LOCUS       NM_025220               3436 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 33 (ADAM33), transcript
            variant 1, mRNA.
ACCESSION   NM_025220
VERSION     NM_025220.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3436)
  AUTHORS   Khoramipour,M., Jalali,A., Abbasi,B. and Hadi Abbasian,M.
  TITLE     Evaluation of the association between clinical parameters and
            ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms with
            the severity of COVID-19
  JOURNAL   Int Immunopharmacol 123, 110707 (2023)
   PUBMED   37499392
  REMARK    GeneRIF: Evaluation of the association between clinical parameters
            and ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms
            with the severity of COVID-19.
REFERENCE   2  (bases 1 to 3436)
  AUTHORS   Lan,J., Zhou,Y., Liu,Y., Xia,Y., Wan,Y. and Cao,J.
  TITLE     Role of ADAM33 short isoform as a tumor suppressor in the
            pathogenesis of thyroid cancer via oncogenic function disruption of
            full-length ADAM33
  JOURNAL   Hum Cell 36 (4), 1451-1463 (2023)
   PUBMED   36977901
  REMARK    GeneRIF: Role of ADAM33 short isoform as a tumor suppressor in the
            pathogenesis of thyroid cancer via oncogenic function disruption of
            full-length ADAM33.
REFERENCE   3  (bases 1 to 3436)
  AUTHORS   Valencia-Perez Rea,D., Falfan-Valencia,R., Fricke-Galindo,I.,
            Buendia-Roldan,I., Chavez-Galan,L., Nava-Quiroz,K.J.,
            Alanis-Ponce,J. and Perez-Rubio,G.
  TITLE     The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is
            Associated with Clinical Markers in Patients with Severe COVID-19
  JOURNAL   Int J Mol Sci 24 (12), 9811 (2023)
   PUBMED   37372959
  REMARK    GeneRIF: The rs16969968 Tobacco Smoking-Related Single-Nucleotide
            Variant Is Associated with Clinical Markers in Patients with Severe
            COVID-19.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3436)
  AUTHORS   Fachri,M., Hatta,M., Massi,M.N., Santoso,A., Wikanningtyas,T.A.,
            Dwiyanti,R., Junita,A.R., Primaguna,M.R. and Sabir,M.
  TITLE     The strong correlation between ADAM33 expression and airway
            inflammation in chronic obstructive pulmonary disease and candidate
            for biomarker and treatment of COPD
  JOURNAL   Sci Rep 11 (1), 23162 (2021)
   PUBMED   34848800
  REMARK    GeneRIF: The strong correlation between ADAM33 expression and
            airway inflammation in chronic obstructive pulmonary disease and
            candidate for biomarker and treatment of COPD.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3436)
  AUTHORS   Yan,F., Hao,Y., Gong,X., Sun,H., Ding,J. and Wang,J.
  TITLE     Silencing a disintegrin and metalloproteinase-33 attenuates the
            proliferation of vascular smooth muscle cells via PI3K/AKT pathway:
            Implications in the pathogenesis of airway vascular remodeling
  JOURNAL   Mol Med Rep 24 (1) (2021)
   PUBMED   33982767
  REMARK    GeneRIF: Silencing a disintegrin and metalloproteinase33 attenuates
            the proliferation of vascular smooth muscle cells via PI3K/AKT
            pathway: Implications in the pathogenesis of airway vascular
            remodeling.
REFERENCE   6  (bases 1 to 3436)
  AUTHORS   Garlisi,C.G., Zou,J., Devito,K.E., Tian,F., Zhu,F.X., Liu,J.,
            Shah,H., Wan,Y., Motasim Billah,M., Egan,R.W. and Umland,S.P.
  TITLE     Human ADAM33: protein maturation and localization
  JOURNAL   Biochem Biophys Res Commun 301 (1), 35-43 (2003)
   PUBMED   12535637
  REMARK    GeneRIF: Data describe the expression and processing of ADAM33
REFERENCE   7  (bases 1 to 3436)
  AUTHORS   Chae,S.C., Yoon,K.H. and Chung,H.T.
  TITLE     Identification of novel polymorphisms in the Adam33 gene
  JOURNAL   J Hum Genet 48 (5), 278-281 (2003)
   PUBMED   12768445
  REMARK    GeneRIF: Novel polymorphisms were identified in ADAM33.
REFERENCE   8  (bases 1 to 3436)
  AUTHORS   Van Eerdewegh,P., Little,R.D., Dupuis,J., Del Mastro,R.G.,
            Falls,K., Simon,J., Torrey,D., Pandit,S., McKenny,J.,
            Braunschweiger,K., Walsh,A., Liu,Z., Hayward,B., Folz,C.,
            Manning,S.P., Bawa,A., Saracino,L., Thackston,M., Benchekroun,Y.,
            Capparell,N., Wang,M., Adair,R., Feng,Y., Dubois,J.,
            FitzGerald,M.G., Huang,H., Gibson,R., Allen,K.M., Pedan,A.,
            Danzig,M.R., Umland,S.P., Egan,R.W., Cuss,F.M., Rorke,S.,
            Clough,J.B., Holloway,J.W., Holgate,S.T. and Keith,T.P.
  TITLE     Association of the ADAM33 gene with asthma and bronchial
            hyperresponsiveness
  JOURNAL   Nature 418 (6896), 426-430 (2002)
   PUBMED   12110844
  REMARK    GeneRIF: genome-wide scan on 460 Caucasian families identified a
            locus on chromosome 20p13 that was linked to asthma (log(10) of the
            likelihood ratio (LOD), 2.94) and bronchial hyperresponsiveness
            (LOD, 3.93)
REFERENCE   9  (bases 1 to 3436)
  AUTHORS   Yoshinaka,T., Nishii,K., Yamada,K., Sawada,H., Nishiwaki,E.,
            Smith,K., Yoshino,K., Ishiguro,H. and Higashiyama,S.
  TITLE     Identification and characterization of novel mouse and human
            ADAM33s with potential metalloprotease activity
  JOURNAL   Gene 282 (1-2), 227-236 (2002)
   PUBMED   11814695
  REMARK    GeneRIF: The human protein shows homology with Xenopus ADAM13
            (44%), human ADAM19 (40%), and human ADAM12 (39%).
REFERENCE   10 (bases 1 to 3436)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358314.1 and AL356755.12.
            
            On Nov 30, 2019 this sequence version replaced NM_025220.4.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins, and have been implicated in a variety of biological
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. This
            protein is a type I transmembrane protein implicated in asthma and
            bronchial hyperresponsiveness. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (alpha).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358314.1, AB055891.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356518.7/ ENSP00000348912.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2657              AY358314.1         108-2764
            2658-3436           AL356755.12        15840-16618         c
FEATURES             Location/Qualifiers
     source          1..3436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3436
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /note="ADAM metallopeptidase domain 33"
                     /db_xref="GeneID:80332"
                     /db_xref="HGNC:HGNC:15478"
                     /db_xref="MIM:607114"
     exon            1..103
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..2448
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /note="isoform alpha preproprotein is encoded by
                     transcript variant 1; a disintegrin and metalloproteinase
                     domain 33; disintegrin and reprolysin metalloproteinase
                     family protein; disintegrin and metalloproteinase
                     domain-containing protein 33; a disintegrin and
                     metalloprotease 33; ADAM 33"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 33 isoform alpha preproprotein"
                     /protein_id="NP_079496.1"
                     /db_xref="CCDS:CCDS13058.1"
                     /db_xref="GeneID:80332"
                     /db_xref="HGNC:HGNC:15478"
                     /db_xref="MIM:607114"
                     /translation="MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHW
                     VLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQ
                     PVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKD
                     FSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVA
                     DHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDAN
                     ATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSE
                     LPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQ
                     LRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCS
                     LRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCA
                     RGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPC
                     AGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGL
                     VEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDK
                     PGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCR
                     RDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSP
                     DPQADQVQMPRSCLW"
     exon            104..183
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..260
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..339
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..416
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..606
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..672
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..744
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..911
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..996
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1139
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1317
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1407
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1603
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1712
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1911
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..1989
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2098
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2246
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2338
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2410
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..3436
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3418..3423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /note="hexamer: AATAAA"
     polyA_site      3436
                     /gene="ADAM33"
                     /gene_synonym="C20orf153; DJ964F7.1"
                     /note="major polyA site"
ORIGIN      
        1 acagctatgg gctggaggcc ccggagagct cgggggaccc cgttgctgct gctgctacta
       61 ctgctgctgc tctggccagt gccaggcgcc ggggtgcttc aaggacatat ccctgggcag
      121 ccagtcaccc cgcactgggt cctggatgga caaccctggc gcaccgtcag cctggaggag
      181 ccggtctcga agccagacat ggggctggtg gccctggagg ctgaaggcca ggagctcctg
      241 cttgagctgg agaagaacca caggctgctg gccccaggat acatagaaac ccactacggc
      301 ccagatgggc agccagtggt gctggccccc aaccacacgg atcattgcca ctaccaaggg
      361 cgagtaaggg gcttccccga ctcctgggta gtcctctgca cctgctctgg gatgagtggc
      421 ctgatcaccc tcagcaggaa tgccagctat tatctgcgtc cctggccacc ccggggctcc
      481 aaggacttct caacccacga gatctttcgg atggagcagc tgctcacctg gaaaggaacc
      541 tgtggccaca gggatcctgg gaacaaagcg ggcatgacca gccttcctgg tggtccccag
      601 agcaggggca ggcgagaagc gcgcaggacc cggaagtacc tggaactgta cattgtggca
      661 gaccacaccc tgttcttgac tcggcaccga aacttgaacc acaccaaaca gcgtctcctg
      721 gaagtcgcca actacgtgga ccagcttctc aggactctgg acattcaggt ggcgctgacc
      781 ggcctggagg tgtggaccga gcgggaccgc agccgcgtca cgcaggacgc caacgccacg
      841 ctctgggcct tcctgcagtg gcgccggggg ctgtgggcgc agcggcccca cgactccgcg
      901 cagctgctca cgggccgcgc cttccagggc gccacagtgg gcctggcgcc cgtcgagggc
      961 atgtgccgcg ccgagagctc gggaggcgtg agcacggacc actcggagct ccccatcggc
     1021 gccgcagcca ccatggccca tgagatcggc cacagcctcg gcctcagcca cgaccccgac
     1081 ggctgctgcg tggaggctgc ggccgagtcc ggaggctgcg tcatggctgc ggccaccggg
     1141 cacccgtttc cgcgcgtgtt cagcgcctgc agccgccgcc agctgcgcgc cttcttccgc
     1201 aaggggggcg gcgcttgcct ctccaatgcc ccggaccccg gactcccggt gccgccggcg
     1261 ctctgcggga acggcttcgt ggaagcgggc gaggagtgtg actgcggccc tggccaggag
     1321 tgccgcgacc tctgctgctt tgctcacaac tgctcgctgc gcccgggggc ccagtgcgcc
     1381 cacggggact gctgcgtgcg ctgcctgctg aagccggctg gagcgctgtg ccgccaggcc
     1441 atgggtgact gtgacctccc tgagttttgc acgggcacct cctcccactg tcccccagac
     1501 gtttacctac tggacggctc accctgtgcc aggggcagtg gctactgctg ggatggcgca
     1561 tgtcccacgc tggagcagca gtgccagcag ctctgggggc ctggctccca cccagctccc
     1621 gaggcctgtt tccaggtggt gaactctgcg ggagatgctc atggaaactg cggccaggac
     1681 agcgagggcc acttcctgcc ctgtgcaggg agggatgccc tgtgtgggaa gctgcagtgc
     1741 cagggtggaa agcccagcct gctcgcaccg cacatggtgc cagtggactc taccgttcac
     1801 ctagatggcc aggaagtgac ttgtcgggga gccttggcac tccccagtgc ccagctggac
     1861 ctgcttggcc tgggcctggt agagccaggc acccagtgtg gacctagaat ggtgtgccag
     1921 agcaggcgct gcaggaagaa tgccttccag gagcttcagc gctgcctgac tgcctgccac
     1981 agccacgggg tttgcaatag caaccataac tgccactgtg ctccaggctg ggctccaccc
     2041 ttctgtgaca agccaggctt tggtggcagc atggacagtg gccctgtgca ggctgaaaac
     2101 catgacacct tcctgctggc catgctcctc agcgtcctgc tgcctctgct cccaggggcc
     2161 ggcctggcct ggtgttgcta ccgactccca ggagcccatc tgcagcgatg cagctggggc
     2221 tgcagaaggg accctgcgtg cagtggcccc aaagatggcc cacacaggga ccaccccctg
     2281 ggcggcgttc accccatgga gttgggcccc acagccactg gacagccctg gcccctggac
     2341 cctgagaact ctcatgagcc cagcagccac cctgagaagc ctctgccagc agtctcgcct
     2401 gacccccaag cagatcaagt ccagatgcca agatcctgcc tctggtgaga ggtagctcct
     2461 aaaatgaaca gatttaaaga caggtggcca ctgacagcca ctccaggaac ttgaactgca
     2521 ggggcagagc cagtgaatca ccggacctcc agcacctgca ggcagcttgg aagtttcttc
     2581 cccgagtgga gcttcgaccc acccactcca ggaacccaga gccacattag aagttcctga
     2641 gggctggaga acactgctgg gcacactctc cagctcaata aaccatcagt cccagaagca
     2701 aaggtcacac agcccctgac ctccctcacc agtggaggct gggtagtgct ggccatccca
     2761 aaagggctct gtcctgggag tctggtgtgt ctcctacatg caatttccac ggacccagct
     2821 ctgtggaggg catgactgct ggccagaagc tagtggtcct ggggccctat ggttcgactg
     2881 agtccacact cccctggagc ctggctggcc tctgcaaaca aacataattt tggggacctt
     2941 ccttcctgtt tcttcccacc ctgtcttctc ccctaggtgg ttcctgagcc cccaccccca
     3001 atcccagtgc tacacctgag gttctggagc tcagaatctg acagcctctc ccccattctg
     3061 tgtgtgtcgg ggggacagag ggaaccattt aagaaaagat accaaagtag aagtcaaaag
     3121 aaagacatgt tggctatagg cgtggtggct catgcctata atcccagcac tttgggaagc
     3181 cggggtagga ggatcaccag aggccagcag gtccacacca gcctgggcaa cacagcaaga
     3241 caccgcatct acagaaaaat tttaaaatta gctgggcgtg gtggtgtgta cctgtaggcc
     3301 tagctgctca ggaggctgaa gcaggaggat cacttgagcc tgagttcaac actgcagtga
     3361 gctatggtgg caccactgca ctccagcctg ggtgacagag caagaccctg tctctaaaat
     3421 aaattttaaa aagaca
//
