LOCUS       XM_017009908            6758 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ADAM metallopeptidase with thrombospondin
            type 1 motif 12 (ADAMTS12), transcript variant X4, mRNA.
ACCESSION   XM_017009908
VERSION     XM_017009908.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..6758
                     /gene="ADAMTS12"
                     /gene_synonym="PRO4389"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 12; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 7 ESTs, 344 long SRA
                     reads, and 100% coverage of the annotated genomic feature
                     by RNAseq alignments, including 7 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:81792"
                     /db_xref="HGNC:HGNC:14605"
                     /db_xref="MIM:606184"
     CDS             124..3105
                     /gene="ADAMTS12"
                     /gene_synonym="PRO4389"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 12 isoform X4"
                     /protein_id="XP_016865397.1"
                     /db_xref="GeneID:81792"
                     /db_xref="HGNC:HGNC:14605"
                     /db_xref="MIM:606184"
                     /translation="MASFLRKCWMLSLMVPLALKAATAEMSVLMAYVRYWMVGCDYEI
                     DSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNF
                     LAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLL
                     FQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGR
                     GMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTM
                     VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSELHWLGPNTVRHSFSCTF
                     SCAHSICFSKELISQSCFTSCSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGL
                     QQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSP
                     SPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSS
                     DTGPTSEGGLVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPE
                     DKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQR
                     PTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEP
                     VLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECS
                     TQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRN
                     LRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDW
                     TKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCD
                     HKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQ
                     THITHTQRQRRQRLLQKSKEL"
ORIGIN      
        1 caccaacatt tcggcagatg cagtgcagtg aatttgacac tgttccctac aagaatgaac
       61 tctaccactg gtttcccatt tttaacccag cacatccttg tgagctctac tgccgaccca
      121 tagatggcca gttttctgag aaaatgctgg atgctgtcat tgatggtacc ccttgctttg
      181 aaggcggcaa cagcagaaat gtctgtatta atggcatatg taaggtattg gatggttggc
      241 tgtgactatg agatcgattc caatgccacc gaggatcgct gcggtgtgtg cctgggagat
      301 ggctcttcct gccagactgt gagaaagatg tttaagcaga aggaaggatc tggttatgtt
      361 gacattgggc tcattccaaa aggagcaagg gacataagag tgatggaaat tgagggagct
      421 ggaaacttcc tggccatcag gagtgaagat cctgaaaaat attacctgaa tggagggttt
      481 attatccagt ggaacgggaa ctataagctg gcagggactg tctttcagta tgacaggaaa
      541 ggagacctgg aaaagctgat ggccacaggt cccaccaatg agtctgtgtg gatccagctt
      601 ctattccagg tgactaaccc tggcatcaag tatgagtaca caatccagaa agatggcctt
      661 gacaatgatg ttgagcagca gatgtacttc tggcagtacg gccactggac agagtgcagt
      721 gtgacctgcg ggacaggtat ccgccgccaa actgcccatt gcataaagaa gggccgcggg
      781 atggtgaaag ctacattctg tgacccagaa acacagccca atgggagaca gaagaagtgc
      841 catgaaaagg cttgtccacc caggtggtgg gcaggggagt gggaagcatg ctcggcgaca
      901 tgcgggcccc acggggagaa gaagcgaacc gtgctgtgca tccagaccat ggtctctgac
      961 gagcaggctc tcccgcccac agactgccag cacctgctga agcccaagac cctcctttcc
     1021 tgcaacagag acatcctgtg cccctcggac tggacagtgg gcaactggag tgagcttcac
     1081 tggttgggtc caaacacagt tcgacactcc ttcagctgta cattctcctg tgctcacagc
     1141 atctgctttt caaaagagct gatttcacag agctgtttta catcatgttc tgtttcctgt
     1201 ggtggtggag tgcggattcg cagtgtcaca tgtgccaaga accatgatga accttgcgat
     1261 gtgacaagga aacccaacag ccgagctctg tgtggcctcc agcaatgccc ttctagccgg
     1321 agagttctga aaccaaacaa aggcactatt tccaatggaa aaaacccacc aacactaaag
     1381 cccgtccctc cacctacatc caggcccaga atgctgacca cacccacagg gcctgagtct
     1441 atgagcacaa gcactccagc aatcagcagc cctagtccta ccacagcctc caaagaagga
     1501 gacctgggtg ggaaacagtg gcaagatagc tcaacccaac ctgagctgag ctctcgctat
     1561 ctcatttcca ctggaagcac ttcccagccc atcctcactt cccaatcctt gagcattcag
     1621 ccaagtgagg aaaatgtttc cagttcagat actggtccta cctcggaggg aggccttgta
     1681 gctacaacaa caagtggttc tggcttgtca tcttcccgca accctatcac ttggcctgtg
     1741 actccatttt acaatacctt gaccaaaggt ccagaaatgg agattcacag tggctcaggg
     1801 gaagaaagag aacagcctga ggacaaagat gaaagcaatc ctgtaatatg gaccaagatc
     1861 agagtacctg gaaatgacgc tccagtggaa agtacagaaa tgccacttgc acctccacta
     1921 acaccagatc tcagcaggga gtcctggtgg ccacccttca gcacagtaat ggaaggactg
     1981 ctccccagcc aaaggcccac tacttccgaa actgggacac ccagagttga ggggatggtt
     2041 actgaaaagc cagccaacac tctgctccct ctgggaggag accaccagcc agaaccctca
     2101 ggaaagacgg caaaccgtaa ccacctgaaa cttccaaaca acatgaacca aacaaaaagt
     2161 tctgaaccag tcctgactga ggaggatgca acaagtctga ttactgaggg ctttttgcta
     2221 aatgcctcca attacaagca gctcacaaac ggccacggct ctgcacactg gatcgtcgga
     2281 aactggagcg agtgctccac cacatgtggc ctgggggcct actggagaag ggtggagtgc
     2341 agcacccaga tggattctga ctgtgcggcc atccagagac ctgaccctgc aaaaagatgc
     2401 cacctccgtc cctgtgctgg ctggaaagtg ggaaactgga gcaagtgctc cagaaactgc
     2461 agtgggggct tcaagatacg cgagattcag tgcgtggaca gccgggacca ccggaacctg
     2521 aggccatttc actgccagtt cctggccggc attcctcccc cattgagcat gagctgtaac
     2581 ccggagccct gtgaggcgtg gcaggtggag ccttggagcc agtgctccag gtcctgtgga
     2641 ggtggagttc aggagagagg agtgttctgt ccaggaggcc tctgtgattg gacaaaaaga
     2701 cccacatcca ccatgtcttg caatgagcac ctgtgctgtc actgggccac tgggaactgg
     2761 gacctgtgtt ccacttcctg tggaggtggc tttcagaaga ggactgtcca atgtgtgccc
     2821 tcagagggca ataaaactga agaccaagac caatgtctat gtgatcacaa acccagacct
     2881 ccagaattca aaaaatgcaa ccagcaggcc tgcaagaaaa gtgccgattt actttgcact
     2941 aaggacaaac tgtcagccag tttctgccag acactgaaag ccatgaagaa atgttctgtg
     3001 cccaccgtga gggctgagtg ctgcttctcg tgtccccaga cacacatcac acacacccaa
     3061 aggcaaagaa ggcaacggtt gctccaaaag tcaaaagaac tctaagccca aaaggaagcc
     3121 agcttccacc agactgcagc agcctgctga ccatgacatg ctttagccct gggagctgct
     3181 tcgttgaggt tttgcttcat atatttcaga ttcagctttg ggtcatgatg aaacaaaatc
     3241 cattgtgttc ctctagccac cgaatgtccc tcacaggagg cctaggctgc cgtacttgct
     3301 gctccctgat aggaaggtga aatagctagg agaatcaggc agcacctggt atcggctcct
     3361 gggaaaggtg ccaggttaga cagatttgtg aaatactgta tttttgttct cccttaaaga
     3421 taaaaacaaa gagaccagct atttccctga ctacctcaag agtatcaggc aacacttacc
     3481 caggggacaa ataatcttct taatttatct tgatgaatac ctttcttttt tttttcttgc
     3541 ctccctgcct ggggcagctg ctatttaaaa tgtcacagcg gagctttagg aacattcctt
     3601 taattcatcc aggcagagga ctgctttctt caccccatgt tcaactaggg caggaagtgc
     3661 tggttacatc cctcagtctc ttcctccatc cctgtagggc tccatatctg ggctgcttag
     3721 agtctcctgc caaccttggg acactagact aagaggaaac aggcataaga aacacagcct
     3781 aaggggttta ggtcacttac acagaaaaca cttctggttt gaagagcatt tctatgaaaa
     3841 ctcgtaaaat gcaaatgagc agaaatcaat ttcttaatat tacagaaaag gaactgtggg
     3901 cctttattct tcccactttc ctggcaaata cacactcctt tgcagaaggg aaaatgtgtc
     3961 ttcctggctg acttcctccc atcctccagt ccccacagga ggcctgagct caggtcccac
     4021 catcgtcttg ctgcaggggc tgtatatgca aagaccacta tgaccagctc tagggctgcc
     4081 acctgtcctc acctcttctc aggttggaaa atggaggttc catattaaaa tatttcaaag
     4141 aaccaggtaa attgtactaa gtacaagaac atagtgcaaa cttctaatct agagaaaaaa
     4201 catttctaaa aagtaaggta aaggggatct actcctcagt gtacccaata tgtagttagt
     4261 cttaaagatc ttttactttg gggagaacag gtgaatcagg gagtccaaag aaactgaaat
     4321 gaaagttaga atgcttgttc tggatgttcc tacctcccac cagaagtcaa agtaggcttg
     4381 gtctcaaatt cagagcaaat ttctagacaa agtgatttct aagggaaggt acttacatga
     4441 actgaaccca gagaaagagg gtaagtgggt gggtggaggg gcataagctt caaatgaaag
     4501 aagatatcag aaccaattct tgacagggag aaaggcaagg atgtggcctt catgtgatgg
     4561 gcagcatatt ttctgactca tgcacagata cacttaatac tcctcatgga acacaatatc
     4621 ccacgtctcc ctttacctat ccgttcagca gaatggtgct attaaaaaaa tggtgctaat
     4681 atctagatgg tggcagaatt aatgtaaaca tagataggca tacaaatggg taagtgtatg
     4741 tgaaactctc catatacatc ttctgttaaa catgtaacgg tgttgctgac caatgccagt
     4801 tttattgctt gggtaccttg aatttaagat ttaatattat gtgcttttta tttttttcca
     4861 agccattaac gtgtattact ctcatgaatt cctgtgaaaa ataaaacagt gggattggga
     4921 tgaaattcaa gatagaccag aaacaggagg aaagtacaaa tgtttaccta aagccagaga
     4981 atttatttct agatgataat tacattattg tattctctgc ctttaaacat aaacattgct
     5041 ggccgatagc aatctctggt gaataatggt tttcgaggag aggagacact taaattgtta
     5101 gtgacatgag tggaggagaa tctgatattt actaatgagg cagtttgcaa agactgtccc
     5161 tgaagtgtag tgtagtcttt cagggggatt catttagtaa gctagattga tttaacctgg
     5221 tactgtacta gcatagggtc aaatacgtgt catcagagac ctgggtatga ccaggcttac
     5281 aaaactcagg aacaaactca gattcctact gacctcaacc aactaaacta ggccaaattt
     5341 ctccgtgtac aaaatggacc acgttattta caatccacgt ggtggagaag atggtagaca
     5401 tgtggagaga gtttggccag gtgctccatt ctaggtcttt ttccagtttc tcaaaggcag
     5461 aacattggct cctaattatt tgccatggat atttgcttcc tgttctggag ctatgttgta
     5521 agacagctgt gtgatgtcca tcattcttga ctccagaatg aagacagggc ttgctgtttt
     5581 ctgtcctgtt ggtatcatct gttgccttgg cgatcactca gtgatgagtc gtcagtattt
     5641 tgacatgtcc cagtgcttgc tgtacaagag gggactcaga tcaacaggaa gactctgaag
     5701 acaggaacct gcatggtatc ttacatcttt gatacttggg tgctgatatg aagcagagtt
     5761 gttgatttac tttatctagg cccttctttc ttctcacctg gatcaagcaa ctgagaagtg
     5821 tatcaggaga cactggatac atatctctat gaaatagaga gggccatcgc agggcctggt
     5881 acttaactac attaacgttc taaaacccag tttggtttac gttgtctttc acagtagtat
     5941 atttagctct tctctggaaa gttgtgggtt aatataattc ttaaacatga aaatgtaatt
     6001 aaacacacca cgagagaaca atattccagg agacttaata gtgattactt tcttcaatca
     6061 ggaaatcgtt tcagtgcctc ctttgtagga atgctttgtt ttgtgatggg ttttcttaaa
     6121 gaagagcaca cctccgtcca atctcctgag acagccacgt ctccgctgac atcccactgt
     6181 gatgctttca gatagtcagt gaatgtttct gataaccttc atccagtatc tgaaacacaa
     6241 tgtgagagat tatattgttt tagataataa catcccattt agttgactaa aatcttccaa
     6301 actctgaaag ctgcacactg ctactccaga gagtgcaggt cttagctctt ctcctttctg
     6361 acttcaagat gaatctttgg gacgatgttt ctggtgcttg gtccacagtg attcactttt
     6421 gaaggagagg ccacatgaca tgaactgcct ggtgttacaa cctagctaac atatttgatg
     6481 ctactcctgt tgtctgtact gcttattcaa gtagtattct aagttatgtt actaaaaaac
     6541 atggtgggta aagcacaatc ctacccatca ttgtcctcca aaataattgt atgacataca
     6601 cggcccagcc cattgccctc cctgcatctc tgtgctgctt tgccatttcc ccttctaccc
     6661 agcctcctca aggggtacct tggtggatat ttcagtactt aaaaccagac tgtaatcata
     6721 acctccctct gtgtggcatc aataaatagc caaactca
//
