LOCUS       XM_017009905            8683 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ADAM metallopeptidase with thrombospondin
            type 1 motif 12 (ADAMTS12), transcript variant X1, mRNA.
ACCESSION   XM_017009905
VERSION     XM_017009905.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017009905.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..8683
                     /gene="ADAMTS12"
                     /gene_synonym="PRO4389"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 12; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 8 ESTs, 526 long SRA
                     reads, and 100% coverage of the annotated genomic feature
                     by RNAseq alignments, including 9 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:81792"
                     /db_xref="HGNC:HGNC:14605"
                     /db_xref="MIM:606184"
     CDS             135..5030
                     /gene="ADAMTS12"
                     /gene_synonym="PRO4389"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 12 isoform X1"
                     /protein_id="XP_016865394.1"
                     /db_xref="GeneID:81792"
                     /db_xref="HGNC:HGNC:14605"
                     /db_xref="MIM:606184"
                     /translation="MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEH
                     FIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDL
                     FFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSAC
                     HGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQ
                     KQELWREKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMN
                     MVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDL
                     NPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAH
                     ELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGF
                     CLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCR
                     SKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAE
                     RLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWF
                     PIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEI
                     DSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNF
                     LAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLL
                     FQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGR
                     GMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTM
                     VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSELHWLGPNTVRHSFSCTF
                     SCAHSICFSKELISQSCFTSCSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGL
                     QQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSP
                     SPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSS
                     DTGPTSEGGLVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPE
                     DKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQR
                     PTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEP
                     VLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECS
                     TQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRN
                     LRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDW
                     TKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCD
                     HKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQ
                     THITHTQRQRRQRLLQKSKEL"
ORIGIN      
        1 agctttgcag tcgctgcctt ctcgcgcctg accatgcacc cctgcatctt cctgctgggc
       61 cacaggcgag cgctttattt ctggagctga gggctaaaac ttttttgact tttcttctcc
      121 tcaacatctg aatcatgcca tgtgcccaga ggagctggct tgcaaacctt tccgtggtgg
      181 ctcagctcct taactttggg gcgctttgct atgggagaca gcctcagcca ggcccggttc
      241 gcttcccgga caggaggcaa gagcatttta tcaagggcct gccagaatac cacgtggtgg
      301 gtccagtccg agtagatgcc agtgggcatt ttttgtcata tggcttgcac tatcccatca
      361 cgagcagcag gaggaagaga gatttggatg gctcagagga ctgggtgtac tacagaattt
      421 ctcacgagga gaaggacctg ttttttaact tgacggtcaa tcaaggattt ctttccaata
      481 gctacatcat ggagaagaga tatgggaacc tctcccatgt taagatgatg gcttcctctg
      541 cccccctctg ccatctcagt ggcacggttc tacagcaggg caccagagtt gggacggcag
      601 ccctcagtgc ctgccatgga ctgactggat ttttccaact accacatgga gactttttca
      661 ttgaacccgt gaagaagcat ccactggttg agggagggta ccacccgcac atcgtttaca
      721 ggaggcagaa agttccagaa accaaggagc caacctgtgg attaaaggac agtgttaaca
      781 tctcccagaa gcaagagcta tggcgggaga agtgggagag gcacaacttg ccaagcagaa
      841 gcctctctcg gcgttccatc agcaaggaga gatgggtgga gacactggtg gtggccgaca
      901 caaagatgat tgaataccat gggagtgaga atgtggagtc ctacatcctc accatcatga
      961 acatggtcac tgggttgttc cataacccaa gcattggcaa tgcaattcac attgttgtgg
     1021 ttcggctcat tctactcgaa gaagaagagc aaggactgaa aatagttcac catgcagaaa
     1081 agacactgtc tagcttctgc aagtggcaga agagtatcaa tcccaagagt gacctcaatc
     1141 ctgttcatca cgacgtggct gtccttctca ccagaaagga catctgtgct ggtttcaatc
     1201 gcccctgcga gaccctgggc ctgtctcacc tttcaggaat gtgtcagcct caccgcagtt
     1261 gtaacatcaa tgaagattcg ggactccctc tggctttcac aattgcccat gagctaggac
     1321 acagcttcgg catccagcat gatgggaaag aaaatgactg tgagcctgtg ggcagacatc
     1381 cgtacatcat gtcccgccag ctccagtacg atcccactcc gctgacatgg tccaagtgca
     1441 gcgaggagta catcacccgc ttcttggacc gaggctgggg gttctgtctt gatgacatac
     1501 ctaaaaagaa aggcttgaag tccaaggtca ttgcccccgg agtgatctat gatgttcacc
     1561 accagtgcca gctacaatat ggacccaatg ctaccttctg ccaggaagta gaaaacgtct
     1621 gccagacact gtggtgctcc gtgaagggct tttgtcgctc taagctggac gctgctgcag
     1681 atggaactca atgtggtgag aagaagtggt gtatggcagg caagtgcatc acagtgggga
     1741 agaaaccaga gagcattcct ggaggctggg gccgctggtc accctggtcc cactgttcca
     1801 ggacctgtgg ggctggagtc cagagcgcag agaggctctg caacaacccc gagccaaagt
     1861 ttggagggaa atattgcact ggagaaagaa aacgctatcg cttgtgcaac gtccacccct
     1921 gtcgctcaga ggcaccaaca tttcggcaga tgcagtgcag tgaatttgac actgttccct
     1981 acaagaatga actctaccac tggtttccca tttttaaccc agcacatcct tgtgagctct
     2041 actgccgacc catagatggc cagttttctg agaaaatgct ggatgctgtc attgatggta
     2101 ccccttgctt tgaaggcggc aacagcagaa atgtctgtat taatggcata tgtaagatgg
     2161 ttggctgtga ctatgagatc gattccaatg ccaccgagga tcgctgcggt gtgtgcctgg
     2221 gagatggctc ttcctgccag actgtgagaa agatgtttaa gcagaaggaa ggatctggtt
     2281 atgttgacat tgggctcatt ccaaaaggag caagggacat aagagtgatg gaaattgagg
     2341 gagctggaaa cttcctggcc atcaggagtg aagatcctga aaaatattac ctgaatggag
     2401 ggtttattat ccagtggaac gggaactata agctggcagg gactgtcttt cagtatgaca
     2461 ggaaaggaga cctggaaaag ctgatggcca caggtcccac caatgagtct gtgtggatcc
     2521 agcttctatt ccaggtgact aaccctggca tcaagtatga gtacacaatc cagaaagatg
     2581 gccttgacaa tgatgttgag cagcagatgt acttctggca gtacggccac tggacagagt
     2641 gcagtgtgac ctgcgggaca ggtatccgcc gccaaactgc ccattgcata aagaagggcc
     2701 gcgggatggt gaaagctaca ttctgtgacc cagaaacaca gcccaatggg agacagaaga
     2761 agtgccatga aaaggcttgt ccacccaggt ggtgggcagg ggagtgggaa gcatgctcgg
     2821 cgacatgcgg gccccacggg gagaagaagc gaaccgtgct gtgcatccag accatggtct
     2881 ctgacgagca ggctctcccg cccacagact gccagcacct gctgaagccc aagaccctcc
     2941 tttcctgcaa cagagacatc ctgtgcccct cggactggac agtgggcaac tggagtgagc
     3001 ttcactggtt gggtccaaac acagttcgac actccttcag ctgtacattc tcctgtgctc
     3061 acagcatctg cttttcaaaa gagctgattt cacagagctg ttttacatca tgttctgttt
     3121 cctgtggtgg tggagtgcgg attcgcagtg tcacatgtgc caagaaccat gatgaacctt
     3181 gcgatgtgac aaggaaaccc aacagccgag ctctgtgtgg cctccagcaa tgcccttcta
     3241 gccggagagt tctgaaacca aacaaaggca ctatttccaa tggaaaaaac ccaccaacac
     3301 taaagcccgt ccctccacct acatccaggc ccagaatgct gaccacaccc acagggcctg
     3361 agtctatgag cacaagcact ccagcaatca gcagccctag tcctaccaca gcctccaaag
     3421 aaggagacct gggtgggaaa cagtggcaag atagctcaac ccaacctgag ctgagctctc
     3481 gctatctcat ttccactgga agcacttccc agcccatcct cacttcccaa tccttgagca
     3541 ttcagccaag tgaggaaaat gtttccagtt cagatactgg tcctacctcg gagggaggcc
     3601 ttgtagctac aacaacaagt ggttctggct tgtcatcttc ccgcaaccct atcacttggc
     3661 ctgtgactcc attttacaat accttgacca aaggtccaga aatggagatt cacagtggct
     3721 caggggaaga aagagaacag cctgaggaca aagatgaaag caatcctgta atatggacca
     3781 agatcagagt acctggaaat gacgctccag tggaaagtac agaaatgcca cttgcacctc
     3841 cactaacacc agatctcagc agggagtcct ggtggccacc cttcagcaca gtaatggaag
     3901 gactgctccc cagccaaagg cccactactt ccgaaactgg gacacccaga gttgagggga
     3961 tggttactga aaagccagcc aacactctgc tccctctggg aggagaccac cagccagaac
     4021 cctcaggaaa gacggcaaac cgtaaccacc tgaaacttcc aaacaacatg aaccaaacaa
     4081 aaagttctga accagtcctg actgaggagg atgcaacaag tctgattact gagggctttt
     4141 tgctaaatgc ctccaattac aagcagctca caaacggcca cggctctgca cactggatcg
     4201 tcggaaactg gagcgagtgc tccaccacat gtggcctggg ggcctactgg agaagggtgg
     4261 agtgcagcac ccagatggat tctgactgtg cggccatcca gagacctgac cctgcaaaaa
     4321 gatgccacct ccgtccctgt gctggctgga aagtgggaaa ctggagcaag tgctccagaa
     4381 actgcagtgg gggcttcaag atacgcgaga ttcagtgcgt ggacagccgg gaccaccgga
     4441 acctgaggcc atttcactgc cagttcctgg ccggcattcc tcccccattg agcatgagct
     4501 gtaacccgga gccctgtgag gcgtggcagg tggagccttg gagccagtgc tccaggtcct
     4561 gtggaggtgg agttcaggag agaggagtgt tctgtccagg aggcctctgt gattggacaa
     4621 aaagacccac atccaccatg tcttgcaatg agcacctgtg ctgtcactgg gccactggga
     4681 actgggacct gtgttccact tcctgtggag gtggctttca gaagaggact gtccaatgtg
     4741 tgccctcaga gggcaataaa actgaagacc aagaccaatg tctatgtgat cacaaaccca
     4801 gacctccaga attcaaaaaa tgcaaccagc aggcctgcaa gaaaagtgcc gatttacttt
     4861 gcactaagga caaactgtca gccagtttct gccagacact gaaagccatg aagaaatgtt
     4921 ctgtgcccac cgtgagggct gagtgctgct tctcgtgtcc ccagacacac atcacacaca
     4981 cccaaaggca aagaaggcaa cggttgctcc aaaagtcaaa agaactctaa gcccaaaagg
     5041 aagccagctt ccaccagact gcagcagcct gctgaccatg acatgcttta gccctgggag
     5101 ctgcttcgtt gaggttttgc ttcatatatt tcagattcag ctttgggtca tgatgaaaca
     5161 aaatccattg tgttcctcta gccaccgaat gtccctcaca ggaggcctag gctgccgtac
     5221 ttgctgctcc ctgataggaa ggtgaaatag ctaggagaat caggcagcac ctggtatcgg
     5281 ctcctgggaa aggtgccagg ttagacagat ttgtgaaata ctgtattttt gttctccctt
     5341 aaagataaaa acaaagagac cagctatttc cctgactacc tcaagagtat caggcaacac
     5401 ttacccaggg gacaaataat cttcttaatt tatcttgatg aatacctttc tttttttttt
     5461 cttgcctccc tgcctggggc agctgctatt taaaatgtca cagcggagct ttaggaacat
     5521 tcctttaatt catccaggca gaggactgct ttcttcaccc catgttcaac tagggcagga
     5581 agtgctggtt acatccctca gtctcttcct ccatccctgt agggctccat atctgggctg
     5641 cttagagtct cctgccaacc ttgggacact agactaagag gaaacaggca taagaaacac
     5701 agcctaaggg gtttaggtca cttacacaga aaacacttct ggtttgaaga gcatttctat
     5761 gaaaactcgt aaaatgcaaa tgagcagaaa tcaatttctt aatattacag aaaaggaact
     5821 gtgggccttt attcttccca ctttcctggc aaatacacac tcctttgcag aagggaaaat
     5881 gtgtcttcct ggctgacttc ctcccatcct ccagtcccca caggaggcct gagctcaggt
     5941 cccaccatcg tcttgctgca ggggctgtat atgcaaagac cactatgacc agctctaggg
     6001 ctgccacctg tcctcacctc ttctcaggtt ggaaaatgga ggttccatat taaaatattt
     6061 caaagaacca ggtaaattgt actaagtaca agaacatagt gcaaacttct aatctagaga
     6121 aaaaacattt ctaaaaagta aggtaaaggg gatctactcc tcagtgtacc caatatgtag
     6181 ttagtcttaa agatctttta ctttggggag aacaggtgaa tcagggagtc caaagaaact
     6241 gaaatgaaag ttagaatgct tgttctggat gttcctacct cccaccagaa gtcaaagtag
     6301 gcttggtctc aaattcagag caaatttcta gacaaagtga tttctaaggg aaggtactta
     6361 catgaactga acccagagaa agagggtaag tgggtgggtg gaggggcata agcttcaaat
     6421 gaaagaagat atcagaacca attcttgaca gggagaaagg caaggatgtg gccttcatgt
     6481 gatgggcagc atattttctg actcatgcac agatacactt aatactcctc atggaacaca
     6541 atatcccacg tctcccttta cctatccgtt cagcagaatg gtgctattaa aaaaatggtg
     6601 ctaatatcta gatggtggca gaattaatgt aaacatagat aggcatacaa atgggtaagt
     6661 gtatgtgaaa ctctccatat acatcttctg ttaaacatgt aacggtgttg ctgaccaatg
     6721 ccagttttat tgcttgggta ccttgaattt aagatttaat attatgtgct ttttattttt
     6781 ttccaagcca ttaacgtgta ttactctcat gaattcctgt gaaaaataaa acagtgggat
     6841 tgggatgaaa ttcaagatag accagaaaca ggaggaaagt acaaatgttt acctaaagcc
     6901 agagaattta tttctagatg ataattacat tattgtattc tctgccttta aacataaaca
     6961 ttgctggccg atagcaatct ctggtgaata atggttttcg aggagaggag acacttaaat
     7021 tgttagtgac atgagtggag gagaatctga tatttactaa tgaggcagtt tgcaaagact
     7081 gtccctgaag tgtagtgtag tctttcaggg ggattcattt agtaagctag attgatttaa
     7141 cctggtactg tactagcata gggtcaaata cgtgtcatca gagacctggg tatgaccagg
     7201 cttacaaaac tcaggaacaa actcagattc ctactgacct caaccaacta aactaggcca
     7261 aatttctccg tgtacaaaat ggaccacgtt atttacaatc cacgtggtgg agaagatggt
     7321 agacatgtgg agagagtttg gccaggtgct ccattctagg tctttttcca gtttctcaaa
     7381 ggcagaacat tggctcctaa ttatttgcca tggatatttg cttcctgttc tggagctatg
     7441 ttgtaagaca gctgtgtgat gtccatcatt cttgactcca gaatgaagac agggcttgct
     7501 gttttctgtc ctgttggtat catctgttgc cttggcgatc actcagtgat gagtcgtcag
     7561 tattttgaca tgtcccagtg cttgctgtac aagaggggac tcagatcaac aggaagactc
     7621 tgaagacagg aacctgcatg gtatcttaca tctttgatac ttgggtgctg atatgaagca
     7681 gagttgttga tttactttat ctaggccctt ctttcttctc acctggatca agcaactgag
     7741 aagtgtatca ggagacactg gatacatatc tctatgaaat agagagggcc atcgcagggc
     7801 ctggtactta actacattaa cgttctaaaa cccagtttgg tttacgttgt ctttcacagt
     7861 agtatattta gctcttctct ggaaagttgt gggttaatat aattcttaaa catgaaaatg
     7921 taattaaaca caccacgaga gaacaatatt ccaggagact taatagtgat tactttcttc
     7981 aatcaggaaa tcgtttcagt gcctcctttg taggaatgct ttgttttgtg atgggttttc
     8041 ttaaagaaga gcacacctcc gtccaatctc ctgagacagc cacgtctccg ctgacatccc
     8101 actgtgatgc tttcagatag tcagtgaatg tttctgataa ccttcatcca gtatctgaaa
     8161 cacaatgtga gagattatat tgttttagat aataacatcc catttagttg actaaaatct
     8221 tccaaactct gaaagctgca cactgctact ccagagagtg caggtcttag ctcttctcct
     8281 ttctgacttc aagatgaatc tttgggacga tgtttctggt gcttggtcca cagtgattca
     8341 cttttgaagg agaggccaca tgacatgaac tgcctggtgt tacaacctag ctaacatatt
     8401 tgatgctact cctgttgtct gtactgctta ttcaagtagt attctaagtt atgttactaa
     8461 aaaacatggt gggtaaagca caatcctacc catcattgtc ctccaaaata attgtatgac
     8521 atacacggcc cagcccattg ccctccctgc atctctgtgc tgctttgcca tttccccttc
     8581 tacccagcct cctcaagggg taccttggtg gatatttcag tacttaaaac cagactgtaa
     8641 tcataacctc cctctgtgtg gcatcaataa atagccaaac tca
//
