LOCUS       NM_003812               6334 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 23 (ADAM23), transcript
            variant 1, mRNA.
ACCESSION   NM_003812
VERSION     NM_003812.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6334)
  AUTHORS   Souza,I.L.M., Oliveira,N.H., Huamani,P.A.M., Martin,A.S.,
            Borgonovo,Z.L.M., Nakao,L.S. and Zanata,S.M.
  TITLE     Endocytosis of the non-catalytic ADAM23: Recycling and long
            half-life properties
  JOURNAL   Exp Cell Res 398 (2), 112415 (2021)
   PUBMED   33296662
  REMARK    GeneRIF: Endocytosis of the non-catalytic ADAM23: Recycling and
            long half-life properties.
REFERENCE   2  (bases 1 to 6334)
  AUTHORS   Zmetakova,I., Kalinkova,L., Smolkova,B., Horvathova Kajabova,V.,
            Cierna,Z., Danihel,L., Bohac,M., Sedlackova,T., Minarik,G.,
            Karaba,M., Benca,J., Cihova,M., Buocikova,V., Miklikova,S., Mego,M.
            and Fridrichova,I.
  TITLE     A disintegrin and metalloprotease 23 hypermethylation predicts
            decreased disease-free survival in low-risk breast cancer patients
  JOURNAL   Cancer Sci 110 (5), 1695-1704 (2019)
   PUBMED   30815959
  REMARK    GeneRIF: Results indicate that ADAM23 is likely involved in breast
            cancer (BC) progression and dissemination of mesenchymal
            circulating tumor cells. ADAM23 methylation has the potential to
            function as a novel prognostic marker.
REFERENCE   3  (bases 1 to 6334)
  AUTHORS   Kalinkova,L., Zmetakova,I., Smolkova,B., Minarik,G., Sedlackova,T.,
            Horvathova Kajabova,V., Cierna,Z., Mego,M. and Fridrichova,I.
  TITLE     Decreased methylation in the SNAI2 and ADAM23 genes associated with
            de-differentiation and haematogenous dissemination in breast
            cancers
  JOURNAL   BMC Cancer 18 (1), 875 (2018)
   PUBMED   30189837
  REMARK    GeneRIF: The relationships between the decreased methylation levels
            of the SNAI2 and ADAM23 genes and cancer de-differentiation and
            haematogenous dissemination, respectively, indicate novel functions
            of those genes in the invasive processes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6334)
  AUTHORS   Choi,J.S., Kim,K.H., Jeon,Y.K., Kim,S.H., Jang,S.G., Ku,J.L. and
            Park,J.G.
  TITLE     Promoter hypermethylation of the ADAM23 gene in colorectal cancer
            cell lines and cancer tissues
  JOURNAL   Int J Cancer 124 (6), 1258-1262 (2009)
   PUBMED   19089928
  REMARK    GeneRIF: ADAM23 may be down-regulated by aberrant promoter
            hypermethylation during the progression of colorectal cancer.
REFERENCE   5  (bases 1 to 6334)
  AUTHORS   Takada,H., Imoto,I., Tsuda,H., Nakanishi,Y., Ichikura,T.,
            Mochizuki,H., Mitsufuji,S., Hosoda,F., Hirohashi,S., Ohki,M. and
            Inazawa,J.
  TITLE     ADAM23, a possible tumor suppressor gene, is frequently silenced in
            gastric cancers by homozygous deletion or aberrant promoter
            hypermethylation
  JOURNAL   Oncogene 24 (54), 8051-8060 (2005)
   PUBMED   16103878
  REMARK    GeneRIF: ADAM23 is frequently silenced in gastric cancers by
            homozygous deletion or aberrant promoter methylation.
REFERENCE   6  (bases 1 to 6334)
  AUTHORS   Costa,F.F., Colin,C., Shinjo,S.M., Zanata,S.M., Marie,S.K.,
            Sogayar,M.C. and Camargo,A.A.
  TITLE     ADAM23 methylation and expression analysis in brain tumors
  JOURNAL   Neurosci Lett 380 (3), 260-264 (2005)
   PUBMED   15862898
  REMARK    GeneRIF: Together, these results indicate that ADAM23
            down-regulation by methylation in brain tumors is a rare event and
            it may help explain why brain tumor metastases are rarely found
            elsewhere in the body.
REFERENCE   7  (bases 1 to 6334)
  AUTHORS   Sun,Y.P., Deng,K.J., Wang,F., Zhang,J., Huang,X., Qiao,S. and
            Zhao,S.
  TITLE     Two novel isoforms of Adam23 expressed in the developmental process
            of mouse and human brains
  JOURNAL   Gene 325, 171-178 (2004)
   PUBMED   14697522
REFERENCE   8  (bases 1 to 6334)
  AUTHORS   Cal,S., Freije,J.M., Lopez,J.M., Takada,Y. and Lopez-Otin,C.
  TITLE     ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via
            interaction with the alphavbeta3 integrin through an
            RGD-independent mechanism
  JOURNAL   Mol Biol Cell 11 (4), 1457-1469 (2000)
   PUBMED   10749942
REFERENCE   9  (bases 1 to 6334)
  AUTHORS   Poindexter,K., Nelson,N., DuBose,R.F., Black,R.A. and Cerretti,D.P.
  TITLE     The identification of seven metalloproteinase-disintegrin (ADAM)
            genes from genomic libraries
  JOURNAL   Gene 237 (1), 61-70 (1999)
   PUBMED   10524237
REFERENCE   10 (bases 1 to 6334)
  AUTHORS   Sagane,K., Ohya,Y., Hasegawa,Y. and Tanaka,I.
  TITLE     Metalloproteinase-like, disintegrin-like, cysteine-rich proteins
            MDC2 and MDC3: novel human cellular disintegrins highly expressed
            in the brain
  JOURNAL   Biochem J 334 (Pt 1) (Pt 1), 93-98 (1998)
   PUBMED   9693107
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009225.4, CN399765.1,
            AB009672.1, AC010731.3 and R43984.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003812.3.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins and have been implicated in a variety of biological
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. It
            is reported that inactivation of this gene is associated with
            tumorigenesis in human cancers. [provided by RefSeq, May 2013].
            
            Transcript Variant: Variants 1 and 2 encode isoforms that are the
            same length, but have distinct protein sequences.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.226371.1, AJ005580.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264377.8/ ENSP00000264377.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC009225.4         22082-22193
            113-325             CN399765.1         93-305
            326-3090            AB009672.1         214-2978
            3091-6038           AC010731.3         27456-30403
            6039-6334           R43984.1           15-310              c
FEATURES             Location/Qualifiers
     source          1..6334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..6334
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /note="ADAM metallopeptidase domain 23"
                     /db_xref="GeneID:8745"
                     /db_xref="HGNC:HGNC:202"
                     /db_xref="MIM:603710"
     exon            1..549
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..2834
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; disintegrin and metalloproteinase
                     domain-containing protein 23; metalloproteinase-like,
                     disintegrin-like, and cysteine-rich protein 3"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 23 isoform 1 preproprotein"
                     /protein_id="NP_003803.1"
                     /db_xref="CCDS:CCDS2369.1"
                     /db_xref="GeneID:8745"
                     /db_xref="HGNC:HGNC:202"
                     /db_xref="MIM:603710"
                     /translation="MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPC
                     RLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNIS
                     YSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGS
                     KFILDLILNNGLLSSDYVEIHYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGL
                     HGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLS
                     ELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVD
                     SIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRIKQHADAVHLISRV
                     TFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKC
                     DCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNG
                     YVEAGEECDCGFHVECYGLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNE
                     CDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDK
                     FCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTS
                     FYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDS
                     KGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPKGPSATNLIIGSI
                     AGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI"
     exon            550..767
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..844
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            845..908
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            909..991
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1055
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1128
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1202
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1268
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1340
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1504
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1589
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1680
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1729
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1829
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1901
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1991
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2072
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2123
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2187
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2293
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2413
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2582
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2694
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2785
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..6334
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3652..3657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /note="hexamer: AATAAG"
     polyA_site      3673
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /note="major polyA site"
     regulatory      6234..6239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /note="hexamer: AATAAA"
     polyA_site      6269
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
     regulatory      6314..6319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /note="hexamer: ATTAAA"
     polyA_site      6334
                     /gene="ADAM23"
                     /gene_synonym="MDC-3; MDC3"
                     /note="major polyA site"
ORIGIN      
        1 atcctcaggc ccggcggcag cccccgcagt cgctgaagcg gccgcgcccg ccgggggagg
       61 gagtagccgc tggggaggct ccaagttggc ggagcggcga ggacccctgg actcctctgc
      121 gtcccgcccc gggagtggct gcgaggctag gcgagccggg aaagggggcg ccgcccagcc
      181 ccgagccccg cgccccgtgc cccgagcccg gagccccctg cccgccgcgg caccatgcgc
      241 gccgagccgg cgtgaccggc tccgcccgcg gccgccccgc agctagcccg gcgctctcgc
      301 cggccacacg gagcggcgcc cgggagctat gagccatgaa gccgcccggc agcagctcgc
      361 ggcagccgcc cctggcgggc tgcagccttg ccggcgcttc ctgcggcccc caacgcggcc
      421 ccgccggctc ggtgcctgcc agcgccccgg cccgcacgcc gccctgccgc ctgcttctcg
      481 tccttctcct gctgcctccg ctcgccgcct cgtcccggcc ccgcgcctgg ggggctgctg
      541 cgcccagcgc tccgcattgg aatgaaactg cagaaaaaaa tttgggagtc ctggcagatg
      601 aagacaatac attgcaacag aatagcagca gtaatatcag ttacagcaat gcaatgcaga
      661 aagaaatcac actgccttca agactcatat attacatcaa ccaagactcg gaaagccctt
      721 atcacgttct tgacacaaag gcaagacacc agcaaaaaca taataaggct gtccatctgg
      781 cccaggcaag cttccagatt gaagccttcg gctccaaatt cattcttgac ctcatactga
      841 acaatggttt gttgtcttct gattatgtgg agattcacta cgaaaatggg aaaccacagt
      901 actctaaggg tggagagcac tgttactacc atggaagcat cagaggcgtc aaagactcca
      961 aggtggctct gtcaacctgc aatggacttc atggcatgtt tgaagatgat accttcgtgt
     1021 atatgataga gccactagag ctggttcatg atgagaaaag cacaggtcga ccacatataa
     1081 tccagaaaac cttggcagga cagtattcta agcaaatgaa gaatctcact atggaaagag
     1141 gtgaccagtg gccctttctc tctgaattac agtggttgaa aagaaggaag agagcagtga
     1201 atccatcacg tggtatattt gaagaaatga aatatttgga acttatgatt gttaatgatc
     1261 acaaaacgta taagaagcat cgctcttctc atgcacatac caacaacttt gcaaagtccg
     1321 tggtcaacct tgtggattct atttacaagg agcagctcaa caccagggtt gtcctggtgg
     1381 ctgtagagac ctggactgag aaggatcaga ttgacatcac caccaaccct gtgcagatgc
     1441 tccatgagtt ctcaaaatac cggcagcgca ttaagcagca tgctgatgct gtgcacctca
     1501 tctcgcgggt gacatttcac tataagagaa gcagtctgag ttactttgga ggtgtctgtt
     1561 ctcgcacaag aggagttggt gtgaatgagt atggtcttcc aatggcagtg gcacaagtat
     1621 tatcgcagag cctggctcaa aaccttggaa tccaatggga accttctagc agaaagccaa
     1681 aatgtgactg cacagaatcc tggggtggct gcatcatgga ggaaacaggg gtgtcccatt
     1741 ctcgaaaatt ttcaaagtgc agcattttgg agtatagaga ctttttacag agaggaggtg
     1801 gagcctgcct tttcaacagg ccaacaaagc tatttgagcc cacggaatgt ggaaatggat
     1861 acgtggaagc tggggaggag tgtgattgtg gttttcatgt ggaatgctat ggattatgct
     1921 gtaagaaatg ttccctctcc aacggggctc actgcagcga cgggccctgc tgtaacaata
     1981 cctcatgtct ttttcagcca cgagggtatg aatgccggga tgctgtgaac gagtgtgata
     2041 ttactgaata ttgtactgga gactctggtc agtgcccacc aaatcttcat aagcaagacg
     2101 gatatgcatg caatcaaaat cagggccgct gctacaatgg cgagtgcaag accagagaca
     2161 accagtgtca gtacatctgg ggaacaaagg ctgcagggtc tgacaagttc tgctatgaaa
     2221 agctgaatac agaaggcact gagaagggaa actgcgggaa ggatggagac cggtggattc
     2281 agtgcagcaa acatgatgtg ttctgtggat tcttactctg taccaatctt actcgagctc
     2341 cacgtattgg tcaacttcag ggtgagatca ttccaacttc cttctaccat caaggccggg
     2401 tgattgactg cagtggtgcc catgtagttt tagatgatga tacggatgtg ggctatgtag
     2461 aagatggaac gccatgtggc ccgtctatga tgtgtttaga tcggaagtgc ctacaaattc
     2521 aagccctaaa tatgagcagc tgtccactcg attccaaggg taaagtctgt tcgggccatg
     2581 gggtgtgtag taatgaagcc acctgcattt gtgatttcac ctgggcaggg acagattgca
     2641 gtatccggga tccagttagg aaccttcacc cccccaagga tgaaggaccc aagggtccta
     2701 gtgccaccaa tctcataata ggctccatcg ctggtgccat cctggtagca gctattgtcc
     2761 ttgggggcac aggctgggga tttaaaaatg tcaagaagag aaggttcgat cctactcagc
     2821 aaggccccat ctgaatcagc tgcgctggat ggacaccgcc ttgcactgtt ggattctggg
     2881 tatgacatac tcgcagcagt gttactggaa ctattaagtt tgtaaacaaa acctttgggt
     2941 ggtaatgact acggagctaa agttggggtg acaaggatgg ggtaaaagaa aactgtctct
     3001 tttggaaata atgtcaaaga acacctttca ccacctgtca gtaaacgggg gagggggcaa
     3061 aagaccatgc tataaaaaga actgttccag aatctttttt ttccctaatg gacgaaggaa
     3121 caacacacac acaaaaatta aatgcaataa aggaatcatt aaaaaaaata gtaaatgatt
     3181 ttttttccct cagcctgctg gcacttaata tcttctaaat gatttggcat gatttttttt
     3241 tctttactac cgatgacaaa ctccagtggc atgaagatct aattttcaaa agggtaaaaa
     3301 ctgcatggca tatatacaac aagctagcaa gccaattctc agcaaaacct gcaacagaat
     3361 tcctaaagtg aagatgacag atgaacacaa agaagctgcc tgggcctctt cacttaaaca
     3421 tgtccccaca ccccatcctc tcggagcccc acttcttacc ccccacctcc caccctctat
     3481 aatccccact ccccattgga gaccaggcca gggcagaact ccacggacct tgctcttgtt
     3541 gattcacttt ccccattgtg ttttctcctg gactgagcat cctttggaaa tgggagctgg
     3601 aatttgaaca atgatgctat tgtatagttc ttttataaat gtaaatatgg aaataagaga
     3661 ttttgacaca tcattttcac ttgtctgtat tgagatattt tccttgtaaa ggttctctgt
     3721 aaacttgagt tgattttttg ctccccatct tttttgtttc ttgtctctct ttctctgtct
     3781 ctgtccttct ctcttgtaac gtgttataca atgactcttg ggcttgctta aaaagacaga
     3841 tatagccaca gatgcaggga gtttgggcac aaaacacgtg cagtttaaag ttggtgtgcg
     3901 ttaaaccaaa aataaaaggg gggacataaa caacaaaata acccatatca aagacacaaa
     3961 attatgtaaa tggaaatata tgtactaagt ttcgaaaatt ttttgatgtc attataaacc
     4021 tatgtaaata atgtaagaaa gtagacaccc tttcagatta atcacaaaag tgccaagctc
     4081 atgattttgg ttttcggttt tgacaatttt ctttccctgt ctttaatgtg aaaggaggat
     4141 aaacttaaag ccttaaataa aaaaattttt ttaaatgtta aaagcttgga aaaaattaag
     4201 ctttccattt tatttgtatt tgttagtgtc aatatttcat ccatgctcat tttcctgcct
     4261 caaaatatat atggtagaac cctattggaa aagtggtaat gggaatagaa ggagcagtta
     4321 cctttgtatc cgcattgtta aaataggctt ttatgctgtg ctgtgctttc aagaaacctt
     4381 gtttgacctc tggcatttta ctgatcagtg gaccgttgca ctggattata atgggattct
     4441 actatataca aatccacatt gttcttctcc ctccagccag atttgcagat gtaatctggg
     4501 ctttccaagt ccctctgagt ttccttcact tttactgatt tttttcttct aaatatggtc
     4561 aagatagctt ctgtcacatg ttaagtaaat aagctgaaga aatttggtcc cggctttgtt
     4621 ttaatgtaca aaccggtatg tgatcacttc agtgagcatc cctctataga tgggctttag
     4681 taaagactgt cccaaagagc ccctacttct ctaatgcccc cccccttttt tttttaggaa
     4741 aagaacatgc agttttactc atcacttctt catgacacca aatccattgc taggtttagc
     4801 tcctggtccc ttttcagcaa gattcatgtt atccgtctta caactttgat tttggaaagt
     4861 attatgtcct aaaaatgcac tgcttaacac agtggggttt ttttcccccg aggtgtcttt
     4921 aactggggaa gtaccacaaa catagagcag agactttaat ttctatattc tacaatagac
     4981 catcaccaaa catcttatca tgttgttgct ttctgagtaa taggtgctac gcaggtaggc
     5041 gggctttctc taggactagg tgtacgttta ttttgtaata acagggctat ctacaaggcc
     5101 tctcagcctt actcctggct tcataggaca caggtagcat ccctctagtc attggcaatg
     5161 gctctttcag ctcggaggaa gcttggagga aactcagatt acttggtatc ttttcctgtt
     5221 gctgcattgc ttagtgtttc cttgttgctg ggtcctactc tctagtagat actaaactgc
     5281 tgtgaagtac accatacaca tttcactaag attccagagc caccttggtg acataacaga
     5341 aacaaaatca tgttggttac aaaacaaatt aaatctctat tgttaacttt taagcatttc
     5401 acaaacaaca ttgtaaatgt gcgatgttac gttttaaatc agaccacagt ggtccccaaa
     5461 tattatgtac atatggcaaa tgtcagtgta actttttgtt acactggcaa tttcataggt
     5521 aatcgaacct atgctccaat gttaaattat ttgtgtatat gtaaaataca caagctttaa
     5581 gctatgtgtg tatgaatatg aaagttaatg caaccatatc aattgtaaaa atggattata
     5641 attatttttg atggtattag gttatgtagt ttcaaactct ttgctgtatt ttgttttgca
     5701 cctgccattc atttgctaat ttttgtggcg tggagattct tttttattaa tttgagctca
     5761 cagcacaagt gtatcactgt ttaatgttac ccaacaagag ttagtgttaa gtgatgatca
     5821 agttcccatt tcacctgctc tacttttgct gcattaatta atgacacccg gatgaggaga
     5881 cgtgcgctaa cttcattgct catctgggat agtgcatgag cccattgaat tagagctgct
     5941 cctactagat aactgagcag tacacataag tgcatgttat gaaacatgaa tcacatagag
     6001 cagtggagtt ttaccaagtg gtgtgtgtgg tttttgtttt ttactatgca aagatgggaa
     6061 atgcacaaac ttttcaaaga ctagtgtctg aagaacttta caaacaatac ttgaaccctt
     6121 tctttaaagt tatcccatca tgttttatag tcattgttgc ttccattgtt agtttccatt
     6181 ttcaagtgct ttgtaatttt ttaagtgcac tacctgaaat tttgtttgaa attaataaat
     6241 tcattcgtat cttgttggct gcctatgaat ggagattcag tagtcattgt atgcatcttt
     6301 aagtcaaatg tgtattaaaa ctttcgttaa cgta
//
