LOCUS       NM_145004               2524 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 32 (ADAM32), transcript
            variant 1, mRNA.
ACCESSION   NM_145004 XM_940500
VERSION     NM_145004.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Choi,I., Woo,J.M., Hong,S., Jung,Y.K., Kim,D.H. and Cho,C.
  TITLE     Identification and characterization of ADAM32 with
            testis-predominant gene expression
  JOURNAL   Gene 304, 151-162 (2003)
   PUBMED   12568724
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105091.3 and AC105185.5.
            
            On Nov 23, 2018 this sequence version replaced NM_145004.6.
            
            Summary: This gene encodes a member of the disintegrin family of
            membrane-anchored proteins that play a role in diverse biological
            processes such as brain development, fertilization, tumor
            development and inflammation. This gene is predominantly expressed
            in the testis. The encoded protein undergoes proteolytic processing
            to generate a mature polypeptide comprised of an metalloprotease,
            disintegrin and epidermal growth factor-like domains. This gene is
            located in a cluster of other disintegrin and metallopeptidase
            family genes on chromosome 8. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034975.2, BC026169.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379907.9/ ENSP00000369238.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC105091.3         44656-44755
            101-180             AC105091.3         55008-55087
            181-242             AC105091.3         73579-73640
            243-318             AC105091.3         84052-84127
            319-395             AC105091.3         86713-86789
            396-567             AC105091.3         88299-88470
            568-636             AC105091.3         97819-97887
            637-708             AC105091.3         101686-101757
            709-875             AC105091.3         101952-102118
            876-957             AC105091.3         106838-106919
            958-1094            AC105091.3         123831-123967
            1095-1275           AC105091.3         148066-148246
            1276-1368           AC105091.3         158532-158624
            1369-1567           AC105091.3         159962-160160
            1568-1676           AC105091.3         168949-169057
            1677-1860           AC105091.3         170821-171004
            1861-1944           AC105185.5         111800-111883       c
            1945-2047           AC105185.5         103450-103552       c
            2048-2204           AC105185.5         100623-100779       c
            2205-2243           AC105185.5         87052-87090         c
            2244-2282           AC105185.5         83616-83654         c
            2283-2321           AC105185.5         82100-82138         c
            2322-2360           AC105185.5         76792-76830         c
            2361-2399           AC105185.5         74342-74380         c
            2400-2524           AC105185.5         73049-73173         c
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..2524
                     /gene="ADAM32"
                     /note="ADAM metallopeptidase domain 32"
                     /db_xref="GeneID:203102"
                     /db_xref="HGNC:HGNC:15479"
                     /db_xref="MIM:618602"
     exon            1..100
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2406
                     /gene="ADAM32"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin and metalloprotease domain 32; a
                     disintegrin and metalloproteinase domain 32; disintegrin
                     and metalloproteinase domain-containing protein 32;
                     metalloproteinase 12-like protein; testicular tissue
                     protein Li 13"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 32 isoform 1 preproprotein"
                     /protein_id="NP_659441.4"
                     /db_xref="CCDS:CCDS47846.1"
                     /db_xref="GeneID:203102"
                     /db_xref="HGNC:HGNC:15479"
                     /db_xref="MIM:618602"
                     /translation="MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEI
                     EYEQISYIIPIDEKLYTVHLKQRYFLADNFMIYLYNQGSMNTYSSDIQTQCYYQGNIE
                     GYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRS
                     LKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVG
                     LANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYL
                     LIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDP
                     KKCQCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKP
                     VCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVEC
                     RPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGK
                     GSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQEN
                     GDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAH
                     VCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENT
                     WLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGS
                     TQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSSSN"
     exon            101..180
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            181..242
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            243..318
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            319..395
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            396..567
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            568..636
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            637..708
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            709..875
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            876..957
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1094
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1275
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1368
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1567
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1676
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1860
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1944
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2047
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2204
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2243
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2282
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2321
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2360
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2399
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2524
                     /gene="ADAM32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM32"
                     /note="hexamer: AATAAA"
     polyA_site      2524
                     /gene="ADAM32"
                     /note="major polyA site"
ORIGIN      
        1 gacttcccaa cggcttcccg ctggcagccc cgaagccgca ccatgttccg cctctggttg
       61 ctgctggccg ggctctgcgg cctcctggcg tcaagacccg gttttcaaaa ttcacttcta
      121 cagatcgtaa ttccagagaa aatccaaaca aatacaaatg acagttcaga aatagaatat
      181 gaacaaatat cctatattat tccaatagat gagaaactgt acactgtgca ccttaaacaa
      241 agatattttt tagcagataa ttttatgatc tatttgtaca atcaaggatc tatgaatact
      301 tattcttcag atattcagac tcaatgctac tatcaaggaa atattgaagg atatccagat
      361 tccatggtca cactcagcac gtgctctgga ctaagaggaa tactgcaatt tgaaaatgtt
      421 tcttatggaa ttgagcctct ggaatctgca gttgaatttc agcatgttct ttacaaatta
      481 aagaatgaag acaatgatat tgcaattttt attgacagaa gcctgaaaga acaaccaatg
      541 gatgacaaca tttttataag tgaaaaatca gaaccagctg ttccagattt atttcctctt
      601 tatctagaaa tgcatattgt ggtggacaaa actttgtatg attactgggg ctctgatagc
      661 atgatagtaa caaataaagt catcgaaatt gttggccttg caaattcaat gttcacccaa
      721 tttaaagtta ctattgtgct gtcatcattg gagttatggt cagatgaaaa taagatttct
      781 acagttggtg aggcagatga attattgcaa aaatttttag aatggaaaca atcttatctt
      841 aacctaaggc ctcatgatat tgcatatcta ctaatttata tggattatcc tcgttatttg
      901 ggagcagtgt ttcctggaac aatgtgtatt actcgttatt ctgcaggagt tgcattgtac
      961 cccaaggaga taactctgga ggcatttgca gttattgtca cccagatgct ggcactcagt
     1021 ctgggaatat catatgacga cccaaagaaa tgtcaatgtt cagaatccac ctgtataatg
     1081 aatccagaag ttgtgcaatc caatggtgtg aagactttta gcagttgcag tttgaggagc
     1141 tttcaaaatt tcatttcaaa tgtgggtgtc aaatgtcttc agaataagcc acaaatgcaa
     1201 aaaaaatctc cgaaaccagt ctgtggcaat ggcagattgg agggaaatga aatctgtgat
     1261 tgtggtactg aggctcaatg tggacctgca agctgttgtg attttcgaac ttgtgtactg
     1321 aaagacggag caaaatgtta taaaggactg tgctgcaaag actgtcaaat tttacaatca
     1381 ggcgttgaat gtaggccgaa agcacatcct gaatgtgaca tcgctgaaaa ttgtaatgga
     1441 acctcaccag aatgtggtcc tgacataact ttaatcaatg gactttcatg caaaaataat
     1501 aagtttattt gttatgacgg agactgccat gatctcgatg cacgttgtga gagtgtattt
     1561 ggaaaaggtt caagaaatgc tccatttgcc tgctatgaag aaatacaatc tcaatcagac
     1621 agatttggga actgtggtag ggatagaaat aacaaatatg tgttctgtgg atggaggaat
     1681 cttatatgtg gaagattagt ttgtacctac cctactcgaa agcctttcca tcaagaaaat
     1741 ggtgatgtga tttatgcttt cgtacgagat tctgtatgca taactgtaga ctacaaattg
     1801 cctcgaacag ttccagatcc actggctgtc aaaaatggct ctcagtgtga tattgggagg
     1861 gtttgtgtaa atcgtgaatg tgtagaatca aggataatta aggcttcagc acatgtttgt
     1921 tcacaacagt gttctggaca tggagtgtgt gattccagaa acaagtgcca ttgttcgcca
     1981 ggctataagc ctccaaactg ccaaatacgt tccaaaggat tttccatatt tcctgaggaa
     2041 gatatgggtt caatcatgga aagagcatct gggaagactg aaaacacctg gcttctaggt
     2101 ttcctcattg ctcttcctat tctcattgta acaaccgcaa tagttttggc aaggaaacag
     2161 ttgaaaaagt ggttcgccaa ggaagaggaa ttcccaagta gcgaatctaa atcggaaggt
     2221 agcacacaga catatgccag ccaatccagc tcagaaggca gcactcagac atatgccagc
     2281 caaaccagat cagaaagcag cagtcaagct gatactagca aatccaaatc agaagatagt
     2341 gctgaagcat atactagcag atccaaatca caggacagta cccaaacaca aagcagtagt
     2401 aactagtgat tccttcagaa ggcaacggat aacatcgaga gtctcgctaa gaaatgaaaa
     2461 ttctgtcttt ccttccgtgg tcacagctga aagaaacaat aaattgagtg tggatcaatt
     2521 tgca
//
