LOCUS       NM_003817               3367 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), mRNA.
ACCESSION   NM_003817
VERSION     NM_003817.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3367)
  AUTHORS   Li,Y., Li,J. and Yang,D.
  TITLE     ADAM7 promotes the proliferation and invasion in trophoblast cells
  JOURNAL   Exp Mol Pathol 121, 104659 (2021)
   PUBMED   34116022
  REMARK    GeneRIF: ADAM7 promotes the proliferation and invasion in
            trophoblast cells.
REFERENCE   2  (bases 1 to 3367)
  AUTHORS   Sprooten,E., Fleming,K.M., Thomson,P.A., Bastin,M.E., Whalley,H.C.,
            Hall,J., Sussmann,J.E., McKirdy,J., Blackwood,D., Lawrie,S.M. and
            McIntosh,A.M.
  TITLE     White matter integrity as an intermediate phenotype: exploratory
            genome-wide association analysis in individuals at high risk of
            bipolar disorder
  JOURNAL   Psychiatry Res 206 (2-3), 223-231 (2013)
   PUBMED   23218918
REFERENCE   3  (bases 1 to 3367)
  AUTHORS   Wei,X., Moncada-Pazos,A., Cal,S., Soria-Valles,C., Gartner,J.,
            Rudloff,U., Lin,J.C., Rosenberg,S.A., Lopez-Otin,C. and Samuels,Y.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Analysis of the disintegrin-metalloproteinases family reveals
            ADAM29 and ADAM7 are often mutated in melanoma
  JOURNAL   Hum Mutat 32 (6), E2148-E2175 (2011)
   PUBMED   21618342
  REMARK    GeneRIF: mutated ADAM27 and ADAM7 genes could play a role in
            melanoma progression.
REFERENCE   4  (bases 1 to 3367)
  AUTHORS   Oh,J.S., Han,C. and Cho,C.
  TITLE     ADAM7 is associated with epididymosomes and integrated into sperm
            plasma membrane
  JOURNAL   Mol Cells 28 (5), 441-446 (2009)
   PUBMED   19855936
REFERENCE   5  (bases 1 to 3367)
  AUTHORS   Oh,J., Woo,J.M., Choi,E., Kim,T., Cho,B.N., Park,Z.Y., Kim,Y.C.,
            Kim,D.H. and Cho,C.
  TITLE     Molecular, biochemical, and cellular characterization of epididymal
            ADAMs, ADAM7 and ADAM28
  JOURNAL   Biochem Biophys Res Commun 331 (4), 1374-1383 (2005)
   PUBMED   15883027
REFERENCE   6  (bases 1 to 3367)
  AUTHORS   Seals,D.F. and Courtneidge,S.A.
  TITLE     The ADAMs family of metalloproteases: multidomain proteins with
            multiple functions
  JOURNAL   Genes Dev 17 (1), 7-30 (2003)
   PUBMED   12514095
  REMARK    Review article
REFERENCE   7  (bases 1 to 3367)
  AUTHORS   Bates,E.E., Fridman,W.H. and Mueller,C.G.
  TITLE     The ADAMDEC1 (decysin) gene structure: evolution by duplication in
            a metalloprotease gene cluster on chromosome 8p12
  JOURNAL   Immunogenetics 54 (2), 96-105 (2002)
   PUBMED   12037602
REFERENCE   8  (bases 1 to 3367)
  AUTHORS   Lin,Y.C., Sun,G.H., Lee,Y.M., Guo,Y.W. and Liu,H.W.
  TITLE     Cloning and characterization of a complementary DNA encoding a
            human epididymis-associated disintegrin and metalloprotease 7
            protein
  JOURNAL   Biol Reprod 65 (3), 944-950 (2001)
   PUBMED   11514362
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292492.1 and AC024958.8.
            
            On May 17, 2019 this sequence version replaced NM_003817.3.
            
            Summary: This gene encodes a member of the ADAMs family of zinc
            proteases. These transmembrane proteins play roles in multiple
            processes including cell signaling, adhesion and migration. The
            encoded protein lacks protease activity and may play roles in
            protein-protein interactions and cell adhesion processes including
            sperm-egg fusion. Mutations in this gene may be involved in the
            progression of melanoma. [provided by RefSeq, Oct 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF215824.1, GQ891358.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2153427,
                                           SAMEA2161674 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000175238.10/ ENSP00000175238.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2706              AK292492.1         35-2740
            2707-3367           AC024958.8         46429-47089         c
FEATURES             Location/Qualifiers
     source          1..3367
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..3367
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /note="ADAM metallopeptidase domain 7"
                     /db_xref="GeneID:8756"
                     /db_xref="HGNC:HGNC:214"
                     /db_xref="MIM:607310"
     exon            1..135
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2348
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /note="a disintegrin and metalloproteinase domain 7;
                     epididymal apical protein I; sperm maturation-related
                     glycoprotein GP-83; disintegrin and metalloproteinase
                     domain-containing protein 7; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 7 preproprotein"
                     /protein_id="NP_003808.2"
                     /db_xref="CCDS:CCDS6045.1"
                     /db_xref="GeneID:8756"
                     /db_xref="HGNC:HGNC:214"
                     /db_xref="MIM:607310"
                     /translation="MLPGCIFLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDTG
                     HTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQ
                     IMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNL
                     RVPYGANYSCTELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHP
                     HNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQE
                     KILKTRKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMA
                     HQLGHNLGMQHDEFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLN
                     IPFPYNFHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCES
                     CQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTRE
                     DQCSELFDDEAIESHDICYKMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGEL
                     SSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNM
                     EKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVACEETLHVTNITILVVVLVLVIVG
                     IGVLILLVRYRKCIKLKQVQSPPTETLGVENKGYFGDEQQIRTEPILPEIHFLNKPAS
                     KDSRGIADPNQSAK"
     exon            136..239
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            240..316
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            317..395
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            396..472
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            473..662
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            663..716
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            717..788
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            789..958
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1043
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1174
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1349
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1439
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1635
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1738
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1925
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2006
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2085
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2191
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2291
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2347
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..3367
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3293..3298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /note="hexamer: AATAAA"
     polyA_site      3320
                     /gene="ADAM7"
                     /gene_synonym="ADAM 7; ADAM-7; EAPI; GP-83; GP83"
                     /note="major polyA site"
ORIGIN      
        1 atccctgcag tggaagtgag gaggaagaaa ggtgaactcc ttttctcaag cacttctgct
       61 ctcctctacc agaatcactc agaatgcttc ccgggtgtat attcttgatg attttactca
      121 ttcctcaggt taaagaaaag ttcatccttg gagtagaggg tcaacaactg gttcgtccta
      181 aaaagcttcc tctgatacag aagcgagata ctggacacac ccatgatgat gacatactga
      241 aaacgtatga agaagaattg ttgtatgaaa taaaactaaa tagaaaaacc ttagtccttc
      301 atcttctaag atccagggag ttcctaggct caaattacag tgaaacattc tactccatga
      361 aaggagaagc gttcaccagg catcctcaga tcatggatca ttgtttttac caaggatcca
      421 tagtacacga atatgattca gctgccagta tcagtacgtg taatggtcta aggggattct
      481 tcagaataaa cgaccaaaga tacctcattg aaccagtgaa atactcagat gagggagaac
      541 atttggtgtt caaatataac ctgagggtgc cgtatggtgc caattattcc tgtacagagc
      601 ttaattttac cagaaaaact gttccagggg ataatgaatc tgaagaagac tccaaaataa
      661 aaggcatcca tgatgaaaag tatgttgaat tgttcattgt tgctgatgat actgtgtatc
      721 gcagaaatgg tcatcctcac aataaactaa ggaaccgaat ttggggaatg gtcaattttg
      781 tcaacatgat ttataaaacc ttaaacatcc atgtgacgtt ggttggcatt gaaatatgga
      841 cacatgaaga taaaatagaa ctatattcaa atatagaaac taccttattg cgtttttcat
      901 tttggcaaga aaagatcctt aaaacacgga aggattttga tcatgttgta ttactcagtg
      961 ggaagtggct ctactcacat gtgcaaggaa tttcttatcc agggggtatg tgcctgccct
     1021 attattccac cagtatcatt aaggatcttt tacctgacac aaacataatt gcaaacagaa
     1081 tggcacatca actggggcat aaccttggga tgcagcatga cgagttccca tgcacctgtc
     1141 cttcaggaaa atgcgtgatg gacagtgatg gaagcattcc tgcactgaaa ttcagtaaat
     1201 gcagccaaaa ccaataccac cagtacttga aggattataa gccaacatgc atgctcaaca
     1261 ttccatttcc ttacaatttt catgatttcc aattttgtgg aaacaagaag ttggatgagg
     1321 gtgaagagtg tgactgtggc cctgctcagg agtgtactaa tccttgctgt gatgcacaca
     1381 catgtgtact gaagccagga tttacttgtg cagaaggaga atgctgtgaa tcttgtcaga
     1441 taaaaaaagc agggtccata tgcagaccgg cgaaagatga atgtgatttt cctgagatgt
     1501 gcactggcca ctcgcctgcc tgtcctaagg accagttcag ggtcaatgga tttccttgca
     1561 agaactcaga aggctactgt ttcatgggga aatgtccaac tcgtgaggat cagtgctctg
     1621 aactatttga tgatgaggca atagagagtc atgatatctg ctacaagatg aatacaaaag
     1681 gaaataaatt tggatactgc aaaaacaagg aaaacagatt tcttccctgt gaggagaaag
     1741 atgtcagatg tggaaagatc tactgcactg gaggggagct ttcctctctc cttggagaag
     1801 acaagactta tcaccttaag gatccccaga agaatgctac tgtcaaatgc aaaactattt
     1861 ttttatacca tgattctaca gacattggcc tggtggcgtc aggaacaaaa tgtggagagg
     1921 gaatggtgtg caacaatggt gaatgtctaa acatggaaaa ggtctatatc tcaaccaatt
     1981 gcccctctca gtgcaatgaa aatcctgtgg atggccacgg actccagtgc cactgtgagg
     2041 aaggacaggc acctgtagcc tgtgaagaaa ccttacatgt taccaatatc accatcttgg
     2101 ttgttgtgct tgtcctggtt attgtcggta tcggagttct tatactatta gttcgttacc
     2161 gaaaatgtat caagttgaag caagttcaga gcccacctac agaaaccctg ggagtggaga
     2221 acaaaggata ctttggtgat gagcagcaga taaggactga gccaatcctg ccagaaattc
     2281 atttcctaaa taaacctgca agtaaagatt caagaggaat cgcagatccc aatcaaagtg
     2341 ccaagtgagc ttgaagttgg atatccaaaa tggccgtgca agcttaggct ggggattctg
     2401 gatgcaacgt ctttacaacc ttacctagat atctgctact cacatttttg gtagtgtttc
     2461 aaacgttctt tatccagaca gacaatgttt aagagaaaca acttatttct gttaatattt
     2521 accggtagaa ttcacaccct ctatcataaa catatgctgc agaaaaaaaa tgtcttgtgg
     2581 tctttcaaat gctctttagc acaatataaa aattcgtaac cttgctgtag tattttccta
     2641 caaaatgtta ctctgctttc ttttaagaat ccaaacttta aggatgataa cttacagtct
     2701 aagaagaaaa cattgcatat aaaaagttac ttttttggaa acataaaagt acgttttaaa
     2761 acttgaacat gacatcatta gcactaattc tggtttaaat gaaagtcctg cagaaatgcc
     2821 aaagaaggca gggcagagcg gcacggattc taggtaatta aaagtgaaag aggcagaaga
     2881 atagtggaca gaactgcagg atagtcctta aaataatggt ggtgggaaag gaaaacacag
     2941 aatgctcctg gcaattctaa attcctaggt ttgcctttct agaattcctt aagaagctga
     3001 cagagaaatc agagggttac aagaatttca gaaaatttac tccaagtgag aggacatact
     3061 cacaactcct atgaagggtt tctaaggtct ttgtcctgtg caatttgaca atgtgccatt
     3121 tctgtgctgt ctctgccctc tccctatccg tttgttatgg gatgggggat taccctggga
     3181 atgatttcag ctgcttctta cacagatgcc tctcaaggtg ttcttttgtg tcctctattt
     3241 tcttcttgtg aactgttaaa gctacatgca ttattttttt tccatttact gaaataaagt
     3301 tttcaagttc taaataaaaa tattctgact cgatgaaata aataaaggct acaaaagaag
     3361 gaagaaa
//
