LOCUS       NM_207197               2936 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 15 (ADAM15), transcript
            variant 6, mRNA.
ACCESSION   NM_207197
VERSION     NM_207197.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2936)
  AUTHORS   Puig-Blasco,L., Piotrowski,K.B., Michaelsen,S.R., Bager,N.S.,
            Areskeviciutie,A., Thorseth,M.L., Sun,X.F., Keller,U.A.D.,
            Kristensen,B.W., Madsen,D.H., Gnosa,S.P. and Kveiborg,M.
  TITLE     Loss of cancer cell-derived ADAM15 alters the tumor
            microenvironment in colorectal tumors
  JOURNAL   Int J Cancer 153 (12), 2068-2081 (2023)
   PUBMED   37602921
  REMARK    GeneRIF: Loss of cancer cell-derived ADAM15 alters the tumor
            microenvironment in colorectal tumors.
REFERENCE   2  (bases 1 to 2936)
  AUTHORS   Aujla,P.K., Hu,M., Hartley,B., Kranrod,J.W., Viveiros,A., Kilic,T.,
            Owen,C.A., Oudit,G.Y., Seubert,J.M., Julien,O. and Kassiri,Z.
  TITLE     Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial
            Hypertrophy and Dilation Through Activation of the Calcineurin
            Pathway
  JOURNAL   Hypertension 80 (1), 97-110 (2023)
   PUBMED   36330793
  REMARK    GeneRIF: Loss of ADAM15 Exacerbates Transition to Decompensated
            Myocardial Hypertrophy and Dilation Through Activation of the
            Calcineurin Pathway.
REFERENCE   3  (bases 1 to 2936)
  AUTHORS   Janczi,T., Meier,F., Fehrl,Y., Kinne,R.W., Bohm,B. and Burkhardt,H.
  TITLE     A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the
            Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts
  JOURNAL   Cells 10 (10), 2705 (2021)
   PUBMED   34685689
  REMARK    GeneRIF: A Novel Pro-Inflammatory Mechanosensing Pathway
            Orchestrated by the Disintegrin Metalloproteinase ADAM15 in
            Synovial Fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2936)
  AUTHORS   Xu,J.H., Guan,Y.J., Zhang,Y.C., Qiu,Z.D., Zhou,Y., Chen,C., Yu,J.
            and Wang,W.X.
  TITLE     ADAM15 correlates with prognosis, immune infiltration and apoptosis
            in hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 13 (16), 20395-20417 (2021)
   PUBMED   34426560
  REMARK    GeneRIF: ADAM15 correlates with prognosis, immune infiltration and
            apoptosis in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 2936)
  AUTHORS   Yang,Q., Pei,R., Wang,Y., Zhou,Y., Yang,M., Chen,X. and Chen,J.
  TITLE     ADAM15 Participates in Tick-Borne Encephalitis Virus Replication
  JOURNAL   J Virol 95 (4), e01926-20 (2021)
   PUBMED   33208450
  REMARK    GeneRIF: ADAM15 Participates in Tick-Borne Encephalitis Virus
            Replication.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2936)
  AUTHORS   Nath,D., Slocombe,P.M., Stephens,P.E., Warn,A., Hutchinson,G.R.,
            Yamada,K.M., Docherty,A.J. and Murphy,G.
  TITLE     Interaction of metargidin (ADAM-15) with alphavbeta3 and
            alpha5beta1 integrins on different haemopoietic cells
  JOURNAL   J Cell Sci 112 (Pt 4), 579-587 (1999)
   PUBMED   9914169
REFERENCE   7  (bases 1 to 2936)
  AUTHORS   Zhang,X.P., Kamata,T., Yokoyama,K., Puzon-McLaughlin,W. and
            Takada,Y.
  TITLE     Specific interaction of the recombinant disintegrin-like domain of
            MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3
  JOURNAL   J Biol Chem 273 (13), 7345-7350 (1998)
   PUBMED   9516430
REFERENCE   8  (bases 1 to 2936)
  AUTHORS   Herren,B., Raines,E.W. and Ross,R.
  TITLE     Expression of a disintegrin-like protein in cultured human vascular
            cells and in vivo
  JOURNAL   FASEB J 11 (2), 173-180 (1997)
   PUBMED   9039960
REFERENCE   9  (bases 1 to 2936)
  AUTHORS   McKie,N., Edwards,T., Dallas,D.J., Houghton,A., Stringer,B.,
            Graham,R., Russell,G. and Croucher,P.I.
  TITLE     Expression of members of a novel membrane linked metalloproteinase
            family (ADAM) in human articular chondrocytes
  JOURNAL   Biochem Biophys Res Commun 230 (2), 335-339 (1997)
   PUBMED   9016778
REFERENCE   10 (bases 1 to 2936)
  AUTHORS   Kratzschmar,J., Lum,L. and Blobel,C.P.
  TITLE     Metargidin, a membrane-anchored metalloprotease-disintegrin protein
            with an RGD integrin binding sequence
  JOURNAL   J Biol Chem 271 (9), 4593-4596 (1996)
   PUBMED   8617717
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY560593.1, AY518542.1,
            AY560599.1 and U41767.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_207197.2.
            
            Summary: The protein encoded by this gene is a member of the ADAM
            (a disintegrin and metalloproteinase) protein family. ADAM family
            members are type I transmembrane glycoproteins known to be involved
            in cell adhesion and proteolytic ectodomain processing of cytokines
            and adhesion molecules. This protein contains multiple functional
            domains including a zinc-binding metalloprotease domain, a
            disintegrin-like domain, as well as a EGF-like domain. Through its
            disintegrin-like domain, this protein specifically interacts with
            the integrin beta chain, beta 3. It also interacts with Src family
            protein-tyrosine kinases in a phosphorylation-dependent manner,
            suggesting that this protein may function in cell-cell adhesion as
            well as in cellular signaling. Multiple alternatively spliced
            transcript variants encoding distinct isoforms have been observed.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (6) encodes the longest isoform
            (6).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY560599.1, SRR11853567.2042.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356955.7/ ENSP00000349436.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-642               AY560593.1         31-672
            643-1718            AY518542.1         572-1647
            1719-2919           AY560599.1         1749-2949
            2920-2936           U41767.1           2709-2725
FEATURES             Location/Qualifiers
     source          1..2936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2936
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /note="ADAM metallopeptidase domain 15"
                     /db_xref="GeneID:8751"
                     /db_xref="HGNC:HGNC:193"
                     /db_xref="MIM:605548"
     exon            1..150
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2663
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /note="isoform 6 preproprotein is encoded by transcript
                     variant 6; a disintegrin and metalloproteinase domain 15
                     (metargidin); metalloproteinase-like, disintegrin-like,
                     and cysteine-rich protein 15; metalloprotease RGD
                     disintegrin protein; disintegrin and metalloproteinase
                     domain-containing protein 15; MDC-15"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 15 isoform 6 preproprotein"
                     /protein_id="NP_997080.1"
                     /db_xref="CCDS:CCDS1087.1"
                     /db_xref="GeneID:8751"
                     /db_xref="HGNC:HGNC:193"
                     /db_xref="MIM:605548"
                     /translation="MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPL
                     EPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQP
                     DGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDL
                     QGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELV
                     IVADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPN
                     PAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMD
                     HSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSN
                     CSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDS
                     LTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGD
                     GEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSG
                     SYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVA
                     QPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPP
                     DCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQS
                     GPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQAELADRPNPPTRPL
                     PADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPP
                     TVSSLYL"
     exon            151..257
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            258..334
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            335..413
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            414..490
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            491..683
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            684..746
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            747..815
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            816..985
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1070
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1219
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1394
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1487
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1792
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1988
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2066
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2139
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2278
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2348
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2423
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2495
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2620
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2936
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2911..2916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /note="hexamer: AATAAA"
     polyA_site      2936
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /note="major polyA site"
ORIGIN      
        1 ctggccgccg gccgctcctc cgcgcgctgt tccgcacttg ctgccctcgc ccggcccgga
       61 gcgccgctgc catgcggctg gcgctgctct gggccctggg gctcctgggc gcgggcagcc
      121 ctctgccttc ctggccgctc ccaaatatag gtggcactga ggagcagcag gcagagtcag
      181 agaaggcccc gagggagccc ttggagcccc aggtccttca ggacgatctc ccaattagcc
      241 tcaaaaaggt gcttcagacc agtctgcctg agcccctgag gatcaagttg gagctggacg
      301 gtgacagtca tatcctggag ctgctacaga atagggagtt ggtcccaggc cgcccaaccc
      361 tggtgtggta ccagcccgat ggcactcggg tggtcagtga gggacacact ttggagaact
      421 gctgctacca gggaagagtg cggggatatg caggctcctg ggtgtccatc tgcacctgct
      481 ctgggctcag aggcttggtg gtcctgaccc cagagagaag ctataccctg gagcaggggc
      541 ctggggacct tcagggtcct cccattattt cgcgaatcca agatctccac ctgccaggcc
      601 acacctgtgc cctgagctgg cgggaatctg tacacactca gaagccacca gagcaccccc
      661 tgggacagcg ccacattcgc cggaggcggg atgtggtaac agagaccaag actgtggagt
      721 tggtgattgt ggctgatcac tcggaggccc agaaataccg ggacttccag cacctgctaa
      781 accgcacact ggaagtggcc ctcttgctgg acacattctt ccggcccctg aatgtacgag
      841 tggcactagt gggcctggag gcctggaccc agcgtgacct ggtggagatc agcccaaacc
      901 cagctgtcac cctcgaaaac ttcctccact ggcgcagggc acatttgctg cctcgattgc
      961 cccatgacag tgcccagctg gtgactggta cttcattctc tgggcctacg gtgggcatgg
     1021 ccattcagaa ctccatctgt tctcctgact tctcaggagg tgtgaacatg gaccactcca
     1081 ccagcatcct gggagtcgcc tcctccatag cccatgagtt gggccacagc ctgggcctgg
     1141 accatgattt gcctgggaat agctgcccct gtccaggtcc agccccagcc aagacctgca
     1201 tcatggaggc ctccacagac ttcctaccag gcctgaactt cagcaactgc agccgacggg
     1261 ccctggagaa agccctcctg gatggaatgg gcagctgcct cttcgaacgg ctgcctagcc
     1321 taccccctat ggctgctttc tgcggaaata tgtttgtgga gccgggcgag cagtgtgact
     1381 gtggcttcct ggatgactgc gtcgatccct gctgtgattc tttgacctgc cagctgaggc
     1441 caggtgcaca gtgtgcatct gacggaccct gttgtcaaaa ttgccagctg cgcccgtctg
     1501 gctggcagtg tcgtcctacc agaggggatt gtgacttgcc tgaattctgc ccaggagaca
     1561 gctcccagtg tccccctgat gtcagcctag gggatggcga gccctgcgct ggcgggcaag
     1621 ctgtgtgcat gcacgggcgt tgtgcctcct atgcccagca gtgccagtca ctttggggac
     1681 ctggagccca gcccgctgcg ccactttgcc tccagacagc taatactcgg ggaaatgctt
     1741 ttgggagctg tgggcgcaac cccagtggca gttatgtgtc ctgcacccct agagatgcca
     1801 tttgtgggca gctccagtgc cagacaggta ggacccagcc tctgctgggc tccatccggg
     1861 atctactctg ggagacaata gatgtgaatg ggactgagct gaactgcagc tgggtgcacc
     1921 tggacctggg cagtgatgtg gcccagcccc tcctgactct gcctggcaca gcctgtggcc
     1981 ctggcctggt gtgtatagac catcgatgcc agcgtgtgga tctcctgggg gcacaggaat
     2041 gtcgaagcaa atgccatgga catggggtct gtgacagcaa caggcactgc tactgtgagg
     2101 agggctgggc accccctgac tgcaccactc agctcaaagc aaccagctcc ctgaccacag
     2161 ggctgctcct cagcctcctg gtcttattgg tcctggtgat gcttggtgcc agctactggt
     2221 accgtgcccg cctgcaccag cgactctgcc agctcaaggg acccacctgc cagtacaggg
     2281 cagcccaatc tggtccctct gaacggccag gacctccgca gagggccctg ctggcacgag
     2341 gcactaagca ggctagtgct ctcagcttcc cggccccccc ttccaggccg ctgccgcctg
     2401 accctgtgtc caagagactc caggctgagc tggctgaccg acccaatccc cctacccgcc
     2461 ctctgcccgc tgacccggtg gtgagaagcc cgaagtctca ggggccagcc aagcccccac
     2521 ccccaaggaa gccactgcct gccgaccccc agggccggtg cccatcgggt gacctgcccg
     2581 gcccaggggc tggaatcccg cccctagtgg taccctccag accagcgcca ccgcctccga
     2641 cagtgtcctc gctctacctc tgacctctcc ggaggttccg ctgcctccaa gccggactta
     2701 gggcttcaag aggcgggcgt gccctctgga gtcccctacc atgactgaag gcgccagaga
     2761 ctggcggtgt cttaagactc cgggcaccgc cacgcgctgt caagcaacac tctgcggacc
     2821 tgccggcgta gttgcagcgg gggcttgggg aggggctggg ggttggacgg gattgaggaa
     2881 ggtccgcaca gcctgtctct gctcagttgc aataaacgtg acatcttggg agcgtt
//
