LOCUS       NM_014479               2348 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ADAM like decysin 1 (ADAMDEC1), transcript variant 1,
            mRNA.
ACCESSION   NM_014479
VERSION     NM_014479.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2348)
  AUTHORS   Wang,X., Gao,F., Cheng,C. and Zhang,Y.
  TITLE     Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell
            injury and atherosclerosis progression
  JOURNAL   Funct Integr Genomics 24 (1), 1 (2023)
   PUBMED   38063920
  REMARK    GeneRIF: Knockdown of ADAMDEC1 ameliorates ox-LDL-induced
            endothelial cell injury and atherosclerosis progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2348)
  AUTHORS   Jia,Y., Huang,X., Shi,H., Wang,M., Chen,J., Zhang,H., Hou,D.,
            Jing,H., Du,J., Han,H. and Zhang,J.
  TITLE     ADAMDEC1 induces EMT and promotes colorectal cancer cells
            metastasis by enhancing Wnt/beta-catenin signaling via negative
            modulation of GSK-3beta
  JOURNAL   Exp Cell Res 429 (2), 113629 (2023)
   PUBMED   37187249
  REMARK    GeneRIF: ADAMDEC1 induces EMT and promotes colorectal cancer cells
            metastasis by enhancing Wnt/beta-catenin signaling via negative
            modulation of GSK-3beta.
REFERENCE   3  (bases 1 to 2348)
  AUTHORS   Zhu,W., Shi,L., Gong,Y., Zhuo,L., Wang,S., Chen,S., Zhang,B. and
            Ke,B.
  TITLE     Upregulation of ADAMDEC1 correlates with tumor progression and
            predicts poor prognosis in non-small cell lung cancer (NSCLC) via
            the PI3K/AKT pathway
  JOURNAL   Thorac Cancer 13 (7), 1027-1039 (2022)
   PUBMED   35178875
  REMARK    GeneRIF: Upregulation of ADAMDEC1 correlates with tumor progression
            and predicts poor prognosis in non-small cell lung cancer (NSCLC)
            via the PI3K/AKT pathway.
REFERENCE   4  (bases 1 to 2348)
  AUTHORS   Liu,X., Huang,H., Li,X., Zheng,X., Zhou,C., Xue,B., He,J., Zhang,Y.
            and Liu,L.
  TITLE     Knockdown of ADAMDEC1 inhibits the progression of glioma in vitro
  JOURNAL   Histol Histopathol 35 (9), 997-1005 (2020)
   PUBMED   32378728
  REMARK    GeneRIF: Knockdown of ADAMDEC1 inhibits the progression of glioma
            in vitro.
REFERENCE   5  (bases 1 to 2348)
  AUTHORS   Liu,T., Deng,Z., Xie,H., Chen,M., Xu,S., Peng,Q., Sha,K., Xiao,W.,
            Zhao,Z. and Li,J.
  TITLE     ADAMDEC1 promotes skin inflammation in rosacea via modulating the
            polarization of M1 macrophages
  JOURNAL   Biochem Biophys Res Commun 521 (1), 64-71 (2020)
   PUBMED   31627897
  REMARK    GeneRIF: The ADAMDEC1 plays a pro-inflammatory role in rosacea via
            modulating the M1 polarization of macrophages.
REFERENCE   6  (bases 1 to 2348)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   7  (bases 1 to 2348)
  AUTHORS   Fritsche,J., Muller,A., Hausmann,M., Rogler,G., Andreesen,R. and
            Kreutz,M.
  TITLE     Inverse regulation of the ADAM-family members, decysin and
            MADDAM/ADAM19 during monocyte differentiation
  JOURNAL   Immunology 110 (4), 450-457 (2003)
   PUBMED   14632642
REFERENCE   8  (bases 1 to 2348)
  AUTHORS   Bates,E.E., Fridman,W.H. and Mueller,C.G.
  TITLE     The ADAMDEC1 (decysin) gene structure: evolution by duplication in
            a metalloprotease gene cluster on chromosome 8p12
  JOURNAL   Immunogenetics 54 (2), 96-105 (2002)
   PUBMED   12037602
  REMARK    GeneRIF: molecular evolution by duplication in a metalloprotease
            gene cluster on chromosome 8p12
REFERENCE   9  (bases 1 to 2348)
  AUTHORS   Mueller,C.G., Cremer,I., Paulet,P.E., Niida,S., Maeda,N.,
            Lebeque,S., Fridman,W.H. and Sautes-Fridman,C.
  TITLE     Mannose receptor ligand-positive cells express the metalloprotease
            decysin in the B cell follicle
  JOURNAL   J Immunol 167 (9), 5052-5060 (2001)
   PUBMED   11673514
REFERENCE   10 (bases 1 to 2348)
  AUTHORS   Mueller,C.G., Rissoan,M.C., Salinas,B., Ait-Yahia,S., Ravel,O.,
            Bridon,J.M., Briere,F., Lebecque,S. and Liu,Y.J.
  TITLE     Polymerase chain reaction selects a novel disintegrin proteinase
            from CD40-activated germinal center dendritic cells
  JOURNAL   J Exp Med 186 (5), 655-663 (1997)
   PUBMED   9271581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC387711.1, Y13323.2, BC069582.1 and AK301007.1.
            
            On Feb 19, 2009 this sequence version replaced NM_014479.2.
            
            Summary: This encoded protein is thought to be a secreted protein
            belonging to the disintegrin metalloproteinase family. Its
            expression is upregulated during dendritic cells maturation. This
            protein may play an important role in dendritic cell function and
            their interactions with germinal center T cells. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is predicted to encode the
            longer protein isoform (1) using a translation initiation site in
            the first exon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13323.2, ERR279855.1537.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256412.8/ ENSP00000256412.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               DC387711.1         1-174
            175-1640            Y13323.2           15-1480
            1641-1749           BC069582.1         1468-1576
            1750-2166           Y13323.2           1589-2005
            2167-2348           AK301007.1         1863-2044
FEATURES             Location/Qualifiers
     source          1..2348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..2348
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /note="ADAM like decysin 1"
                     /db_xref="GeneID:27299"
                     /db_xref="HGNC:HGNC:16299"
                     /db_xref="MIM:606393"
     exon            1..308
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1633
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; disintegrin protease; decysin; ADAM-like
                     protein decysin-1; a disintegrin and metalloproteinase
                     domain-like protein decysin-1"
                     /codon_start=1
                     /product="ADAM DEC1 isoform 1 precursor"
                     /protein_id="NP_055294.1"
                     /db_xref="CCDS:CCDS6044.1"
                     /db_xref="GeneID:27299"
                     /db_xref="HGNC:HGNC:16299"
                     /db_xref="MIM:606393"
                     /translation="MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEI
                     VCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDY
                     TETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIK
                     PLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQK
                     YIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDK
                     IKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVA
                     VIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSC
                     RAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEAL
                     TCKLKPGTDCGGDAPNHTTE"
     exon            309..427
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            428..504
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            505..583
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            584..660
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            661..847
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            848..910
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            911..982
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1149
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1231
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1362
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1540
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1626
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..2348
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2326..2331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /note="hexamer: AATAAA"
     polyA_site      2348
                     /gene="ADAMDEC1"
                     /gene_synonym="M12.219"
                     /note="major polyA site"
ORIGIN      
        1 agatgtgagt cctcaatgag ctataaccac agccataaat atctctcaaa gatgaggaac
       61 attctcatga tgttgacact gcaatttttt gacaatttcc caacactctt aagaaacatt
      121 ccccaatctc acacgaaaag tgggggtttt aattttcttg ttcaacttct aaagagaaat
      181 tggagaagat aaaactggac actggggaga ccacaacttc atgctgcgtg ggatctccca
      241 gctacctgca gtggccacca tgtcttgggt cctgctgcct gtactttggc tcattgttca
      301 aactcaagca atagccataa agcaaacacc tgaattaacg ctccatgaaa tagtttgtcc
      361 taaaaaactt cacattttac acaaaagaga gatcaagaac aaccagacag aaaagcatgg
      421 caaagaggaa aggtatgaac ctgaagttca atatcagatg atcttaaatg gagaagaaat
      481 cattctctcc ctacaaaaaa ccaagcacct cctggggcca gactacactg aaacattgta
      541 ctcacccaga ggagaggaaa ttaccacgaa acctgagaac atggaacact gttactataa
      601 aggaaacatc ctaaatgaaa agaattctgt tgccagcatc agtacttgtg acgggttgag
      661 aggatacttc acacatcatc accaaagata ccagataaaa cctctgaaaa gcacagacga
      721 gaaagaacat gccgtcttta catctaacca ggaggaacaa gacccagcta accacacatg
      781 tggtgtgaag agcactgacg ggaaacaagg cccaattcga atctctagat cactcaaaag
      841 cccagagaaa gaagactttc ttcgggcaca gaaatacatt gatctctatt tggtgctgga
      901 taatgccttt tataagaact ataatgagaa tctaactctg ataagaagct ttgtgtttga
      961 tgtgatgaac ctactcaatg tgatatataa caccatagat gttcaagtgg ccttggtagg
     1021 tatggaaatc tggtctgatg gggataagat aaaggtggtg cccagcgcaa gcaccacgtt
     1081 tgacaacttc ctgagatggc acagttctaa cctggggaaa aagatccacg accatgctca
     1141 gcttctcagc gggattagct tcaacaatcg acgtgtggga ctggcagctt caaattcctt
     1201 gtgttcccca tcttcggttg ctgttattga ggctaaaaaa aagaataatg tggctcttgt
     1261 aggagtgatg tcacatgagc tgggccatgt ccttggtatg cctgatgttc cattcaacac
     1321 caagtgtccc tctggcagtt gtgtgatgaa tcagtatctg agttcaaaat tcccaaagga
     1381 tttcagtaca tcttgccgtg cacattttga aagatacctt ttatctcaga aaccaaagtg
     1441 cctgctgcaa gcacctattc ctacaaatat aatgacaaca ccagtgtgtg ggaaccacct
     1501 tctagaagtg ggagaagact gtgattgtgg ctctcctaag gagtgtacca atctctgctg
     1561 tgaagcccta acgtgtaaac tgaagcctgg aactgattgc ggaggagatg ctccaaacca
     1621 taccacagag tgaatccaaa agtctgcttc actgagatgc taccttgcca ggacaagaac
     1681 caagaactct aactgtccca ggaatcttgt gaattttcac ccataatggt ctttcacttg
     1741 tcattctact ttctatattg ttatcagtcc aggaaacagg taaacagatg taattagaga
     1801 cattggctct ttgtttaggc ctaatctttc tttttacttt tttttttctt ttttcttttt
     1861 ttttaaagat catgaatttg tgacttagtt ctgccctttg gagaacaaaa gaaagcagtc
     1921 ttccatcaaa tcaccttaaa atgcacggct aaactattca gagttaacac tccagaattg
     1981 ttaaattaca agtactatgc tttaatgctt ctttcatctt actagtatgg cctataaaaa
     2041 aaataatacc acttgatggg tgaaggcttt ggcaatagaa agaagaatag aattcaggtt
     2101 ttatgttatt cctctgtgtt cacttcgcct tgctcttgaa agtgcagtat ttttctacat
     2161 catgtcaaga atgattcaat gtaaatattt ttcattttat catgtatatc ctatacacac
     2221 atctccttca tcatcatata tgaagtttat tttgagaagt ctacattgct tacattttaa
     2281 ttgagccagc aaagaaggct taatgattta ttgaaccata atgtcaataa aaacacaact
     2341 tttgaggc
//
