LOCUS       NP_620686                950 aa            linear   PRI 30-APR-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 15
            preproprotein [Homo sapiens].
ACCESSION   NP_620686
VERSION     NP_620686.1
DBSOURCE    REFSEQ: accession NM_139055.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 950)
  AUTHORS   Boschann,F., Cogulu,M.O., Pehlivan,D., Balachandran,S.,
            Vallecillo-Garcia,P., Grochowski,C.M., Hansmeier,N.R., Coban
            Akdemir,Z.H., Prada-Medina,C.A., Aykut,A., Fischer-Zirnsak,B.,
            Badura,S., Durmaz,B., Ozkinay,F., Hagerling,R., Posey,J.E.,
            Stricker,S., Gillessen-Kaesbach,G., Spielmann,M., Horn,D.,
            Brockmann,K., Lupski,J.R., Kornak,U. and Schmidt,J.
  TITLE     Biallelic variants in ADAMTS15 cause a novel form of distal
            arthrogryposis
  JOURNAL   Genet Med 24 (10), 2187-2193 (2022)
   PUBMED   35962790
  REMARK    GeneRIF: Biallelic variants in ADAMTS15 cause a novel form of
            distal arthrogryposis.
            Erratum:[Genet Med. 2023 May;25(5):100799. doi:
            10.1016/j.gim.2023.100799. PMID: 36853234]
REFERENCE   2  (residues 1 to 950)
  AUTHORS   Binder,M.J., McCoombe,S., Williams,E.D., McCulloch,D.R. and
            Ward,A.C.
  TITLE     ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer
  JOURNAL   Biomolecules 10 (5), 682 (2020)
   PUBMED   32354091
  REMARK    GeneRIF: ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 950)
  AUTHORS   Gueye,N.A., Mead,T.J., Koch,C.D., Biscotti,C.V., Falcone,T. and
            Apte,S.S.
  TITLE     Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex
            Steroid Receptor Expression in Uterine Leiomyoma
  JOURNAL   J Clin Endocrinol Metab 102 (5), 1631-1641 (2017)
   PUBMED   28323982
  REMARK    GeneRIF: ADAMTS4 and ADAMTS15 were upregulated in symptomatic
            uterine leiomyomas.
REFERENCE   4  (residues 1 to 950)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: ADAMTS15 expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   5  (residues 1 to 950)
  AUTHORS   Guo,C., Tsigkou,A. and Lee,M.H.
  TITLE     ADAMTS13 and 15 are not regulated by the full length and N-terminal
            domain forms of TIMP-1, -2, -3 and -4
  JOURNAL   Biomed Rep 4 (1), 73-78 (2016)
   PUBMED   26870338
REFERENCE   6  (residues 1 to 950)
  AUTHORS   Molokwu,C.N., Adeniji,O.O., Chandrasekharan,S., Hamdy,F.C. and
            Buttle,D.J.
  TITLE     Androgen regulates ADAMTS15 gene expression in prostate cancer
            cells
  JOURNAL   Cancer Invest 28 (7), 698-710 (2010)
   PUBMED   20590445
  REMARK    GeneRIF: ADAMTS-15 but not ADAMTS-1 expression was downregulated by
            androgen in LNCaP prostate cancer cells, possibly through androgen
            response elements associated with the gene
REFERENCE   7  (residues 1 to 950)
  AUTHORS   Viloria,C.G., Obaya,A.J., Moncada-Pazos,A., Llamazares,M.,
            Astudillo,A., Capella,G., Cal,S. and Lopez-Otin,C.
  TITLE     Genetic inactivation of ADAMTS15 metalloprotease in human
            colorectal cancer
  JOURNAL   Cancer Res 69 (11), 4926-4934 (2009)
   PUBMED   19458070
  REMARK    GeneRIF: ADAMTS15 may be target of inactivating mutations in human
            cancer.
REFERENCE   8  (residues 1 to 950)
  AUTHORS   Porter,S., Span,P.N., Sweep,F.C., Tjan-Heijnen,V.C.,
            Pennington,C.J., Pedersen,T.X., Johnsen,M., Lund,L.R., Romer,J. and
            Edwards,D.R.
  TITLE     ADAMTS8 and ADAMTS15 expression predicts survival in human breast
            carcinoma
  JOURNAL   Int J Cancer 118 (5), 1241-1247 (2006)
   PUBMED   16152618
  REMARK    GeneRIF: ADAMTS8 and ADAMTS15 have emerged as novel predictors of
            survival in patients with breast carcinoma
REFERENCE   9  (residues 1 to 950)
  AUTHORS   Cross,N.A., Chandrasekharan,S., Jokonya,N., Fowles,A., Hamdy,F.C.,
            Buttle,D.J. and Eaton,C.L.
  TITLE     The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and
            TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation
            of versican
  JOURNAL   Prostate 63 (3), 269-275 (2005)
   PUBMED   15599946
  REMARK    GeneRIF: negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15
            coupled with increases in their inhibitor, TIMP-3 may aid the
            accumulation of versican in the stromal compartment of the prostate
            in BPH and prostate cancer
REFERENCE   10 (residues 1 to 950)
  AUTHORS   Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and
            Lopez-Otin,C.
  TITLE     Cloning, expression analysis, and structural characterization of
            seven novel human ADAMTSs, a family of metalloproteinases with
            disintegrin and thrombospondin-1 domains
  JOURNAL   Gene 283 (1-2), 49-62 (2002)
   PUBMED   11867212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002986.2 and AP003459.2.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motifs) protein family.
            ADAMTS family members share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature enzyme, which may play a role in versican processing during
            skeletal muscle development. This gene may function as a tumor
            suppressor in colorectal and breast cancers. [provided by RefSeq,
            May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.5727.1,
                                           SRR18074967.3117889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299164.4/ ENSP00000299164.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..950
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     Protein         1..950
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 15 preproprotein"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 15; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 15, preproprotein; metalloprotease disintegrin 15
                     with thrombospondin domains"
                     /calculated_mol_wt=101587
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1718
     Region          24..149
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Site            141
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TE58.1)"
     Region          151..172
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TE58.1)"
     Region          172..179
                     /region_name="Cysteine switch. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TE58.1)"
     mat_peptide     213..950
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 15. /id=PRO_0000029193"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TE58.1)"
                     /calculated_mol_wt=80516
     Region          218..424
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(361..362,365,371)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          438..505
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          519..571
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Site            591
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TE58.1)"
     Region          <616..682
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Site            623
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TE58.1)"
     Site            679
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TE58.1)"
     Region          684..801
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          701..838
                     /region_name="Spacer"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TE58.1)"
     Region          798..822
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TE58.1)"
     Region          843..894
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          897..950
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..950
                     /gene="ADAMTS15"
                     /gene_synonym="DA12"
                     /coded_by="NM_139055.4:330..3182"
                     /db_xref="CCDS:CCDS8488.1"
                     /db_xref="GeneID:170689"
                     /db_xref="HGNC:HGNC:16305"
                     /db_xref="MIM:607509"
ORIGIN      
        1 mlllgiltla fagrtaggse perevvvpir ldpdingrry ywrgpedsgd qglifqitaf
       61 qedfylhltp daqflapafs tehlgvplqg ltggssdlrr cfysgdvnae pdsfaavslc
      121 gglrgafgyr gaeyvisplp nasapaaqrn sqgahllqrr gvpggpsgdp tsrcgvasgw
      181 npailraldp ykprragfge srsrrrsgra krfvsipryv etlvvadesm vkfhgadleh
      241 ylltllataa rlyrhpsiln pinivvvkvl llrdrdsgpk vtgnaaltlr nfcawqkkln
      301 kvsdkhpeyw dtailftrqd lcgattcdtl gmadvgtmcd pkrscsvied dglpsaftta
      361 helghvfnmp hdnvkvceev fgklranhmm sptliqidra npwsacsaai itdfldsghg
      421 dclldqpskp islpedlpga sytlsqqcel afgvgskpcp ymqyctklwc tgkakgqmvc
      481 qtrhfpwadg tscgegklcl kgacverhnl nkhrvdgswa kwdpygpcsr tcgggvqlar
      541 rqctnptpan ggkycegvrv kyrscnlepc pssasgksfr eeqceafngy nhstnrltla
      601 vawvpkysgv sprdkcklic rangtgyfyv lapkvvdgtl cspdstsvcv qgkcikagcd
      661 gnlgskkrfd kcgvcggdnk sckkvtglft kpmhgynfvv aipagassid irqrgykgli
      721 gddnylalkn sqgkyllngh fvvsaverdl vvkgsllrys gtgtaveslq asrpileplt
      781 vevlsvgkmt pprvrysfyl pkepredkss hpkdprgpsv lhnsvlslsn qveqpddrpp
      841 arwvagswgp csascgsglq kravdcrgsa gqrtvpacda ahrpvetqac gepcptwels
      901 awspcskscg rgfqrrslkc vghggrllar dqcnlhrkpq eldfcvlrpc
//
