LOCUS       NM_001109               3259 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 8 (ADAM8), transcript
            variant 1, mRNA.
ACCESSION   NM_001109
VERSION     NM_001109.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3259)
  AUTHORS   Zhang,Z., Mao,H., Li,F., Wang,D. and Liu,Y.
  TITLE     METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis progression
            by up-regulating ADAM8
  JOURNAL   Int J Rheum Dis 27 (9), e15323 (2024)
   PUBMED   39221886
  REMARK    GeneRIF: METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis
            progression by up-regulating ADAM8.
REFERENCE   2  (bases 1 to 3259)
  AUTHORS   Qu,H., Mao,M., Wang,K., Mu,Z. and Hu,B.
  TITLE     Knockdown of ADAM8 inhibits the proliferation, migration, invasion,
            and tumorigenesis of renal clear cell carcinoma cells to enhance
            the immunotherapy efficacy
  JOURNAL   Transl Res 266, 32-48 (2024)
   PUBMED   37992987
  REMARK    GeneRIF: Knockdown of ADAM8 inhibits the proliferation, migration,
            invasion, and tumorigenesis of renal clear cell carcinoma cells to
            enhance the immunotherapy efficacy.
REFERENCE   3  (bases 1 to 3259)
  AUTHORS   Cook,L., Sengelmann,M., Winkler,B., Nagl,C., Koch,S., Schlomann,U.,
            Slater,E.P., Miller,M.A., von Strandmann,E.P., Dorsam,B.,
            Preusser,C. and Bartsch,J.W.
  TITLE     ADAM8-Dependent Extracellular Signaling in the Tumor
            Microenvironment Involves Regulated Release of Lipocalin 2 and
            MMP-9
  JOURNAL   Int J Mol Sci 23 (4), 1976 (2022)
   PUBMED   35216088
  REMARK    GeneRIF: ADAM8-Dependent Extracellular Signaling in the Tumor
            Microenvironment Involves Regulated Release of Lipocalin 2 and
            MMP-9.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3259)
  AUTHORS   Park,G.B., Choi,S., Yoon,Y.S. and Kim,D.
  TITLE     TrkB/C-induced HOXC6 activation enhances the ADAM8-mediated
            metastasis of chemoresistant colon cancer cells
  JOURNAL   Mol Med Rep 23 (6) (2021)
   PUBMED   33846772
  REMARK    GeneRIF: TrkB/C-induced HOXC6 activation enhances the
            ADAM8-mediated metastasis of chemoresistant colon cancer cells.
REFERENCE   5  (bases 1 to 3259)
  AUTHORS   Li,Y., Guo,S., Zhao,K., Conrad,C., Driescher,C., Rothbart,V.,
            Schlomann,U., Guerreiro,H., Bopp,M.H., Konig,A., Carl,B.,
            Pagenstecher,A., Nimsky,C. and Bartsch,J.W.
  TITLE     ADAM8 affects glioblastoma progression by regulating
            osteopontin-mediated angiogenesis
  JOURNAL   Biol Chem 402 (2), 195-206 (2020)
   PUBMED   33544472
  REMARK    GeneRIF: ADAM8 affects glioblastoma progression by regulating
            osteopontin-mediated angiogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3259)
  AUTHORS   Johansson,M.W., Lye,M.H., Barthel,S.R., Duffy,A.K., Annis,D.S. and
            Mosher,D.F.
  TITLE     Eosinophils adhere to vascular cell adhesion molecule-1 via
            podosomes
  JOURNAL   Am J Respir Cell Mol Biol 31 (4), 413-422 (2004)
   PUBMED   15220135
REFERENCE   7  (bases 1 to 3259)
  AUTHORS   Fourie,A.M., Coles,F., Moreno,V. and Karlsson,L.
  TITLE     Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on
            synthetic peptide substrates and in ectodomain cleavage of CD23
  JOURNAL   J Biol Chem 278 (33), 30469-30477 (2003)
   PUBMED   12777399
REFERENCE   8  (bases 1 to 3259)
  AUTHORS   Amour,A., Knight,C.G., English,W.R., Webster,A., Slocombe,P.M.,
            Knauper,V., Docherty,A.J., Becherer,J.D., Blobel,C.P. and Murphy,G.
  TITLE     The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs
  JOURNAL   FEBS Lett 524 (1-3), 154-158 (2002)
   PUBMED   12135759
REFERENCE   9  (bases 1 to 3259)
  AUTHORS   Yamamoto,S., Higuchi,Y., Yoshiyama,K., Shimizu,E., Kataoka,M.,
            Hijiya,N. and Matsuura,K.
  TITLE     ADAM family proteins in the immune system
  JOURNAL   Immunol Today 20 (6), 278-284 (1999)
   PUBMED   10354553
  REMARK    Review article
REFERENCE   10 (bases 1 to 3259)
  AUTHORS   Yoshiyama,K., Higuchi,Y., Kataoka,M., Matsuura,K. and Yamamoto,S.
  TITLE     CD156 (human ADAM8): expression, primary amino acid sequence, and
            gene location
  JOURNAL   Genomics 41 (1), 56-62 (1997)
   PUBMED   9126482
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312834.1, DC408787.1,
            DA936506.1, AL592071.13 and BQ007791.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001109.4.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins, and have been implicated in a variety of biological
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. The
            protein encoded by this gene may be involved in cell adhesion
            during neurodegeneration, and it is thought to be a target for
            allergic respiratory diseases, including asthma. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312834.1, D26579.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445355.8/ ENSP00000453302.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AK312834.1         1-153
            154-291             DC408787.1         182-319
            292-950             AK312834.1         292-950
            951-1296            DA936506.1         33-378
            1297-2019           AK312834.1         1297-2019
            2020-2020           AL592071.13        27726-27726         c
            2021-2526           AK312834.1         2021-2526
            2527-2589           AL592071.13        21977-22039         c
            2590-3259           BQ007791.1         17-686              c
FEATURES             Location/Qualifiers
     source          1..3259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..3259
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /note="ADAM metallopeptidase domain 8"
                     /db_xref="GeneID:101"
                     /db_xref="HGNC:HGNC:215"
                     /db_xref="MIM:602267"
     exon            1..97
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2526
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /EC_number="3.4.24.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; a disintegrin and metalloproteinase domain 8;
                     cell surface antigen MS2; disintegrin and
                     metalloproteinase domain-containing protein 8; human
                     leukocyte differentiation antigen"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 8 isoform 1 precursor"
                     /protein_id="NP_001100.3"
                     /db_xref="CCDS:CCDS31319.2"
                     /db_xref="GeneID:101"
                     /db_xref="HGNC:HGNC:215"
                     /db_xref="MIM:602267"
                     /translation="MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRR
                     ALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQ
                     DHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHL
                     LQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGS
                     EAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQA
                     RQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAH
                     EMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQ
                     SVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAH
                     GTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCSGGYCYNGAC
                     PTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKGGQQPLGRAIC
                     IVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCN
                     HKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKAR
                     SRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPA
                     SSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPA
                     EGAVGPKVALKPPIQRKQGAGAPTAP"
     exon            98..201
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            202..278
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            279..357
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            358..434
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..624
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..687
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..756
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            757..926
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1008
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1157
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1335
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1425
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1615
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1685
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1836
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1914
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..1999
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2114
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2304
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2370
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2448
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..3259
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3242..3247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /note="hexamer: AATAAA"
     polyA_site      3259
                     /gene="ADAM8"
                     /gene_synonym="CD156; CD156a; MS2"
                     /note="major polyA site"
ORIGIN      
        1 agaccgtgtc ccgcggggct gtcacctccg cctctgctcc ccgacccggc catgcgcggc
       61 ctcgggctct ggctgctggg cgcgatgatg ctgcctgcga ttgcccccag ccggccctgg
      121 gccctcatgg agcagtatga ggtcgtgttg ccgtggcgtc tgccaggccc ccgagtccgc
      181 cgagctctgc cctcccactt gggcctgcac ccagagaggg tgagctacgt ccttggggcc
      241 acagggcaca acttcaccct ccacctgcgg aagaacaggg acctgctggg ctccggctac
      301 acagagacct atacggctgc caatggctcc gaggtgacgg agcagcctcg cgggcaggac
      361 cactgcttct accagggcca cgtagagggg tacccggact cagccgccag cctcagcacc
      421 tgtgccggcc tcaggggttt cttccaggtg gggtcagacc tgcacctgat cgagcccctg
      481 gatgaaggtg gcgagggcgg acggcacgcc gtgtaccagg ctgagcacct gctgcagacg
      541 gccgggacct gcggggtcag cgacgacagc ctgggcagcc tcctgggacc ccggacggca
      601 gccgtcttca ggcctcggcc cggggactct ctgccatccc gagagacccg ctacgtggag
      661 ctgtatgtgg tcgtggacaa tgcagagttc cagatgctgg ggagcgaagc agccgtgcgt
      721 catcgggtgc tggaggtggt gaatcacgtg gacaagctat atcagaaact caacttccgt
      781 gtggtcctgg tgggcctgga gatttggaat agtcaggaca ggttccacgt cagccccgac
      841 cccagtgtca cactggagaa cctcctgacc tggcaggcac ggcaacggac acggcggcac
      901 ctgcatgaca acgtacagct catcacgggt gtcgacttca ccgggactac cgtggggttt
      961 gccagggtgt ccgccatgtg ctcccacagc tcaggggctg tgaaccagga ccacagcaag
     1021 aaccccgtgg gcgtggcctg taccatggcc catgagatgg gccacaacct gggcatggac
     1081 catgatgaga acgtccaggg ctgccgctgc caggaacgct tcgaggccgg ccgctgcatc
     1141 atggcgggca gcattggctc cagtttcccc aggatgttca gtgactgcag ccaggcctac
     1201 ctggagagct ttttggagcg gccgcagtcg gtgtgcctcg ccaacgcccc tgacctcagc
     1261 cacctggtgg gcggccccgt gtgtgggaac ctgtttgtgg agcgtgggga gcagtgcgac
     1321 tgcggccccc ccgaggactg ccggaaccgc tgctgcaact ctaccacctg ccagctggct
     1381 gagggggccc agtgtgcgca cggtacctgc tgccaggagt gcaaggtgaa gccggctggt
     1441 gagctgtgcc gtcccaagaa ggacatgtgt gacctcgagg agttctgtga cggccggcac
     1501 cctgagtgcc cggaagacgc cttccaggag aacggcacgc cctgctccgg gggctactgc
     1561 tacaacgggg cctgtcccac actggcccag cagtgccagg ccttctgggg gccaggtggg
     1621 caggctgccg aggagtcctg cttctcctat gacatcctac caggctgcaa ggccagccgg
     1681 tacagggctg acatgtgtgg cgttctgcag tgcaagggtg ggcagcagcc cctggggcgt
     1741 gccatctgca tcgtggatgt gtgccacgcg ctcaccacag aggatggcac tgcgtatgaa
     1801 ccagtgcccg agggcacccg gtgtggacca gagaaggttt gctggaaagg acgttgccag
     1861 gacttacacg tttacagatc cagcaactgc tctgcccagt gccacaacca tggggtgtgc
     1921 aaccacaagc aggagtgcca ctgccacgcg ggctgggccc cgccccactg cgcgaagctg
     1981 ctgactgagg tgcacgcagc gtccgggagc ctccccgtct tcgtggtggt ggttctggtg
     2041 ctcctggcag ttgtgctggt caccctggca ggcatcatcg tctaccgcaa agcccggagc
     2101 cgcatcctga gcaggaacgt ggctcccaag accacaatgg ggcgctccaa ccccctgttc
     2161 caccaggctg ccagccgcgt gccggccaag ggcggggctc cagccccatc caggggcccc
     2221 caagagctgg tccccaccac ccacccgggc cagcccgccc gacacccggc ctcctcggtg
     2281 gctctgaaga ggccgccccc tgctcctccg gtcactgtgt ccagcccacc cttcccagtt
     2341 cctgtctaca cccggcaggc accaaagcag gtcatcaagc caacgttcgc acccccagtg
     2401 cccccagtca aacccggggc tggtgcggcc aaccctggtc cagctgaggg tgctgttggc
     2461 ccaaaggttg ccctgaagcc ccccatccag aggaagcaag gagccggagc tcccacagca
     2521 ccctaggggg gcacctgcgc ctgtgtggaa atttggagaa gttgcggcag agaagccatg
     2581 cgttccagca ttccacggtc cagctagtgc cgctcagccc tagaccctga ctttgcaggc
     2641 tcagctgctg ttctaacctc aggaatgcat ctacctgaga ggctcctgct gtccacgccc
     2701 tcagccaatt ccttctcccc gccttggcca cgtgtagccc cagctgtctg caggcaccag
     2761 gctgggatga gctgtgtgct tgcgggtgcg tgtgtgtgta cgtgtctcca ggtggccgct
     2821 ggtctcccgc tgtgttcagg aggccacata tacagcccct cccagccaca cctgcccctg
     2881 ctctggggcc tgctgagccg gctgccctgg gcacccggtt ccaggcagca cagacgtggg
     2941 gcatccccag aaagactcca tcccaggacc aggttcccct gcgtgctctt cgagagggtg
     3001 tcagtgagca gactgcaccc caagctcccg actccaggtc ccctgatctt ggggcctgtt
     3061 tcccatggga ttcaagaggg acagccccag ctttgtgtgt gtttaagctt aggaatcgcc
     3121 tttatggaaa gggctatgtg ggagagtcag ctatcttgtc tggttttctt gagacctcag
     3181 atgtgtgttc agcagggctg aaagctttta ttctttaata atgagaaatg tatattttac
     3241 taataaatta ttgaccgag
//
