LOCUS       NM_006988               5183 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
            1 (ADAMTS1), mRNA.
ACCESSION   NM_006988
VERSION     NM_006988.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5183)
  AUTHORS   Wen,Y.C., Lin,Y.W., Ho,K.H., Yang,Y.C., Lai,F.R., Chu,C.Y.,
            Chen,J.Q., Lee,W.J. and Chien,M.H.
  TITLE     The oncogenic ADAMTS1-VCAN-EGFR cyclic axis drives anoikis
            resistance and invasion in renal cell carcinoma
  JOURNAL   Cell Mol Biol Lett 29 (1), 126 (2024)
   PUBMED   39333870
  REMARK    GeneRIF: The oncogenic ADAMTS1-VCAN-EGFR cyclic axis drives anoikis
            resistance and invasion in renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5183)
  AUTHORS   Chien,M.H., Yang,Y.C., Ho,K.H., Ding,Y.F., Chen,L.H., Chiu,W.K.,
            Chen,J.Q., Tung,M.C., Hsiao,M. and Lee,W.J.
  TITLE     Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and
            cervical lymph node metastasis of oral squamous cell carcinoma
  JOURNAL   Cell Death Dis 15 (1), 82 (2024)
   PUBMED   38263290
  REMARK    GeneRIF: Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes
            the EMT and cervical lymph node metastasis of oral squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5183)
  AUTHORS   Silva,S.V., Lima,M.A., Hodgson,L., Freitas,V.M. and
            Rodriguez-Manzaneque,J.C.
  TITLE     ADAMTS-1 has nuclear localization in cells with epithelial origin
            and leads to decreased cell migration
  JOURNAL   Exp Cell Res 433 (2), 113852 (2023)
   PUBMED   37951335
  REMARK    GeneRIF: ADAMTS-1 has nuclear localization in cells with epithelial
            origin and leads to decreased cell migration.
REFERENCE   4  (bases 1 to 5183)
  AUTHORS   Shi,W., Scialdone,A.P., Emerson,J.I., Mei,L., Wasson,L.K.,
            Davies,H.A., Seidman,C.E., Seidman,J.G., Cook,J.G. and Conlon,F.L.
  TITLE     Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by
            Repressing ADAMTS1
  JOURNAL   Circ Res 133 (1), 48-67 (2023)
   PUBMED   37254794
  REMARK    GeneRIF: Missense Mutation in Human CHD4 Causes Ventricular
            Noncompaction by Repressing ADAMTS1.
REFERENCE   5  (bases 1 to 5183)
  AUTHORS   Wang,S., Zhang,J., Wang,K., Zhao,Y. and Liu,D.
  TITLE     ADAMTS1 as potential prognostic biomarker promotes malignant
            invasion of glioma
  JOURNAL   Int J Clin Oncol 28 (1), 52-68 (2023)
   PUBMED   36371587
  REMARK    GeneRIF: ADAMTS1 as potential prognostic biomarker promotes
            malignant invasion of glioma.
REFERENCE   6  (bases 1 to 5183)
  AUTHORS   Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S.,
            Lombardo,M. and Iruela-Arispe,M.L.
  TITLE     METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a
            new family of proteins with angio-inhibitory activity
  JOURNAL   J Biol Chem 274 (33), 23349-23357 (1999)
   PUBMED   10438512
REFERENCE   7  (bases 1 to 5183)
  AUTHORS   Kuno,K., Terashima,Y. and Matsushima,K.
  TITLE     ADAMTS-1 is an active metalloproteinase associated with the
            extracellular matrix
  JOURNAL   J Biol Chem 274 (26), 18821-18826 (1999)
   PUBMED   10373500
REFERENCE   8  (bases 1 to 5183)
  AUTHORS   Tang,B.L. and Hong,W.
  TITLE     ADAMTS: a novel family of proteases with an ADAM protease domain
            and thrombospondin 1 repeats
  JOURNAL   FEBS Lett 445 (2-3), 223-225 (1999)
   PUBMED   10094461
  REMARK    Review article
REFERENCE   9  (bases 1 to 5183)
  AUTHORS   Kuno,K. and Matsushima,K.
  TITLE     ADAMTS-1 protein anchors at the extracellular matrix through the
            thrombospondin type I motifs and its spacing region
  JOURNAL   J Biol Chem 273 (22), 13912-13917 (1998)
   PUBMED   9593739
REFERENCE   10 (bases 1 to 5183)
  AUTHORS   Kuno,K., Kanada,N., Nakashima,E., Fujiki,F., Ichimura,F. and
            Matsushima,K.
  TITLE     Molecular cloning of a gene encoding a new type of
            metalloproteinase-disintegrin family protein with thrombospondin
            motifs as an inflammation associated gene
  JOURNAL   J Biol Chem 272 (1), 556-562 (1997)
   PUBMED   8995297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314475.1, AF207664.1 and
            AP001599.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006988.4.
            
            Summary: This gene encodes a member of the ADAMTS (a disintegrin
            and metalloproteinase with thrombospondin motif) protein family.
            Members of the family share several distinct protein modules,
            including a propeptide region, a metalloproteinase domain, a
            disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
            Individual members of this family differ in the number of
            C-terminal TS motifs, and some have unique C-terminal domains. The
            protein encoded by this gene contains two disintegrin loops and
            three C-terminal TS motifs and has anti-angiogenic activity. The
            expression of this gene may be associated with various inflammatory
            processes as well as development of cancer cachexia. This gene is
            likely to be necessary for normal growth, fertility, and organ
            morphology and function. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036515.2, SRR1803617.273049.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2155371
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284984.8/ ENSP00000284984.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-753               AK314475.1         1-753
            754-3722            AF207664.1         741-3709
            3723-3797           AF207664.1         3711-3785
            3798-4651           AF207664.1         3787-4640
            4652-5183           AP001599.1         38227-38758         c
FEATURES             Location/Qualifiers
     source          1..5183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.3"
     gene            1..5183
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 1"
                     /db_xref="GeneID:9510"
                     /db_xref="HGNC:HGNC:217"
                     /db_xref="MIM:605174"
     exon            1..1185
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..3359
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 1; human
                     metalloproteinase with thrombospondin type 1 motifs;
                     metalloprotease and thrombospondin-1; a disintegrin and
                     metalloproteinase with thrombospondin motifs 1; METH-1;
                     ADAM-TS1; ADAMTS-1; ADAM-TS 1"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 1 preproprotein"
                     /protein_id="NP_008919.3"
                     /db_xref="CCDS:CCDS33524.1"
                     /db_xref="GeneID:9510"
                     /db_xref="HGNC:HGNC:217"
                     /db_xref="MIM:605174"
                     /translation="MQRAVPEGFGRRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALL
                     AVSDALGRPSEEDEELVVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTL
                     QNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQP
                     LPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDE
                     GTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGS
                     GLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCN
                     WQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDG
                     LQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYM
                     ITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCST
                     LWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWG
                     PWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREE
                     QCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTP
                     CSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHD
                     IITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVV
                     LRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFS
                     AWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQL
                     GEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS"
     exon            1186..1532
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1665
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1833
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2120
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2307
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2483
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2659
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..5183
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4506..4511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /note="hexamer: AATAAA"
     polyA_site      4527
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
     regulatory      4631..4636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /note="hexamer: AATAAA"
     polyA_site      4651
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /note="major polyA site"
     regulatory      5163..5168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
                     /note="hexamer: ATTAAA"
     polyA_site      5183
                     /gene="ADAMTS1"
                     /gene_synonym="C3-C5; METH1"
ORIGIN      
        1 gcactcgctg gaaagcggct ccgagccagg ggctattgca aagccagggt gcgctaccgg
       61 acggagaggg gagagccctg agcagagtga gcaacatcgc agccaaggcg gaggccgaag
      121 aggggcgcca ggcaccaatc tccgcgttgc ctcagccccg gaggcgcccc agagcgcttc
      181 ttgtcccagc agagccactc tgcctgcgcc tgcctctcag tgtctccaac tttgcgctgg
      241 aagaaaaact tcccgcgcgc cggcagaact gcagcgcctc cttttagtga ctccgggagc
      301 ttcggctgta gccggctctg cgcgcccttc caacgaataa tagaaattgt taattttaac
      361 aatccagagc aggccaacga ggctttgctc tcccgacccg aactaaaggt ccctcgctcc
      421 gtgcgctgct acgagcggtg tctcctgggg ctccaatgca gcgagctgtg cccgaggggt
      481 tcggaaggcg caagctgggc agcgacatgg ggaacgcgga gcgggctccg gggtctcgga
      541 gctttgggcc agtacccacg ctgctgctgc tcgccgcggc gctactggcc gtgtcggacg
      601 cactcgggcg cccctccgag gaggacgagg agctagtggt gccggagctg gagcgcgccc
      661 cgggacacgg gaccacgcgc ctccgcctgc acgcctttga ccagcagctg gatctggagc
      721 tgcggcccga cagcagcttt ttggcgcccg gcttcacgct ccagaacgtg gggcgcaaat
      781 ccgggtccga gacgccgctt ccggaaaccg acctggcgca ctgcttctac tccggcaccg
      841 tgaatggcga tcccagctcg gctgccgccc tcagcctctg cgagggcgtg cgcggcgcct
      901 tctacctgct gggggaggcg tatttcatcc agccgctgcc cgccgccagc gagcgcctcg
      961 ccaccgccgc cccaggggag aagccgccgg caccactaca gttccacctc ctgcggcgga
     1021 atcggcaggg cgacgtcggc ggcacgtgcg gggtcgtgga cgacgagccc cggccgactg
     1081 ggaaagcgga gaccgaagac gaggacgaag ggactgaggg cgaggacgaa ggggctcagt
     1141 ggtcgccgca ggacccggca ctgcaaggcg taggacagcc cacaggaact ggaagcataa
     1201 gaaagaagcg atttgtgtcc agtcaccgct atgtggaaac catgcttgtg gcagaccagt
     1261 cgatggcaga attccacggc agtggtctaa agcattacct tctcacgttg ttttcggtgg
     1321 cagccagatt gtacaaacac cccagcattc gtaattcagt tagcctggtg gtggtgaaga
     1381 tcttggtcat ccacgatgaa cagaaggggc cggaagtgac ctccaatgct gccctcactc
     1441 tgcggaactt ttgcaactgg cagaagcagc acaacccacc cagtgaccgg gatgcagagc
     1501 actatgacac agcaattctt ttcaccagac aggacttgtg tgggtcccag acatgtgata
     1561 ctcttgggat ggctgatgtt ggaactgtgt gtgatccgag cagaagctgc tccgtcatag
     1621 aagatgatgg tttacaagct gccttcacca cagcccatga attaggccac gtgtttaaca
     1681 tgccacatga tgatgcaaag cagtgtgcca gccttaatgg tgtgaaccag gattcccaca
     1741 tgatggcgtc aatgctttcc aacctggacc acagccagcc ttggtctcct tgcagtgcct
     1801 acatgattac atcatttctg gataatggtc atggggaatg tttgatggac aagcctcaga
     1861 atcccataca gctcccaggc gatctccctg gcacctcgta cgatgccaac cggcagtgcc
     1921 agtttacatt tggggaggac tccaaacact gccccgatgc agccagcaca tgtagcacct
     1981 tgtggtgtac cggcacctct ggtggggtgc tggtgtgtca aaccaaacac ttcccgtggg
     2041 cggatggcac cagctgtgga gaagggaaat ggtgtatcaa cggcaagtgt gtgaacaaaa
     2101 ccgacagaaa gcattttgat acgccttttc atggaagctg gggaatgtgg gggccttggg
     2161 gagactgttc gagaacgtgc ggtggaggag tccagtacac gatgagggaa tgtgacaacc
     2221 cagtcccaaa gaatggaggg aagtactgtg aaggcaaacg agtgcgctac agatcctgta
     2281 accttgagga ctgtccagac aataatggaa aaacctttag agaggaacaa tgtgaagcac
     2341 acaacgagtt ttcaaaagct tcctttggga gtgggcctgc ggtggaatgg attcccaagt
     2401 acgctggcgt ctcaccaaag gacaggtgca agctcatctg ccaagccaaa ggcattggct
     2461 acttcttcgt tttgcagccc aaggttgtag atggtactcc atgtagccca gattccacct
     2521 ctgtctgtgt gcaaggacag tgtgtaaaag ctggttgtga tcgcatcata gactccaaaa
     2581 agaagtttga taaatgtggt gtttgcgggg gaaatggatc tacttgtaaa aaaatatcag
     2641 gatcagttac tagtgcaaaa cctggatatc atgatatcat cacaattcca actggagcca
     2701 ccaacatcga agtgaaacag cggaaccaga ggggatccag gaacaatggc agctttcttg
     2761 ccatcaaagc tgctgatggc acatatattc ttaatggtga ctacactttg tccaccttag
     2821 agcaagacat tatgtacaaa ggtgttgtct tgaggtacag cggctcctct gcggcattgg
     2881 aaagaattcg cagctttagc cctctcaaag agcccttgac catccaggtt cttactgtgg
     2941 gcaatgccct tcgacctaaa attaaataca cctacttcgt aaagaagaag aaggaatctt
     3001 tcaatgctat ccccactttt tcagcatggg tcattgaaga gtggggcgaa tgttctaagt
     3061 catgtgaatt gggttggcag agaagactgg tagaatgccg agacattaat ggacagcctg
     3121 cttccgagtg tgcaaaggaa gtgaagccag ccagcaccag accttgtgca gaccatccct
     3181 gcccccagtg gcagctgggg gagtggtcat catgttctaa gacctgtggg aagggttaca
     3241 aaaaaagaag cttgaagtgt ctgtcccatg atggaggggt gttatctcat gagagctgtg
     3301 atcctttaaa gaaacctaaa catttcatag acttttgcac aatggcagaa tgcagttaag
     3361 tggtttaagt ggtgttagct ttgagggcaa ggcaaagtga ggaagggctg gtgcagggaa
     3421 agcaagaagg ctggagggat ccagcgtatc ttgccagtaa ccagtgaggt gtatcagtaa
     3481 ggtgggatta tgggggtaga tagaaaagga gttgaatcat cagagtaaac tgccagttgc
     3541 aaatttgata ggatagttag tgaggattat taacctctga gcagtgatat agcataataa
     3601 agccccgggc attattatta ttatttcttt tgttacatct attacaagtt tagaaaaaac
     3661 aaagcaattg tcaaaaaaag ttagaactat tacaacccct gtttcctggt acttatcaaa
     3721 tacttagtat catgggggtt gggaaatgaa aagtaggaga aaagtgagat tttactaaga
     3781 cctgttttac tttacctcac taacaatggg gggagaaagg agtacaaata ggatctttga
     3841 ccagcactgt ttatggctgc tatggtttca gagaatgttt atacattatt tctaccgaga
     3901 attaaaactt cagattgttc aacatgagag aaaggctcag caacgtgaaa taacgcaaat
     3961 ggcttcctct ttcctttttt ggaccatctc agtctttatt tgtgtaattc attttgagga
     4021 aaaaacaact ccatgtattt attcaagtgc attaaagtct acaatggaaa aaaagcagtg
     4081 aagcattaga tgctggtaaa agctagagga gacacaatga gcttagtacc tccaacttcc
     4141 tttctttcct accatgtaac cctgctttgg gaatatggat gtaaagaagt aacttgtgtc
     4201 tcatgaaaat cagtacaatc acacaaggag gatgaaacgc cggaacaaaa atgaggtgtg
     4261 tagaacaggg tcccacaggt ttggggacat tgagatcact tgtcttgtgg tggggaggct
     4321 gctgaggggt agcaggtcca tctccagcag ctggtccaac agtcgtatcc tggtgaatgt
     4381 ctgttcagct cttctgtgag aatatgattt tttccatatg tatatagtaa aatatgttac
     4441 tataaattac atgtacttta taagtattgg tttgggtgtt ccttccaaga aggactatag
     4501 ttagtaataa atgcctataa taacatattt atttttatac atttatttct aatgaaaaaa
     4561 acttttaaat tatatcgctt ttgtggaagt gcatataaaa tagagtattt atacaatata
     4621 tgttactaga aataaaagaa cacttttgga atgtgtgtgt ctgttttttg aagtgggaat
     4681 tcattcctag gaaggaaacc tgaggcacaa atattgaatc tgaagaccga attattttct
     4741 taaattattt ggcaataaga ttttgttcta gaggaaggtg aagcaagacg gctgaataga
     4801 agattttttt ctaatgagat gtatttctta tatccttggt atacatgatt gctaaaaaga
     4861 aagaaattta tgatgtcatt tgttactaat gtatctaata atatacatca gtggttggca
     4921 aacttctttt gtaaaaagcc aaatggtaaa tatttgcaac tttgtcaatc ctgtcaataa
     4981 ctatcctgtc aataccatct atgtcacaac tgctcaactg tgctgttgta gcacaaaact
     5041 agccataaag aatgagtaag tgaatggaca tggctgtgtt ctaaaaaaac tacttgcaaa
     5101 aacaaataat gggtcagatt tgttctgcag attcagtttg ccaaccctgg tatataccat
     5161 aaattaaatg gaaagagctt tca
//
