LOCUS       NM_003183               4391 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), transcript
            variant 1, mRNA.
ACCESSION   NM_003183
VERSION     NM_003183.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4391)
  AUTHORS   Shi,L., Hu,Y., Zeng,H., Shi,H., Xu,W., Sun,Y., Chu,H., Ji,C. and
            Qian,H.
  TITLE     Mesenchymal stem cell-derived extracellular vesicles ameliorate
            renal interstitial fibrosis via the miR-13474/ADAM17 axis
  JOURNAL   Sci Rep 14 (1), 17703 (2024)
   PUBMED   39085289
  REMARK    GeneRIF: Mesenchymal stem cell-derived extracellular vesicles
            ameliorate renal interstitial fibrosis via the miR-13474/ADAM17
            axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4391)
  AUTHORS   Dolla,G., Nicolas,S., Dos Santos,L.R., Bourgeois,A.,
            Pardossi-Piquard,R., Bihl,F., Zaghrini,C., Justino,J., Payre,C.,
            Mansuelle,P., Garbers,C., Ronco,P., Checler,F., Lambeau,G. and
            Petit-Paitel,A.
  TITLE     Ectodomain shedding of PLA2R1 is mediated by the metalloproteases
            ADAM10 and ADAM17
  JOURNAL   J Biol Chem 300 (7), 107480 (2024)
   PUBMED   38897568
  REMARK    GeneRIF: Ectodomain shedding of PLA2R1 is mediated by the
            metalloproteases ADAM10 and ADAM17.
REFERENCE   3  (bases 1 to 4391)
  AUTHORS   Babendreyer,A., Kieselhorst,J., Rinkens,C., Lyashenko,A.M.,
            Dusterhoft,S., Jahr,H., Craveiro,R.B., Wolf,M. and Ludwig,A.
  TITLE     Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes
            osteoclast differentiation
  JOURNAL   Cell Commun Signal 22 (1), 322 (2024)
   PUBMED   38863060
  REMARK    GeneRIF: Downregulation of the metalloproteinases ADAM10 or ADAM17
            promotes osteoclast differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4391)
  AUTHORS   Lu,F., Zhao,H., Dai,Y., Wang,Y., Lee,C.H. and Freeman,M.
  TITLE     Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to
            control the release of growth factor and inflammatory signals
  JOURNAL   Mol Cell 84 (11), 2152-2165 (2024)
   PUBMED   38781971
  REMARK    GeneRIF: Cryo-EM reveals that iRhom2 restrains ADAM17 protease
            activity to control the release of growth factor and inflammatory
            signals.
REFERENCE   5  (bases 1 to 4391)
  AUTHORS   Lisi,S., D'Amore,M. and Sisto,M.
  TITLE     ADAM17 at the interface between inflammation and autoimmunity
  JOURNAL   Immunol Lett 162 (1 Pt A), 159-169 (2014)
   PUBMED   25171914
  REMARK    Review article
REFERENCE   6  (bases 1 to 4391)
  AUTHORS   Schroeter,E.H., Kisslinger,J.A. and Kopan,R.
  TITLE     Notch-1 signalling requires ligand-induced proteolytic release of
            intracellular domain
  JOURNAL   Nature 393 (6683), 382-386 (1998)
   PUBMED   9620803
REFERENCE   7  (bases 1 to 4391)
  AUTHORS   Patel,I.R., Attur,M.G., Patel,R.N., Stuchin,S.A., Abagyan,R.A.,
            Abramson,S.B. and Amin,A.R.
  TITLE     TNF-alpha convertase enzyme from human arthritis-affected
            cartilage: isolation of cDNA by differential display, expression of
            the active enzyme, and regulation of TNF-alpha
  JOURNAL   J Immunol 160 (9), 4570-4579 (1998)
   PUBMED   9574564
REFERENCE   8  (bases 1 to 4391)
  AUTHORS   Maskos,K., Fernandez-Catalan,C., Huber,R., Bourenkov,G.P.,
            Bartunik,H., Ellestad,G.A., Reddy,P., Wolfson,M.F., Rauch,C.T.,
            Castner,B.J., Davis,R., Clarke,H.R., Petersen,M., Fitzner,J.N.,
            Cerretti,D.P., March,C.J., Paxton,R.J., Black,R.A. and Bode,W.
  TITLE     Crystal structure of the catalytic domain of human tumor necrosis
            factor-alpha-converting enzyme
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3408-3412 (1998)
   PUBMED   9520379
REFERENCE   9  (bases 1 to 4391)
  AUTHORS   Moss,M.L., Jin,S.L., Milla,M.E., Bickett,D.M., Burkhart,W.,
            Carter,H.L., Chen,W.J., Clay,W.C., Didsbury,J.R., Hassler,D.,
            Hoffman,C.R., Kost,T.A., Lambert,M.H., Leesnitzer,M.A.,
            McCauley,P., McGeehan,G., Mitchell,J., Moyer,M., Pahel,G.,
            Rocque,W., Overton,L.K., Schoenen,F., Seaton,T., Su,J.L.,
            Becherer,J.D. et al.
  TITLE     Cloning of a disintegrin metalloproteinase that processes precursor
            tumour-necrosis factor-alpha
  JOURNAL   Nature 385 (6618), 733-736 (1997)
   PUBMED   9034191
  REMARK    Erratum:[Nature 1997 Apr 17;386(6626):738]
REFERENCE   10 (bases 1 to 4391)
  AUTHORS   Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L.,
            Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S.,
            Nelson,N., Boiani,N., Schooley,K.A., Gerhart,M., Davis,R.,
            Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and
            Cerretti,D.P.
  TITLE     A metalloproteinase disintegrin that releases tumour-necrosis
            factor-alpha from cells
  JOURNAL   Nature 385 (6618), 729-733 (1997)
   PUBMED   9034190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073195.5, GQ402545.1 and
            AC080162.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2018 this sequence version replaced NM_003183.5.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease domain) family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins, and have been implicated in a variety of biologic
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. The
            encoded preproprotein is proteolytically processed to generate the
            mature protease. The encoded protease functions in the ectodomain
            shedding of tumor necrosis factor-alpha, in which soluble tumor
            necrosis factor-alpha is released from the membrane-bound
            precursor. This protease also functions in the processing of
            numerous other substrates, including cell adhesion proteins,
            cytokine and growth factor receptors and epidermal growth factor
            (EGF) receptor ligands, and plays a prominent role in the
            activation of the Notch signaling pathway. Elevated expression of
            this gene has been observed in specific cell types derived from
            psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's
            disease patients, suggesting that the encoded protein may play a
            role in autoimmune disease. Additionally, this protease may play a
            role in viral infection through its cleavage of ACE2, the cellular
            receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug
            2020].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ402545.1, U92649.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for COVID-19 treatment
            MANE Ensembl match     :: ENST00000310823.8/ ENSP00000309968.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC073195.5         25094-25135         c
            43-3606             GQ402545.1         1-3564
            3607-4391           AC080162.7         135547-136331       c
FEATURES             Location/Qualifiers
     source          1..4391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..4391
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /note="ADAM metallopeptidase domain 17"
                     /db_xref="GeneID:6868"
                     /db_xref="HGNC:HGNC:195"
                     /db_xref="MIM:603639"
     exon            1..322
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2700
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /EC_number="3.4.24.86"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; snake venom-like protease; tumor necrosis
                     factor, alpha, converting enzyme; TNF-alpha converting
                     enzyme; disintegrin and metalloproteinase
                     domain-containing protein 17; ADAM metallopeptidase domain
                     18; TNF-alpha convertase; cartilage snake venom-like
                     protease; TNF-alpha convertase enzyme; a disintegrin and
                     metalloproteinase 17"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 17 isoform 1 preproprotein"
                     /protein_id="NP_003174.3"
                     /db_xref="CCDS:CCDS1665.1"
                     /db_xref="GeneID:6868"
                     /db_xref="HGNC:HGNC:195"
                     /db_xref="MIM:603639"
                     /translation="MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDI
                     LSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGK
                     NESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTK
                     DKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADP
                     DPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYG
                     IQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCL
                     AHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGK
                     TILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
                     SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTL
                     KEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTV
                     CLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFL
                     RKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLI
                     FWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQ
                     PAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDH
                     PVTRSEKAASFKLQRQNRVDSKETEC"
     exon            323..455
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            456..586
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            587..675
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            676..844
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            845..978
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1068
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1182
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1327
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1416
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1569
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1769
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1873
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2008
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2139
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2218
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2307
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2358
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..4391
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4271..4276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /note="hexamer: TATAAA"
     polyA_site      4294
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /note="major polyA site"
     regulatory      4370..4375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /note="hexamer: AATAAA"
     polyA_site      4391
                     /gene="ADAM17"
                     /gene_synonym="ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE"
                     /note="major polyA site"
ORIGIN      
        1 agcggcggcc ggaagctggc tgagccggcc tttggtaacg ccacctgcac ttctgggggc
       61 gtcgagcctg gcggtagaat cttcccagta ggcggcgcgg gagggaaaag aggattgagg
      121 ggctaggccg ggcggatccc gtcctccccc gatgtgagca gttttccgaa accccgtcag
      181 gcgaaggctg cccagagagg tggagtcggt agcggggccg ggaacatgag gcagtctctc
      241 ctattcctga ccagcgtggt tcctttcgtg ctggcgccgc gacctccgga tgacccgggc
      301 ttcggccccc accagagact cgagaagctt gattctttgc tctcagacta cgatattctc
      361 tctttatcta atatccagca gcattcggta agaaaaagag atctacagac ttcaacacat
      421 gtagaaacac tactaacttt ttcagctttg aaaaggcatt ttaaattata cctgacatca
      481 agtactgaac gtttttcaca aaatttcaag gtcgtggtgg tggatggtaa aaacgaaagc
      541 gagtacactg taaaatggca ggacttcttc actggacacg tggttggtga gcctgactct
      601 agggttctag cccacataag agatgatgat gttataatca gaatcaacac agatggggcc
      661 gaatataaca tagagccact ttggagattt gttaatgata ccaaagacaa aagaatgtta
      721 gtttataaat ctgaagatat caagaatgtt tcacgtttgc agtctccaaa agtgtgtggt
      781 tatttaaaag tggataatga agagttgctc ccaaaagggt tagtagacag agaaccacct
      841 gaagagcttg ttcatcgagt gaaaagaaga gctgacccag atcccatgaa gaacacgtgt
      901 aaattattgg tggtagcaga tcatcgcttc tacagataca tgggcagagg ggaagagagt
      961 acaactacaa attacttaat agagctaatt gacagagttg atgacatcta tcggaacact
     1021 tcatgggata atgcaggttt taaaggctat ggaatacaga tagagcagat tcgcattctc
     1081 aagtctccac aagaggtaaa acctggtgaa aagcactaca acatggcaaa aagttaccca
     1141 aatgaagaaa aggatgcttg ggatgtgaag atgttgctag agcaatttag ctttgatata
     1201 gctgaggaag catctaaagt ttgcttggca caccttttca cataccaaga ttttgatatg
     1261 ggaactcttg gattagctta tgttggctct cccagagcaa acagccatgg aggtgtttgt
     1321 ccaaaggctt attatagccc agttgggaag aaaaatatct atttgaatag tggtttgacg
     1381 agcacaaaga attatggtaa aaccatcctt acaaaggaag ctgacctggt tacaactcat
     1441 gaattgggac ataattttgg agcagaacat gatccggatg gtctagcaga atgtgccccg
     1501 aatgaggacc agggagggaa atatgtcatg tatcccatag ctgtgagtgg cgatcacgag
     1561 aacaataaga tgttttcaaa ctgcagtaaa caatcaatct ataagaccat tgaaagtaag
     1621 gcccaggagt gttttcaaga acgcagcaat aaagtttgtg ggaactcgag ggtggatgaa
     1681 ggagaagagt gtgatcctgg catcatgtat ctgaacaacg acacctgctg caacagcgac
     1741 tgcacgttga aggaaggtgt ccagtgcagt gacaggaaca gtccttgctg taaaaactgt
     1801 cagtttgaga ctgcccagaa gaagtgccag gaggcgatta atgctacttg caaaggcgtg
     1861 tcctactgca caggtaatag cagtgagtgc ccgcctccag gaaatgctga agatgacact
     1921 gtttgcttgg atcttggcaa gtgtaaggat gggaaatgca tccctttctg cgagagggaa
     1981 cagcagctgg agtcctgtgc atgtaatgaa actgacaact cctgcaaggt gtgctgcagg
     2041 gacctttctg gccgctgtgt gccctatgtc gatgctgaac aaaagaactt atttttgagg
     2101 aaaggaaagc cctgtacagt aggattttgt gacatgaatg gcaaatgtga gaaacgagta
     2161 caggatgtaa ttgaacgatt ttgggatttc attgaccagc tgagcatcaa tacttttgga
     2221 aagtttttag cagacaacat cgttgggtct gtcctggttt tctccttgat attttggatt
     2281 cctttcagca ttcttgtcca ttgtgtggat aagaaattgg ataaacagta tgaatctctg
     2341 tctctgtttc accccagtaa cgtcgaaatg ctgagcagca tggattctgc atcggttcgc
     2401 attatcaaac cctttcctgc gccccagact ccaggccgcc tgcagcctgc ccctgtgatc
     2461 ccttcggcgc cagcagctcc aaaactggac caccagagaa tggacaccat ccaggaagac
     2521 cccagcacag actcacatat ggacgaggat gggtttgaga aggacccctt cccaaatagc
     2581 agcacagctg ccaagtcatt tgaggatctc acggaccatc cggtcaccag aagtgaaaag
     2641 gctgcctcct ttaaactgca gcgtcagaat cgtgttgaca gcaaagaaac agagtgctaa
     2701 tttagttctc agctcttctg acttaagtgt gcaaaatatt tttatagatt tgacctacaa
     2761 atcaatcaca gcttgtattt tgtgaagact gggaagtgac ttagcagatg ctggtcatgt
     2821 gtttgaactt cctgcaggta aacagttctt gtgtggtttg gcccttctcc ttttgaaaag
     2881 gtaaggtgaa ggtgaatcta gcttattttg aggctttcag gttttagttt ttaaaatatc
     2941 ttttgacctg tggtgcaaaa gcagaaaata cagctggatt gggttatgaa tatttacgtt
     3001 tttgtaaatt aatcttttat attgataaca gcactgacta gggaaatgat cagttttttt
     3061 ttatacactg taatgaaccg ctgaatatga ggcatttggc atttatttgt gatgacaact
     3121 ggaatagttt tttttttttt tttttttttt tgccttcaac taaaaacaaa ggagataaat
     3181 ctagtataca ttgtctctaa attgtgggtc tatttctagt tattacccag agtttttatg
     3241 tagcagggaa aatatatatc taaatttaga aatcatttgg gttaatatgg ctcttcataa
     3301 ttctaagact aatgctctct agaaacctaa ccacctacct tacagtgagg gctatacatg
     3361 gtagccagtt gaatttatgg aatctaccaa ctgtttaggg ccctgatttg ctgggcagtt
     3421 tttctgtatt ttataagtat cttcatgtat ccctgttact gatagggata catgctctta
     3481 gaaaattcac tattggctgg gagtggtggc tcatgcctgt aatcccagca cttggagagg
     3541 ctgaggttgc gccactacac tccagcctgg gtgacagagt gagactctgc ctcaaaaaaa
     3601 aaaaaaaaaa aaaaaaattc actatctaca aacctagaat atttaaaata caaagattgc
     3661 ctgttttcaa acactattga ataagagggt gagatatttc ttaacaacaa caacaacaaa
     3721 aaaaacaggt tgttttgaat gtgatgagcc agccaggaga tagaatacta cctgccctta
     3781 gggttggggg ctgtccccac aagacttgat acttcagaaa ccctttttat tgacccacaa
     3841 gcagatattt gaattacttc ttactttatt gctccaggat tctggatggg ctgcatttac
     3901 tgtgtgaagg ataaaaatca ttagcctgga ttctgatttc tataaattgc cattaaaagc
     3961 tttttttccc ctaagaactg aaatgtgctc accagccaaa acattttaac ttgtaaattt
     4021 tgagggcagt taaccaaacc tgtgactaat catatctcct cctacccccc atttccaagg
     4081 acatttgtta ctcagatact tgttatacta atacttgaac ttgtacctta tggtatttgc
     4141 tatcttttaa ctagtcatga tattcttata ctttagttac acttttggaa tttgatacaa
     4201 ggttgagtgg ggtgtgtggg tgtatgtatg agtgaaacag ttctcaaaag aatgtaagaa
     4261 aaaccatttt tataaaattg tgacttttta aaaacatagt ctttgtcatt tatagaatta
     4321 acaagctgct cagggtatat tttatagctg tagcactgat atctgcatta ataaatactg
     4381 tcgaaacaca a
//
