LOCUS       XM_047421272            6981 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ADAM metallopeptidase domain 28 (ADAM28),
            transcript variant X10, mRNA.
ACCESSION   XM_047421272
VERSION     XM_047421272.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6981
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..6981
                     /gene="ADAM28"
                     /gene_synonym="ADAM 28; eMDC II; eMDCII; MDC-L; MDCL"
                     /note="ADAM metallopeptidase domain 28; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 14 ESTs, 36 long SRA reads, and 99% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     7 samples with support for all annotated introns"
                     /db_xref="GeneID:10863"
                     /db_xref="HGNC:HGNC:206"
                     /db_xref="MIM:606188"
     CDS             224..2371
                     /gene="ADAM28"
                     /gene_synonym="ADAM 28; eMDC II; eMDCII; MDC-L; MDCL"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 28 isoform X8"
                     /protein_id="XP_047277228.1"
                     /db_xref="GeneID:10863"
                     /db_xref="HGNC:HGNC:206"
                     /db_xref="MIM:606188"
                     /translation="MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDD
                     CYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDE
                     KNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRY
                     NENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSK
                     WRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGT
                     MAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC
                     LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGEC
                     CEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCP
                     TLQEQCTELWGPGTEVADKSCYNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQG
                     GSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKS
                     TNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAM
                     VIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLPVEGN
                     EPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA"
ORIGIN      
        1 aagtggttta tcctataaga cttcatccac tgcataaaag agaggccaaa gagccagagc
       61 aacagttcct gtcatccatg aaaataagct gagtccatca acctctactt atctaggccc
      121 acatttgggg gaaatttata gcctgggatt actgacagca gagcagacct caacaactga
      181 ggatttaagc aaagaacaat ttgaaactga attaaagtat aaaatgacaa ttaatggaaa
      241 aattgcagtg ctttatttga aaaaaaacaa gaacctcctt gcaccaggct acacggaaac
      301 atattataat tccactggaa aggagatcac cacaagccca caaattatgg atgattgtta
      361 ttatcaagga catattctta atgaaaaggt ttctgacgct agcatcagca catgtagggg
      421 tctaaggggc tacttcagtc agggggatca aagatacttt attgaacctt taagccccat
      481 acatcgggat ggacaggagc atgcactctt caagtataac cctgatgaaa agaattatga
      541 cagcacctgt gggatggatg gtgtgttgtg ggcccacgat ttgcagcaga acattgccct
      601 acctgccacc aaactagtaa aattgaaaga caggaaggtt caggaacatg agaaatacat
      661 agaatattat ttggtcctgg ataatggtga gtttaaaagg tacaatgaga atcaagatga
      721 gatcagaaag agggtatttg agatggctaa ttatgtcaac atgctttata aaaagctcaa
      781 tactcatgtg gccttagttg gtatggaaat ctggactgac aaggataaga taaagataac
      841 cccaaatgca agcttcacct tggagaattt ttctaaatgg agggggagtg ttctctcaag
      901 aagaaagcgt catgatattg ctcagttaat cacagcaaca gaacttgctg gaacgactgt
      961 gggtcttgca tttatgtcta caatgtgttc tccttattct gttggcgttg ttcaggacca
     1021 cagcgataat cttcttagag ttgcagggac aatggcacat gaaatgggcc acaactttgg
     1081 aatgtttcat gacgactatt cttgcaagtg tccttctaca atatgtgtga tggacaaagc
     1141 actgagcttc tatataccca cagacttcag ttcctgcagc cgtctcagct atgacaagtt
     1201 ttttgaagat aaattatcaa attgcctctt taatgctcca ttgcctacag atatcatatc
     1261 cactccaatt tgtgggaacc agttggtgga aatgggagag gactgtgatt gtgggacatc
     1321 tgaggaatgt accaatattt gctgtgatgc taagacatgt aaaatcaaag caacttttca
     1381 atgtgcatta ggagaatgtt gtgaaaaatg ccaatttaaa aaggctggga tggtgtgcag
     1441 accagcaaaa gatgagtgcg acctgcctga aatgtgtaat ggtaaatctg gtaattgtcc
     1501 tgatgataga ttccaagtca atggcttccc ttgccatcac gggaagggcc actgcttgat
     1561 ggggacatgc cccacactgc aggagcagtg cacagagctg tggggaccag gaactgaggt
     1621 tgcagataag tcatgttaca acaggaatga aggtgggtca aagtacgggt actgtcgcag
     1681 agtggatgac acactcattc cctgcaaagc aaatgatacc atgtgtggga agttgttctg
     1741 tcaaggtggg tcggataatt tgccctggaa aggacggata gtgactttcc tgacatgtaa
     1801 aacatttgat cctgaagaca caagtcaaga aataggcatg gtggccaatg gaactaagtg
     1861 tggcgataac aaggtttgca ttaatgcaga atgtgtggat attgagaaag cctacaaatc
     1921 aaccaattgc tcatctaagt gcaaaggaca tgctgtgtgt gaccatgagc tccagtgtca
     1981 atgtgaggaa ggatggatcc ctcccgactg cgatgactcc tcagtggtct tccacttctc
     2041 cattgtggtt ggggtgctgt tcccaatggc ggtcattttt gtggtggttg ctatggtaat
     2101 ccggcaccag agctccagag aaaagcagaa gaaagatcag aggccactat ctaccactgg
     2161 caccaggcca cacaaacaga agaggaaacc ccagatggta aaggctgttc aaccccaaga
     2221 gatgagtcag atgaagcccc atgtgtatga tctgccagta gaaggcaatg agcccccagc
     2281 ctcttttcat aaagacacaa acgcacttcc ccctactgtt ttcaaggata atccagtgtc
     2341 tacacctaag gactcaaatc caaaagcatg aagcaacagc taagcaagaa ctaatggcta
     2401 aattatcaac ttggaaaact ggaaaatctg gatggcagag aaatatacta tctatctcac
     2461 cagtatttgc tctcgactca agaaggttaa cattttctga ttcatgttag actttgaaga
     2521 gactaaagaa aattttcaag aggaacatat gcctgagaac ctttgcatga atttaaaatt
     2581 tcaattatcc attcttataa gaaggaagat gattgtaaag aaatatctcc gaagttaaaa
     2641 tctgtaatag gaattgattc attctctaat gaaaacaaaa cataaaaaca tcacactaat
     2701 cttggaggaa taagaaaaat tgtacatcca ttaaatgtac aattgattgc aacatcttga
     2761 ttgttttaac cattaacttg tcaaattaca atcacagtta agaaaatgat gtaaaattct
     2821 gttttgtgga tctctttcct agattagctt ctgaaatcat tattagctat atcatttgag
     2881 gttttctaca atttggtata actaagaatt taaaaatgtt ttatcatata tatttgtata
     2941 attaattact ggcatggtta aagtggtttt cactttttaa atggagaaaa tttcagttaa
     3001 attaatagga taaaccaggt tgcgaactgg tgacctgtag gccatgtttg cactgcaaat
     3061 atatttggtc tgaatgatat tgatattgga cacatagtac ttttacatgt tttgaatgta
     3121 ttgctaatat ttaaaaattg agagatcttg cataaacaat agattcccag ctttgtcaga
     3181 tgtaatctaa aagtaatccg atgctttgtc aacaacagac ttacattgcc catagcaacc
     3241 gtcagcttag ttgatgggta atgtagcaaa cactattggt ttcctaccaa ataatcccct
     3301 ttttcctggc ttttagaaca ataattttgt tcacctgccc acttctagga aagaatatcc
     3361 tatctaatct atctatctca gggataaatc cctatccttt taagtaagtc aagtcaatta
     3421 aaataacctc atttttcctt gctagtggtc gacttggaga tgattttata atcctccccc
     3481 tccctttttt tttttgctag taagacgaca gaggaattat gttacaacac ttctggaaaa
     3541 tttttcctcg tctctttttc tggatatggg catctgaata ctctagctgg tactgctgcg
     3601 ctccacacgg tgattatgaa ggctgaaaaa gatagataga gcagaaagat gaaaagaata
     3661 aaacctggcc tttcaatgat gtcatggaat tggtagatca gtgactgctg gagttacctc
     3721 acactttctt ggtactcctt attatatgag ccatacattt tccttgttgt ttaagccatt
     3781 ttgaattgga ttttctctca ctttcaacag agatcatcct aactagtaaa gtagctgttt
     3841 ccataatcag ggaacatgct ttagttcatc atcacagcta cagtttttct tgtatttgtc
     3901 tgcttcaccc atttctatca atcacttacc tggtccccac aggcctgtcg cttcatgagg
     3961 aactttatgg ttcatttacc cttgcagtat gaggttctag ataagcccac tctggcctca
     4021 aaagtgaagc tcagtcctca ggaaatccag agtccactga tcaaatcact gtcaaggata
     4081 caggcttttt ctccatgtgg catttgcaga agaacaactt taaaagtaga gctttatctg
     4141 ccctgtgagg tttcagaaga ccctcccctg acccagaaat aaatccctat ttcctggaaa
     4201 gccattatgt actcgtgacc aacttgtgaa cttttctgtg ttgttgttgt tgttttttaa
     4261 atatctgtcc ccagtaatag attcacctaa tcctttttta tactgatgga atggaaatct
     4321 taaatctatg aatcctcaac tagccatgta ccataaccca agcaaaaact aaaccataca
     4381 ctctcaaaag cagtggcatg tgaacatgcc tgcaagttcc taaatgatgt cactaggtcc
     4441 ctgatgcaga tgcatcatac gtcctatttg aagagaagaa atgcagtaca atgacaggaa
     4501 aaccattatt ttatcataga actgcgaacc caagtcctac aatgtttccc tttcagctca
     4561 actgcagaat agtttagaac agactttttg atttcacaat actgtttcca cacttactta
     4621 tatccgtaac tttctaactt taagggaatt ccgcttattt gacatttaac tacctcagat
     4681 atgccaccaa acctgttttc atcattagtt atttttacct tgtctacttt aaaacagtga
     4741 aattattagg ttaaattatg tttttatcca gttactctaa gataccttag tgtttgtcta
     4801 cttattacaa ctcaccaaat tactggtttt atatggcctt tgggaaggct tttagctttt
     4861 tataaaataa tgaagtatgc atgaaaagaa agcaaatttt agttggttgc agtcagagaa
     4921 tatggaaagg gttattatta taattaggat tttattattc acattggaaa tcactgctat
     4981 gtgttaagga attgaaggtg gcctctggct agcagccatt aagaaaatga gcccctgagt
     5041 tcaacgaccc tcaaatgaag tgaagtctac caataaccac tgaataagct tggaatttta
     5101 gattccttcc cagctgaatc ttgacttcag ccttgtgaga caccctgaag tagaggatgc
     5161 agctaaattt tgtccagatt acacacccac agaaactgta tgataattaa tatgtgttgt
     5221 ttaaagttgt tatggtttgg agatatttgt tatgcagcaa tagatagctg atacaaggaa
     5281 gtagagaaca aacattttct attagtctgt tttcacatgg ctataaagaa taccacctga
     5341 gactgggtaa tttataaaga aaggaggatt aattgactca gatttccaca tggcctagga
     5401 ggcctcagga aacttacaat catgatgaaa gaggaagcag aaacatctca tatgatggaa
     5461 gatgtgtatg aaggaggaac tgtcaaacac ttataaaacc atcagatctc ttgagagctt
     5521 actatctcga caaaagcatg ggggaaacca cccccatgat ccaatcacct cccacctggt
     5581 ccctccctca acatgtggag attatagcaa ttaaaaaaat gagatttggg gggatggaca
     5641 cagagccaaa ccatataatg ttttaaatgc tccagatagg tttaggtaaa attaactata
     5701 tttaataggc tttcatcact gcaaaacttt ttttcctttc tttgtgtctc tagtctcttc
     5761 catttgttct cccttcttta ctagcaccga ggatttgctt gaaatctctg atagccagta
     5821 ttctcattta tcatattctt tctcactttg tgtttccttg gtaattttgg ataactcctt
     5881 aaatttatct tccaaattac tggtttttat attctgtact gtcagtcctc ctgttcacta
     5941 atttcaaaat ttatagttgt ttctcttgtt tacttatata gttgtttctc ttgtttactt
     6001 aataacattc tcttctttcc tatcagttta attttataaa ggctaaccaa ttaactgttt
     6061 ttaacttata tttccagata ttttaaaaat taaagcaaaa tgtgtataaa ctttattact
     6121 gcttcccaca gtaaatattt ttcagaagta catgctttct cagccacttg actagtatgt
     6181 tccccatcat tcaaagacac cattatttcc taagtgttat attgctattt ttcagttggt
     6241 gcatccaata ttattatcag ctttaatatt gtttcatcat atgtcattgt tcaaagaatc
     6301 catctcttga gcgtaagcta aataatttgc atacactagc atctggatgt aatatggaaa
     6361 aatatggaaa tggttggggt gataagcaag tcttgcatat tcttttctcc tcaatttttt
     6421 ttctccaaag tgggccaagc caagagtggc acagctgtgt ggagatactg agctccacct
     6481 tgtcagggaa gatcccaact caggagaaaa cacctctaac aaaatctgta gccacgttgg
     6541 cacatctgcc cttgaattca ctttgtctct tttgctgctt ccataaaaag gctttccctt
     6601 gacaatgtta ggcacttttt agcaactagg cctgggtggt ctgctacaat gcccaacact
     6661 taatacagta tcactattac tgttagtagt atgctaagcg aatactattg ttataaaaaa
     6721 aatcctaagc atgaaaatta cggtatacaa tttattgtga aggcaacttc ttgtgaacat
     6781 taaacggttt atctccttca cctcatatta aagtccatac tcttgggata tatctgacat
     6841 ctcaatatta aatgactaag atgactaagt cgtttatgtt gctcccacct cacacaaagt
     6901 taaaactatt tgttacttta aatagtttga caatgttatt ttaaaatctg gacaaatcac
     6961 aaatataaaa tacttattta a
//
