LOCUS       NM_080722               5557 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            14 (ADAMTS14), transcript variant 2, mRNA.
ACCESSION   NM_080722
VERSION     NM_080722.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5557)
  AUTHORS   Carter,E.P., Yoneten,K.K., Gavara,N., Tyler,E.J., Gauthier,V.,
            Murray,E.R., Ten Dijke,P., Cameron,A.J., Pearce,O. and Grose,R.P.
  TITLE     Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast
            differentiation and function
  JOURNAL   J Pathol 262 (1), 90-104 (2024)
   PUBMED   37929635
  REMARK    GeneRIF: Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast
            differentiation and function.
REFERENCE   2  (bases 1 to 5557)
  AUTHORS   Qin,M., Gao,Y., Zhang,M., Wu,J., Liu,Y., Jiang,Y., Zhang,X.,
            Wang,X., Yang,Y. and Gao,Y.
  TITLE     Association between ADAMTS14_rs4747096 gene polymorphism and bone
            mineral density of Chinese Han population residing in fluorine
            exposed areas in ShanXi Province, China
  JOURNAL   Environ Sci Pollut Res Int 30 (48), 106059-106067 (2023)
   PUBMED   37725302
  REMARK    GeneRIF: Association between ADAMTS14_rs4747096 gene polymorphism
            and bone mineral density of Chinese Han population residing in
            fluorine exposed areas in ShanXi Province, China.
REFERENCE   3  (bases 1 to 5557)
  AUTHORS   Li,B., Li,X., Zhang,L. and Mou,L.
  TITLE     Correlation investigation between a single nucleotide polymorphism
            in ADAMTS14 (rs4747096) and osteoarthritis: a meta-analysis
  JOURNAL   J Orthop Surg Res 18 (1), 575 (2023)
   PUBMED   37550675
  REMARK    GeneRIF: Correlation investigation between a single nucleotide
            polymorphism in ADAMTS14 (rs4747096) and osteoarthritis: a
            meta-analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5557)
  AUTHORS   Kentistou,K.A., Luan,J., Wittemans,L.B.L., Hambly,C., Klaric,L.,
            Kutalik,Z., Speakman,J.R., Wareham,N.J., Kendall,T.J.,
            Langenberg,C., Wilson,J.F., Joshi,P.K. and Morton,N.M.
  TITLE     Large scale phenotype imputation and in vivo functional validation
            implicate ADAMTS14 as an adiposity gene
  JOURNAL   Nat Commun 14 (1), 307 (2023)
   PUBMED   36658113
  REMARK    GeneRIF: Large scale phenotype imputation and in vivo functional
            validation implicate ADAMTS14 as an adiposity gene.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5557)
  AUTHORS   Chen,Y., Ji,H., Liu,S., Xing,Q., Zhu,B. and Wang,Y.
  TITLE     Survival Prognosis, Tumor Immune Landscape, and Immune Responses of
            ADAMTS14 in Clear Cell Renal Cell Carcinoma and Its Potential
            Mechanisms
  JOURNAL   Front Immunol 13, 790608 (2022)
   PUBMED   35572505
  REMARK    GeneRIF: Survival Prognosis, Tumor Immune Landscape, and Immune
            Responses of ADAMTS14 in Clear Cell Renal Cell Carcinoma and Its
            Potential Mechanisms.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5557)
  AUTHORS   Bekhouche,M. and Colige,A.
  TITLE     The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology
  JOURNAL   Matrix Biol 44-46, 46-53 (2015)
   PUBMED   25863161
  REMARK    GeneRIF: Data indicate that ADAMTS2, 3 and 14 cleave the
            amino-propeptide of fibrillar collagens. [review]
            Review article
REFERENCE   7  (bases 1 to 5557)
  AUTHORS   Goertsches,R., Comabella,M., Navarro,A., Perkal,H. and Montalban,X.
  TITLE     Genetic association between polymorphisms in the ADAMTS14 gene and
            multiple sclerosis
  JOURNAL   J Neuroimmunol 164 (1-2), 140-147 (2005)
   PUBMED   15913795
  REMARK    GeneRIF: This study suggest potentially important role for the
            ADAMTS14 gene in predisposition to MS.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5557)
  AUTHORS   Colige,A., Vandenberghe,I., Thiry,M., Lambert,C.A., Van Beeumen,J.,
            Li,S.W., Prockop,D.J., Lapiere,C.M. and Nusgens,B.V.
  TITLE     Cloning and characterization of ADAMTS-14, a novel ADAMTS
            displaying high homology with ADAMTS-2 and ADAMTS-3
  JOURNAL   J Biol Chem 277 (8), 5756-5766 (2002)
   PUBMED   11741898
REFERENCE   9  (bases 1 to 5557)
  AUTHORS   Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and
            Lopez-Otin,C.
  TITLE     Cloning, expression analysis, and structural characterization of
            seven novel human ADAMTSs, a family of metalloproteinases with
            disintegrin and thrombospondin-1 domains
  JOURNAL   Gene 283 (1-2), 49-62 (2002)
   PUBMED   11867212
REFERENCE   10 (bases 1 to 5557)
  AUTHORS   Bolz,H., Ramirez,A., von Brederlow,B. and Kubisch,C.
  TITLE     Characterization of ADAMTS14, a novel member of the ADAMTS
            metalloproteinase family
  JOURNAL   Biochim Biophys Acta 1522 (3), 221-225 (2001)
   PUBMED   11779638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355344.20, CN398634.1,
            AF358666.1, AK128469.1, AF366351.1 and AL358817.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 12, 2016 this sequence version replaced NM_080722.3.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motif) protein family.
            Members of the family share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            encoded preproprotein is proteolytically processed to generate the
            mature enzyme. This enzyme cleaves amino-terminal propeptides from
            type I procollagen, a necessary step in the formation of collagen
            fibers. Mutations in this gene may be associated with
            osteoarthritis in human patients. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (2) represents the shorter
            transcript and encodes the shorter isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ345098.1, AF358666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373207.2/ ENSP00000362303.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL355344.20        145112-145156
            46-236              CN398634.1         17-207
            237-260             AL355344.20        145348-145371
            261-297             CN398634.1         232-268
            298-2045            AF358666.1         1-1748
            2046-2221           AK128469.1         639-814
            2222-3994           AF366351.1         1852-3624
            3995-5557           AL358817.19        85994-87556
FEATURES             Location/Qualifiers
     source          1..5557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..5557
                     /gene="ADAMTS14"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 14"
                     /db_xref="GeneID:140766"
                     /db_xref="HGNC:HGNC:14899"
                     /db_xref="MIM:607506"
     exon            1..379
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..3969
                     /gene="ADAMTS14"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 14; a
                     disintegrin and metalloproteinase with thrombospondin
                     motifs 14"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 14 isoform 2 preproprotein"
                     /protein_id="NP_542453.2"
                     /db_xref="CCDS:CCDS7306.1"
                     /db_xref="GeneID:140766"
                     /db_xref="HGNC:HGNC:14899"
                     /db_xref="MIM:607506"
                     /translation="MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPC
                     STDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVG
                     RHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTG
                     MPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAE
                     PDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHG
                     KEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQ
                     VCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGYAPVTGMCHPLRSCALNHEDGFSS
                     AFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYL
                     PSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCS
                     HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSR
                     SCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSY
                     YVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCAR
                     GECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGAR
                     HIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKT
                     SGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSW
                     APCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTE
                     EWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQW
                     RLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV
                     RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRL
                     CCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHG
                     RATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVPEDKGQ
                     PGEDLRHPGTSLPAASPVT"
     exon            380..819
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            820..976
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1167
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1251
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1399
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1505
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1649
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1782
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1896
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2045
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2221
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2355
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2479
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2560
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2724
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2893
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3026
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3234
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3364
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3475
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..5557
                     /gene="ADAMTS14"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5557
                     /gene="ADAMTS14"
                     /note="major polyA site"
ORIGIN      
        1 actgcgcggg cgggctgacc gaccagccgg cagttggcac cgggtgcgct ggcgcgtcag
       61 tggccccgct ctccagccgg cagcctcgcg cgcccggagc cagcggtcca ggcggcggcg
      121 ccgcgcaggg gacccggagc aggcgggagg gaagcagcta ggcggggagg cggctgaggc
      181 ggcagcggcg gcagccagcc ggtgctccga cagcccgggg cgcaccctag cctcgccgcc
      241 ctcagcctgg gacttgggga tcgggcgctt gcccagcccg cgtcccagcg cggccacatg
      301 gctccactcc gcgcgctgct gtcctacctg ctgcctttgc actgtgcgct ctgcgccgcc
      361 gcgggcagcc ggaccccaga gctgcacctc tctggaaagc tcagtgacta tggtgtgaca
      421 gtgccctgca gcacagactt tcggggacgc ttcctctccc acgtggtgtc tggcccagca
      481 gcagcctctg cagggagcat ggtagtggac acgccaccca cactaccacg acactccagt
      541 cacctccggg tggctcgcag ccctctgcac ccaggaggga ccctgtggcc tggcagggtg
      601 gggcgccact ccctctactt caatgtcact gttttcggga aggaactgca cttgcgcctg
      661 cggcccaatc ggaggttggt agtgccagga tcctcagtgg agtggcagga ggattttcgg
      721 gagctgttcc ggcagccctt acggcaggag tgtgtgtaca ctggaggtgt cactggaatg
      781 cctggggcag ctgttgccat cagcaactgt gacggattgg cgggcctcat ccgcacagac
      841 agcaccgact tcttcattga gcctctggag cggggccagc aggagaagga ggccagcggg
      901 aggacacatg tggtgtaccg ccgggaggcc gtccagcagg agtgggcaga acctgacggg
      961 gacctgcaca atgaagcctt tggcctggga gaccttccca acctgctggg cctggtgggg
     1021 gaccagctgg gcgacacaga gcggaagcgg cggcatgcca agccaggcag ctacagcatc
     1081 gaggtgctgc tggtggtgga cgactcggtg gttcgcttcc atggcaagga gcatgtgcag
     1141 aactatgtcc tcaccctcat gaatatcgta gatgagattt accacgatga gtccctgggg
     1201 gttcatataa atattgccct cgtccgcttg atcatggttg gctaccgaca gtccctgagc
     1261 ctgatcgagc gcgggaaccc ctcacgcagc ctggagcagg tgtgtcgctg ggcacactcc
     1321 cagcagcgcc aggaccccag ccacgctgag caccatgacc acgttgtgtt cctcacccgg
     1381 caggactttg ggccctcagg gtatgcaccc gtcactggca tgtgtcaccc cctgaggagc
     1441 tgtgccctca accatgagga tggcttctcc tcagccttcg tgatagctca tgagaccggc
     1501 cacgtgctcg gcatggagca tgacggtcag gggaatggct gtgcagatga gaccagcctg
     1561 ggcagcgtca tggcgcccct ggtgcaggct gccttccacc gcttccattg gtcccgctgc
     1621 agcaagctgg agctcagccg ctacctcccc tcctacgact gcctcctcga tgaccccttt
     1681 gatcctgcct ggccccagcc cccagagctg cctgggatca actactcaat ggatgagcag
     1741 tgccgctttg actttggcag tggctaccag acctgcttgg cattcaggac ctttgagccc
     1801 tgcaagcagc tgtggtgcag ccatcctgac aacccgtact tctgcaagac caagaagggg
     1861 cccccgctgg atgggactga gtgtgcaccc ggcaagtggt gcttcaaagg tcactgcatc
     1921 tggaagtcgc cggagcagac atatggccag gatggaggct ggagctcctg gaccaagttt
     1981 gggtcatgtt cgcggtcatg tgggggcggg gtgcgatccc gcagccggag ctgcaacaac
     2041 ccctccccag cctatggagg ccgcctgtgc ttagggccca tgttcgagta ccaggtctgc
     2101 aacagcgagg agtgccctgg gacctacgag gacttccggg cccagcagtg tgccaagcgc
     2161 aactcctact atgtgcacca gaatgccaag cacagctggg tgccctacga gcctgacgat
     2221 gacgcccaga agtgtgagct gatctgccag tcggcggaca cgggggacgt ggtgttcatg
     2281 aaccaggtgg ttcacgatgg gacacgctgc agctaccggg acccatacag cgtctgtgcg
     2341 cgtggcgagt gtgtgcctgt cggctgtgac aaggaggtgg ggtccatgaa ggcggatgac
     2401 aagtgtggag tctgcggggg tgacaactcc cactgcagga ctgtgaaggg gacgctgggc
     2461 aaggcctcca agcaggcagg agctctcaag ctggtgcaga tcccagcagg tgccaggcac
     2521 atccagattg aggcactgga gaagtccccc caccgcattg tggtgaagaa ccaggtcacc
     2581 ggcagcttca tcctcaaccc caagggcaag gaagccacaa gccggacctt caccgccatg
     2641 ggcctggagt gggaggatgc ggtggaggat gccaaggaaa gcctcaagac cagcgggccc
     2701 ctgcctgaag ccattgccat cctggctctc cccccaactg agggtggccc ccgcagcagc
     2761 ctggcctaca agtacgtcat ccatgaggac ctgctgcccc ttatcgggag caacaatgtg
     2821 ctcctggagg agatggacac ctatgagtgg gcgctcaaga gctgggcccc ctgcagcaag
     2881 gcctgtggag gagggatcca gttcaccaaa tacggctgcc ggcgcagacg agaccaccac
     2941 atggtgcagc gacacctgtg tgaccacaag aagaggccca agcccatccg ccggcgctgc
     3001 aaccagcacc cgtgctctca gcctgtgtgg gtgacggagg agtggggtgc ctgcagccgg
     3061 agctgtggga agctgggggt gcagacacgg gggatacagt gcctgctgcc cctctccaat
     3121 ggaacccaca aggtcatgcc ggccaaagcc tgcgccgggg accggcctga ggcccgacgg
     3181 ccctgtctcc gagtgccctg cccagcccag tggaggctgg gagcctggtc ccagtgctct
     3241 gccacctgtg gagagggcat ccagcagcgg caggtggtgt gcaggaccaa cgccaacagc
     3301 ctcgggcatt gcgaggggga taggccagac actgtccagg tctgcagcct gcccgcctgt
     3361 ggaggaaatc accagaactc cacggtgagg gccgatgtct gggaacttgg gacgccagag
     3421 gggcagtggg tgccacaatc tgaaccccta catcccatta acaagatatc atcaacggag
     3481 ccctgcacgg gagacaggtc tgtcttctgc cagatggaag tgctcgatcg ctactgctcc
     3541 attcccggct accaccggct ctgctgtgtg tcctgcatca agaaggcctc gggccccaac
     3601 cctggcccag accctggccc aacctcactg ccccccttct ccactcctgg aagcccctta
     3661 ccaggacccc aggaccctgc agatgctgca gagcctcctg gaaagccaac gggatcagag
     3721 gaccatcagc atggccgagc cacacagctc ccaggagctc tggatacaag ctccccaggg
     3781 acccagcatc cctttgcccc tgagacacca atccctggag catcctggag catctcccct
     3841 accacccccg gggggctgcc ttggggctgg actcagacac ctacgccagt ccctgaggac
     3901 aaagggcaac ctggagaaga cctgagacat cccggcacca gcctccctgc tgcctccccg
     3961 gtgacatgag ctgtgccctg ccatcccact ggcacgttta cactctgtgt actgccccgt
     4021 gactcccagc tcagaggaca cacatagcag ggcaggcgca agcacagact tcattttaaa
     4081 tcattcgcct tcttctcgtt tggggctgtg atgctcttta ccccacaaag cggggtggga
     4141 ggaagacaaa gatcagggaa agccctaatc ggagatacct cagcaagctg cccccggcgg
     4201 gactgaccct ctcagggccc ctgttggtct cccctgccaa gaccagggtc aactattgct
     4261 ccctcctcac agaccctggg cctgggcagg tctgaatccc ggctggtctg tagctagaag
     4321 ctgtcagggc tgcctgcctt cccggaactg tgaggacccc tgtggaggcc ctgcatattt
     4381 ggcccctctc cccagaaagg caaagcaggg ccagggtagg tgggggactg ttcacagcca
     4441 ggccgagagg aggggggcct gggaatgtgg catgaggctt cccagctgca gggctggagg
     4501 gggtggaaca caaggtgatc gcaggcccag ctcctggaag ccaagagctc catgcagttc
     4561 caccagctga ggccaggcag cagaggccag tttgtctttg ctggccagaa gatggtgctc
     4621 atggccatac tctggccttg cagatgtcac tagtgttact tctagtgact ccagattaca
     4681 gactggcccc ccaatctcac cccagcccac cagagaaggg ggctcaggac accctggacc
     4741 ccaagtcctc agcatccagg gatttccaaa ctggcgctca ctccctgact ccaccaggat
     4801 ggcaacttca attatcactc tcagcctgga aggggactct gtgggacaca gagggaacac
     4861 gatttctcag gctgtccctt caatcattgc ccttctccga agatcgctcc tgctggagtc
     4921 ggacatcttc atcttctacc tggctcaagc tgggccagag tgtgtggttc tcccaggggt
     4981 ggttggaccc caggactgag gaccagagtc cactcatagc ctggccctgg agatgacaag
     5041 ggccacccag gccaagtgcc ccagggcagg gtgccagccc ctggcctggt gctggagtgg
     5101 ggaagacaca ctcacccacg gtgctgtaag ggcctgagct gtgctcagct gccggccatg
     5161 ctacctccaa gggacaggta acagtcttag atcctctggc tctcaggaag tggcaggggg
     5221 tcccaggaca cctccggggt cttggaggat gtctcctaaa ctcctgccag gtgatagagg
     5281 tgcttctcac ttcttccttc cccaaggcaa aggggctgtt ctgagccagc ctggaggaac
     5341 atgagtagtg ggcccctggc ctgcaacccc tttggagagt ggaggtcctg gggggctccc
     5401 cgccctcccc ctgttgccct cccctccctg ggatgctggg gcacacgcgg agtcattcct
     5461 gtgagaacca gcctggcctg tgttaaactc ttgtgccttg gaaatccaga tctttaaaat
     5521 tttatgtatt tattaacatc gccattggac cccaaaa
//
