LOCUS       NM_003816               4112 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 9 (ADAM9), transcript
            variant 1, mRNA.
ACCESSION   NM_003816
VERSION     NM_003816.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4112)
  AUTHORS   Jiang,L., Huang,W., Cao,M., Jiang,Y., Li,S., Li,M., Yang,R., Wu,Z.,
            Wang,Y., Lv,C. and Huang,Z.
  TITLE     Deciphering the oncogenic potential of ADAM9 in hepatocellular
            carcinoma through bioinformatics and experimental approaches
  JOURNAL   Sci Rep 14 (1), 26432 (2024)
   PUBMED   39488509
  REMARK    GeneRIF: Deciphering the oncogenic potential of ADAM9 in
            hepatocellular carcinoma through bioinformatics and experimental
            approaches.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4112)
  AUTHORS   Xu,S. and Dong,W.
  TITLE     LncRNA NEAT1 targets miR-125/ADAM9 mediated NF-kappaB pathway in
            inflammatory response of rosacea
  JOURNAL   Skin Res Technol 30 (7), e13630 (2024)
   PUBMED   38988131
  REMARK    GeneRIF: LncRNA NEAT1 targets miR-125/ADAM9 mediated NF-kappaB
            pathway in inflammatory response of rosacea.
REFERENCE   3  (bases 1 to 4112)
  AUTHORS   Bazzone,L.E., Zhu,J., King,M., Liu,G., Guo,Z., MacKay,C.R.,
            Kyawe,P.P., Qaisar,N., Rojas-Quintero,J., Owen,C.A., Brass,A.L.,
            McDougall,W., Baer,C.E., Cashman,T., Trivedi,C.M., Gack,M.U.,
            Finberg,R.W. and Kurt-Jones,E.A.
  TITLE     ADAM9 promotes type I interferon-mediated innate immunity during
            encephalomyocarditis virus infection
  JOURNAL   Nat Commun 15 (1), 4153 (2024)
   PUBMED   38755212
  REMARK    GeneRIF: ADAM9 promotes type I interferon-mediated innate immunity
            during encephalomyocarditis virus infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4112)
  AUTHORS   Liu,J., Wang,Y., Zhang,S., Sun,L. and Shi,Y.
  TITLE     ADAM9 deubiquitination induced by USP22 suppresses proliferation,
            migration, invasion, and epithelial-mesenchymal transition of
            trophoblast cells in preeclampsia
  JOURNAL   Placenta 146, 50-57 (2024)
   PUBMED   38176298
  REMARK    GeneRIF: ADAM9 deubiquitination induced by USP22 suppresses
            proliferation, migration, invasion, and epithelial-mesenchymal
            transition of trophoblast cells in preeclampsia.
REFERENCE   5  (bases 1 to 4112)
  AUTHORS   Chang,A.C., Lin,L.W., Chen,Y.C., Chen,P.C., Liu,S.C., Tai,H.C.,
            Wu,H.C., Sung,S.Y., Lin,T.H. and Tang,C.H.
  TITLE     The ADAM9/WISP-1 axis cooperates with osteoblasts to stimulate
            primary prostate tumor growth and metastasis
  JOURNAL   Int J Biol Sci 19 (3), 760-771 (2023)
   PUBMED   36778124
  REMARK    GeneRIF: The ADAM9/WISP-1 axis cooperates with osteoblasts to
            stimulate primary prostate tumor growth and metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4112)
  AUTHORS   Roghani,M., Becherer,J.D., Moss,M.L., Atherton,R.E.,
            Erdjument-Bromage,H., Arribas,J., Blackburn,R.K., Weskamp,G.,
            Tempst,P. and Blobel,C.P.
  TITLE     Metalloprotease-disintegrin MDC9: intracellular maturation and
            catalytic activity
  JOURNAL   J Biol Chem 274 (6), 3531-3540 (1999)
   PUBMED   9920899
REFERENCE   7  (bases 1 to 4112)
  AUTHORS   Izumi,Y., Hirata,M., Hasuwa,H., Iwamoto,R., Umata,T., Miyado,K.,
            Tamai,Y., Kurisaki,T., Sehara-Fujisawa,A., Ohno,S. and Mekada,E.
  TITLE     A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and
            PKCdelta are involved in TPA-induced ectodomain shedding of
            membrane-anchored heparin-binding EGF-like growth factor
  JOURNAL   EMBO J 17 (24), 7260-7272 (1998)
   PUBMED   9857183
REFERENCE   8  (bases 1 to 4112)
  AUTHORS   McKie,N., Edwards,T., Dallas,D.J., Houghton,A., Stringer,B.,
            Graham,R., Russell,G. and Croucher,P.I.
  TITLE     Expression of members of a novel membrane linked metalloproteinase
            family (ADAM) in human articular chondrocytes
  JOURNAL   Biochem Biophys Res Commun 230 (2), 335-339 (1997)
   PUBMED   9016778
REFERENCE   9  (bases 1 to 4112)
  AUTHORS   McKie,N., Dallas,D.J., Edwards,T., Apperley,J.F., Russell,R.G. and
            Croucher,P.I.
  TITLE     Cloning of a novel membrane-linked metalloproteinase from human
            myeloma cells
  JOURNAL   Biochem J 318 (Pt 2) (Pt 2), 459-462 (1996)
   PUBMED   8809033
REFERENCE   10 (bases 1 to 4112)
  AUTHORS   Weskamp,G., Kratzschmar,J., Reid,M.S. and Blobel,C.P.
  TITLE     MDC9, a widely expressed cellular disintegrin containing
            cytoplasmic SH3 ligand domains
  JOURNAL   J Cell Biol 132 (4), 717-726 (1996)
   PUBMED   8647900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108863.4 and AC105091.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003816.2.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins, and have been implicated in a variety of biological
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. The
            protein encoded by this gene interacts with SH3 domain-containing
            proteins, binds mitotic arrest deficient 2 beta protein, and is
            also involved in TPA-induced ectodomain shedding of
            membrane-anchored heparin-binding EGF-like growth factor. Several
            alternatively spliced transcript variants have been identified for
            this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) represents the protein coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.37167.1,
                                           SRR1660805.170969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000487273.7/ ENSP00000419446.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC108863.4         101874-102061
            189-286             AC108863.4         112787-112884
            287-345             AC108863.4         116559-116617
            346-424             AC108863.4         118866-118944
            425-501             AC108863.4         121019-121095
            502-697             AC108863.4         122120-122315
            698-763             AC108863.4         123754-123819
            764-835             AC108863.4         126544-126615
            836-1005            AC108863.4         128057-128226
            1006-1087           AC108863.4         130704-130785
            1088-1221           AC108863.4         131578-131711
            1222-1393           AC108863.4         146847-147018
            1394-1486           AC108863.4         159382-159474
            1487-1682           AC108863.4         160478-160673
            1683-1788           AC108863.4         176199-176304
            1789-1972           AC108863.4         182129-182312
            1973-2053           AC108863.4         187542-187622
            2054-2159           AC108863.4         187869-187974
            2160-2301           AC108863.4         194948-195089
            2302-2389           AC108863.4         196160-196247
            2390-2457           AC105091.3         38785-38852
            2458-4112           AC105091.3         40529-42183
FEATURES             Location/Qualifiers
     source          1..4112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..4112
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /note="ADAM metallopeptidase domain 9"
                     /db_xref="GeneID:8754"
                     /db_xref="HGNC:HGNC:216"
                     /db_xref="MIM:602713"
     exon            1..188
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2551
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /note="cone rod dystrophy 9; ADAM metallopeptidase domain
                     9 (meltrin gamma); disintegrin and metalloproteinase
                     domain-containing protein 9; myeloma cell
                     metalloproteinase; cellular disintegrin-related protein;
                     metalloprotease/disintegrin/cysteine-rich protein 9"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 9 precursor"
                     /protein_id="NP_003807.1"
                     /db_xref="CCDS:CCDS6112.1"
                     /db_xref="GeneID:8754"
                     /db_xref="HGNC:HGNC:216"
                     /db_xref="MIM:602713"
                     /translation="MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYE
                     IITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGT
                     LITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEH
                     IIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFI
                     VVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGG
                     AGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFG
                     QITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEK
                     LTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLK
                     SFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNN
                     KAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATG
                     NALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCG
                     AGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSV
                     DSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDG
                     KNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVS
                     SQGNLIPARPAPAPPLYSSLT"
     exon            189..286
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            287..345
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            346..424
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            425..501
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            502..697
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            698..763
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            764..835
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1005
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1087
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1221
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1393
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1486
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1682
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1788
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1972
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2053
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2159
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2301
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2389
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2457
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..4112
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3832..3837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /note="hexamer: AATAAA"
     polyA_site      3852
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /note="major polyA site"
     regulatory      4088..4093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
                     /note="hexamer: ATTAAA"
     polyA_site      4112
                     /gene="ADAM9"
                     /gene_synonym="CORD9; MCMP; MDC9; Mltng"
ORIGIN      
        1 agacttgggg ccccggcagg gttggaaaat gatggaagag gcggaggtgg aggcgaccga
       61 gtgctgagag gaacctgcgg aatcggccga gatggggtct ggcgcgcgct ttccctcggg
      121 gacccttcgt gtccggtggt tgctgttgct tggcctggtg ggcccagtcc tcggtgcggc
      181 gcggccaggc tttcaacaga cctcacatct ttcttcttat gaaattataa ctccttggag
      241 attaactaga gaaagaagag aagcccctag gccctattca aaacaagtat cttatgttat
      301 tcaggctgaa ggaaaagagc atattattca cttggaaagg aacaaagacc ttttgcctga
      361 agattttgtg gtttatactt acaacaagga agggacttta atcactgacc atcccaatat
      421 acagaatcat tgtcattatc ggggctatgt ggagggagtt cataattcat ccattgctct
      481 tagcgactgt tttggactca gaggattgct gcatttagag aatgcgagtt atgggattga
      541 acccctgcag aacagctctc attttgagca catcatttat cgaatggatg atgtctacaa
      601 agagcctctg aaatgtggag tttccaacaa ggatatagag aaagaaactg caaaggatga
      661 agaggaagag cctcccagca tgactcagct acttcgaaga agaagagctg tcttgccaca
      721 gacccggtat gtggagctgt tcattgtcgt agacaaggaa aggtatgaca tgatgggaag
      781 aaatcagact gctgtgagag aagagatgat tctcctggca aactacttgg atagtatgta
      841 tattatgtta aatattcgaa ttgtgctagt tggactggag atttggacca atggaaacct
      901 gatcaacata gttgggggtg ctggtgatgt gctggggaac ttcgtgcagt ggcgggaaaa
      961 gtttcttatc acacgtcgga gacatgacag tgcacagcta gttctaaaga aaggttttgg
     1021 tggaactgca ggaatggcat ttgtgggaac agtgtgttca aggagccacg caggcgggat
     1081 taatgtgttt ggacaaatca ctgtggagac atttgcttcc attgttgctc atgaattggg
     1141 tcataatctt ggaatgaatc acgatgatgg gagagattgt tcctgtggag caaagagctg
     1201 catcatgaat tcaggagcat cgggttccag aaactttagc agttgcagtg cagaggactt
     1261 tgagaagtta actttaaata aaggaggaaa ctgccttctt aatattccaa agcctgatga
     1321 agcctatagt gctccctcct gtggtaataa gttggtggac gctggggaag agtgtgactg
     1381 tggtactcca aaggaatgtg aattggaccc ttgctgcgaa ggaagtacct gtaagcttaa
     1441 atcatttgct gagtgtgcat atggtgactg ttgtaaagac tgtcggttcc ttccaggagg
     1501 tactttatgc cgaggaaaaa ccagtgagtg tgatgttcca gagtactgca atggttcttc
     1561 tcagttctgt cagccagatg tttttattca gaatggatat ccttgccaga ataacaaagc
     1621 ctattgctac aacggcatgt gccagtatta tgatgctcaa tgtcaagtca tctttggctc
     1681 aaaagccaag gctgccccca aagattgttt cattgaagtg aattctaaag gtgacagatt
     1741 tggcaattgt ggtttctctg gcaatgaata caagaagtgt gccactggga atgctttgtg
     1801 tggaaagctt cagtgtgaga atgtacaaga gatacctgta tttggaattg tgcctgctat
     1861 tattcaaacg cctagtcgag gcaccaaatg ttggggtgtg gatttccagc taggatcaga
     1921 tgttccagat cctgggatgg ttaacgaagg cacaaaatgt ggtgctggaa agatctgtag
     1981 aaacttccag tgtgtagatg cttctgttct gaattatgac tgtgatgttc agaaaaagtg
     2041 tcatggacat ggggtatgta atagcaataa gaattgtcac tgtgaaaatg gctgggctcc
     2101 cccaaattgt gagactaaag gatacggagg aagtgtggac agtggaccta catacaatga
     2161 aatgaatact gcattgaggg acggacttct ggtcttcttc ttcctaattg ttccccttat
     2221 tgtctgtgct atttttatct tcatcaagag ggatcaactg tggagaagct acttcagaaa
     2281 gaagagatca caaacatatg agtcagatgg caaaaatcaa gcaaaccctt ctagacagcc
     2341 ggggagtgtt cctcgacatg tttctccagt gacacctccc agagaagttc ctatatatgc
     2401 aaacagattt gcagtaccaa cctatgcagc caagcaacct cagcagttcc catcaaggcc
     2461 acctccacca caaccgaaag tatcatctca gggaaactta attcctgccc gtcctgctcc
     2521 tgcacctcct ttatatagtt ccctcacttg atttttttaa ccttcttttt gcaaatgtct
     2581 tcagggaact gagctaatac tttttttttt tcttgatgtt ttcttgaaaa gcctttctgt
     2641 tgcaactatg aatgaaaaca aaacaccaca aaacagactt cactaacaca gaaaaacaga
     2701 aactgagtgt gagagttgtg aaatacaagg aaatgcagta aagccaggga atttacaata
     2761 acatttccgt ttccatcatt gaataagtct tattcagtca tcggtgaggt taatgcacta
     2821 atcatggatt ttttgaacat gttattgcag tgattctcaa attaactgta ttggtgtaag
     2881 agttttgtca ttaagtgttt aagtgttatt ctgaattttc taccttagtt atcattaatg
     2941 tagttcctca ttgaacatgt gataatctaa tacctgtgaa aactgactaa tcagctgcca
     3001 ataatatcta atatttttca tcatgcacga attaataatc atcatactct agaatcttgt
     3061 ctgtcactca ctacatgaat aagcaaatat tgtcttcaaa agaatgcaca agaaccacaa
     3121 ttaagatgtc atattatttt gaaagtacaa aatatactaa aagagtgtgt gtgtattcac
     3181 gcagttactc gcttccattt ttatgacctt tcaactatag gtaataactc ttagagaaat
     3241 taatttaata ttagaatttc tattatgaat catgtgaaag catgacattc gttcacaata
     3301 gcactatttt aaataaatta taagctttaa ggtacgaagt atttaataga tctaatcaaa
     3361 tatgttgatt catggctata ataaagcagg agcaattata aaatcttcaa tcaattgaac
     3421 ttttacaaaa ccacttgaga atttcatgag cactttaaaa tctgaacttt caaagcttgc
     3481 tattaaatca tttagaatgt ttacatttac taaggtgtgc tgggtcatgt aaaatattag
     3541 acactaatat tttcatagaa attaggctgg agaaagaagg aagaaatggt tttcttaaat
     3601 acctacaaaa aagttactgt ggtatctatg agttatcatc ttagctgtgt taaaaatgaa
     3661 tttttactat ggcagatatg gtatggatcg taaaatttta agcactaaaa attttttcat
     3721 aacctttcat aataaagttt aataataggt ttattaactg aatttcatta gttttttaaa
     3781 agtgtttttg gtttgtgtat atatacatat acaaatacaa catttacaat aaataaaata
     3841 cttgaaattc tcttttgtgt ctcctagtag cttcctactc aactatttat aatctcatta
     3901 attaaaaagt tataatttta gataaaaatt ctagtcaaat ttttacagat attatctcac
     3961 taattttcag acttttgcca aagtgtgcac aatggctttt tgttaataaa gaacagatta
     4021 gttttgaaga aggcaaaaat ttcagttttc tgaagacagc atgttatttt aacaatcaag
     4081 tatacatatt aaaaattgtg agcaatctca aa
//
