LOCUS       NM_033274               6481 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 19 (ADAM19), mRNA.
ACCESSION   NM_033274
VERSION     NM_033274.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6481)
  AUTHORS   Wang,J., Gong,M., Xiong,Z., Zhao,Y. and Xing,D.
  TITLE     ADAM19 and TUBB1 Correlate with Tumor Infiltrating Immune Cells and
            Predicts Prognosis in Osteosarcoma
  JOURNAL   Comb Chem High Throughput Screen 26 (1), 135-148 (2023)
   PUBMED   35388751
  REMARK    GeneRIF: ADAM19 and TUBB1 Correlate with Tumor Infiltrating Immune
            Cells and Predicts Prognosis in Osteosarcoma.
REFERENCE   2  (bases 1 to 6481)
  AUTHORS   Qiu,Z., Zhong,Z., Zhang,Y., Tan,H., Deng,B. and Meng,G.
  TITLE     Human umbilical cord mesenchymal stem cell-derived exosomal
            miR-335-5p attenuates the inflammation and tubular
            epithelial-myofibroblast transdifferentiation of renal tubular
            epithelial cells by reducing ADAM19 protein levels
  JOURNAL   Stem Cell Res Ther 13 (1), 373 (2022)
   PUBMED   35902972
  REMARK    GeneRIF: Human umbilical cord mesenchymal stem cell-derived
            exosomal miR-335-5p attenuates the inflammation and tubular
            epithelial-myofibroblast transdifferentiation of renal tubular
            epithelial cells by reducing ADAM19 protein levels.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6481)
  AUTHORS   Kong,R., Gao,J., Zhang,J., Ji,L., Yu,Y., Zhang,L. and Zhao,D.
  TITLE     Synovial mesenchymal stem cell-derived exosomal miR-320c enhances
            chondrogenesis by targeting ADAM19
  JOURNAL   Future Med Chem 14 (2), 81-96 (2022)
   PUBMED   34927445
  REMARK    GeneRIF: Synovial mesenchymal stem cell-derived exosomal miR-320c
            enhances chondrogenesis by targeting ADAM19.
REFERENCE   4  (bases 1 to 6481)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6481)
  AUTHORS   Kang,T., Zhao,Y.G., Pei,D., Sucic,J.F. and Sang,Q.X.
  TITLE     Intracellular activation of human adamalysin 19/disintegrin and
            metalloproteinase 19 by furin occurs via one of the two consecutive
            recognition sites
  JOURNAL   J Biol Chem 277 (28), 25583-25591 (2002)
   PUBMED   12006600
  REMARK    GeneRIF: activation by furin via one of two consecutive recognition
            sites
REFERENCE   6  (bases 1 to 6481)
  AUTHORS   Diaz-Rodriguez,E., Montero,J.C., Esparis-Ogando,A., Yuste,L. and
            Pandiella,A.
  TITLE     Extracellular signal-regulated kinase phosphorylates tumor necrosis
            factor alpha-converting enzyme at threonine 735: a potential role
            in regulated shedding
  JOURNAL   Mol Biol Cell 13 (6), 2031-2044 (2002)
   PUBMED   12058067
REFERENCE   7  (bases 1 to 6481)
  AUTHORS   Zhao,Y.G., Wei,P. and Sang,Q.X.
  TITLE     Inhibitory antibodies against endopeptidase activity of human
            adamalysin 19
  JOURNAL   Biochem Biophys Res Commun 289 (1), 288-294 (2001)
   PUBMED   11708814
REFERENCE   8  (bases 1 to 6481)
  AUTHORS   Wei,P., Zhao,Y.G., Zhuang,L., Ruben,S. and Sang,Q.X.
  TITLE     Expression and enzymatic activity of human disintegrin and
            metalloproteinase ADAM19/meltrin beta
  JOURNAL   Biochem Biophys Res Commun 280 (3), 744-755 (2001)
   PUBMED   11162584
REFERENCE   9  (bases 1 to 6481)
  AUTHORS   Fritsche,J., Moser,M., Faust,S., Peuker,A., Buttner,R.,
            Andreesen,R. and Kreutz,M.
  TITLE     Molecular cloning and characterization of a human metalloprotease
            disintegrin--a novel marker for dendritic cell differentiation
  JOURNAL   Blood 96 (2), 732-739 (2000)
   PUBMED   10887142
REFERENCE   10 (bases 1 to 6481)
  AUTHORS   Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB
            (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb
            to mouse chromosome 11
  JOURNAL   Genomics 54 (1), 178-179 (1998)
   PUBMED   9806848
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK308182.1, AF311317.1,
            AC008676.6 and BC024214.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_033274.4.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins and have been implicated in a variety of biological
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. This
            member is a type I transmembrane protein and serves as a marker for
            dendritic cell differentiation. It has been demonstrated to be an
            active metalloproteinase, which may be involved in normal
            physiological processes such as cell migration, cell adhesion,
            cell-cell and cell-matrix interactions, and signal transduction. It
            is proposed to play a role in pathological processes, such as
            cancer, inflammatory diseases, renal diseases, and Alzheimer's
            disease. [provided by RefSeq, May 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13786.2, SRR11853565.24071.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257527.9/ ENSP00000257527.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2332              AK308182.1         1-2332
            2333-3261           AF311317.1         2290-3218
            3262-6318           AC008676.6         73825-76881
            6319-6481           BC024214.2         1686-1848
FEATURES             Location/Qualifiers
     source          1..6481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..6481
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /note="ADAM metallopeptidase domain 19"
                     /db_xref="GeneID:8728"
                     /db_xref="HGNC:HGNC:197"
                     /db_xref="MIM:603640"
     exon            1..173
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            174..259
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            260..330
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            331..409
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            410..486
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            487..679
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            680..745
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            746..817
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            818..984
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1069
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1209
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1387
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1477
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1673
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1782
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1987
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2065
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2174
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2319
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2404
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2629
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2782
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..6481
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6454..6459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /note="hexamer: AATGAA"
     polyA_site      6481
                     /gene="ADAM19"
                     /gene_synonym="FKSG34; MADDAM; MLTNB"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgcct ccaccgccgg gcagtgggca ggtatggctg agggcgtgtg agcgccgagc
       61 gctaagggcc gccgccacca tgccaggggg cgcaggcgcc gcccggctct gcttgctggc
      121 gtttgccctg cagcccctcc ggccgcgggc ggcgcgggag cctggatgga caagaggaag
      181 tgaggaaggc agccccaagc tgcagcatga acttatcata cctcagtgga agacttcaga
      241 aagccccgtg agagaaaagc atccactcaa agctgagctc agggtaatgg ctgaggggcg
      301 agaactgatc ctggacctgg agaagaatga gcaacttttt gctccttcct acacagaaac
      361 ccattatact tcaagtggta accctcaaac caccacacgg aaattggagg atcactgctt
      421 ttaccacggc acggtgaggg agacagaact gtccagcgtc acgctcagca cttgccgagg
      481 aattagagga ctgattacgg tgagcagcaa cctcagctac gtcatcgagc ccctccctga
      541 cagcaagggc caacacctta tttacagatc tgaacatctc aagccgcccc cgggaaactg
      601 tgggttcgag cactccaagc ccaccaccag ggactgggct cttcagttta cacaacagac
      661 caagaagcga cctcgcagga tgaaaaggga agatttaaac tccatgaagt atgtggagct
      721 ttacctcgtg gctgattatt tagagtttca gaagaatcga cgagaccagg acgccaccaa
      781 acacaagctc atagagatcg ccaactatgt tgataagttt taccgatcct tgaacatccg
      841 gattgctctc gtgggcttgg aagtgtggac ccacgggaac atgtgtgaag tttcagagaa
      901 tccatattct accctctggt cctttctcag ttggaggcgc aagctgcttg cccagaagta
      961 ccatgacaac gcccaattaa tcacgggcat gtccttccac ggcaccacca tcggcctggc
     1021 ccccctcatg gccatgtgct ctgtgtacca gtctggagga gtcaacatgg accactccga
     1081 gaatgccatt ggcgtggctg ccaccatggc ccacgagatg ggccacaact ttggcatgac
     1141 ccatgattct gcagattgct gctcggccag tgcggctgat ggtgggtgca tcatggcagc
     1201 tgccactggg cacccctttc ccaaagtgtt caatggatgc aacaggaggg agctggacag
     1261 gtatctgcag tcaggtggtg gaatgtgtct ctccaacatg ccagacacca ggatgttgta
     1321 tggaggccgg aggtgtggga acgggtatct ggaagatggg gaagagtgtg actgtggaga
     1381 agaagaggaa tgtaacaacc cctgctgcaa tgcctctaat tgtaccctga ggccgggggc
     1441 ggagtgtgct cacggctcct gctgccacca gtgtaagctg ttggctcctg ggaccctgtg
     1501 ccgcgagcag gccaggcagt gtgacctccc ggagttctgt acgggcaagt ctccccactg
     1561 ccctaccaac ttctaccaga tggatggtac cccctgtgag ggcggccagg cctactgcta
     1621 caacggcatg tgcctcacct accaggagca gtgccagcag ctgtggggac ccggagcccg
     1681 acctgcccct gacctctgct tcgagaaggt gaatgtggca ggagacacct ttggaaactg
     1741 tggaaaggac atgaatggtg aacacaggaa gtgcaacatg agagatgcga agtgtgggaa
     1801 gatccagtgt cagagctctg aggcccggcc cctggagtcc aacgcggtgc ccattgacac
     1861 cactatcatc atgaatggga ggcagatcca gtgccggggc acccacgtct accgaggtcc
     1921 tgaggaggag ggtgacatgc tggacccagg gctggtgatg actggaacca agtgtggcta
     1981 caaccatatt tgctttgagg ggcagtgcag gaacacctcc ttctttgaaa ctgaaggctg
     2041 tgggaagaag tgcaatggcc atggggtctg taacaacaac cagaactgcc actgcctgcc
     2101 gggctgggcc ccgcccttct gcaacacacc gggccacggg ggcagtatcg acagtgggcc
     2161 tatgccccct gagagtgtgg gtcctgtggt agctggagtg ttggtggcca tcttggtgct
     2221 ggcggtcctc atgctgatgt actactgctg cagacagaac aacaaactag gccaactcaa
     2281 gccctcagct ctcccttcca agctgaggca acagttcagt tgtcccttca gggtttctca
     2341 gaacagcggg actggtcatg ccaacccaac tttcaagctg cagacgcccc agggcaagcg
     2401 aaaggtgatc aacactccgg aaatcctgcg gaagccctcc cagcctcctc cccggccccc
     2461 tccagattat ctgcgtggtg ggtccccacc tgcaccactg ccagctcacc tgagcagggc
     2521 tgctaggaac tccccagggc ccgggtctca aatagagagg acggagtcgt ccaggaggcc
     2581 tcctccaagc cggccaattc cccccgcacc aaattgcatc gtttcccagg acttctccag
     2641 gcctcggccg ccccagaagg cactcccggc aaacccagtg ccaggccgca ggagcctccc
     2701 caggccagga ggtgcatccc cactgcggcc ccctggtgct ggccctcagc agtcccggcc
     2761 tctggcagca cttgccccaa agtttccaga atacagatca cagagggctg gagggatgat
     2821 tagctcgaaa atctagacct gtccaagggg cttctccctt tccttgagct ctctggacac
     2881 tgcagaggac ccatggccat ggaaccctga agaagcatgt ctggccgcct ctgagctcct
     2941 cccaccctcc tccaggaacc tccacatctc caaaaatctc cctgttgact cagtgcctcc
     3001 tcggcttcct tggaagccca gagggactat gatctgatgg cctctaggtg ttgttttgtg
     3061 caatatacag ccccaggtag ggaggggaga gtatgaggag ggtgactggc agcttctcct
     3121 ccagactcct agccccgagg tgctgatgga gatgctcaag gccagcaagc ccctcaggcc
     3181 agcacttcgc ttgcagaagc catccattca ctcctggggt gcagggcacg caagagagct
     3241 tcccattgct tctgctctcc tcagaggtcc cgggctggat ggaggctggt acttacccac
     3301 cccttttagc ttttagggat taaggaaggg tcaagccagc cactgctgtg gccctgccca
     3361 gggcttggtt gagggaacgg cttctggctg tatggctgca tgtgacaagc cacgtcccct
     3421 cccacctctc cccaaacccc tgcatccctg tattcacacg ggtcactctg actcagacag
     3481 gtactattcg taggcagtgt agacagcagg aggagcaccg ggcttgggct tcctctgagc
     3541 cgtgatgcca aaggttgcga ctcctgactc tggataattt ttagttgctc tttgttttct
     3601 ctgccgcact ttcctggtgc cccacgcttt tctctcttcc ttcccctctc attctccctc
     3661 taatgtgtgg tgctttggtg agcaaaccct cagcagtcct gaccttcggg tgaccaggtg
     3721 cttgtgacct acaagtcaga gtcctctctc acagtcggcc actggatttc cctcactggc
     3781 tctcaggagt gtgaccagag tagacttggg gcatggccat tggggtcata tgtttatttt
     3841 tcattgtgtt ttgtgacctc agcagggtgg gggtcttcct ccttactcta agctaaatct
     3901 aggtgaggtt tccccttagg gagcccagct atttacaaag tacacacgag ggagcaggct
     3961 ggtcattgac ttcgggctgg accgttgccc tctgagcaga gaacagaccc atttctggga
     4021 gctgcccgag atcactggag aaggcagcca gcagcagctg cactggaaca gtcagagcag
     4081 ggagcctctt cctcaaccca gctttttgtc attcacttcc ttttgttctc tctctggtca
     4141 ctgcccttac ctgaccctca cagaaagaga gctctgagca ggtgaggggg tctgcggtgg
     4201 ctcctgtctt ccctgcagca gggaaggagg gccgtgtggt gctttgctag ataggacggt
     4261 ttttgcaaag cacctggaga tgtttgctgg gagatagact cccactccac aaaggtgctg
     4321 ggtggctctc cggacaggag ctggcctgac tctcactcct ctgaggcttt cctggggcct
     4381 cctcccatcc tgccatgagc aattgtttgc tcttgaaaac ctcactgcaa ggctgaggct
     4441 gagcttctga ttcaccaccc cagggcctcc ttatagttct ctgcacacaa taggtgcttc
     4501 ttggatgttc ttgggtttgg aaataagtgg aaaatacggg atgtacccct gggggaaaag
     4561 cctgggttgg gtttagaaag atctcaggaa aatgagtttc tcttccctca gggtggctgt
     4621 gatacaggtt ccccatgtcc ttgccgtggg tcatccttgc tgtgggtcat ccttgctgtg
     4681 gagatccatt ccccaccttt cctgtggccc aaccttttat ttaaatgtgc taccctctgc
     4741 ctcaaggctt ggttcctgga aagtaaaggt gaaaacatcc cctttcaccc ctctgcaaaa
     4801 caaacaagca acatcctcaa aacccaaccc catgcctcac agagcttcct gtggcttctc
     4861 cagcctttct ccctcacatc aggaggtaga tagctctgaa atgacagcgc cacagccata
     4921 gtgactgcat gagccatctg aacctgcagt ccaccctccc tggaaccaca ccagaaagag
     4981 acctgggttg tcgttttctt gctttttgtt ttgttttgtt ttattatttt catatcacct
     5041 ccatcccata aagttgtact gtgaactgga agatggtgga atgttttgga atttgataga
     5101 ctttcggcaa ccagttctac taatgcttca ctcctggctc tgttcaggga ggctgcccag
     5161 gaggaagact ggccattatg catccccttt tctttccagt gcccagtatg ctgttttgag
     5221 gtgtcaaata caaataaatc tgggcttagg gaaggagaga ccttattcca aagcacgatt
     5281 gcagaagggg aaagggaata ttgcaaaagg gagaggaagg ggccttatgg gaatagtgaa
     5341 aaggctcaga ccgaccgatg gcaagatctg caagcgtctc aaagcccagg cagaaaagga
     5401 cttttctttt attggaagaa gtaaacatgg ctagaaagaa ccacgttcag ggaatgacgt
     5461 tgtgcccagc cttttttttt tttttttttt ttttgtctcc aggggagggg ctgtttgctg
     5521 gctcaggctg aggatggccc aaagtccagg gtctggtggg gaggagggaa gcttaactca
     5581 agtttgggtt agtgagttag caagctcttt gtgcagatgg ggatgtaggt aaatcttttt
     5641 aaaagtgaaa ttaacctcct gccaatttta caacccaaga attttttttt aagggccttg
     5701 gagccatctc taaaacaaac ctcaagggat ttagtgccct gtctccctgt ctctagaagc
     5761 cttagcctgg gcacctggct caatcttgta actgcctgct agccatagat tcctttcagc
     5821 cttgctgact tctccctata aaagtaaagc ctttttctgc cccagctctg agacacttgc
     5881 agatcttaag gtctgagact tgctgatttt ctggttggag tgtttttttg tattgccata
     5941 gtcccttccc cctgaagcaa tagcccctcc ccacctcctg caatacgcct ttccaatctt
     6001 tattggaagt ctctccctgc ctacttccta atttattctt atttgacaga gggtatggaa
     6061 gacttgcaat ttgaaaactg gggaccagtt ccaaagtcag taattgtgtt aaccacgtgt
     6121 ataacagctc tgctggacac ccaagaaagc catgggaacg ccaactggaa aggtcccctt
     6181 ccccagggga gcctgcgaag gagaggttct gtagaatcca agcccacatt tccaaagtca
     6241 cccccaacgc gtcctctcac accgtccact gtgcgtttgt atgtgtctgg gatccagggc
     6301 aatgtgaatt ttctttttat ttgggagatt gttcacggaa aacagatctt cttctctctt
     6361 gtccacctat taattgttta caatatttgt acatctatgc aaaatacttg aatgggccat
     6421 ggtgcctttt ttccttgtta gtatttaatt aaaaatgaat tgtttgtcat ttgcaatgtt
     6481 a
//
