LOCUS       NM_003814               2784 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 20 (ADAM20), mRNA.
ACCESSION   NM_003814
VERSION     NM_003814.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2784)
  AUTHORS   Sha,Y.W., Xu,X., Ji,Z.Y., Mei,L.B., Qiu,P.P., Ji,H., Li,P., Li,L.
            and Liu,W.W.
  TITLE     Sperm-egg fusion disorder in a Chinese male patient was associated
            with a rare ADAM20 variant
  JOURNAL   Oncotarget 9 (2), 2086-2091 (2017)
   PUBMED   29416755
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2784)
  AUTHORS   Yoshimura,T., Tomita,T., Dixon,M.F., Axon,A.T., Robinson,P.A. and
            Crabtree,J.E.
  TITLE     ADAMs (a disintegrin and metalloproteinase) messenger RNA
            expression in Helicobacter pylori-infected, normal, and neoplastic
            gastric mucosa
  JOURNAL   J Infect Dis 185 (3), 332-340 (2002)
   PUBMED   11807715
REFERENCE   3  (bases 1 to 2784)
  AUTHORS   Poindexter,K., Nelson,N., DuBose,R.F., Black,R.A. and Cerretti,D.P.
  TITLE     The identification of seven metalloproteinase-disintegrin (ADAM)
            genes from genomic libraries
  JOURNAL   Gene 237 (1), 61-70 (1999)
   PUBMED   10524237
REFERENCE   4  (bases 1 to 2784)
  AUTHORS   Hooft van Huijsduijnen,R.
  TITLE     ADAM 20 and 21; two novel human testis-specific membrane
            metalloproteases with similarity to fertilin-alpha
  JOURNAL   Gene 206 (2), 273-282 (1998)
   PUBMED   9469942
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC025378.1, AA400588.1 and
            AA400496.1.
            
            On Oct 23, 2018 this sequence version replaced NM_003814.4.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins, and have been implicated in a variety of biological
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. The
            expression of this gene is testis-specific. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025378.1, DB049896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000256389.5/
                                                ENSP00000256389.3
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               BC025378.1         15-222
            209-570             AA400588.1         198-559
            571-2781            BC025378.1         585-2795
            2782-2784           AA400496.1         3-5                 c
FEATURES             Location/Qualifiers
     source          1..2784
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..2784
                     /gene="ADAM20"
                     /note="ADAM metallopeptidase domain 20"
                     /db_xref="GeneID:8748"
                     /db_xref="HGNC:HGNC:199"
                     /db_xref="MIM:603712"
     exon            1..208
                     /gene="ADAM20"
                     /inference="alignment:Splign:2.1.0"
     exon            209..2784
                     /gene="ADAM20"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..2565
                     /gene="ADAM20"
                     /note="a disintegrin and metalloproteinase domain 20;
                     disintegrin and metalloproteinase domain-containing
                     protein 20; ADAM 20"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 20 preproprotein"
                     /protein_id="NP_003805.4"
                     /db_xref="CCDS:CCDS32111.2"
                     /db_xref="GeneID:8748"
                     /db_xref="HGNC:HGNC:199"
                     /db_xref="MIM:603712"
                     /translation="MAVGEPLVHIRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVI
                     PLKVISRGRGAKAPGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQ
                     PFIQDDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYK
                     IDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNI
                     RYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVL
                     EDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLV
                     VFAITLGHELGHNLGMQHDTQWCVCELQWCIMHAYRKVTTKFSNCSYAQYWDSTISSG
                     LCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFG
                     ICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCNVNAFCYEKTC
                     NNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRVQC
                     ENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKK
                     CASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGGSADSGPPPKNNM
                     EGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEEG"
     regulatory      2762..2767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM20"
                     /note="hexamer: ATTAAA"
     polyA_site      2784
                     /gene="ADAM20"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgttta agactagggt catgcccaca tcaatctcag attcccattt tatctttctt
       61 ttttggtatc actcctagta ccaagtcttg tgtctgtcaa tatcctgtcc aaaaaagaaa
      121 aacacaccaa ggaaaattaa tataggaaaa atttaaaaag ttattagagg actgaaaata
      181 taaaaatgga acactgaaag acacagagtt tttattttca gcactgcagc tctgatggtc
      241 cagctccacc aggacacaga tccccagatc cctaaaggtc agccatgcac cctgaacagc
      301 tcagagggag gagccagacc agcagtgcct cacaccttgt tctcttctgc tctagacaga
      361 tggctccata atgacagctt cataatggca gtgggtgagc ccctggtgca catcagggtc
      421 actcttctgc tgctctggtt tgggatgttt ttgtctattt ctggccactc tcaggccagg
      481 ccctcccagt atttcacttc tccagaagtg gtgatccctt tgaaggtgat cagcaggggc
      541 agaggtgcaa aggctcctgg atggctctcc tatagcctgc ggtttggggg acagagatac
      601 attgtccaca tgagggtaaa taagctgttg tttgctgcac accttcctgt gttcacctac
      661 acagagcagc atgccctgct ccaggatcag cccttcatcc aggatgactg ctactaccat
      721 ggttatgtgg agggggtccc tgagtccttg gttgccctta gtacctgttc tgggggcttt
      781 cttggaatgc tacagataaa tgaccttgtt tatgaaatca agccaattag tgtttctgcc
      841 acatttgaac acctagtata taagatagac agtgatgata cacagtttcc acctatgaga
      901 tgtgggttaa cagaagagaa aatagcacac cagatggagt tgcaattgtc atataatttc
      961 actctgaagc aaagttcttt tgtgggctgg tggacccatc agcggtttgt tgagctggta
     1021 gtggtcgtgg ataatattag atatcttttc tctcaaagta atgcaacaac agtgcagcat
     1081 gaagtattta acgttgtcaa tatagtggat tccttctatc atcctttgga ggttgatgta
     1141 attttgactg gaattgatat atggactgca tcaaatccac ttcctaccag tggagaccta
     1201 gataatgttt tagaggactt ttctatttgg aagaattata accttaataa tcgactacaa
     1261 catgatgttg cacatctttt cataaaagac acacaaggca tgaagcttgg tgttgcctat
     1321 gttaaaggaa tatgccagaa tccttttaat actggagttg atgtttttga agacaacagg
     1381 ttggtcgttt ttgcaattac tttgggccac gagcttggtc ataatttggg tatgcaacat
     1441 gacacccagt ggtgtgtgtg cgagctacag tggtgcataa tgcatgccta tagaaaggtg
     1501 acaactaaat ttagcaactg cagttatgcc caatattggg acagtactat cagtagtgga
     1561 ttatgtattc aaccgcctcc atatccaggg aatatattta gactgaagta ctgtgggaat
     1621 ctagtggttg aagaagggga ggaatgtgac tgtggaacca tacggcagtg tgcaaaagat
     1681 ccctgttgtc tgttaaactg tactctacat cctggggctg cttgtgcttt tggaatatgt
     1741 tgcaaagact gcaaatttct gccatcagga actttatgta gacaacaagt tggtgaatgt
     1801 gaccttccag agtggtgcaa tgggacatcc catcaatgcc cagatgatgt gtatgtgcag
     1861 gacgggatct cctgtaatgt gaatgccttc tgctatgaaa agacgtgtaa taaccatgat
     1921 atacaatgta aagagatttt tggccaagat gcaaggagtg catctcagag ttgctaccaa
     1981 gaaatcaaca cccaaggaaa ccgtttcggt cactgtggta ttgtaggcac aacatatgta
     2041 aaatgttgga cccctgatat catgtgtggg agggttcagt gtgaaaatgt gggagtaatt
     2101 cccaatctga tagagcattc tacagtgcag cagtttcacc tcaatgacac cacttgctgg
     2161 ggcactgatt atcatttagg gatggctata cctgatattg gtgaggtgaa agatggcaca
     2221 gtatgtggtc cagaaaagat ctgcatccgt aagaagtgtg ccagtatggt tcatctgtca
     2281 caagcctgtc agcctaagac ctgcaacatg aggggaatct gcaacaacaa acaacactgt
     2341 cactgcaacc atgaatgggc acccccatac tgcaaggaca aaggctatgg aggtagtgct
     2401 gatagtggcc cacctcctaa gaacaacatg gaaggattaa atgtgatggg aaagttgcgt
     2461 tacctgtcac tattgtgcct tcttcctttg gttgcttttt tattattttg cttacatgtg
     2521 ctttttaaga aacgcacaaa aagtaaagaa gatgaagaag gataagagaa atgggaaaaa
     2581 gaaggagact aaactttata cttcattttt aatatccaat tttttaatag aaaaatatga
     2641 agccatgtct cactgtttaa ataaaacttc atggacattt catgtcagga ttgcaagcat
     2701 tagctatcac agcaaaggat tcctagccta ttcttactta ctctacagtg tcttaagcaa
     2761 tattaaaggt tccttttccc agaa
//
