LOCUS       NM_001464               2610 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 2 (ADAM2), transcript
            variant 1, mRNA.
ACCESSION   NM_001464
VERSION     NM_001464.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Gundogan,G.I., Irez,T. and Bozkurt,H.H.
  TITLE     Is there a relationship between infertility and fertilin beta
            protein distribution?
  JOURNAL   Rev Int Androl 20 (4), 240-248 (2022)
   PUBMED   35933293
  REMARK    GeneRIF: Is there a relationship between infertility and fertilin
            beta protein distribution?
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Heidari,M., Darbani,S., Darbandi,M., Lakpour,N., Fathi,Z.,
            Zarnani,A.H., Zeraati,H., Akhondi,M.M. and Sadeghi,M.R.
  TITLE     Assessing the potential of HSPA2 and ADAM2 as two biomarkers for
            human sperm selection
  JOURNAL   Hum Fertil (Camb) 23 (2), 123-133 (2020)
   PUBMED   30463455
  REMARK    GeneRIF: Assessing the potential of HSPA2 and ADAM2 as two
            biomarkers for human sperm selection.
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Maheswaran,E., Pedersen,C.B., Ditzel,H.J. and Gjerstorff,M.F.
  TITLE     Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in
            Lung and Breast Cancer
  JOURNAL   PLoS One 10 (8), e0134967 (2015)
   PUBMED   26252478
  REMARK    GeneRIF: ADAM2, CALR3 and SAGE1 cancer/testis antigens are not
            promising targets for immunotherapy of breast and lung cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Cho,C.
  TITLE     Testicular and epididymal ADAMs: expression and function during
            fertilization
  JOURNAL   Nat Rev Urol 9 (10), 550-560 (2012)
   PUBMED   22926424
  REMARK    Review article
REFERENCE   5  (bases 1 to 2610)
  AUTHORS   Brocker,C.N., Vasiliou,V. and Nebert,D.W.
  TITLE     Evolutionary divergence and functions of the ADAM and ADAMTS gene
            families
  JOURNAL   Hum Genomics 4 (1), 43-55 (2009)
   PUBMED   19951893
REFERENCE   6  (bases 1 to 2610)
  AUTHORS   Chen,M.S., Tung,K.S., Coonrod,S.A., Takahashi,Y., Bigler,D.,
            Chang,A., Yamashita,Y., Kincade,P.W., Herr,J.C. and White,J.M.
  TITLE     Role of the integrin-associated protein CD9 in binding between
            sperm ADAM 2 and the egg integrin alpha6beta1: implications for
            murine fertilization
  JOURNAL   Proc Natl Acad Sci U S A 96 (21), 11830-11835 (1999)
   PUBMED   10518536
REFERENCE   7  (bases 1 to 2610)
  AUTHORS   Chen,H. and Sampson,N.S.
  TITLE     Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1
            integrin is the receptor for sperm fertilinbeta
  JOURNAL   Chem Biol 6 (1), 1-10 (1999)
   PUBMED   9889149
REFERENCE   8  (bases 1 to 2610)
  AUTHORS   Vidaeus,C.M., von Kapp-Herr,C., Golden,W.L., Eddy,R.L., Shows,T.B.
            and Herr,J.C.
  TITLE     Human fertilin beta: identification, characterization, and
            chromosomal mapping of an ADAM gene family member
  JOURNAL   Mol Reprod Dev 46 (3), 363-369 (1997)
   PUBMED   9041139
REFERENCE   9  (bases 1 to 2610)
  AUTHORS   Burkin,H.R., Burkin,D.J., Davey,P.M., Griffin,D.K. and Affara,N.A.
  TITLE     Mapping, sequence, and expression analysis of the human fertilin
            beta gene (FTNB)
  JOURNAL   Genomics 40 (1), 190-192 (1997)
   PUBMED   9070941
REFERENCE   10 (bases 1 to 2610)
  AUTHORS   Gupta,S.K., Alves,K., Palladino,L.O., Mark,G.E. and Hollis,G.F.
  TITLE     Molecular cloning of the human fertilin beta subunit
  JOURNAL   Biochem Biophys Res Commun 224 (2), 318-326 (1996)
   PUBMED   8702389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP005902.2, AJ133005.1 and
            U38805.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001464.4.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins, and have been implicated in a variety of biological
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. The
            encoded protein is a subunit of an integral sperm membrane
            glycoprotein called fertilin, which plays an important role in
            sperm-egg interactions. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U38805.1, U52370.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265708.9/ ENSP00000265708.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AP005902.2         113911-113948       c
            39-2268             AJ133005.1         1-2230
            2269-2610           U38805.1           2295-2636
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..2610
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /note="ADAM metallopeptidase domain 2"
                     /db_xref="GeneID:2515"
                     /db_xref="HGNC:HGNC:198"
                     /db_xref="MIM:601533"
     exon            1..97
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2250
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; cancer/testis antigen 15; disintegrin and
                     metalloproteinase domain-containing protein 2; fertilin
                     subunit beta"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 2 isoform 1 preproprotein"
                     /protein_id="NP_001455.3"
                     /db_xref="CCDS:CCDS34884.1"
                     /db_xref="GeneID:2515"
                     /db_xref="HGNC:HGNC:198"
                     /db_xref="MIM:601533"
                     /translation="MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQ
                     ASYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYP
                     KSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIES
                     RDLSFKLQSVEPQQDFAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVS
                     FNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSN
                     YVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGA
                     VCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKL
                     EAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFE
                     ECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGP
                     SECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYAN
                     ISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDR
                     GVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHS
                     KPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG"
     exon            98..174
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            175..230
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            231..309
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            310..386
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            387..555
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            556..612
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            613..684
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            685..851
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            852..933
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1070
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1254
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1353
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1549
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1655
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1839
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1917
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2056
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2216
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2280
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2610
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2585..2590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /note="hexamer: ATTAAA"
     polyA_site      2610
                     /gene="ADAM2"
                     /gene_synonym="CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30;
                     PH30-beta"
                     /note="major polyA site"
ORIGIN      
        1 accaactgcc attattccgg ctgggaccca ggacttcaag ccatgtggcg cgtcttgttt
       61 ctgctcagcg ggctcggcgg gctgcggatg gacagtaatt ttgatagttt acctgtgcaa
      121 attacagttc cggagaaaat acggtcaata ataaaggaag gaattgaatc gcaggcatcc
      181 tacaaaattg taattgaagg gaaaccatat actgtgaatt taatgcaaaa aaacttttta
      241 ccccataatt ttagagttta cagttatagt ggcacaggaa ttatgaaacc acttgaccaa
      301 gattttcaga atttctgcca ctaccaaggg tatattgaag gttatccaaa atctgtggtg
      361 atggttagca catgtactgg actcaggggc gtactacagt ttgaaaatgt tagttatgga
      421 atagaacccc tggagtcttc agttggcttt gaacatgtaa tttaccaagt aaaacataag
      481 aaagcagatg tttccttata taatgagaag gatattgaat caagagatct gtcctttaaa
      541 ttacaaagcg tagagccaca gcaagatttt gcaaagtata tagaaatgca tgttatagtt
      601 gaaaaacaat tgtataatca tatggggtct gatacaactg ttgtcgctca aaaagttttc
      661 cagttgattg gattgacgaa tgctattttt gtttcattta atattacaat tattctgtct
      721 tcattggagc tttggataga tgaaaataaa attgcaacca ctggagaagc taatgagtta
      781 ttacacacat ttttaagatg gaaaacatct tatcttgttt tacgtcctca tgatgtggca
      841 tttttacttg tttacagaga aaagtcaaat tatgttggtg caacctttca agggaagatg
      901 tgtgatgcaa actatgcagg aggtgttgtt ctgcacccca gaaccataag tctggaatca
      961 cttgcagtta ttttagctca attattgagc cttagtatgg ggatcactta tgatgacatt
     1021 aacaaatgcc agtgctcagg agctgtctgc attatgaatc cagaagcaat tcatttcagt
     1081 ggtgtgaaga tctttagtaa ctgcagcttc gaagactttg cacattttat ttcaaagcag
     1141 aagtcccagt gtcttcacaa tcagcctcgc ttagatcctt ttttcaaaca gcaagcagtg
     1201 tgtggtaatg caaagctgga agcaggagag gagtgtgact gtgggactga acaggattgt
     1261 gcccttattg gagaaacatg ctgtgatatt gccacatgta gatttaaagc cggttcaaac
     1321 tgtgctgaag gaccatgctg cgaaaactgt ctatttatgt caaaagaaag aatgtgtagg
     1381 ccttcctttg aagaatgcga cctccctgaa tattgcaatg gatcatctgc atcatgccca
     1441 gaaaaccact atgttcagac tgggcatccg tgtggactga atcaatggat ctgtatagat
     1501 ggagtttgta tgagtgggga taaacaatgt acagacacat ttggcaaaga agtagagttt
     1561 ggcccttcag aatgttattc tcaccttaat tcaaagactg atgtatctgg aaactgtggt
     1621 ataagtgatt caggatacac acagtgtgaa gctgacaatc tgcagtgcgg aaaattaata
     1681 tgtaaatatg taggtaaatt tttattacaa attccaagag ccactattat ttatgccaac
     1741 ataagtggac atctctgcat tgctgtggaa tttgccagtg atcatgcaga cagccaaaag
     1801 atgtggataa aagatggaac ttcttgtggt tcaaataagg tttgcaggaa tcaaagatgt
     1861 gtgagttctt catacttggg ttatgattgt actactgaca aatgcaatga tagaggtgta
     1921 tgcaataaca aaaagcactg tcactgtagt gcttcatatt tacctccaga ttgctcagtt
     1981 caatcagatc tatggcctgg tgggagtatt gacagtggca attttccacc tgtagctata
     2041 ccagccagac tccctgaaag gcgctacatt gagaacattt accattccaa accaatgaga
     2101 tggccatttt tcttattcat tcctttcttt attattttct gtgtactgat tgctataatg
     2161 gtgaaagtta atttccaaag gaaaaaatgg agaactgagg actattcaag cgatgagcaa
     2221 cctgaaagtg agagtgaacc taaagggtag tctggacaac agagatgcca tgatatcact
     2281 tcttctagag taattatctg tgatggatgg acacaaaaaa atggaaagaa aagaatgtac
     2341 attacctggt ttcctgggat tcaaacctgc atattgtgat tttaatttga ccagaaaata
     2401 tgatatatat gtataatttc acagataatt tacttattta aaaatgcatg ataatgagtt
     2461 ttacattaca aatttctgtt tttttaaagt tatcttacgc tatttctgtt ggttagtaga
     2521 cactaattct gtcagtaggg gcatggtata aggaaatatc ataatgtaat gaggtggtac
     2581 tatgattaaa agccactgtt acatttcaaa
//
