LOCUS       XM_017009909            6673 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ADAM metallopeptidase with thrombospondin
            type 1 motif 12 (ADAMTS12), transcript variant X5, mRNA.
ACCESSION   XM_017009909
VERSION     XM_017009909.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017009909.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..6673
                     /gene="ADAMTS12"
                     /gene_synonym="PRO4389"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 12; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 7 ESTs, 344 long SRA
                     reads, and 100% coverage of the annotated genomic feature
                     by RNAseq alignments, including 3 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:81792"
                     /db_xref="HGNC:HGNC:14605"
                     /db_xref="MIM:606184"
     CDS             51..3020
                     /gene="ADAMTS12"
                     /gene_synonym="PRO4389"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 12 isoform X5"
                     /protein_id="XP_016865398.1"
                     /db_xref="GeneID:81792"
                     /db_xref="HGNC:HGNC:14605"
                     /db_xref="MIM:606184"
                     /translation="MSLQKYSLCKVVIAFVQGCGVCRGFFIIRHTRMVGCDYEIDSNA
                     TEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIR
                     SEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVT
                     NPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVK
                     ATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE
                     QALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSELHWLGPNTVRHSFSCTFSCAH
                     SICFSKELISQSCFTSCSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCP
                     SSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTT
                     ASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGP
                     TSEGGLVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDE
                     SNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTTS
                     ETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTE
                     EDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMD
                     SDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPF
                     HCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRP
                     TSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPR
                     PPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTHIT
                     HTQRQRRQRLLQKSKEL"
ORIGIN      
        1 aataacaagg gtgacgccaa tccaaggttg ctcaggaagt tgctgggcag atgtcattgc
       61 aaaagtattc tttgtgtaag gttgtgatag cctttgtgca aggttgtggt gtttgcagag
      121 gctttttcat catcaggcat acaaggatgg ttggctgtga ctatgagatc gattccaatg
      181 ccaccgagga tcgctgcggt gtgtgcctgg gagatggctc ttcctgccag actgtgagaa
      241 agatgtttaa gcagaaggaa ggatctggtt atgttgacat tgggctcatt ccaaaaggag
      301 caagggacat aagagtgatg gaaattgagg gagctggaaa cttcctggcc atcaggagtg
      361 aagatcctga aaaatattac ctgaatggag ggtttattat ccagtggaac gggaactata
      421 agctggcagg gactgtcttt cagtatgaca ggaaaggaga cctggaaaag ctgatggcca
      481 caggtcccac caatgagtct gtgtggatcc agcttctatt ccaggtgact aaccctggca
      541 tcaagtatga gtacacaatc cagaaagatg gccttgacaa tgatgttgag cagcagatgt
      601 acttctggca gtacggccac tggacagagt gcagtgtgac ctgcgggaca ggtatccgcc
      661 gccaaactgc ccattgcata aagaagggcc gcgggatggt gaaagctaca ttctgtgacc
      721 cagaaacaca gcccaatggg agacagaaga agtgccatga aaaggcttgt ccacccaggt
      781 ggtgggcagg ggagtgggaa gcatgctcgg cgacatgcgg gccccacggg gagaagaagc
      841 gaaccgtgct gtgcatccag accatggtct ctgacgagca ggctctcccg cccacagact
      901 gccagcacct gctgaagccc aagaccctcc tttcctgcaa cagagacatc ctgtgcccct
      961 cggactggac agtgggcaac tggagtgagc ttcactggtt gggtccaaac acagttcgac
     1021 actccttcag ctgtacattc tcctgtgctc acagcatctg cttttcaaaa gagctgattt
     1081 cacagagctg ttttacatca tgttctgttt cctgtggtgg tggagtgcgg attcgcagtg
     1141 tcacatgtgc caagaaccat gatgaacctt gcgatgtgac aaggaaaccc aacagccgag
     1201 ctctgtgtgg cctccagcaa tgcccttcta gccggagagt tctgaaacca aacaaaggca
     1261 ctatttccaa tggaaaaaac ccaccaacac taaagcccgt ccctccacct acatccaggc
     1321 ccagaatgct gaccacaccc acagggcctg agtctatgag cacaagcact ccagcaatca
     1381 gcagccctag tcctaccaca gcctccaaag aaggagacct gggtgggaaa cagtggcaag
     1441 atagctcaac ccaacctgag ctgagctctc gctatctcat ttccactgga agcacttccc
     1501 agcccatcct cacttcccaa tccttgagca ttcagccaag tgaggaaaat gtttccagtt
     1561 cagatactgg tcctacctcg gagggaggcc ttgtagctac aacaacaagt ggttctggct
     1621 tgtcatcttc ccgcaaccct atcacttggc ctgtgactcc attttacaat accttgacca
     1681 aaggtccaga aatggagatt cacagtggct caggggaaga aagagaacag cctgaggaca
     1741 aagatgaaag caatcctgta atatggacca agatcagagt acctggaaat gacgctccag
     1801 tggaaagtac agaaatgcca cttgcacctc cactaacacc agatctcagc agggagtcct
     1861 ggtggccacc cttcagcaca gtaatggaag gactgctccc cagccaaagg cccactactt
     1921 ccgaaactgg gacacccaga gttgagggga tggttactga aaagccagcc aacactctgc
     1981 tccctctggg aggagaccac cagccagaac cctcaggaaa gacggcaaac cgtaaccacc
     2041 tgaaacttcc aaacaacatg aaccaaacaa aaagttctga accagtcctg actgaggagg
     2101 atgcaacaag tctgattact gagggctttt tgctaaatgc ctccaattac aagcagctca
     2161 caaacggcca cggctctgca cactggatcg tcggaaactg gagcgagtgc tccaccacat
     2221 gtggcctggg ggcctactgg agaagggtgg agtgcagcac ccagatggat tctgactgtg
     2281 cggccatcca gagacctgac cctgcaaaaa gatgccacct ccgtccctgt gctggctgga
     2341 aagtgggaaa ctggagcaag tgctccagaa actgcagtgg gggcttcaag atacgcgaga
     2401 ttcagtgcgt ggacagccgg gaccaccgga acctgaggcc atttcactgc cagttcctgg
     2461 ccggcattcc tcccccattg agcatgagct gtaacccgga gccctgtgag gcgtggcagg
     2521 tggagccttg gagccagtgc tccaggtcct gtggaggtgg agttcaggag agaggagtgt
     2581 tctgtccagg aggcctctgt gattggacaa aaagacccac atccaccatg tcttgcaatg
     2641 agcacctgtg ctgtcactgg gccactggga actgggacct gtgttccact tcctgtggag
     2701 gtggctttca gaagaggact gtccaatgtg tgccctcaga gggcaataaa actgaagacc
     2761 aagaccaatg tctatgtgat cacaaaccca gacctccaga attcaaaaaa tgcaaccagc
     2821 aggcctgcaa gaaaagtgcc gatttacttt gcactaagga caaactgtca gccagtttct
     2881 gccagacact gaaagccatg aagaaatgtt ctgtgcccac cgtgagggct gagtgctgct
     2941 tctcgtgtcc ccagacacac atcacacaca cccaaaggca aagaaggcaa cggttgctcc
     3001 aaaagtcaaa agaactctaa gcccaaaagg aagccagctt ccaccagact gcagcagcct
     3061 gctgaccatg acatgcttta gccctgggag ctgcttcgtt gaggttttgc ttcatatatt
     3121 tcagattcag ctttgggtca tgatgaaaca aaatccattg tgttcctcta gccaccgaat
     3181 gtccctcaca ggaggcctag gctgccgtac ttgctgctcc ctgataggaa ggtgaaatag
     3241 ctaggagaat caggcagcac ctggtatcgg ctcctgggaa aggtgccagg ttagacagat
     3301 ttgtgaaata ctgtattttt gttctccctt aaagataaaa acaaagagac cagctatttc
     3361 cctgactacc tcaagagtat caggcaacac ttacccaggg gacaaataat cttcttaatt
     3421 tatcttgatg aatacctttc tttttttttt cttgcctccc tgcctggggc agctgctatt
     3481 taaaatgtca cagcggagct ttaggaacat tcctttaatt catccaggca gaggactgct
     3541 ttcttcaccc catgttcaac tagggcagga agtgctggtt acatccctca gtctcttcct
     3601 ccatccctgt agggctccat atctgggctg cttagagtct cctgccaacc ttgggacact
     3661 agactaagag gaaacaggca taagaaacac agcctaaggg gtttaggtca cttacacaga
     3721 aaacacttct ggtttgaaga gcatttctat gaaaactcgt aaaatgcaaa tgagcagaaa
     3781 tcaatttctt aatattacag aaaaggaact gtgggccttt attcttccca ctttcctggc
     3841 aaatacacac tcctttgcag aagggaaaat gtgtcttcct ggctgacttc ctcccatcct
     3901 ccagtcccca caggaggcct gagctcaggt cccaccatcg tcttgctgca ggggctgtat
     3961 atgcaaagac cactatgacc agctctaggg ctgccacctg tcctcacctc ttctcaggtt
     4021 ggaaaatgga ggttccatat taaaatattt caaagaacca ggtaaattgt actaagtaca
     4081 agaacatagt gcaaacttct aatctagaga aaaaacattt ctaaaaagta aggtaaaggg
     4141 gatctactcc tcagtgtacc caatatgtag ttagtcttaa agatctttta ctttggggag
     4201 aacaggtgaa tcagggagtc caaagaaact gaaatgaaag ttagaatgct tgttctggat
     4261 gttcctacct cccaccagaa gtcaaagtag gcttggtctc aaattcagag caaatttcta
     4321 gacaaagtga tttctaaggg aaggtactta catgaactga acccagagaa agagggtaag
     4381 tgggtgggtg gaggggcata agcttcaaat gaaagaagat atcagaacca attcttgaca
     4441 gggagaaagg caaggatgtg gccttcatgt gatgggcagc atattttctg actcatgcac
     4501 agatacactt aatactcctc atggaacaca atatcccacg tctcccttta cctatccgtt
     4561 cagcagaatg gtgctattaa aaaaatggtg ctaatatcta gatggtggca gaattaatgt
     4621 aaacatagat aggcatacaa atgggtaagt gtatgtgaaa ctctccatat acatcttctg
     4681 ttaaacatgt aacggtgttg ctgaccaatg ccagttttat tgcttgggta ccttgaattt
     4741 aagatttaat attatgtgct ttttattttt ttccaagcca ttaacgtgta ttactctcat
     4801 gaattcctgt gaaaaataaa acagtgggat tgggatgaaa ttcaagatag accagaaaca
     4861 ggaggaaagt acaaatgttt acctaaagcc agagaattta tttctagatg ataattacat
     4921 tattgtattc tctgccttta aacataaaca ttgctggccg atagcaatct ctggtgaata
     4981 atggttttcg aggagaggag acacttaaat tgttagtgac atgagtggag gagaatctga
     5041 tatttactaa tgaggcagtt tgcaaagact gtccctgaag tgtagtgtag tctttcaggg
     5101 ggattcattt agtaagctag attgatttaa cctggtactg tactagcata gggtcaaata
     5161 cgtgtcatca gagacctggg tatgaccagg cttacaaaac tcaggaacaa actcagattc
     5221 ctactgacct caaccaacta aactaggcca aatttctccg tgtacaaaat ggaccacgtt
     5281 atttacaatc cacgtggtgg agaagatggt agacatgtgg agagagtttg gccaggtgct
     5341 ccattctagg tctttttcca gtttctcaaa ggcagaacat tggctcctaa ttatttgcca
     5401 tggatatttg cttcctgttc tggagctatg ttgtaagaca gctgtgtgat gtccatcatt
     5461 cttgactcca gaatgaagac agggcttgct gttttctgtc ctgttggtat catctgttgc
     5521 cttggcgatc actcagtgat gagtcgtcag tattttgaca tgtcccagtg cttgctgtac
     5581 aagaggggac tcagatcaac aggaagactc tgaagacagg aacctgcatg gtatcttaca
     5641 tctttgatac ttgggtgctg atatgaagca gagttgttga tttactttat ctaggccctt
     5701 ctttcttctc acctggatca agcaactgag aagtgtatca ggagacactg gatacatatc
     5761 tctatgaaat agagagggcc atcgcagggc ctggtactta actacattaa cgttctaaaa
     5821 cccagtttgg tttacgttgt ctttcacagt agtatattta gctcttctct ggaaagttgt
     5881 gggttaatat aattcttaaa catgaaaatg taattaaaca caccacgaga gaacaatatt
     5941 ccaggagact taatagtgat tactttcttc aatcaggaaa tcgtttcagt gcctcctttg
     6001 taggaatgct ttgttttgtg atgggttttc ttaaagaaga gcacacctcc gtccaatctc
     6061 ctgagacagc cacgtctccg ctgacatccc actgtgatgc tttcagatag tcagtgaatg
     6121 tttctgataa ccttcatcca gtatctgaaa cacaatgtga gagattatat tgttttagat
     6181 aataacatcc catttagttg actaaaatct tccaaactct gaaagctgca cactgctact
     6241 ccagagagtg caggtcttag ctcttctcct ttctgacttc aagatgaatc tttgggacga
     6301 tgtttctggt gcttggtcca cagtgattca cttttgaagg agaggccaca tgacatgaac
     6361 tgcctggtgt tacaacctag ctaacatatt tgatgctact cctgttgtct gtactgctta
     6421 ttcaagtagt attctaagtt atgttactaa aaaacatggt gggtaaagca caatcctacc
     6481 catcattgtc ctccaaaata attgtatgac atacacggcc cagcccattg ccctccctgc
     6541 atctctgtgc tgctttgcca tttccccttc tacccagcct cctcaagggg taccttggtg
     6601 gatatttcag tacttaaaac cagactgtaa tcataacctc cctctgtgtg gcatcaataa
     6661 atagccaaac tca
//
