LOCUS       NM_139055               6006 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            15 (ADAMTS15), mRNA.
ACCESSION   NM_139055
VERSION     NM_139055.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6006)
  AUTHORS   Boschann,F., Cogulu,M.O., Pehlivan,D., Balachandran,S.,
            Vallecillo-Garcia,P., Grochowski,C.M., Hansmeier,N.R., Coban
            Akdemir,Z.H., Prada-Medina,C.A., Aykut,A., Fischer-Zirnsak,B.,
            Badura,S., Durmaz,B., Ozkinay,F., Hagerling,R., Posey,J.E.,
            Stricker,S., Gillessen-Kaesbach,G., Spielmann,M., Horn,D.,
            Brockmann,K., Lupski,J.R., Kornak,U. and Schmidt,J.
  TITLE     Biallelic variants in ADAMTS15 cause a novel form of distal
            arthrogryposis
  JOURNAL   Genet Med 24 (10), 2187-2193 (2022)
   PUBMED   35962790
  REMARK    GeneRIF: Biallelic variants in ADAMTS15 cause a novel form of
            distal arthrogryposis.
            Erratum:[Genet Med. 2023 May;25(5):100799. doi:
            10.1016/j.gim.2023.100799.. PMID: 36853234]
REFERENCE   2  (bases 1 to 6006)
  AUTHORS   Binder,M.J., McCoombe,S., Williams,E.D., McCulloch,D.R. and
            Ward,A.C.
  TITLE     ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer
  JOURNAL   Biomolecules 10 (5), 682 (2020)
   PUBMED   32354091
  REMARK    GeneRIF: ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6006)
  AUTHORS   Gueye,N.A., Mead,T.J., Koch,C.D., Biscotti,C.V., Falcone,T. and
            Apte,S.S.
  TITLE     Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex
            Steroid Receptor Expression in Uterine Leiomyoma
  JOURNAL   J Clin Endocrinol Metab 102 (5), 1631-1641 (2017)
   PUBMED   28323982
  REMARK    GeneRIF: ADAMTS4 and ADAMTS15 were upregulated in symptomatic
            uterine leiomyomas.
REFERENCE   4  (bases 1 to 6006)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: ADAMTS15 expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   5  (bases 1 to 6006)
  AUTHORS   Guo,C., Tsigkou,A. and Lee,M.H.
  TITLE     ADAMTS13 and 15 are not regulated by the full length and N-terminal
            domain forms of TIMP-1, -2, -3 and -4
  JOURNAL   Biomed Rep 4 (1), 73-78 (2016)
   PUBMED   26870338
REFERENCE   6  (bases 1 to 6006)
  AUTHORS   Molokwu,C.N., Adeniji,O.O., Chandrasekharan,S., Hamdy,F.C. and
            Buttle,D.J.
  TITLE     Androgen regulates ADAMTS15 gene expression in prostate cancer
            cells
  JOURNAL   Cancer Invest 28 (7), 698-710 (2010)
   PUBMED   20590445
  REMARK    GeneRIF: ADAMTS-15 but not ADAMTS-1 expression was downregulated by
            androgen in LNCaP prostate cancer cells, possibly through androgen
            response elements associated with the gene
REFERENCE   7  (bases 1 to 6006)
  AUTHORS   Viloria,C.G., Obaya,A.J., Moncada-Pazos,A., Llamazares,M.,
            Astudillo,A., Capella,G., Cal,S. and Lopez-Otin,C.
  TITLE     Genetic inactivation of ADAMTS15 metalloprotease in human
            colorectal cancer
  JOURNAL   Cancer Res 69 (11), 4926-4934 (2009)
   PUBMED   19458070
  REMARK    GeneRIF: ADAMTS15 may be target of inactivating mutations in human
            cancer.
REFERENCE   8  (bases 1 to 6006)
  AUTHORS   Porter,S., Span,P.N., Sweep,F.C., Tjan-Heijnen,V.C.,
            Pennington,C.J., Pedersen,T.X., Johnsen,M., Lund,L.R., Romer,J. and
            Edwards,D.R.
  TITLE     ADAMTS8 and ADAMTS15 expression predicts survival in human breast
            carcinoma
  JOURNAL   Int J Cancer 118 (5), 1241-1247 (2006)
   PUBMED   16152618
  REMARK    GeneRIF: ADAMTS8 and ADAMTS15 have emerged as novel predictors of
            survival in patients with breast carcinoma
REFERENCE   9  (bases 1 to 6006)
  AUTHORS   Cross,N.A., Chandrasekharan,S., Jokonya,N., Fowles,A., Hamdy,F.C.,
            Buttle,D.J. and Eaton,C.L.
  TITLE     The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and
            TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation
            of versican
  JOURNAL   Prostate 63 (3), 269-275 (2005)
   PUBMED   15599946
  REMARK    GeneRIF: negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15
            coupled with increases in their inhibitor, TIMP-3 may aid the
            accumulation of versican in the stromal compartment of the prostate
            in BPH and prostate cancer
REFERENCE   10 (bases 1 to 6006)
  AUTHORS   Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and
            Lopez-Otin,C.
  TITLE     Cloning, expression analysis, and structural characterization of
            seven novel human ADAMTSs, a family of metalloproteinases with
            disintegrin and thrombospondin-1 domains
  JOURNAL   Gene 283 (1-2), 49-62 (2002)
   PUBMED   11867212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002986.2 and AP003459.2.
            
            On Sep 17, 2020 this sequence version replaced NM_139055.3.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            ADAMTS family members share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature enzyme, which may play a role in versican processing during
            skeletal muscle development. This gene may function as a tumor
            suppressor in colorectal and breast cancers. [provided by RefSeq,
            May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.5727.1,
                                           SRR18074967.3117889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299164.4/ ENSP00000299164.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1286              AP002986.2         133786-135071
            1287-1419           AP002986.2         146630-146762
            1420-1587           AP002986.2         147228-147395
            1588-1871           AP002986.2         147638-147921
            1872-2049           AP002986.2         154403-154580
            2050-2231           AP003459.2         1346-1527
            2232-2407           AP003459.2         1634-1809
            2408-6006           AP003459.2         3473-7071
FEATURES             Location/Qualifiers
     source          1..6006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..6006
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 15"
                     /db_xref="GeneID:170689"
                     /db_xref="HGNC:HGNC:16305"
                     /db_xref="MIM:607509"
     exon            1..1286
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..3182
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 15; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 15, preproprotein; metalloprotease disintegrin 15
                     with thrombospondin domains"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 15 preproprotein"
                     /protein_id="NP_620686.1"
                     /db_xref="CCDS:CCDS8488.1"
                     /db_xref="GeneID:170689"
                     /db_xref="HGNC:HGNC:16305"
                     /db_xref="MIM:607509"
                     /translation="MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRG
                     PEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCF
                     YSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRR
                     GVPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPR
                     YVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRD
                     SGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMAD
                     VGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSP
                     TLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDLPGASYTLSQQCEL
                     AFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERH
                     NLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCN
                     LEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANG
                     TGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSC
                     KKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGH
                     FVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSF
                     YLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCG
                     SGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELSAWSPCSKSCGRGFQ
                     RRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC"
     exon            1287..1419
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1587
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1871
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2049
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2231
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2407
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..6006
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5980..5985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /note="hexamer: AATAAA"
     polyA_site      6006
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /note="major polyA site"
ORIGIN      
        1 gcgctgcgag tggctgcggt tgcgagaagc cgcccggcac cttccgctag ttctcggctg
       61 caaatcttcg tccttgcact tgacagcgat tgtacttaag ctcccagggc gcgctttgct
      121 tggaaaggca caggtaggaa gcgcgggctg ccgggtgcac gctcgccgcc ctgggaggag
      181 tctccctccc ttggctctcc tttctgggaa ctgccggctg tcccgtagcg ttggcggttc
      241 cagagtgcgg gctgcacgga gaccgcggca gcggccggag agcccggccc agccccttcc
      301 cacagcgcgg cggtgcgctg cccggcgcca tgcttctgct gggcatccta accctggctt
      361 tcgccgggcg aaccgctgga ggctctgagc cagagcggga ggtagtcgtt cccatccgac
      421 tggacccgga cattaacggc cgccgctact actggcgggg tcccgaggac tccggggatc
      481 agggactcat ttttcagatc acagcatttc aggaggactt ttacctacac ctgacgccgg
      541 atgctcagtt cttggctccc gccttctcca ctgagcatct gggcgtcccc ctccaggggc
      601 tcaccggggg ctcttcagac ctgcgacgct gcttctattc tggggacgtg aacgccgagc
      661 cggactcgtt cgctgctgtg agcctgtgcg gggggctccg cggagccttt ggctaccgag
      721 gcgccgagta tgtcattagc ccgctgccca atgctagcgc gccggcggcg cagcgcaaca
      781 gccagggcgc acaccttctc cagcgccggg gtgttccggg cgggccttcc ggagacccca
      841 cctctcgctg cggggtggcc tcgggctgga accccgccat cctacgggcc ctggaccctt
      901 acaagccgcg gcgggcgggc ttcggggaga gtcgtagccg gcgcaggtct gggcgcgcca
      961 agcgtttcgt gtctatcccg cggtacgtgg agacgctggt ggtcgcggac gagtcaatgg
     1021 tcaagttcca cggcgcggac ctggaacatt atctgctgac gctgctggca acggcggcgc
     1081 gactctaccg ccatcccagc atcctcaacc ccatcaacat cgttgtggtc aaggtgctgc
     1141 ttcttagaga tcgtgactcc gggcccaagg tcaccggcaa tgcggccctg acgctgcgca
     1201 acttctgtgc ctggcagaag aagctgaaca aagtgagtga caagcacccc gagtactggg
     1261 acactgccat cctcttcacc aggcaggacc tgtgtggagc caccacctgt gacaccctgg
     1321 gcatggctga tgtgggtacc atgtgtgacc ccaagagaag ctgctctgtc attgaggacg
     1381 atgggcttcc atcagccttc accactgccc acgagctggg ccacgtgttc aacatgcccc
     1441 atgacaatgt gaaagtctgt gaggaggtgt ttgggaagct ccgagccaac cacatgatgt
     1501 ccccgaccct catccagatc gaccgtgcca acccctggtc agcctgcagt gctgccatca
     1561 tcaccgactt cctggacagc gggcacggtg actgcctcct ggaccaaccc agcaagccca
     1621 tctccctgcc cgaggatctg ccgggcgcca gctacaccct gagccagcag tgcgagctgg
     1681 cttttggcgt gggctccaag ccctgtcctt acatgcagta ctgcaccaag ctgtggtgca
     1741 ccgggaaggc caagggacag atggtgtgcc agacccgcca cttcccctgg gccgatggca
     1801 ccagctgtgg cgagggcaag ctctgcctca aaggggcctg cgtggagaga cacaacctca
     1861 acaagcacag ggtggatggt tcctgggcca aatgggatcc ctatggcccc tgctcgcgca
     1921 catgtggtgg gggcgtgcag ctggccagga ggcagtgcac caaccccacc cctgccaacg
     1981 ggggcaagta ctgcgaggga gtgagggtga aataccgatc ctgcaatctg gagccctgcc
     2041 ccagctcagc ctccggaaag agcttccggg aggagcagtg tgaggctttc aacggctaca
     2101 accacagcac caaccggctc actctcgccg tggcatgggt gcccaagtac tccggcgtgt
     2161 ctccccggga caagtgcaag ctcatctgcc gagccaatgg cactggctac ttctatgtgc
     2221 tggcacccaa ggtggtggac ggcacgctgt gctctcctga ctccacctcc gtctgtgtcc
     2281 aaggcaagtg catcaaggct ggctgtgatg ggaacctggg ctccaagaag agattcgaca
     2341 agtgtggggt gtgtggggga gacaataaga gctgcaagaa ggtgactgga ctcttcacca
     2401 agcccatgca tggctacaat ttcgtggtgg ccatccccgc aggcgcctca agcatcgaca
     2461 tccgccagcg cggttacaaa gggctgatcg gggatgacaa ctacctggct ctgaagaaca
     2521 gccaaggcaa gtacctgctc aacgggcatt tcgtggtgtc ggcggtggag cgggacctgg
     2581 tggtgaaggg cagtctgctg cggtacagcg gcacgggcac agcggtggag agcctgcagg
     2641 cttcccggcc catcctggag ccgctgaccg tggaggtcct ctccgtgggg aagatgacac
     2701 cgccccgggt ccgctactcc ttctatctgc ccaaagagcc tcgggaggac aagtcctctc
     2761 atcccaagga cccccgggga ccctctgtct tgcacaacag cgtcctcagc ctctccaacc
     2821 aggtggagca gccggacgac aggccccctg cacgctgggt ggctggcagc tgggggccgt
     2881 gctccgcgag ctgcggcagt ggcctgcaga agcgggcggt ggactgccgg ggctccgccg
     2941 ggcagcgcac ggtccctgcc tgtgatgcag cccatcggcc cgtggagaca caagcctgcg
     3001 gggagccctg ccccacctgg gagctcagcg cctggtcacc ctgctccaag agctgcggcc
     3061 ggggatttca gaggcgctca ctcaagtgtg tgggccacgg aggccggctg ctggcccggg
     3121 accagtgcaa cttgcaccgc aagccccagg agctggactt ctgcgtcctg aggccgtgct
     3181 gagtggggtc atcgctttct ccccctcact ctccacccca ctgatatgcc agcgttctgc
     3241 cagctggagt agcgggcaga ggacggtggc caggggctca cgccacgatg tcacccacat
     3301 ccggggacaa ggaccatggg ctggggcgag aggttccctc ctcctccctg gactgggcag
     3361 agggaagccc aggaactccc gcacagtcta cctcaggccc cgctcctcgg gccggttgcg
     3421 gggagaggct ttgaggtgca gggcagaagg tgctgaggcc cagtttccaa ggaacttgga
     3481 ggatgggcac cttccaggca gaacttcagg gaccccggcc cccagaacgg aggccacagg
     3541 ctgctggaag agccatgtcc cagcagcttg gcaccctcag gtggccccat gggctctgag
     3601 ccgtgtctga acgaggcagg gttttcacgg tgcttttagc ccactttcct ttttgaactg
     3661 acatggacta agcaataaaa gctggctggg gctgggcaga agccacgggg agagtgagat
     3721 tagggcccct ggagcctggc actccacctt ggaagacgtg gacgtgcaca gggagtcccg
     3781 aggtttctca tcctgcactc ttggccctcc tataaagaag cagcctctcc ttcctctgat
     3841 gtgcagggtg taggactagt ggtagggctg ccacggaagt gtcctctgag gctctgcagg
     3901 tagcggggaa agccagtagg gagtctgctg tcttcttcaa gatggagccg gccattacag
     3961 aaagatgttg acatttgcta ggggctatgc agtctgtggc tgatgcaggg agttttcaga
     4021 aagttctgga gggttctgct gtcactggac tggggttggt gctgagctct gggcctggct
     4081 ttgggagatg tcaccctggg atagggagga ggaagctgca tttctaatgg cttcctcctc
     4141 cagagaggca cgtatatgca ggctgacatc cgagggtctg tgtcgcctca gacagccctg
     4201 acagtggcca cagtcccgta cccattgtga ggggctgggg catgcctagg agggctaggt
     4261 gctgaacatc tatgtgccta taaactcgtc ttcgttccaa acagctactg ctgtctgccc
     4321 tgggcacgtc acgttgcatc ctaggcctta gcttctccac tgtttgctac ctcagattat
     4381 gccctctggg aacccagccg tatccctccc ctaggacagt ggtgacctgg tccttccacc
     4441 acactcagtc tttggagagc gagctgtcca gccacagaaa tgagggtgtg gtgcgtggct
     4501 tcctgctccc cacagcccag ccccctgttg gggctccaaa gccgaagaca gggcctcttc
     4561 agactccttg ggagtaggtt tcaggaggca ccaagaatca atgactgacc cagggggcct
     4621 ggcagccact agtatgaact gctggagacc tgtctgtctt atagacatgt caggaaaata
     4681 gaaacaggca ttttctctag ctccaagtgg ggagatattt tggggtcaca gcttctttgg
     4741 ctaagcaggg tgtttcttga aggttcagat gccccactgt gtacatggga tattctgctt
     4801 ctgagtgtag gtgatgaatc caggtcctca gtggagaatt ttctggagct aagatcaaag
     4861 catgtgtctt cctgggagag aagagttccg ttcttttatg tgggtttccc taatagtcag
     4921 aatccacaaa ccagccagcc agccagccaa gcctctgcga tgatgttctc atccggtcta
     4981 acgctgggct ggaaaccttg gacagagttc atgcgggggc agagggggtg ccagtctctg
     5041 aggcagggct gcagtcaccc ctgaagaact aagtgaacag gaacccctct gtgccagtga
     5101 ccactgtggg gctaaaggga caaaaaggac cagggtacca ggcagaagca gatccttgat
     5161 agctgacgac agcactgcgc cctgtgcttg gtgcactccc tccttcagga ggagagggtg
     5221 gcatggggtc tgtgcgggat ggcaggggga ttgggtgggt gggaagagag gtgccatcgg
     5281 taggaggctg gcctccagta gaggagagca gcttttgcca tcagtcactt tacaaaccat
     5341 ttcaaggaag gacaacctct ctggctcctg acacaagcca ggcctcggtg cttttatctg
     5401 ttgtggtggt ttttcttctt tcccttttta aaagacgcat gaccaagaca acctagggag
     5461 tttgtcttgc ttgcctttga ctatttcctt aatccaacca tgctctcgag ggctgagcag
     5521 agactagact caaggcacag gtttctggtg atggagtaaa gttacagcgg tatctcatgt
     5581 ctacacaaga agaggaacgt tctgaaagct ccaacaactt cttgaggggg atggaccaat
     5641 acagctttgg gctcaggatt ccctagcctc ctctgcccat cgcgtgcact gattggagga
     5701 gtctggccca aacactctca tatgaacctc gacatgctgg agtggggtct ggcaggagct
     5761 gatgacagtt tgagggactt gagtgtccct agcctggcag ttggctcccg gaagcactag
     5821 acactgacac tcattggtag accctccctc cccgccgttg tgtttggttc ttttgcactc
     5881 catgtactgc agaaggatgg aaggacctgg gtgctggctg ggctgtgtat actgtgtata
     5941 caagggagct ggctgctgag gtgaccacag ccttctccta ataaagctgt aagtatttaa
     6001 aacctg
//
