LOCUS       NM_014269               3325 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 29 (ADAM29), transcript
            variant 1, mRNA.
ACCESSION   NM_014269 NM_021779 NM_021780
VERSION     NM_014269.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3325)
  AUTHORS   Zhao,M., Jia,W., Jiang,W.G., Wang,P., DU,G., Cheng,S. and Song,M.
  TITLE     ADAM29 Expression in Human Breast Cancer and its Effects on Breast
            Cancer Cells In Vitro
  JOURNAL   Anticancer Res 36 (3), 1251-1258 (2016)
   PUBMED   26977022
  REMARK    GeneRIF: Increased transcript expression of ADAM29 was observed in
            breast cancer tissues compared to normal ones. The expression of
            ADAM29 and its mutations in different domains significantly
            influenced proliferation, migration and invasion of breast cancer
            cells in vitro.
REFERENCE   2  (bases 1 to 3325)
  AUTHORS   Lin,S.W., Tsai,C.N., Lee,Y.S., Chu,S.F. and Chen,N.H.
  TITLE     Gene expression profiles in peripheral blood mononuclear cells of
            Asian obstructive sleep apnea patients
  JOURNAL   Biomed J 37 (2), 60-70 (2014)
   PUBMED   24732660
  REMARK    GeneRIF: PCMC expression of ADAM29, FLRT2, and SLC18A3 could be
            assessed as part of a routine screen to help identify individuals
            at risk of severe Obstructive sleep apnea in Asian populations
REFERENCE   3  (bases 1 to 3325)
  AUTHORS   Michailidou,K., Hall,P., Gonzalez-Neira,A., Ghoussaini,M.,
            Dennis,J., Milne,R.L., Schmidt,M.K., Chang-Claude,J., Bojesen,S.E.,
            Bolla,M.K., Wang,Q., Dicks,E., Lee,A., Turnbull,C., Rahman,N.,
            Fletcher,O., Peto,J., Gibson,L., Dos Santos Silva,I.,
            Nevanlinna,H., Muranen,T.A., Aittomaki,K., Blomqvist,C., Czene,K.,
            Irwanto,A., Liu,J., Waisfisz,Q., Meijers-Heijboer,H., Adank,M., van
            der Luijt,R.B., Hein,R., Dahmen,N., Beckman,L., Meindl,A.,
            Schmutzler,R.K., Muller-Myhsok,B., Lichtner,P., Hopper,J.L.,
            Southey,M.C., Makalic,E., Schmidt,D.F., Uitterlinden,A.G.,
            Hofman,A., Hunter,D.J., Chanock,S.J., Vincent,D., Bacot,F.,
            Tessier,D.C., Canisius,S., Wessels,L.F., Haiman,C.A., Shah,M.,
            Luben,R., Brown,J., Luccarini,C., Schoof,N., Humphreys,K., Li,J.,
            Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Couch,F.J., Wang,X.,
            Vachon,C., Stevens,K.N., Lambrechts,D., Moisse,M., Paridaens,R.,
            Christiaens,M.R., Rudolph,A., Nickels,S., Flesch-Janys,D.,
            Johnson,N., Aitken,Z., Aaltonen,K., Heikkinen,T., Broeks,A.,
            Veer,L.J., van der Schoot,C.E., Guenel,P., Truong,T.,
            Laurent-Puig,P., Menegaux,F., Marme,F., Schneeweiss,A., Sohn,C.,
            Burwinkel,B., Zamora,M.P., Perez,J.I., Pita,G., Alonso,M.R.,
            Cox,A., Brock,I.W., Cross,S.S., Reed,M.W., Sawyer,E.J.,
            Tomlinson,I., Kerin,M.J., Miller,N., Henderson,B.E., Schumacher,F.,
            Le Marchand,L., Andrulis,I.L., Knight,J.A., Glendon,G.,
            Mulligan,A.M., Lindblom,A., Margolin,S., Hooning,M.J.,
            Hollestelle,A., van den Ouweland,A.M., Jager,A., Bui,Q.M.,
            Stone,J., Dite,G.S., Apicella,C., Tsimiklis,H., Giles,G.G.,
            Severi,G., Baglietto,L., Fasching,P.A., Haeberle,L., Ekici,A.B.,
            Beckmann,M.W., Brenner,H., Muller,H., Arndt,V., Stegmaier,C.,
            Swerdlow,A., Ashworth,A., Orr,N., Jones,M., Figueroa,J.,
            Lissowska,J., Brinton,L., Goldberg,M.S., Labreche,F., Dumont,M.,
            Winqvist,R., Pylkas,K., Jukkola-Vuorinen,A., Grip,M., Brauch,H.,
            Hamann,U., Bruning,T., Radice,P., Peterlongo,P., Manoukian,S.,
            Bonanni,B., Devilee,P., Tollenaar,R.A., Seynaeve,C., van
            Asperen,C.J., Jakubowska,A., Lubinski,J., Jaworska,K., Durda,K.,
            Mannermaa,A., Kataja,V., Kosma,V.M., Hartikainen,J.M.,
            Bogdanova,N.V., Antonenkova,N.N., Dork,T., Kristensen,V.N.,
            Anton-Culver,H., Slager,S., Toland,A.E., Edge,S., Fostira,F.,
            Kang,D., Yoo,K.Y., Noh,D.Y., Matsuo,K., Ito,H., Iwata,H., Sueta,A.,
            Wu,A.H., Tseng,C.C., Van Den Berg,D., Stram,D.O., Shu,X.O., Lu,W.,
            Gao,Y.T., Cai,H., Teo,S.H., Yip,C.H., Phuah,S.Y., Cornes,B.K.,
            Hartman,M., Miao,H., Lim,W.Y., Sng,J.H., Muir,K., Lophatananon,A.,
            Stewart-Brown,S., Siriwanarangsan,P., Shen,C.Y., Hsiung,C.N.,
            Wu,P.E., Ding,S.L., Sangrajrang,S., Gaborieau,V., Brennan,P.,
            McKay,J., Blot,W.J., Signorello,L.B., Cai,Q., Zheng,W.,
            Deming-Halverson,S., Shrubsole,M., Long,J., Simard,J.,
            Garcia-Closas,M., Pharoah,P.D., Chenevix-Trench,G., Dunning,A.M.,
            Benitez,J. and Easton,D.F.
  CONSRTM   Breast and Ovarian Cancer Susceptibility Collaboration; Hereditary
            Breast and Ovarian Cancer Research Group Netherlands (HEBON);
            kConFab Investigators; Australian Ovarian Cancer Study Group;
            GENICA (Gene Environment Interaction and Breast Cancer in Germany)
            Network
  TITLE     Large-scale genotyping identifies 41 new loci associated with
            breast cancer risk
  JOURNAL   Nat Genet 45 (4), 353-361 (2013)
   PUBMED   23535729
REFERENCE   4  (bases 1 to 3325)
  AUTHORS   Wei,X., Moncada-Pazos,A., Cal,S., Soria-Valles,C., Gartner,J.,
            Rudloff,U., Lin,J.C., Rosenberg,S.A., Lopez-Otin,C. and Samuels,Y.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Analysis of the disintegrin-metalloproteinases family reveals
            ADAM29 and ADAM7 are often mutated in melanoma
  JOURNAL   Hum Mutat 32 (6), E2148-E2175 (2011)
   PUBMED   21618342
  REMARK    GeneRIF: mutated ADAM27 and ADAM7 genes could play a role in
            melanoma progression.
REFERENCE   5  (bases 1 to 3325)
  AUTHORS   Maloum,K., Settegrana,C., Chapiro,E., Cazin,B., Lepretre,S.,
            Delmer,A., Leporrier,M., Dreyfus,B., Tournilhac,O., Mahe,B.,
            Nguyen-Khac,F., Lesty,C., Davi,F. and Merle-Beral,H.
  TITLE     IGHV gene mutational status and LPL/ADAM29 gene expression as
            clinical outcome predictors in CLL patients in remission following
            treatment with oral fludarabine plus cyclophosphamide
  JOURNAL   Ann Hematol 88 (12), 1215-1221 (2009)
   PUBMED   19340428
  REMARK    GeneRIF: Results support the use of LPL and ADAM29 gene expression
            associated to IGHV mutational status for predicting the clinical
            outcome of patients treated by oral fludarabine + cyclophosphamide
            and could be considered for treatment strategies.
REFERENCE   6  (bases 1 to 3325)
  AUTHORS   Oppezzo,P., Vasconcelos,Y., Settegrana,C., Jeannel,D., Vuillier,F.,
            Legarff-Tavernier,M., Kimura,E.Y., Bechet,S., Dumas,G.,
            Brissard,M., Merle-Beral,H., Yamamoto,M., Dighiero,G. and Davi,F.
  CONSRTM   French Cooperative Group on CLL
  TITLE     The LPL/ADAM29 expression ratio is a novel prognosis indicator in
            chronic lymphocytic leukemia
  JOURNAL   Blood 106 (2), 650-657 (2005)
   PUBMED   15802535
  REMARK    GeneRIF: quantification of LPL and ADAM29 gene expression is a
            strong prognostic indicator in CLL, providing better prognostic
            assessment than ZAP-70 in advanced stages of the disease
REFERENCE   7  (bases 1 to 3325)
  AUTHORS   Xu,R., Cai,J., Xu,T., Zhou,W., Ying,B., Deng,K., Zhao,S. and Li,C.
  TITLE     Molecular cloning and mapping of a novel ADAM gene (ADAM29) to
            human chromosome 4
  JOURNAL   Genomics 62 (3), 537-539 (1999)
   PUBMED   10644455
REFERENCE   8  (bases 1 to 3325)
  AUTHORS   Cerretti,D.P., DuBose,R.F., Black,R.A. and Nelson,N.
  TITLE     Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs
            that show testis-specific gene expression
  JOURNAL   Biochem Biophys Res Commun 263 (3), 810-815 (1999)
   PUBMED   10512762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB073142.1, DB078034.1,
            DB080702.1, AK292410.1 and BC036070.1.
            
            On Aug 1, 2008 this sequence version replaced NM_014269.3.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins, and have been implicated in a variety of biological
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. The
            protein encoded by this gene is highly expressed in testis and may
            be involved in human spermatogenesis. Alternative splicing results
            in multiple transcript variants that encode the same protein.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the functional
            protein. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD625434.1, CD625429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359240.7/ ENSP00000352177.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                DB073142.1         1-49
            50-237              DB078034.1         3-190
            238-729             DB080702.1         86-577
            730-3306            AK292410.1         579-3155
            3307-3325           BC036070.1         3206-3224
FEATURES             Location/Qualifiers
     source          1..3325
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..3325
                     /gene="ADAM29"
                     /gene_synonym="CT73; svph1"
                     /note="ADAM metallopeptidase domain 29"
                     /db_xref="GeneID:11086"
                     /db_xref="HGNC:HGNC:207"
                     /db_xref="MIM:604778"
     exon            1..114
                     /gene="ADAM29"
                     /gene_synonym="CT73; svph1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..220
                     /gene="ADAM29"
                     /gene_synonym="CT73; svph1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..409
                     /gene="ADAM29"
                     /gene_synonym="CT73; svph1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..490
                     /gene="ADAM29"
                     /gene_synonym="CT73; svph1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..3325
                     /gene="ADAM29"
                     /gene_synonym="CT73; svph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             671..3133
                     /gene="ADAM29"
                     /gene_synonym="CT73; svph1"
                     /note="a disintegrin and metalloproteinase domain 29;
                     cancer/testis antigen 73; disintegrin and
                     metalloproteinase domain-containing protein 29;
                     metallaproteinase-disintegrin (ADAM29); testis secretory
                     sperm-binding protein Li 207a; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 29 preproprotein"
                     /protein_id="NP_055084.3"
                     /db_xref="CCDS:CCDS3823.1"
                     /db_xref="GeneID:11086"
                     /db_xref="HGNC:HGNC:207"
                     /db_xref="MIM:604778"
                     /translation="MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTR
                     GMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYY
                     HGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFS
                     TMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERND
                     SKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSEN
                     ITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHL
                     GHNLGMNHDEDTCRCSQPRCIMHEGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTK
                     DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLP
                     SGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKERGYCYEKSCHDRNEQCRRI
                     FGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMS
                     DHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSN
                     CSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCIL
                     LLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQ
                     SQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPPVMPSQSHPQLTPSQSQPP
                     VTPSQRQPQLMPSQSQPPVTPS"
     regulatory      3304..3309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM29"
                     /gene_synonym="CT73; svph1"
                     /note="hexamer: ATTAAA"
     polyA_site      3325
                     /gene="ADAM29"
                     /gene_synonym="CT73; svph1"
                     /note="major polyA site"
ORIGIN      
        1 gtgacatcac atccactaac caaatggggt ggtgtgagta tctcctataa aataaaagct
       61 ctcctgatgg cctgttcctg cacatttcct gaggacgccc tcgatcacaa gcagcttgct
      121 ggatgaataa aggaaagaag gtttatatac actaataata gaaatgtttt gggatggttc
      181 atgatttcga aaagcttcag agaaaataaa gatgcttaat gttagagtac aaaacattct
      241 ccctgcagtc tcacgaactg tgaacaaaaa ctgaagtgaa aactcatagt gcataactcg
      301 tcaatactcc tgtgatcgta taaccatcag caagaaaaca aatttgattg agcccccatc
      361 cagtcctctt tgcgtggaat cagacctctt ttgcagtgga aaggagcaga gaatgtgact
      421 ttcctgaaca acaggagcaa gaatcaatgc cagattctct tctctaaaaa taatcaattt
      481 gttactacag tgctgcagct ctgatggttc aactctgcca aaagatggat ctttaatgat
      541 tagcactaca cactgaccaa ctcagaagaa ggagccacac cacctgtgac tccagccctg
      601 acttctgctc tggaccagtg tttccataac agggacttca aaatcactgt gatttgaagc
      661 ctttttgaac atgaagatgt tactcctgct gcattgcctt ggggtgtttc tgtcctgttc
      721 tggacacatc caggatgagc acccccaata tcacagccct ccggatgtgg tgattcctgt
      781 gaggataact ggcaccacca gaggcatgac acctccaggc tggctctcct atatcctgcc
      841 ctttggaggc cagaaacaca ttatccacat aaaggtcaag aagcttttgt tttccaaaca
      901 cctccctgtg ttcacctaca cagaccaggg tgctatcctt gaggaccagc catttgtcca
      961 gaataactgc tactatcatg gttatgtgga aggggaccca gaatccctgg tttccctcag
     1021 tacctgtttt gggggttttc aaggaatatt acagataaat gactttgctt atgaaatcaa
     1081 gcccctagca ttttctacca cgtttgaaca tctggtatac aagatggaca gtgaggagaa
     1141 acaattttca accatgagat ccggatttat gcaaaatgaa ataacatgcc gaatggaatt
     1201 tgaagaaatt gataattcca ctcagaagca aagttcttat gtgggctggt ggatccattt
     1261 taggattgtt gaaattgtag tcgtcattga taattatctg tacattcgtt atgaaaggaa
     1321 cgactcaaag ttgctggagg atctatatgt tattgttaat atagtggatt ccattttgga
     1381 tgtcattggt gttaaggtgt tattatttgg tttggagatc tggaccaata aaaacctcat
     1441 tgtagtagat gatgtaagga aatctgtgca cctgtattgc aagtggaagt cggagaacat
     1501 tacgccccgg atgcaacatg acacctcaca tcttttcaca actctaggat taagagggtt
     1561 aagtggcata ggagctttta gaggaatgtg tacaccacac cgtagttgtg caattgttac
     1621 tttcatgaac aaaactttgg gcactttttc aattgcagtg gctcatcatc taggtcataa
     1681 tttgggcatg aaccatgatg aggatacatg tcgttgttca caacctagat gcataatgca
     1741 tgaaggcaac ccaccaataa ctaaatttag caattgtagt tatggtgatt tttgggaata
     1801 tactgtagag aggacaaagt gtttgcttga aacagtacac acaaaggaca tctttaatgt
     1861 gaagcgctgt gggaatggtg ttgttgaaga aggagaagag tgtgactgtg gacctttaaa
     1921 gcattgtgca aaagatccct gctgtctgtc aaattgcact ctgactgatg gttctacttg
     1981 tgcttttggg ctttgttgca aagactgcaa gttcctacca tcagggaaag tgtgtagaaa
     2041 ggaggtcaat gaatgtgatc ttccagagtg gtgcaatggt acttcccata agtgcccaga
     2101 tgacttttat gtggaagatg gaattccctg taaggagagg ggctactgct atgaaaagag
     2161 ctgtcatgac cgcaatgaac agtgtaggag gatttttggt gcaggcgcaa atactgcaag
     2221 tgagacttgc tacaaagaat tgaacacctt aggtgaccgt gttggtcact gtggtatcaa
     2281 aaatgctaca tatataaagt gtaatatctc agatgtccag tgtggaagaa ttcagtgtga
     2341 gaatgtgaca gaaattccca atatgagtga tcatactact gtgcattggg ctcgcttcaa
     2401 tgacataatg tgctggagta ctgattacca tttggggatg aagggacctg atattggtga
     2461 agtgaaagat ggaacagagt gtgggataga tcatatatgc atccacaggc actgtgtcca
     2521 tataaccatc ttgaatagta attgctcacc tgcattttgt aacaagaggg gcatctgcaa
     2581 caataaacat cactgccatt gcaattatct gtgggaccct cccaactgcc tgataaaagg
     2641 ctatggaggt agtgttgaca gtggcccacc ccctaagaga aagaagaaaa agaagttctg
     2701 ttatctgtgt atattgttgc ttattgtttt gtttatttta ttatgttgtc tttatcgact
     2761 ttgtaaaaaa agtaaaccaa taaaaaagca gcaagatgtt caaactccat ctgcaaaaga
     2821 agaggaaaaa attcagcgtc gacctcatga gttacctccc cagagtcaac cttgggtgat
     2881 gccttcccag agtcaacctc ctgtgacgcc ttcccagagt catcctcagg tgatgccttc
     2941 ccagagtcaa cctcctgtga caccctccca gagtcaacct cgggtgatgc cttctcagag
     3001 tcaacctcct gtgatgcctt cccagagtca tcctcagttg acgccttccc agagtcaacc
     3061 tcctgtgaca ccctcccaga ggcaacctca gttgatgcct tcccagagtc aacctcctgt
     3121 gacgccctcc tagagccaac ctcagttgat gccttcccag agtcaacctc ctgtgacgcc
     3181 ctcccagagc caacctcggg tgacaccctc ccagagtcaa cctcatgtga caccttaccg
     3241 gagtaaaagt ggtaaacaaa agcaatcagt accaattcca aaaactgtat ccagaaaagg
     3301 tacattaaaa aaataattcc tagta
//
