LOCUS       NM_139056               4979 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            16 (ADAMTS16), transcript variant 1, mRNA.
ACCESSION   NM_139056
VERSION     NM_139056.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4979)
  AUTHORS   Lin,Y., Yang,Q., Lin,X., Liu,X., Qian,Y., Xu,D., Cao,N., Han,X.,
            Zhu,Y., Hu,W., He,X., Yu,Z., Kong,X., Zhu,L., Zhong,Z., Liu,K.,
            Zhou,B., Wang,Y., Peng,J., Zhu,W. and Wang,J.
  TITLE     Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency
            Leads to Bicuspid Aortic Valve With Raphe Formation
  JOURNAL   Circulation 149 (8), 605-626 (2024)
   PUBMED   38018454
  REMARK    GeneRIF: Extracellular Matrix Disorganization Caused by ADAMTS16
            Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.
REFERENCE   2  (bases 1 to 4979)
  AUTHORS   Kordowski,F., Kolarova,J., Schafmayer,C., Buch,S., Goldmann,T.,
            Marwitz,S., Kugler,C., Scheufele,S., Gassling,V., Nemeth,C.G.,
            Brosch,M., Hampe,J., Lucius,R., Roder,C., Kalthoff,H., Siebert,R.,
            Ammerpohl,O. and Reiss,K.
  TITLE     Aberrant DNA methylation of ADAMTS16 in colorectal and other
            epithelial cancers
  JOURNAL   BMC Cancer 18 (1), 796 (2018)
   PUBMED   30081852
  REMARK    GeneRIF: ADAMTS16 is novel gene with cancer-specific promoter
            hypermethylation in colorectal cancer, lung cancer and oral
            squamous cell carcinoma patients implicating ADAMTS16 as potential
            biomarker for these tumors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4979)
  AUTHORS   Cipriani,V., Silva,R.S., Arno,G., Pontikos,N., Kalhoro,A.,
            Valeina,S., Inashkina,I., Audere,M., Rutka,K., Puech,B.,
            Michaelides,M., van Heyningen,V., Lace,B., Webster,A.R. and
            Moore,A.T.
  TITLE     Duplication events downstream of IRX1 cause North Carolina macular
            dystrophy at the MCDR3 locus
  JOURNAL   Sci Rep 7 (1), 7512 (2017)
   PUBMED   28790370
  REMARK    GeneRIF: Through a combination of sequencing studies on eighteen
            North Carolina macular dystrophy families, two novel overlapping
            duplications at the MCDR3 locus, in a gene desert downstream of
            IRX1 and upstream of ADAMTS16, have been reported.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4979)
  AUTHORS   Pekcan,M.K., Sarikaya,E., Tokmak,A., Alisik,M., Alkan,A.,
            Ozaksit,G. and Erel,O.
  TITLE     ADAMTS-3, -13, -16, and -19 levels in patients with habitual
            abortion
  JOURNAL   Kaohsiung J Med Sci 33 (1), 30-35 (2017)
   PUBMED   28088271
  REMARK    GeneRIF: The pregnancy loss rate seems to be affected by both
            ADAMTS-3 and ADAMTS-16.
REFERENCE   5  (bases 1 to 4979)
  AUTHORS   Gunes,M.F., Akpinar,M.B., Comertoglu,I., Akyol,S., Demircelik,B.,
            Gurel,O.M., Aynekin,B., Erdemli,H.K., Ates,M., Eryonucu,B. and
            Demircan,K.
  TITLE     The Investigation of a Disintegrin and Metalloproteinase with
            ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic
            Aneurysms and Dissections
  JOURNAL   Clin Lab 62 (3), 425-433 (2016)
   PUBMED   27156333
REFERENCE   6  (bases 1 to 4979)
  AUTHORS   Joe,B., Saad,Y., Dhindaw,S., Lee,N.H., Frank,B.C., Achinike,O.H.,
            Luu,T.V., Gopalakrishnan,K., Toland,E.J., Farms,P.,
            Yerga-Woolwine,S., Manickavasagam,E., Rapp,J.P., Garrett,M.R.,
            Coe,D., Apte,S.S., Rankinen,T., Perusse,L., Ehret,G.B.,
            Ganesh,S.K., Cooper,R.S., O'Connor,A., Rice,T., Weder,A.B.,
            Chakravarti,A., Rao,D.C. and Bouchard,C.
  TITLE     Positional identification of variants of Adamts16 linked to
            inherited hypertension
  JOURNAL   Hum Mol Genet 18 (15), 2825-2838 (2009)
   PUBMED   19423552
  REMARK    GeneRIF: Blood pressure is associated with SNPs of ADAMTS16 in
            human.
            Erratum:[Hum Mol Genet. 2011 Nov 1;20(21):4297. Dhindaw, Seema
            [added]]
REFERENCE   7  (bases 1 to 4979)
  AUTHORS   Gao,S., De Geyter,C., Kossowska,K. and Zhang,H.
  TITLE     FSH stimulates the expression of the ADAMTS-16 protease in mature
            human ovarian follicles
  JOURNAL   Mol Hum Reprod 13 (7), 465-471 (2007)
   PUBMED   17519324
  REMARK    GeneRIF: These studies provide the first evidence that ADAMTS-16 is
            an active protease and suggest a physiological role of ADAMTS-16 in
            ovarian follicles, at least during the pre-ovulatory phase.
REFERENCE   8  (bases 1 to 4979)
  AUTHORS   Zeng,W., Corcoran,C., Collins-Racie,L.A., Lavallie,E.R.,
            Morris,E.A. and Flannery,C.R.
  TITLE     Glycosaminoglycan-binding properties and aggrecanase activities of
            truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and
            -18
  JOURNAL   Biochim Biophys Acta 1760 (3), 517-524 (2006)
   PUBMED   16507336
  REMARK    GeneRIF: comparison of the effects of C-terminal truncation on the
            GAG-binding properties and aggrecanase activity of ADAMTS-5
            relative to three other ADAMTS family members, ADAMTS-9, ADAMTS-16
            and ADAMTS-18
REFERENCE   9  (bases 1 to 4979)
  AUTHORS   Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and
            Lopez-Otin,C.
  TITLE     Cloning, expression analysis, and structural characterization of
            seven novel human ADAMTSs, a family of metalloproteinases with
            disintegrin and thrombospondin-1 domains
  JOURNAL   Gene 283 (1-2), 49-62 (2002)
   PUBMED   11867212
REFERENCE   10 (bases 1 to 4979)
  AUTHORS   Konig,K., Bockhorn,V., Dietel,W. and Schubert,H.
  TITLE     [Photochemotherapy of experimental tumors in animals using various
            photosensitizers]
  JOURNAL   Z Urol Nephrol 82 (11), 601-607 (1989)
   PUBMED   2618185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ266047.1, AB095949.1,
            BQ774377.1 and AC091978.3.
            
            On Nov 23, 2018 this sequence version replaced NM_139056.3.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            ADAMTS family members share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature protein, which may inhibit chondrosarcoma cell proliferation
            and migration. This gene may regulate blood pressure. [provided by
            RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3368000.1,
                                           SRR18074967.3893967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162328, SAMN02400289
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274181.7/ ENSP00000274181.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1839              DQ266047.1         1-1839
            1840-4974           AB095949.1         1095-4229
            4975-4977           BQ774377.1         19-21               c
            4978-4979           AC091978.3         96103-96104
FEATURES             Location/Qualifiers
     source          1..4979
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.32"
     gene            1..4979
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 16"
                     /db_xref="GeneID:170690"
                     /db_xref="HGNC:HGNC:17108"
                     /db_xref="MIM:607510"
     exon            1..210
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..3813
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 16; a disintegrin
                     and metalloproteinase with thrombospondin motifs 16;
                     ADAM-TS16; ADAMTS-16; ADAM-TS 16"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 16 preproprotein"
                     /protein_id="NP_620687.2"
                     /db_xref="CCDS:CCDS43299.1"
                     /db_xref="GeneID:170690"
                     /db_xref="HGNC:HGNC:17108"
                     /db_xref="MIM:607510"
                     /translation="MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPR
                     PPPPAERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLK
                     GSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVA
                     LSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASE
                     VLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLR
                     HKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGN
                     INIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDIC
                     SWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMC
                     KKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLP
                     GELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHD
                     MWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKF
                     CEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLY
                     CIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNG
                     NNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLN
                     GHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYS
                     MPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTR
                     PVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ
                     PAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVC
                     TSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYR
                     ELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGV
                     QTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLVPQHG
                     MCSHKFYGKQCCKTCSKSNL"
     exon            211..313
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            314..639
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            640..901
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1101
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1185
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1345
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1451
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1589
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1743
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1839
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1988
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2161
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2292
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2416
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2661
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2800
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2927
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3129
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3324
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3549
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3697
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..4979
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4955..4960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /note="hexamer: AATAAA"
     polyA_site      4979
                     /gene="ADAMTS16"
                     /gene_synonym="ADAMTS16s"
                     /note="major polyA site"
ORIGIN      
        1 agtaataacc ccggcgcggc ggcggagtcg ctgtggggaa tcctcccgcg ctctgcctgg
       61 gtcgggtcct ccctgcccgc tcgcacgctg ccggccgggg accctccggt ggcccctagc
      121 ccctcggagc gctcctggat gaagccccgc gcgcgcggat ggcggggctt ggcggcgctg
      181 tggatgctgt tggcgcaggt ggccgagcag gcacctgcgt gcgccatggg acccgcagcg
      241 gcagcgcctg ggagcccgag cgtcccgcgt cctcctccac ccgcggagcg gccgggctgg
      301 atggaaaagg gcgaatatga cctggtctct gcctacgagg ttgaccacag gggcgattac
      361 gtgtcccatg aaatcatgca ccatcagcgg cggagaagag cagtgcccgt gtccgaggtt
      421 gagtctcttc accttcggct gaaaggctcc aggcacgact tccacatgga tctgaggact
      481 tccagcagcc tagtggctcc tggctttatt gtgcagacgt tgggaaagac aggcactaag
      541 tctgtgcaga ctttaccgcc agaggacttc tgtttctatc aaggctcttt gcgatcacac
      601 agaaactcct cagtggccct ttcaacctgc caaggcttgt caggcatgat acgaacagaa
      661 gaggcagatt acttcctaag gccacttcct tcacacctct catggaaact cggcagagct
      721 gcccaaggca gctcgccatc ccacgtactg tacaagagat ccacagagcc ccatgctcct
      781 ggggccagtg aggtcctggt gacctcaagg acatgggagc tggcacatca acccctgcac
      841 agcagcgacc ttcgcctggg actgccacaa aagcagcatt tctgtggaag acgcaagaaa
      901 tacatgcccc agcctcccaa ggaagacctc ttcatcttgc cagatgagta taagtcttgc
      961 ttacggcata agcgctctct tctgaggtcc catagaaatg aagaactgaa cgtggagacc
     1021 ttggtggtgg tcgacaaaaa gatgatgcaa aaccatggcc atgaaaatat caccacctac
     1081 gtgctcacga tactcaacat ggtatctgct ttattcaaag atggaacaat aggaggaaac
     1141 atcaacattg caattgtagg tctgattctt ctagaagatg aacagccagg actggtgata
     1201 agtcaccacg cagaccacac cttaagtagc ttctgccagt ggcagtctgg attgatgggg
     1261 aaagatggga ctcgtcatga ccacgccatc ttactgactg gtctggatat atgttcctgg
     1321 aagaatgagc cctgtgacac tttgggattt gcacccataa gtggaatgtg tagtaaatat
     1381 cgcagctgca cgattaatga agatacaggt cttggactgg ccttcaccat tgcccatgag
     1441 tctggacaca actttggcat gattcatgat ggagaaggga acatgtgcaa aaagtccgag
     1501 ggcaacatca tgtcccctac attggcagga cgcaatggag tcttctcctg gtcaccctgc
     1561 agccgccagt atctacacaa atttctaagc accgctcaag ctatctgcct tgctgatcag
     1621 ccaaagcctg tgaaggaata caagtatcct gagaaattgc caggagaatt atatgatgca
     1681 aacacacagt gcaagtggca gttcggagag aaagccaagc tctgcatgct ggactttaaa
     1741 aaggacatct gtaaagccct gtggtgccat cgtattggaa ggaaatgtga gactaaattt
     1801 atgccagcag cagaaggcac aatttgtggg catgacatgt ggtgccgggg aggacagtgt
     1861 gtgaaatatg gtgatgaagg ccccaagccc acccatggcc actggtcgga ctggtcttct
     1921 tggtccccat gctccaggac ctgcggaggg ggagtatctc ataggagtcg cctctgcacc
     1981 aaccccaagc catcgcatgg agggaagttc tgtgagggct ccactcgcac tctgaagctc
     2041 tgcaacagtc agaaatgtcc ccgggacagt gttgacttcc gtgctgctca gtgtgccgag
     2101 cacaacagca gacgattcag agggcggcac tacaagtgga agccttacac tcaagtagaa
     2161 gatcaggact tatgcaaact ctactgtatc gcagaaggat ttgatttctt cttttctttg
     2221 tcaaataaag tcaaagatgg gactccatgc tcggaggata gccgtaatgt ttgtatagat
     2281 gggatatgtg agagagttgg atgtgacaat gtccttggat ctgatgctgt tgaagacgtc
     2341 tgtggggtgt gtaacgggaa taactcagcc tgcacgattc acaggggtct ctacaccaag
     2401 caccaccaca ccaaccagta ttatcacatg gtcaccattc cttctggagc ccggagtatc
     2461 cgcatctatg aaatgaacgt ctctacctcc tacatttctg tgcgcaatgc cctcagaagg
     2521 tactacctga atgggcactg gaccgtggac tggcccggcc ggtacaaatt ttcgggcact
     2581 actttcgact acagacggtc ctataatgag cccgagaact taatcgctac tggaccaacc
     2641 aacgagacac tgattgtgga gctgctgttt cagggaagga acccgggtgt tgcctgggaa
     2701 tactccatgc ctcgcttggg gaccgagaag cagccccctg cccagcccag ctacacttgg
     2761 gccatcgtgc gctctgagtg ctccgtgtcc tgcggagggg gacagatgac cgtgagagag
     2821 ggctgctaca gagacctgaa gtttcaagta aatatgtcct tctgcaatcc caagacacga
     2881 cctgtcacgg ggctggtgcc ttgcaaagta tctgcctgtc ctcccagctg gtccgtgggg
     2941 aactggagtg cctgcagtcg gacgtgtggc gggggtgccc agagccgccc cgtgcagtgc
     3001 acacggcggg tgcactatga ctcggagcca gtcccggcca gcctgtgccc tcagcctgct
     3061 ccctccagca ggcaggcctg caactctcag agctgcccac ctgcatggag cgccgggccc
     3121 tgggcagagt gctcacacac ctgtgggaag gggtggagga agcgggcagt ggcctgtaag
     3181 agcaccaacc cctcggccag agcgcagctg ctgcccgacg ctgtctgcac ctccgagccc
     3241 aagcccagga tgcatgaagc ctgtctgctt cagcgctgcc acaagcccaa gaagctgcag
     3301 tggctggtgt ccgcctggtc ccagtgctct gtgacatgtg aaagaggaac acagaaaaga
     3361 ttcttaaaat gtgctgaaaa gtatgtttct ggaaagtatc gagagctggc ctcaaagaag
     3421 tgctcacatt tgccgaagcc cagcctggag ctggaacgtg cctgcgcccc gcttccatgc
     3481 cccaggcacc ccccatttgc tgctgcggga ccctcgaggg gcagctggtt tgcctcaccc
     3541 tggtctcagt gcacggccag ctgtggggga ggcgttcaga cgaggtccgt gcagtgcctg
     3601 gctgggggcc ggccggcctc aggctgcctc ctgcaccaga agccttcggc ctccctggcc
     3661 tgcaacactc acttctgccc cattgcagag aagaaagatg ccttctgcaa agactacttc
     3721 cactggtgct acctggtacc ccagcacggg atgtgcagcc acaagttcta cggcaagcag
     3781 tgctgcaaga cttgctctaa gtccaacttg tgagttggga ccgctctccg tagcagagaa
     3841 agtgcctgcg tggcacagaa atttcccaca aatgagctgt gcaatctacg tcggaataca
     3901 tccaaggaag agcaaagcca aaagaagaaa accgtgttag gctctttgac caggagtgta
     3961 tgtatgtgtt tcactgtgag cctgggtgca gacctgtgtc cccatgcaca cagtgtctcc
     4021 tgtcaggctg aaatgtggca ccctggcaga cagagctgtg gctcgtgagg cagaaggcag
     4081 gcaccacaac gggagaggca gcactcaccc ctgcctgttg cagctaaatc aagtcaaaaa
     4141 gacaggcgag gctgaacttg ctaaatgtct ggtgccttag aaaaagaagg aaaggccatg
     4201 aaataaggaa aacatacaaa atatgtaccc cctagttcac cagcctcccc tcccactagg
     4261 agggcccctc gagccatcag gagtgaccaa cttcctgggt ggaggtcagg ggagctccag
     4321 gaggctgccc aggctcctcc tcctcctccc cagcggccga gcatctctta ccaggaacct
     4381 ggagccaccg ccggagccag cgtcatctct agggtcactg gccaggggac tgcattctgg
     4441 tttgggactt tgcctatgga aatgggaaaa atgaaattcc tgctaaggtg cttctatctc
     4501 tttcagattc atgcattgaa ggagagattt tttatacttt atgttttatc tttctcagtt
     4561 atttgcaagt gagtgtcctt ttaaaaacac acttcttcat gcttttcttt gtaaatgaca
     4621 gatcgaagta taggttacat caaaacccta ccatcctgag aagagttatg gttctattat
     4681 agcagacgtc agccacacag cctatgtgac aataacctta gagtcctgtg ttttgttttt
     4741 gtgtgttgtg agattttaat cttttttttt tcggtgagtc tggccatttc tataatgcca
     4801 ggtgggaagc caggctgcgg gtgttagggt gggaatctgc ccggcgtctc tggcaccctc
     4861 cctgccatcc tcagtgcggc tgctgttctc ctgtccggtg ctgtggctcc attccaaagg
     4921 ggcacctgga tatttatatt tgctgaagtt ttataataaa gtttatatgg tacagtgtg
//
