,
            Rideout,A.L., Dickinson,J., Callewaert,B. and Hubmacher,D.
  TITLE     A novel ADAMTS17 variant that causes Weill-Marchesani syndrome 4
            alters fibrillin-1 and collagen type I deposition in the
            extracellular matrix
  JOURNAL   Matrix Biol 88, 1-18 (2020)
   PUBMED   31726086
  REMARK    GeneRIF: A novel ADAMTS17 variant that causes Weill-Marchesani
            syndrome 4 alters fibrillin-1 and collagen type I deposition in the
            extracellular matrix.
REFERENCE   6  (bases 1 to 6329)
  AUTHORS   Morales,J., Al-Sharif,L., Khalil,D.S., Shinwari,J.M., Bavi,P.,
            Al-Mahrouqi,R.A., Al-Rajhi,A., Alkuraya,F.S., Meyer,B.F. and Al
            Tassan,N.
  TITLE     Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular
            myopia, ectopia lentis, glaucoma, spherophakia, and short stature
  JOURNAL   Am J Hum Genet 85 (5), 558-568 (2009)
   PUBMED   19836009
  REMARK    GeneRIF: Homozygous mutation in ADAMTS17 causes lenticular myopia,
            ectopia lentis, glaucoma, spheropakia, and short stature.
REFERENCE   7  (bases 1 to 6329)
  AUTHORS   Sovio,U., Bennett,A.J., Millwood,I.Y., Molitor,J., O'Reilly,P.F.,
            Timpson,N.J., Kaakinen,M., Laitinen,J., Haukka,J., Pillas,D.,
            Tzoulaki,I., Molitor,J., Hoggart,C., Coin,L.J., Whittaker,J.,
            Pouta,A., Hartikainen,A.L., Freimer,N.B., Widen,E., Peltonen,L.,
            Elliott,P., McCarthy,M.I. and Jarvelin,M.R.
  TITLE     Genetic determinants of height growth assessed longitudinally from
            infancy to adulthood in the northern Finland birth cohort 1966
  JOURNAL   PLoS Genet 5 (3), e1000409 (2009)
   PUBMED   19266077
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6329)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   9  (bases 1 to 6329)
  AUTHORS   Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and
            Lopez-Otin,C.
  TITLE     Cloning, expression analysis, and structural characterization of
            seven novel human ADAMTSs, a family of metalloproteinases with
            disintegrin and thrombospondin-1 domains
  JOURNAL   Gene 283 (1-2), 49-62 (2002)
   PUBMED   11867212
REFERENCE   10 (bases 1 to 6329)
  AUTHORS   Marzin,P., Cormier-Daire,V. and Tsilou,E.
  TITLE     Weill-Marchesani Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301293
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB279404.1, AJ315735.1,
            AC113187.6 and AC084855.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_139057.3.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            ADAMTS family members share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature protein, which may promote breast cancer cell growth and
            survival. Mutations in this gene are associated with a
            Weill-Marchesani-like syndrome, which is characterized by
            lenticular myopia, ectopia lentis, glaucoma, spherophakia, and
            short stature. [provided by RefSeq, May 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ315735.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268070.9/ ENSP00000268070.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                DB279404.1         31-83
            54-1092             AJ315735.1         1-1039
            1093-1107           AC113187.6         147223-147237       c
            1108-1151           AC113187.6         139880-139923       c
            1152-3356           AJ315735.1         1099-3303
            3357-6329           AC084855.4         108951-111923       c
FEATURES             Location/Qualifiers
     source          1..6329
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..6329
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 17"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
     exon            1..155
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..3364
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 17; a disintegrin
                     and metalloproteinase with thrombospondin motifs 17"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 preproprotein"
                     /protein_id="NP_620688.2"
                     /db_xref="CCDS:CCDS10383.1"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
                     /translation="MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVR
                     PDDVHLPPLPAAPGPRRRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRF
                     LSRGFEVEEAGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQ
                     VLIQPLNNSQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRD
                     WRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIK
                     INIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPP
                     LVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELG
                     HNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLV
                     TDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSC
                     KTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFR
                     QRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLT
                     AVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGS
                     AAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQIAGTT
                     VRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQ
                     DSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC
                     NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQ
                     SCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSG
                     CYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCND
                     RINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKM
                     RQPPPNS"
     exon            156..526
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            527..692
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            693..865
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            866..949
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1107
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1151
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1257
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1398
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1549
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1651
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1797
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1964
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2092
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2213
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2371
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2531
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2667
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2872
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3025
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3203
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..6329
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6308..6313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /note="hexamer: AATAAA"
     polyA_site      6329
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /note="major polyA site"
ORIGIN      
        1 actccggctg gcgccgccgc ctagcgcgct cctgcttcgc cgccacggtc cgggggggct
       61 gccggtcccg ggtaccatgt gtgacggcgc cctgctgcct ccgctcgtcc tgcccgtgct
      121 gctgctgctg gtttggggac tggacccggg cacagctgtc ggcgacgcgg cggccgacgt
      181 ggaggtggtg ctcccgtggc gggtgcgccc cgacgacgtg cacctgccgc cgctgcccgc
      241 agcccccggg ccccgacggc ggcgacgccc ccgcacgccc ccagccgccc cgcgcgcccg
      301 gcccggagag cgcgccctgc tgctgcacct gccggccttc gggcgcgacc tgtaccttca
      361 gctgcgccgc gacctgcgct tcctgtcccg aggcttcgag gtggaggagg cgggcgcggc
      421 ccggcgccgc ggccgccccg ccgagctgtg cttctactcg ggccgtgtgc tcggccaccc
      481 cggctccctc gtctcgctca gcgcctgcgg cgccgccggc ggcctggttg gcctcattca
      541 gcttgggcag gagcaggtgc taatccagcc cctcaacaac tcccagggcc cattcagtgg
      601 acgagaacat ctgatcaggc gcaaatggtc cttgaccccc agcccttctg ctgaggccca
      661 gagacctgag cagctctgca aggttctaac agaaaagaag aagccgacgt ggggcaggcc
      721 ttcgcgggac tggcgggagc ggaggaacgc tatccggctc accagcgagc acacggtgga
      781 gaccctggtg gtggccgacg ccgacatggt gcagtaccac ggggccgagg ccgcccagag
      841 gttcatcctg accgtcatga acatggtata caatatgttt cagcaccaga gcctggggat
      901 taaaattaac attcaagtga ccaagcttgt cctgctacga caacgtcccg ctaagttgtc
      961 cattgggcac catggtgagc ggtccctgga gagcttctgt cactggcaga acgaggagta
     1021 tggaggagcg cgatacctcg gcaataacca ggttcccggc gggaaggacg acccgcccct
     1081 ggtggatgct gccgtgtttg tgaccaggac agatttctgt gtacacaagg atgaaccgtg
     1141 tgacactgtt ggaattgctt acttaggagg tgtgtgcagt gctaagagga agtgtgtgct
     1201 tgccgaagac aatggtctca atttggcctt taccatcgcc catgagctgg gccacaactt
     1261 gggcatgaac cacgacgatg accactcatc ttgcgctggc aggtcccaca tcatgtcagg
     1321 agagtgggtg aaaggccgga acccaagtga cctctcttgg tcctcctgca gccgagatga
     1381 ccttgaaaac ttcctcaagt caaaagtcag cacctgcttg ctagtcacgg accccagaag
     1441 ccagcacaca gtacgcctcc cgcacaagct gccgggcatg cactacagtg ccaacgagca
     1501 gtgccagatc ctgtttggca tgaatgccac cttctgcaga aacatggagc atctaatgtg
     1561 tgctggactg tggtgcctgg tagaaggaga cacatcctgc aagaccaagc tggaccctcc
     1621 cctggatggc accgagtgtg gggcagacaa gtggtgccgc gcgggggagt gcgtgagcaa
     1681 gacgcccatc ccggagcatg tggacggaga ctggagcccg tggggcgcct ggagcatgtg
     1741 cagccgaaca tgtgggacgg gagcccgctt caggcagagg aaatgtgaca accccccccc
     1801 tgggcctgga ggcacacact gcccgggtgc cagtgtagaa catgcggtct gcgagaacct
     1861 gccctgcccc aagggtctgc ccagcttccg ggaccagcag tgccaggcac acgaccggct
     1921 gagccccaag aagaaaggcc tgctgacagc cgtggtggtt gacgataagc catgtgaact
     1981 ctactgctcg cccctcggga aggagtcccc actgctggtg gccgacaggg tcctggacgg
     2041 tacaccctgc gggccctacg agactgatct ctgcgtgcac ggcaagtgcc agaaaatcgg
     2101 ctgtgacggc atcatcgggt ctgcagccaa agaggacaga tgcggggtct gcagcgggga
     2161 cggcaagacc tgccacttgg tgaagggcga cttcagccac gcccggggga cagctctcaa
     2221 agactcgggt aaggggtcca tcaacagtga ctggaagata gagctccccg gagagttcca
     2281 gattgcaggc acaactgttc gctatgtgag aagggggctg tgggagaaga tctctgccaa
     2341 gggaccaacc aaactaccgc tgcacttgat ggtgttgtta tttcacgacc aagattatgg
     2401 aattcattat gaatacactg ttcctgtaaa ccgcactgcg gaaaatcaaa gcgaaccaga
     2461 aaaaccgcag gactctttgt tcatctggac ccacagcggc tgggaagggt gcagtgtgca
     2521 gtgcggcgga ggggagcgca gaaccatcgt ctcgtgtaca cggattgtca acaagaccac
     2581 aactctggtg aacgacagtg actgccctca agcaagccgc ccagagcccc aggtccgaag
     2641 gtgcaacttg cacccctgcc agtcacggtg ggtggcaggc ccgtggagcc cctgctcggc
     2701 gacctgtgag aaaggcttcc agcaccggga ggtgacctgc gtgtaccagc tgcagaacgg
     2761 cacacacgtc gctacgcggc ccctctactg cccgggcccc cggccggcgg cagtgcagag
     2821 ctgtgaaggc caggactgcc tgtccatctg ggaggcgtct gagtggtcac agtgctctgc
     2881 cagctgtggt aaaggggtgt ggaaacggac cgtggcgtgc accaactcac aagggaaatg
     2941 cgacgcatcc acgaggccga gagccgagga ggcctgcgag gactactcag gctgctacga
     3001 gtggaaaact ggggactggt ctacgtgctc gtcgacctgc gggaagggcc tgcagtcccg
     3061 ggtggtgcag tgcatgcaca aggtcacagg gcgccacggc agcgagtgcc ccgccctctc
     3121 gaagcctgcc ccctacagac agtgctacca ggaggtctgc aacgacagga tcaacgccaa
     3181 caccatcacc tccccccgcc ttgctgctct gacctacaaa tgcacacgag accagtggac
     3241 ggtatattgc cgggtcatcc gagaaaagaa cctctgccag gacatgcggt ggtaccagcg
     3301 ctgctgccag acctgcaggg acttctatgc aaacaagatg cgccagccac cgccgaactc
     3361 gtgacacgca gtcccaaggg tcgctcaaag ctcagactca ggtctgaaac ccacccaccc
     3421 gcaagcctac cagccttgtg gccacgcccc cacccggctg ccacaagaat ccaactacat
     3481 agaacatgag cgtggacttg gcgtttgcca ttagtgcttc cgtacttaat atattgttaa
     3541 cagccactgg ctggctttct acagtgagga gaaagtaggc atgagtcaca aagtaacttc
     3601 aatttctagg atttcaggta cctcgaaggg aagcacctct ggcagacaac cgtcaagaga
     3661 gagacatcat ttagtgttct tgtcttgact cgcttttgac atttgaattt ccagtgcttg
     3721 gtatatcatg gaggaaacat ccccaaaacg agacatgcta gaaaaggctt tattctgaaa
     3781 gccggcgaca ccatggaggg aggggcaggt gttggtgagc ctctgcccgt ggcttctctg
     3841 gggagggccg ggctgcttag cacacgtttc tctccatcta ccttcttgac cacatgagaa
     3901 ccaggacgtt gcctccatgc ccgtctctga gaacatagtc tctaaatcct aggtgttgcc
     3961 ttggaagtct cgtgcgtgga gtgtaaatct atatatgcca gcgaggacag cagtgccacg
     4021 cagttcatac cacccgcatg ggaagaatgt tccaagagag tctgggtttg gggaagcatc
     4081 taattttcag agctctgctg tccaccgtgt agggaaacag aagggcctct cttcaaggtg
     4141 ctgtgacata agaaacggta attgcggtga tggggttgct tcctaaggca aaggtaagct
     4201 tgggccagct tcactggggc ggatgggcac ctgccccgcc ttccgggaac atccactctg
     4261 gcctgcactt cctaaagctt tgtaccttag agatgctgta ccacatccca gtggctttct
     4321 accgaccgtg gccatttatc tgaaggtaag acgacatttg ggacctctga ggacacaagc
     4381 ccaggcctag gatctgtaga gcaaggcctg actgctctat cctggcacgg agcagcctga
     4441 tgtgccagga ccaggggagg aacgccatct ggctggcact gctgcacacc cgccgagcct
     4501 tcctgtagcc ccagactttg tggtacccat tatcatcacg cctgtcatca ttgacccatc
     4561 ttcttggtgg ggcaaggatg atgcatgatg aaggaaggtc cttcccccct gcagccccct
     4621 tacgcctggc agcagacaag cagagtggcc tctttgagag cacagaggat ggtagcaccc
     4681 tacctgcaag gaggccgggc agggacccta gatgccagga ggcctgtttt gctcaccaac
     4741 ttggtgggca tttcatgggt gcttatgttc taggacttta ccgtaaataa cacctcctcc
     4801 ctgatttcag acggaaggtc tcacttggac ttccatggga tcatctccct gtgcttcttg
     4861 atttattggt gctgtgtttc tgtgttttgt tttgttacat gtcacaaccg tagagttagc
     4921 ttaaatcaga aagaagcctc tctgccttct ccaccctgtc ttacgagctg tgtttttgtt
     4981 tttactaccc tagaggcaga gaagcggtag ggatgtcagg gaatttactc acttccactt
     5041 gaatcaacga gaagtgttga gaaacttccg tgggtgctct gtggaaagaa ccgagggtgt
     5101 caggatggag cggcccaccc tcgccccgcg gcctgcgcag actgctgtcc tccccttcag
     5161 gcctggccac cagcagactc ccatgaattc ccattttcac aaagccctca aaattttggg
     5221 ggcgctgagg ttcaattttc ttcatcccca aatgaactgt taattcactg aaagacattt
     5281 agacttttgc agccaaggag cagagccggg caagctcact aaggaagcct tagcttggtc
     5341 tcctgcatgg gccccggggc ctccagatat gcccactgtc accctggcaa gggccccaca
     5401 ccctcagaat gaaaaggatt gattgggtta ttgtcagata cccccattag ttcccctaaa
     5461 gtctgcatct gcagagctct tttagctcat ctttttgttg tcggtgttgt tttttgagac
     5521 agagtctccc tctgttgccc aggctggagt gcagtggcgc gatctcagct cattgaaagc
     5581 tccgcctccc gggttcaggc cattcttctg cctcaccctc cccagtagct gggactacag
     5641 gcgcccacca ccacgcccac ctactttttt gtatttttac tagagacggg gtttcaccat
     5701 gttagccagg atggtctcga tctcctgacc tcatgatcca cccgcctcag ccttccaaag
     5761 tgctgggatt acaggagtga gccaccgcgc ccggcctttt agcttatctt gaaatccacc
     5821 agcctacctt ctgttcatgg cacgagcagt gatttcagtg aaaccatcat aaacattctt
     5881 gttccactag atgctgatca cagcagtgat gtttctgtgt taataccctg tactgtccct
     5941 cgagtactgt acctttgtgc ttgcacacgt gtcactaacg cacgtgttac cagagtctca
     6001 cgaccctacg gtgctatttt tattggtgca aaattaaacc ctctcagctg accgttgctg
     6061 gataggatca gaatgcagga aaagagcctc tatggcaata cgattgtcct tttttcgttt
     6121 cagagtcaaa tgtatctatt ttccattcgt taacttgcat tacatactgt acccatggaa
     6181 tttttgtttt actttttggg gctggttttg aaaggaaaaa aaacggaaga caaacattgg
     6241 acgccattat acatgaaaat tatatagaaa aattaatcat ttcattggaa gcaagttgaa
     6301 tatgtgtaat aaaatgtttt tccataaca
//
