LOCUS       NM_139027               4399 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            13 (ADAMTS13), transcript variant 2, mRNA.
ACCESSION   NM_139027
VERSION     NM_139027.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4399)
  AUTHORS   Otmani,H.E., Vanhoorelbeke,K. and Tersteeg,C.
  TITLE     Improving our understanding on the clinical role of
            plasmin-mediated von Willebrand factor degradation
  JOURNAL   Curr Opin Hematol 31 (5), 245-250 (2024)
   PUBMED   38723202
  REMARK    GeneRIF: Improving our understanding on the clinical role of
            plasmin-mediated von Willebrand factor degradation.
            Review article
REFERENCE   2  (bases 1 to 4399)
  AUTHORS   Plaimauer,B., Zimmermann,K., Volkel,D., Antoine,G.,
            Kerschbaumer,R., Jenab,P., Furlan,M., Gerritsen,H., Lammle,B.,
            Schwarz,H.P. and Scheiflinger,F.
  TITLE     Cloning, expression, and functional characterization of the von
            Willebrand factor-cleaving protease (ADAMTS13)
  JOURNAL   Blood 100 (10), 3626-3632 (2002)
   PUBMED   12393399
  REMARK    GeneRIF: Cloning, expression, and functional characterization of
            the von Willebrand factor-cleaving protease (ADAMTS13).
REFERENCE   3  (bases 1 to 4399)
  AUTHORS   Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and
            Lopez-Otin,C.
  TITLE     Cloning, expression analysis, and structural characterization of
            seven novel human ADAMTSs, a family of metalloproteinases with
            disintegrin and thrombospondin-1 domains
  JOURNAL   Gene 283 (1-2), 49-62 (2002)
   PUBMED   11867212
REFERENCE   4  (bases 1 to 4399)
  AUTHORS   Fujimura,Y., Matsumoto,M., Yagi,H., Yoshioka,A., Matsui,T. and
            Titani,K.
  TITLE     Von Willebrand factor-cleaving protease and Upshaw-Schulman
            syndrome
  JOURNAL   Int J Hematol 75 (1), 25-34 (2002)
   PUBMED   11843286
  REMARK    GeneRIF: VWF-CPis composed of a single polypeptide with a molecular
            mass of approx. 190 kD,and cDNA cloning indicated it is uniquely
            produced in the liver. Its gene is on chromosome 9q34.
            Review article
REFERENCE   5  (bases 1 to 4399)
  AUTHORS   Zheng,X., Chung,D., Takayama,T.K., Majerus,E.M., Sadler,J.E. and
            Fujikawa,K.
  TITLE     Structure of von Willebrand factor-cleaving protease (ADAMTS13), a
            metalloprotease involved in thrombotic thrombocytopenic purpura
  JOURNAL   J Biol Chem 276 (44), 41059-41063 (2001)
   PUBMED   11557746
REFERENCE   6  (bases 1 to 4399)
  AUTHORS   Levy,G.G., Nichols,W.C., Lian,E.C., Foroud,T., McClintick,J.N.,
            McGee,B.M., Yang,A.Y., Siemieniak,D.R., Stark,K.R., Gruppo,R.,
            Sarode,R., Shurin,S.B., Chandrasekaran,V., Stabler,S.P., Sabio,H.,
            Bouhassira,E.E., Upshaw,J.D. Jr., Ginsburg,D. and Tsai,H.M.
  TITLE     Mutations in a member of the ADAMTS gene family cause thrombotic
            thrombocytopenic purpura
  JOURNAL   Nature 413 (6855), 488-494 (2001)
   PUBMED   11586351
  REMARK    GeneRIF: mutation of gene causes thrombotic thrombocytopenic
            purpura
REFERENCE   7  (bases 1 to 4399)
  AUTHORS   Soejima,K., Mimura,N., Hirashima,M., Maeda,H., Hamamoto,T.,
            Nakagaki,T. and Nozaki,C.
  TITLE     A novel human metalloprotease synthesized in the liver and secreted
            into the blood: possibly, the von Willebrand factor-cleaving
            protease?
  JOURNAL   J Biochem 130 (4), 475-480 (2001)
   PUBMED   11574066
  REMARK    Erratum:[J Biochem (Tokyo) 2001 Nov;130(5):719]
REFERENCE   8  (bases 1 to 4399)
  AUTHORS   Fujikawa,K., Suzuki,H., McMullen,B. and Chung,D.
  TITLE     Purification of human von Willebrand factor-cleaving protease and
            its identification as a new member of the metalloproteinase family
  JOURNAL   Blood 98 (6), 1662-1666 (2001)
   PUBMED   11535495
REFERENCE   9  (bases 1 to 4399)
  AUTHORS   Gerritsen,H.E., Robles,R., Lammle,B. and Furlan,M.
  TITLE     Partial amino acid sequence of purified von Willebrand
            factor-cleaving protease
  JOURNAL   Blood 98 (6), 1654-1661 (2001)
   PUBMED   11535494
REFERENCE   10 (bases 1 to 4399)
  AUTHORS   Furlan,M., Robles,R. and Lammle,B.
  TITLE     Partial purification and characterization of a protease from human
            plasma cleaving von Willebrand factor to fragments produced by in
            vivo proteolysis
  JOURNAL   Blood 87 (10), 4223-4234 (1996)
   PUBMED   8639781
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL593848.15.
            
            On Mar 28, 2020 this sequence version replaced NM_139027.5.
            
            Summary: This gene encodes a member of a family of proteins
            containing several distinct regions, including a metalloproteinase
            domain, a disintegrin-like domain, and a thrombospondin type 1 (TS)
            motif. The enzyme encoded by this gene specifically cleaves von
            Willebrand Factor (vWF). Defects in this gene are associated with
            thrombotic thrombocytopenic purpura. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ420810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355699.7/ ENSP00000347927.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AL593848.15        73882-74063
            183-249             AL593848.15        74616-74682
            250-407             AL593848.15        75836-75993
            408-491             AL593848.15        77044-77127
            492-616             AL593848.15        77453-77577
            617-763             AL593848.15        77714-77860
            764-901             AL593848.15        80149-80286
            902-1064            AL593848.15        81454-81616
            1065-1169           AL593848.15        84103-84207
            1170-1321           AL593848.15        84893-85044
            1322-1385           AL593848.15        85156-85219
            1386-1512           AL593848.15        88344-88470
            1513-1661           AL593848.15        89264-89412
            1662-1782           AL593848.15        89761-89881
            1783-1863           AL593848.15        90881-90961
            1864-2045           AL593848.15        91859-92040
            2046-2181           AL593848.15        93914-94049
            2182-2311           AL593848.15        94129-94258
            2312-2497           AL593848.15        94891-95076
            2498-2687           AL593848.15        96378-96567
            2688-2808           AL593848.15        97214-97334
            2809-2938           AL593848.15        100114-100243
            2939-3121           AL593848.15        101298-101480
            3122-3326           AL593848.15        105930-106134
            3327-3477           AL593848.15        106800-106950
            3478-3624           AL593848.15        107584-107730
            3625-3801           AL593848.15        108058-108234
            3802-3986           AL593848.15        109425-109609
            3987-4399           AL593848.15        110489-110901
FEATURES             Location/Qualifiers
     source          1..4399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..4399
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 13"
                     /db_xref="GeneID:11093"
                     /db_xref="HGNC:HGNC:1366"
                     /db_xref="MIM:604134"
     exon            1..182
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..4193
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /EC_number="3.4.24.87"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; von Willebrand factor-cleaving protease; a
                     disintegrin-like and metalloprotease (reprolysin type)
                     with thrombospondin type 1 motif, 13; vWF-cleaving
                     protease"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 13 isoform 2 preproprotein"
                     /protein_id="NP_620596.2"
                     /db_xref="CCDS:CCDS6972.1"
                     /db_xref="GeneID:11093"
                     /db_xref="HGNC:HGNC:1366"
                     /db_xref="MIM:604134"
                     /translation="MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQ
                     AVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTER
                     YVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQT
                     INPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDL
                     GVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA
                     GRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQA
                     LSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGP
                     RSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQC
                     ARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRC
                     MPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGR
                     AREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDG
                     RVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKP
                     RQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLE
                     PCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALET
                     CNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAP
                     EPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLME
                     LRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVR
                     RILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGL
                     GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSC
                     GDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGT
                     IDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM
                     TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPA
                     TSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQV
                     LYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT"
     exon            183..249
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            250..407
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            408..491
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            492..616
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            617..763
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            764..901
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1064
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1169
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1321
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1385
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1512
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1661
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1782
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1863
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2045
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2181
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2311
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2497
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2687
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2808
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2938
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3121
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3326
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3477
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3624
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3801
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..3986
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4399
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4381..4386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /note="hexamer: AATAAA"
     polyA_site      4399
                     /gene="ADAMTS13"
                     /gene_synonym="ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP;
                     VWFCP"
                     /note="major polyA site"
ORIGIN      
        1 attccatact gaccagattc ccagtcacca aggccccctc tcactccgct ccactcctcg
       61 ggctggctct cctgaggatg caccagcgtc acccccgggc aagatgccct cccctctgtg
      121 tggccggaat ccttgcctgt ggctttctcc tgggctgctg gggaccctcc catttccagc
      181 agagttgtct tcaggctttg gagccacagg ccgtgtcttc ttacttgagc cctggtgctc
      241 ccttaaaagg ccgccctcct tcccctggct tccagaggca gaggcagagg cagaggcggg
      301 ctgcaggcgg catcctacac ctggagctgc tggtggccgt gggccccgat gtcttccagg
      361 ctcaccagga ggacacagag cgctatgtgc tcaccaacct caacatcggg gcagaactgc
      421 ttcgggaccc gtccctgggg gctcagtttc gggtgcacct ggtgaagatg gtcattctga
      481 cagagcctga gggtgctcca aatatcacag ccaacctcac ctcgtccctg ctgagcgtct
      541 gtgggtggag ccagaccatc aaccctgagg acgacacgga tcctggccat gctgacctgg
      601 tcctctatat cactaggttt gacctggagt tgcctgatgg taaccggcag gtgcggggcg
      661 tcacccagct gggcggtgcc tgctccccaa cctggagctg cctcattacc gaggacactg
      721 gcttcgacct gggagtcacc attgcccatg agattgggca cagcttcggc ctggagcacg
      781 acggcgcgcc cggcagcggc tgcggcccca gcggacacgt gatggcttcg gacggcgccg
      841 cgccccgcgc cggcctcgcc tggtccccct gcagccgccg gcagctgctg agcctgctca
      901 gcgcaggacg ggcgcgctgc gtgtgggacc cgccgcggcc tcaacccggg tccgcggggc
      961 acccgccgga tgcgcagcct ggcctctact acagcgccaa cgagcagtgc cgcgtggcct
     1021 tcggccccaa ggctgtcgcc tgcaccttcg ccagggagca cctggatatg tgccaggccc
     1081 tctcctgcca cacagacccg ctggaccaaa gcagctgcag ccgcctcctc gttcctctcc
     1141 tggatgggac agaatgtggc gtggagaagt ggtgctccaa gggtcgctgc cgctccctgg
     1201 tggagctgac ccccatagca gcagtgcatg ggcgctggtc tagctggggt ccccgaagtc
     1261 cttgctcccg ctcctgcgga ggaggtgtgg tcaccaggag gcggcagtgc aacaacccca
     1321 gacctgcctt tggggggcgt gcatgtgttg gtgctgacct ccaggccgag atgtgcaaca
     1381 ctcaggcctg cgagaagacc cagctggagt tcatgtcgca acagtgcgcc aggaccgacg
     1441 gccagccgct gcgctcctcc cctggcggcg cctccttcta ccactggggt gctgctgtac
     1501 cacacagcca aggggatgct ctgtgcagac acatgtgccg ggccattggc gagagcttca
     1561 tcatgaagcg tggagacagc ttcctcgatg ggacccggtg tatgccaagt ggcccccggg
     1621 aggacgggac cctgagcctg tgtgtgtcgg gcagctgcag gacatttggc tgtgatggta
     1681 ggatggactc ccagcaggta tgggacaggt gccaggtgtg tggtggggac aacagcacgt
     1741 gcagcccacg gaagggctct ttcacagctg gcagagcgag agaatatgtc acgtttctga
     1801 cagttacccc caacctgacc agtgtctaca ttgccaacca caggcctctc ttcacacact
     1861 tggcggtgag gatcggaggg cgctatgtcg tggctgggaa gatgagcatc tcccctaaca
     1921 ccacctaccc ctccctcctg gaggatggtc gtgtcgagta cagagtggcc ctcaccgagg
     1981 accggctgcc ccgcctggag gagatccgca tctggggacc cctccaggaa gatgctgaca
     2041 tccaggttta caggcggtat ggcgaggagt atggcaacct cacccgccca gacatcacct
     2101 tcacctactt ccagcctaag ccacggcagg cctgggtgtg ggccgctgtg cgtgggccct
     2161 gctcggtgag ctgtggggca gggctgcgct gggtaaacta cagctgcctg gaccaggcca
     2221 ggaaggagtt ggtggagact gtccagtgcc aagggagcca gcagccacca gcgtggccag
     2281 aggcctgcgt gctcgaaccc tgccctccct actgggcggt gggagacttc ggcccatgca
     2341 gcgcctcctg tgggggtggc ctgcgggagc ggccagtgcg ctgcgtggag gcccagggca
     2401 gcctcctgaa gacattgccc ccagcccggt gcagagcagg ggcccagcag ccagctgtgg
     2461 cgctggaaac ctgcaacccc cagccctgcc ctgccaggtg ggaggtgtca gagcccagct
     2521 catgcacatc agctggtgga gcaggcctgg ccttggagaa cgagacctgt gtgccagggg
     2581 cagatggcct ggaggctcca gtgactgagg ggcctggctc cgtagatgag aagctgcctg
     2641 cccctgagcc ctgtgtcggg atgtcatgtc ctccaggctg gggccatctg gatgccacct
     2701 ctgcagggga gaaggctccc tccccatggg gcagcatcag gacgggggct caagctgcac
     2761 acgtgtggac ccctgcggca gggtcgtgct ccgtctcctg cgggcgaggt ctgatggagc
     2821 tgcgtttcct gtgcatggac tctgccctca gggtgcctgt ccaggaagag ctgtgtggcc
     2881 tggcaagcaa gcctgggagc cggcgggagg tctgccaggc tgtcccgtgc cctgctcggt
     2941 ggcagtacaa gctggcggcc tgcagcgtga gctgtgggag aggggtcgtg cggaggatcc
     3001 tgtattgtgc ccgggcccat ggggaggacg atggtgagga gatcctgttg gacacccagt
     3061 gccaggggct gcctcgcccg gaaccccagg aggcctgcag cctggagccc tgcccaccta
     3121 ggtggaaagt catgtccctt ggcccatgtt cggccagctg tggccttggc actgctagac
     3181 gctcggtggc ctgtgtgcag ctcgaccaag gccaggacgt ggaggtggac gaggcggcct
     3241 gtgcggcgct ggtgcggccc gaggccagtg tcccctgtct cattgccgac tgcacctacc
     3301 gctggcatgt tggcacctgg atggagtgct ctgtttcctg tggggatggc atccagcgcc
     3361 ggcgtgacac ctgcctcgga ccccaggccc aggcgcctgt gccagctgat ttctgccagc
     3421 acttgcccaa gccggtgact gtgcgtggct gctgggctgg gccctgtgtg ggacagggtg
     3481 cctgtggcag gcagcacctt gagccaacag gaaccattga catgcgaggc ccagggcagg
     3541 cagactgtgc agtggccatt gggcggcccc tcggggaggt ggtgaccctc cgcgtccttg
     3601 agagttctct caactgcagt gcgggggaca tgttgctgct ttggggccgg ctcacctgga
     3661 ggaagatgtg caggaagctg ttggacatga ctttcagctc caagaccaac acgctggtgg
     3721 tgaggcagcg ctgcgggcgg ccaggaggtg gggtgctgct gcggtatggg agccagcttg
     3781 ctcctgaaac cttctacaga gaatgtgaca tgcagctctt tgggccctgg ggtgaaatcg
     3841 tgagcccctc gctgagtcca gccacgagta atgcaggggg ctgccggctc ttcattaatg
     3901 tggctccgca cgcacggatt gccatccatg ccctggccac caacatgggc gctgggaccg
     3961 agggagccaa tgccagctac atcttgatcc gggacaccca cagcttgagg accacagcgt
     4021 tccatgggca gcaggtgctc tactgggagt cagagagcag ccaggctgag atggagttca
     4081 gcgagggctt cctgaaggct caggccagcc tgcggggcca gtactggacc ctccaatcat
     4141 gggtaccgga gatgcaggac cctcagtcct ggaagggaaa ggaaggaacc tgagggtcat
     4201 tgaacatttg ttccgtgtct ggccagccct ggagggttga cccctggtct cagtgctttc
     4261 caattcgaac tttttccaat cttaggtatc tactttagag tcttctccaa tgtccaaaag
     4321 gctagggggt tggaggtggg gactctggaa aagcagcccc catttcctcg ggtaccaata
     4381 aataaaacat gcaggctga
//
