LOCUS       NM_014237               2400 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 18 (ADAM18), transcript
            variant 1, mRNA.
ACCESSION   NM_014237
VERSION     NM_014237.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2400)
  AUTHORS   Lingappa,J.R., Petrovski,S., Kahle,E., Fellay,J., Shianna,K.,
            McElrath,M.J., Thomas,K.K., Baeten,J.M., Celum,C., Wald,A., de
            Bruyn,G., Mullins,J.I., Nakku-Joloba,E., Farquhar,C., Essex,M.,
            Donnell,D., Kiarie,J., Haynes,B. and Goldstein,D.
  CONSRTM   Partners in Prevention HSV/HIV Transmission Study Team
  TITLE     Genomewide association study for determinants of HIV-1 acquisition
            and viral set point in HIV-1 serodiscordant couples with quantified
            virus exposure
  JOURNAL   PLoS One 6 (12), e28632 (2011)
   PUBMED   22174851
REFERENCE   2  (bases 1 to 2400)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   3  (bases 1 to 2400)
  AUTHORS   Frayne,J., Hurd,E.A. and Hall,L.
  TITLE     Human tMDC III: a sperm protein with a potential role in oocyte
            recognition
  JOURNAL   Mol Hum Reprod 8 (9), 817-822 (2002)
   PUBMED   12200459
  REMARK    GeneRIF: we have determined the complete nucleotide sequence of
            human tMDC III cDNA , human tMDC III contains a putative
            integrin-binding glu-cys-asp (ECD) motif, the relevance of which is
            discussed in the context of a possible role in oolemma binding.
REFERENCE   4  (bases 1 to 2400)
  AUTHORS   Zhu,G.Z., Lin,Y., Myles,D.G. and Primakoff,P.
  TITLE     Identification of four novel ADAMs with potential roles in
            spermatogenesis and fertilization
  JOURNAL   Gene 234 (2), 227-237 (1999)
   PUBMED   10395895
REFERENCE   5  (bases 1 to 2400)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L., Perry,A.C., Jones,R. and Hall,L.
  TITLE     Macaque MDC family of proteins: sequence analysis, tissue
            distribution and processing in the male reproductive tract
  JOURNAL   Mol Hum Reprod 4 (5), 429-437 (1998)
   PUBMED   9665629
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB049415.1, AK313961.1,
            AY358321.1 and AC136365.5.
            
            On Nov 22, 2018 this sequence version replaced NM_014237.2.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins, and have been implicated in a variety of biologic
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. The
            encoded preproprotein is proteolytically processed to generate the
            mature sperm surface protein. Alternative splicing results in
            multiple transcript variants, at least one of which encodes an
            isoform that is proteolytically processed. [provided by RefSeq, Feb
            2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform 1 (disintegrin and metalloproteinase
            domain-containing protein 18).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313961.1, BC121045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265707.10/ ENSP00000265707.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB049415.1         1-10
            11-2275             AK313961.1         1-2265
            2276-2399           AY358321.1         2191-2314
            2400-2400           AC136365.5         90320-90320         c
FEATURES             Location/Qualifiers
     source          1..2400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..2400
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /note="ADAM metallopeptidase domain 18"
                     /db_xref="GeneID:8749"
                     /db_xref="HGNC:HGNC:196"
                     /db_xref="MIM:619495"
     exon            1..110
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2275
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin and metalloproteinase domain 18;
                     disintegrin and metalloproteinase domain-containing
                     protein 18; transmembrane metalloproteinase-like,
                     disintegrin-like, and cysteine-rich protein III"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 18 isoform 1 preproprotein"
                     /protein_id="NP_055052.1"
                     /db_xref="CCDS:CCDS6113.1"
                     /db_xref="GeneID:8749"
                     /db_xref="HGNC:HGNC:196"
                     /db_xref="MIM:619495"
                     /translation="MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERK
                     MIYIITIDGQPYTLHLGKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFP
                     NSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHI
                     WQKDQPYKVPLNSQIKNLSKLLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLV
                     NTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLV
                     YRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ
                     CFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPV
                     CGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPC
                     RKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGK
                     GAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQ
                     STVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNC
                     NATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDGNFQKSGDFYTEKGYN
                     THWNNWFILSFCIFLPFFIVFTTVIFKRNEISKSCNRENAEYNRNSSVVSESDDVGH"
     exon            111..187
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            188..243
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            244..322
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            323..399
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            400..577
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            578..643
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            644..715
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            716..882
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            883..964
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1101
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1285
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1381
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1580
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1686
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1876
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1957
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2072
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2232
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2400
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2378..2383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /note="hexamer: AATAAA"
     polyA_site      2400
                     /gene="ADAM18"
                     /gene_synonym="ADAM27; tMDCIII"
                     /note="major polyA site"
ORIGIN      
        1 aacgctgctc aacggtctct gtccttggct gtggctcctg cgctctggct gagccatgtt
       61 ccttctcctc gccctcctca ctgagcttgg aagactgcaa gcccacgaag gttctgaagg
      121 aatatttctg catgtcacag ttccacggaa gattaagtca aatgacagtg aagtttcaga
      181 gaggaagatg atttacatca ttacaattga tggacaacct tacactctac atctcggaaa
      241 acaatcattc ttaccccaga actttttggt ttatacatat aatgaaactg gatctttgca
      301 ttctgtgtct ccatatttta tgatgcattg ccattaccaa ggatatgctg ccgaatttcc
      361 aaattcattt gtgacactca gtatatgttc tggtctcagg ggatttctcc agtttgaaaa
      421 tatcagttat ggaattgaac cagtagaatc ttcagcaaga tttgagcata taatttatca
      481 aatgaaaaat aatgatccaa atgtatccat tttagcagta aattacagtc atatttggca
      541 gaaagaccag ccctacaaag ttcctttaaa ctcacagata aaaaatcttt caaaactatt
      601 accccaatat ctggaaatat acattatagt ggaaaaagct ttgtatgatt atatgggatc
      661 tgaaatgatg gctgtaacac aaaaaattgt ccaggttatt gggcttgtca acactatgtt
      721 tacccagttc aaattgactg ttatactgtc ttccttggaa ttgtggtcaa atgaaaacca
      781 gatttccacc agtggggatg ctgatgatat attacaaaga tttttggcat ggaaacggga
      841 ctatctcatc ctacggcccc atgacatagc atacttactt gtttacagga aacatcctaa
      901 atatgtggga gcaacatttc ctggcactgt atgcaataaa agctatgatg caggtattgc
      961 tatgtatcca gatgcaatag gtttggaggg attttcggtt attatagctc aactgcttgg
     1021 ccttaatgta ggattaacat atgatgacat cactcagtgt ttctgtctga gagctacatg
     1081 catcatgaat catgaagcag tgagtgccag tggtagaaag atttttagca actgcagcat
     1141 gcacgactat agatattttg tttcaaaatt tgagactaaa tgccttcaga agctttcaaa
     1201 tttgcaacca ttacatcaaa atcaaccagt gtgtggtaat gggattttgg aatccaatga
     1261 agaatgtgac tgtggtaata aaaatgaatg tcaatttaag aagtgctgtg attataacac
     1321 atgtaaactg aagggctcag taaaatgtgg ttctggacca tgttgtacat caaagtgtga
     1381 gttgtcaata gcaggcactc catgtagaaa gagtattgat ccagagtgtg attttacaga
     1441 gtactgcaat ggaacctcta gtaattgtgt tcctgacact tatgcattga atggccgttt
     1501 gtgcaagttg ggaactgcct attgctataa cggacaatgt caaactactg ataaccagtg
     1561 tgccaagata tttggaaaag gtgctcaagg tgctccattt gcctgtttta aagaagttaa
     1621 ttctctgcat gaaagatctg aaaactgtgg ttttaaaaat tcacaaccat taccttgtga
     1681 acggaaggat gttctctgtg gaaaattagc ttgtgttcag ccacataaaa atgctaataa
     1741 aagtgacgct caatctacag tttattcata tattcaagac catgtatgtg tatctatagc
     1801 cactggttcc tccatgagat cagatggaac agacaatgcc tatgtggctg atggcaccat
     1861 gtgtggtcca gaaatgtact gtgtaaataa aacctgcaga aaagttcatt taatgggata
     1921 taactgtaat gccaccacaa aatgcaaagg gaaagggata tgtaataatt ttggtaattg
     1981 tcaatgcttc cctggacata gacctccaga ttgtaaattc cagtttggtt ccccaggggg
     2041 tagtattgat gatggaaatt ttcagaaatc tggtgacttt tatactgaaa aaggctacaa
     2101 tacacactgg aacaactggt ttattctgag tttctgcatt tttctgccgt ttttcatagt
     2161 tttcaccact gtgatcttta aaagaaatga aataagtaaa tcatgtaaca gagagaatgc
     2221 agagtataat cgtaattcat ccgttgtatc agaaagcgat gacgtgggac attaatattg
     2281 cacagaactt ccatagcaaa taacctaaag gaacgaatgt gctttattta taaccttacg
     2341 ttatccccaa tgcattgtaa atgtcaaact tttggaaaat aaagcctgcg tgccctccca
//
