LOCUS       NM_030957               4251 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            10 (ADAMTS10), transcript variant 1, mRNA.
ACCESSION   NM_030957
VERSION     NM_030957.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4251)
  AUTHORS   Levitas,A., Aspit,L., Lowenthal,N., Shaki,D., Krymko,H.,
            Slanovic,L., Yagev,R. and Parvari,R.
  TITLE     A Novel Mutation in the ADAMTS10 Associated with Weil-Marchesani
            Syndrome with a Unique Presentation of Developed Membranes Causing
            Severe Stenosis of the Supra Pulmonic, Supramitral, and Subaortic
            Areas in the Heart
  JOURNAL   Int J Mol Sci 24 (10), 8864 (2023)
   PUBMED   37240210
  REMARK    GeneRIF: A Novel Mutation in the ADAMTS10 Associated with
            Weil-Marchesani Syndrome with a Unique Presentation of Developed
            Membranes Causing Severe Stenosis of the Supra Pulmonic,
            Supramitral, and Subaortic Areas in the Heart.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4251)
  AUTHORS   Zhou,J., Li,T., Chen,H., Jiang,Y., Zhao,Y., Huang,J., Chen,Z.,
            Tang,X., Huang,Z. and Yang,Z.
  TITLE     ADAMTS10 inhibits aggressiveness via JAK/STAT/c-MYC pathway and
            reprograms macrophage to create an anti-malignant microenvironment
            in gastric cancer
  JOURNAL   Gastric Cancer 25 (6), 1002-1016 (2022)
   PUBMED   35925524
  REMARK    GeneRIF: ADAMTS10 inhibits aggressiveness via JAK/STAT/c-MYC
            pathway and reprograms macrophage to create an anti-malignant
            microenvironment in gastric cancer.
REFERENCE   3  (bases 1 to 4251)
  AUTHORS   Aviram,R., Zaffryar-Eilot,S., Hubmacher,D., Grunwald,H., Maki,J.M.,
            Myllyharju,J., Apte,S.S. and Hasson,P.
  TITLE     Interactions between lysyl oxidases and ADAMTS proteins suggest a
            novel crosstalk between two extracellular matrix families
  JOURNAL   Matrix Biol 75-76, 114-125 (2019)
   PUBMED   29758265
REFERENCE   4  (bases 1 to 4251)
  AUTHORS   Cain,S.A., Mularczyk,E.J., Singh,M., Massam-Wu,T. and Kielty,C.M.
  TITLE     ADAMTS-10 and -6 differentially regulate cell-cell junctions and
            focal adhesions
  JOURNAL   Sci Rep 6, 35956 (2016)
   PUBMED   27779234
  REMARK    GeneRIF: Using siRNA, over-expression and mutagenesis, it was found
            ADAMTS6 inhibits and ADAMTS10 is required for focal adhesions,
            epithelial cell-cell junction formation, and microfibril
            deposition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4251)
  AUTHORS   Kuchtey,J., Kunkel,J., Esson,D., Sapienza,J.S., Ward,D.A.,
            Plummer,C.E., Gelatt,K.N. and Kuchtey,R.W.
  TITLE     Screening ADAMTS10 in dog populations supports Gly661Arg as the
            glaucoma-causing variant in beagles
  JOURNAL   Invest Ophthalmol Vis Sci 54 (3), 1881-1886 (2013)
   PUBMED   23422823
  REMARK    GeneRIF: These findings support the Gly661Arg mutation of ADAMTS10
            as the likely cause of POAG in beagles.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4251)
  AUTHORS   Apte,S.S.
  TITLE     A disintegrin-like and metalloprotease (reprolysin type) with
            thrombospondin type 1 motifs: the ADAMTS family
  JOURNAL   Int J Biochem Cell Biol 36 (6), 981-985 (2004)
   PUBMED   15094112
  REMARK    Review article
REFERENCE   7  (bases 1 to 4251)
  AUTHORS   Faivre,L., Dollfus,H., Lyonnet,S., Alembik,Y., Megarbane,A.,
            Samples,J., Gorlin,R.J., Alswaid,A., Feingold,J., Le Merrer,M.,
            Munnich,A. and Cormier-Daire,V.
  TITLE     Clinical homogeneity and genetic heterogeneity in Weill-Marchesani
            syndrome
  JOURNAL   Am J Med Genet A 123A (2), 204-207 (2003)
   PUBMED   14598350
  REMARK    Review article
REFERENCE   8  (bases 1 to 4251)
  AUTHORS   Faivre,L., Megarbane,A., Alswaid,A., Zylberberg,L., Aldohayan,N.,
            Campos-Xavier,B., Bacq,D., Legeai-Mallet,L., Bonaventure,J.,
            Munnich,A. and Cormier-Daire,V.
  TITLE     Homozygosity mapping of a Weill-Marchesani syndrome locus to
            chromosome 19p13.3-p13.2
  JOURNAL   Hum Genet 110 (4), 366-370 (2002)
   PUBMED   11941487
REFERENCE   9  (bases 1 to 4251)
  AUTHORS   Tang,B.L.
  TITLE     ADAMTS: a novel family of extracellular matrix proteases
  JOURNAL   Int J Biochem Cell Biol 33 (1), 33-44 (2001)
   PUBMED   11167130
  REMARK    Review article
REFERENCE   10 (bases 1 to 4251)
  AUTHORS   Marzin,P., Cormier-Daire,V. and Tsilou,E.
  TITLE     Weill-Marchesani Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301293
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN431169.1, AB209515.1,
            AF163762.1, BC029308.1, AC130469.2, AK131414.1 and BF510205.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_030957.3.
            
            Summary: This gene belongs to the ADAMTS (a disintegrin and
            metalloproteinase domain with thrombospondin type-1 motifs) family
            of zinc-dependent proteases. ADAMTS proteases are complex secreted
            enzymes containing a prometalloprotease domain of the reprolysin
            type attached to an ancillary domain with a highly conserved
            structure that includes at least one thrombospondin type 1 repeat.
            They have been demonstrated to have important roles in connective
            tissue organization, coagulation, inflammation, arthritis,
            angiogenesis and cell migration. The product of this gene plays a
            major role in growth and in skin, lens, and heart development. It
            is also a candidate gene for autosomal recessive Weill-Marchesani
            syndrome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF163762.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000597188.6/ ENSP00000471851.1
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               CN431169.1         26-212
            188-1096            AB209515.1         39-947
            1097-2568           AB209515.1         953-2424
            2569-3003           AF163762.1         2205-2639
            3004-3428           BC029308.1         371-795
            3429-3588           AF163762.1         3065-3224
            3589-3589           AC130469.2         23035-23035         c
            3590-3836           AK131414.1         1799-2045
            3837-4249           AK131414.1         2047-2459
            4250-4251           BF510205.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..4251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4251
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 10"
                     /db_xref="GeneID:81794"
                     /db_xref="HGNC:HGNC:13201"
                     /db_xref="MIM:608990"
     exon            1..72
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            73..187
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..374
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..3598
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin-like and metalloprotease
                     (reprolysin type) with thrombospondin type 1 motif, 10;
                     zinc metalloendopeptidase; a disintegrin and
                     metalloproteinase with thrombospondin motifs 10; ADAM-TS
                     10"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 10 isoform 1 preproprotein"
                     /protein_id="NP_112219.3"
                     /db_xref="CCDS:CCDS12206.1"
                     /db_xref="GeneID:81794"
                     /db_xref="HGNC:HGNC:13201"
                     /db_xref="MIM:608990"
                     /translation="MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFP
                     TRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHV
                     SVEYWTREGLAWQRAARPHCLYAGHLQGQASSSHVAISTCGGLHGLIVADEEEYLIEP
                     LHGGPKGSRSPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPAR
                     PLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQ
                     DSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPEN
                     GVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAH
                     EIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLG
                     LCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRC
                     ITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGG
                     VSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGK
                     FYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGC
                     DRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLN
                     LSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASL
                     IVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQL
                     DSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRR
                     VSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCK
                     SADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRC
                     TSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCS
                     RAYFRQMCCKTCHGH"
     exon            375..721
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..878
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1096
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1180
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1326
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1370
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1476
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1623
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1765
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1873
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2019
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2083
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2186
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2320
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2444
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2525
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2689
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2816
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2946
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3151
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3328
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3488
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..4251
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4219..4224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /note="hexamer: AATAAA"
     polyA_site      4251
                     /gene="ADAMTS10"
                     /gene_synonym="ADAM-TS10; ADAMTS-10; WMS; WMS1"
                     /note="major polyA site"
ORIGIN      
        1 ccctcccttc ctgcgcgcgc ggggcggcga gacagcggcg gcgacggcgc ggaggccccg
       61 ggcgcggcgc aggctccaaa gaagaagaaa ccaaggccca gagagggagg cccaggtgca
      121 gggagcaggc gagggaagga tccgtacagg ggcccaacac tactccacca accgaagccc
      181 ccaaaaggag cccggtgatg ctgcgaaggc tgtgaacagg ggaggcggca ctgtgggggc
      241 tgccggcagc cggggctggg gagagacatg tggacacgtg gcctctatgg ctcccgcctg
      301 ccagatcctc cgctgggccc tcgccctggg gctgggcctc atgttcgagg tcacgcacgc
      361 cttccggtct caagatgagt tcctgtccag tctggagagc tatgagatcg ccttccccac
      421 ccgcgtggac cacaacgggg cactgctggc cttctcgcca cctcctcccc ggaggcagcg
      481 ccgcggcacg ggggccacag ccgagtcccg cctcttctac aaagtggcct cgcccagcac
      541 ccacttcctg ctgaacctga cccgcagctc ccgtctactg gcagggcacg tctccgtgga
      601 gtactggaca cgggagggcc tggcctggca gagggcggcc cggccccact gcctctacgc
      661 tggtcacctg cagggccagg ccagcagctc ccatgtggcc atcagcacct gtggaggcct
      721 gcacggcctg atcgtggcag acgaggaaga gtacctgatt gagcccctgc acggtgggcc
      781 caagggttct cggagcccgg aggaaagtgg accacatgtg gtgtacaagc gttcctctct
      841 gcgtcacccc cacctggaca cagcctgtgg agtgagagat gagaaaccgt ggaaagggcg
      901 gccatggtgg ctgcggacct tgaagccacc gcctgccagg cccctgggga atgaaacaga
      961 gcgtggccag ccaggcctga agcgatcggt cagccgagag cgctacgtgg agaccctggt
     1021 ggtggctgac aagatgatgg tggcctatca cgggcgccgg gatgtggagc agtatgtcct
     1081 ggccatcatg aacattgttg ccaaactttt ccaggactcg agtctgggaa gcaccgttaa
     1141 catcctcgta actcgcctca tcctgctcac ggaggaccag cccactctgg agatcaccca
     1201 ccatgccggg aagtccctgg acagcttctg taagtggcag aaatccatcg tgaaccacag
     1261 cggccatggc aatgccattc cagagaacgg tgtggctaac catgacacag cagtgctcat
     1321 cacacgctat gacatctgca tctacaagaa caaaccctgc ggcacactag gcctggcccc
     1381 ggtgggcgga atgtgtgagc gcgagagaag ctgcagcgtc aatgaggaca ttggcctggc
     1441 cacagcgttc accattgccc acgagatcgg gcacacattc ggcatgaacc atgacggcgt
     1501 gggaaacagc tgtggggccc gtggtcagga cccagccaag ctcatggctg cccacattac
     1561 catgaagacc aacccattcg tgtggtcatc ctgcagccgt gactacatca ccagctttct
     1621 agactcgggc ctggggctct gcctgaacaa ccggcccccc agacaggact ttgtgtaccc
     1681 gacagtggca ccgggccaag cctacgatgc agatgagcaa tgccgctttc agcatggagt
     1741 caaatcgcgt cagtgtaaat acggggaggt ctgcagcgag ctgtggtgtc tgagcaagag
     1801 caaccggtgc atcaccaaca gcatcccggc cgccgagggc acgctgtgcc agacgcacac
     1861 catcgacaag gggtggtgct acaaacgggt ctgtgtcccc tttgggtcgc gcccagaggg
     1921 tgtggacgga gcctgggggc cgtggactcc atggggcgac tgcagccgga cctgtggcgg
     1981 cggcgtgtcc tcttctagcc gtcactgcga cagccccagg ccaaccatcg ggggcaagta
     2041 ctgtctgggt gagagaaggc ggcaccgctc ctgcaacacg gatgactgtc cccctggctc
     2101 ccaggacttc agagaagtgc agtgttctga atttgacagc atccctttcc gtgggaaatt
     2161 ctacaagtgg aaaacgtacc ggggaggggg cgtgaaggcc tgctcgctca cgtgcctagc
     2221 ggaaggcttc aacttctaca cggagagggc ggcagccgtg gtggacggga caccctgccg
     2281 tccagacacg gtggacattt gcgtcagtgg cgaatgcaag cacgtgggct gcgaccgagt
     2341 cctgggctcc gacctgcggg aggacaagtg ccgagtgtgt ggcggtgacg gcagtgcctg
     2401 cgagaccatc gagggcgtct tcagcccagc ctcacctggg gccgggtacg aggatgtcgt
     2461 ctggattccc aaaggctccg tccacatctt catccaggat ctgaacctct ctctcagtca
     2521 cttggccctg aagggagacc aggagtccct gctgctggag gggctgcctg ggacccccca
     2581 gccccaccgt ctgcctctag ctgggaccac ctttcaactg cgacaggggc cagaccaggt
     2641 ccagagcctc gaagccctgg gaccgattaa tgcatctctc atcgtcatgg tgctggcccg
     2701 gaccgagctg cctgccctcc gctaccgctt caatgccccc atcgcccgtg actcgctgcc
     2761 cccctactcc tggcactatg cgccctggac caagtgctcg gcccagtgtg caggcggtag
     2821 ccaggtgcag gcggtggagt gccgcaacca gctggacagc tccgcggtcg ccccccacta
     2881 ctgcagtgcc cacagcaagc tgcccaaaag gcagcgcgcc tgcaacacgg agccttgccc
     2941 tccagactgg gttgtaggga actggtcgct ctgcagccgc agctgcgatg caggcgtgcg
     3001 cagccgctcg gtcgtgtgcc agcgccgcgt ctctgccgcg gaggagaagg cgctggacga
     3061 cagcgcatgc ccgcagccgc gcccacctgt actggaggcc tgccacggcc ccacttgccc
     3121 tccggagtgg gcggccctcg actggtctga gtgcaccccc agctgcgggc cgggcctccg
     3181 ccaccgcgtg gtcctttgca agagcgcaga ccaccgcgcc acgctgcccc cggcgcactg
     3241 ctcacccgcc gccaagccac cggccaccat gcgctgcaac ttgcgccgct gccccccggc
     3301 ccgctgggtg gctggcgagt ggggtgagtg ctctgcacag tgcggcgtcg ggcagcggca
     3361 gcgctcggtg cgctgcacca gccacacggg ccaggcgtcg cacgagtgca cggaggccct
     3421 gcggccgccc accacgcagc agtgtgaggc caagtgcgac agcccaaccc ccggggacgg
     3481 ccctgaagag tgcaaggatg tgaacaaggt cgcctactgc cccctggtgc tcaaatttca
     3541 gttctgcagc cgagcctact tccgccagat gtgctgcaaa acctgccatg gccactaggg
     3601 ggcgcgcggc acccggagcc acagctggcg gggtctccgc cgccagccct gcagcgggcc
     3661 ggccagaggg ggccccgggg gggcgggaac tgggagggaa gggtgagacg gagccggaag
     3721 ttatttattg ggaacccctg cagggccctg gctgggggga tggagagggg ctggctatcc
     3781 ccccagagcc cctcttcagc atccgcccct tccagttcac atagtgagac cccccctcca
     3841 gggtgggtct ggggagggga cagctgttca ccccagcacc ctttgaaccc acccttaggg
     3901 agtccccaac actccccccc tcctttgatc ggaatatgta ctgtgaagag taggggtggg
     3961 gaggtggtct gccggtgccc tgccccccag cactgcccta cccctccact ccgagctggg
     4021 ggggaatctg tgtctgctat gggagggggg ggggtagcac cacctccctg acaccctccc
     4081 ctgacctgac tagggggagg atccacccca acctctgccc tgcccgcccc aggggcaccc
     4141 cgacatccag gccaccccct catggtgcta cagaccctgc cctggggccc acacactcct
     4201 gccaggaagc cctacatcaa taaagttctg tcttgtgtag atttctacga a
//
