LOCUS       NM_001261464            2819 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 15 (ADAM15), transcript
            variant 7, mRNA.
ACCESSION   NM_001261464
VERSION     NM_001261464.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2819)
  AUTHORS   Puig-Blasco,L., Piotrowski,K.B., Michaelsen,S.R., Bager,N.S.,
            Areskeviciutie,A., Thorseth,M.L., Sun,X.F., Keller,U.A.D.,
            Kristensen,B.W., Madsen,D.H., Gnosa,S.P. and Kveiborg,M.
  TITLE     Loss of cancer cell-derived ADAM15 alters the tumor
            microenvironment in colorectal tumors
  JOURNAL   Int J Cancer 153 (12), 2068-2081 (2023)
   PUBMED   37602921
  REMARK    GeneRIF: Loss of cancer cell-derived ADAM15 alters the tumor
            microenvironment in colorectal tumors.
REFERENCE   2  (bases 1 to 2819)
  AUTHORS   Aujla,P.K., Hu,M., Hartley,B., Kranrod,J.W., Viveiros,A., Kilic,T.,
            Owen,C.A., Oudit,G.Y., Seubert,J.M., Julien,O. and Kassiri,Z.
  TITLE     Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial
            Hypertrophy and Dilation Through Activation of the Calcineurin
            Pathway
  JOURNAL   Hypertension 80 (1), 97-110 (2023)
   PUBMED   36330793
  REMARK    GeneRIF: Loss of ADAM15 Exacerbates Transition to Decompensated
            Myocardial Hypertrophy and Dilation Through Activation of the
            Calcineurin Pathway.
REFERENCE   3  (bases 1 to 2819)
  AUTHORS   Janczi,T., Meier,F., Fehrl,Y., Kinne,R.W., Bohm,B. and Burkhardt,H.
  TITLE     A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the
            Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts
  JOURNAL   Cells 10 (10), 2705 (2021)
   PUBMED   34685689
  REMARK    GeneRIF: A Novel Pro-Inflammatory Mechanosensing Pathway
            Orchestrated by the Disintegrin Metalloproteinase ADAM15 in
            Synovial Fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2819)
  AUTHORS   Xu,J.H., Guan,Y.J., Zhang,Y.C., Qiu,Z.D., Zhou,Y., Chen,C., Yu,J.
            and Wang,W.X.
  TITLE     ADAM15 correlates with prognosis, immune infiltration and apoptosis
            in hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 13 (16), 20395-20417 (2021)
   PUBMED   34426560
  REMARK    GeneRIF: ADAM15 correlates with prognosis, immune infiltration and
            apoptosis in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 2819)
  AUTHORS   Yang,Q., Pei,R., Wang,Y., Zhou,Y., Yang,M., Chen,X. and Chen,J.
  TITLE     ADAM15 Participates in Tick-Borne Encephalitis Virus Replication
  JOURNAL   J Virol 95 (4), e01926-20 (2021)
   PUBMED   33208450
  REMARK    GeneRIF: ADAM15 Participates in Tick-Borne Encephalitis Virus
            Replication.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2819)
  AUTHORS   Nath,D., Slocombe,P.M., Stephens,P.E., Warn,A., Hutchinson,G.R.,
            Yamada,K.M., Docherty,A.J. and Murphy,G.
  TITLE     Interaction of metargidin (ADAM-15) with alphavbeta3 and
            alpha5beta1 integrins on different haemopoietic cells
  JOURNAL   J Cell Sci 112 (Pt 4), 579-587 (1999)
   PUBMED   9914169
REFERENCE   7  (bases 1 to 2819)
  AUTHORS   Zhang,X.P., Kamata,T., Yokoyama,K., Puzon-McLaughlin,W. and
            Takada,Y.
  TITLE     Specific interaction of the recombinant disintegrin-like domain of
            MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3
  JOURNAL   J Biol Chem 273 (13), 7345-7350 (1998)
   PUBMED   9516430
REFERENCE   8  (bases 1 to 2819)
  AUTHORS   Herren,B., Raines,E.W. and Ross,R.
  TITLE     Expression of a disintegrin-like protein in cultured human vascular
            cells and in vivo
  JOURNAL   FASEB J 11 (2), 173-180 (1997)
   PUBMED   9039960
REFERENCE   9  (bases 1 to 2819)
  AUTHORS   McKie,N., Edwards,T., Dallas,D.J., Houghton,A., Stringer,B.,
            Graham,R., Russell,G. and Croucher,P.I.
  TITLE     Expression of members of a novel membrane linked metalloproteinase
            family (ADAM) in human articular chondrocytes
  JOURNAL   Biochem Biophys Res Commun 230 (2), 335-339 (1997)
   PUBMED   9016778
REFERENCE   10 (bases 1 to 2819)
  AUTHORS   Kratzschmar,J., Lum,L. and Blobel,C.P.
  TITLE     Metargidin, a membrane-anchored metalloprotease-disintegrin protein
            with an RGD integrin binding sequence
  JOURNAL   J Biol Chem 271 (9), 4593-4596 (1996)
   PUBMED   8617717
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL451085.20, AK296925.1,
            AL691442.32 and BM971880.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001261464.1.
            
            Summary: The protein encoded by this gene is a member of the ADAM
            (a disintegrin and metalloproteinase) protein family. ADAM family
            members are type I transmembrane glycoproteins known to be involved
            in cell adhesion and proteolytic ectodomain processing of cytokines
            and adhesion molecules. This protein contains multiple functional
            domains including a zinc-binding metalloprotease domain, a
            disintegrin-like domain, as well as a EGF-like domain. Through its
            disintegrin-like domain, this protein specifically interacts with
            the integrin beta chain, beta 3. It also interacts with Src family
            protein-tyrosine kinases in a phosphorylation-dependent manner,
            suggesting that this protein may function in cell-cell adhesion as
            well as in cellular signaling. Multiple alternatively spliced
            transcript variants encoding distinct isoforms have been observed.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (7) lacks two alternate in-frame
            exons in the 3' coding region compared to variant 6. The resulting
            protein (isoform 7) is shorter compared to isoform 6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296925.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL451085.20        179754-179788
            36-672              AK296925.1         1-637
            673-673             AL691442.32        2738-2738
            674-746             AK296925.1         639-711
            747-747             AL691442.32        4095-4095
            748-956             AK296925.1         713-921
            957-957             AL691442.32        4463-4463
            958-2713            AK296925.1         923-2678
            2714-2819           BM971880.1         20-125              c
FEATURES             Location/Qualifiers
     source          1..2819
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2819
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /note="ADAM metallopeptidase domain 15"
                     /db_xref="GeneID:8751"
                     /db_xref="HGNC:HGNC:193"
                     /db_xref="MIM:605548"
     exon            1..150
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2546
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /note="isoform 7 preproprotein is encoded by transcript
                     variant 7; a disintegrin and metalloproteinase domain 15
                     (metargidin); metalloproteinase-like, disintegrin-like,
                     and cysteine-rich protein 15; metalloprotease RGD
                     disintegrin protein; disintegrin and metalloproteinase
                     domain-containing protein 15; MDC-15"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 15 isoform 7 preproprotein"
                     /protein_id="NP_001248393.1"
                     /db_xref="CCDS:CCDS58031.1"
                     /db_xref="GeneID:8751"
                     /db_xref="HGNC:HGNC:193"
                     /db_xref="MIM:605548"
                     /translation="MRLALLWALGLLGAGSPLPSWPLPNIVLSWGVLGPAGGTEEQQA
                     ESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVP
                     GRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERS
                     YTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDV
                     VTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWT
                     QRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICS
                     PDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEAST
                     DFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQCDCGFL
                     DDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSS
                     QCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNA
                     FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSW
                     VHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRH
                     CYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQRLCQLKG
                     PTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPPRKPLPADPQGRCPSGDLPG
                     PGAGIPPLVVPSRPAPPPPTVSSLYL"
     exon            151..287
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            288..364
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            365..443
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            444..520
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            521..713
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            714..776
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            777..845
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1015
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1100
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1249
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1424
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1517
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1822
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2018
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2096
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2169
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2308
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2378
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2503
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2819
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2794..2799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /note="hexamer: AATAAA"
     polyA_site      2819
                     /gene="ADAM15"
                     /gene_synonym="MDC15"
                     /note="major polyA site"
ORIGIN      
        1 ctggccgccg gccgctcctc cgcgcgctgt tccgcacttg ctgccctcgc ccggcccgga
       61 gcgccgctgc catgcggctg gcgctgctct gggccctggg gctcctgggc gcgggcagcc
      121 ctctgccttc ctggccgctc ccaaatatag tactgtcttg gggtgtcctg ggacctgcag
      181 gtggcactga ggagcagcag gcagagtcag agaaggcccc gagggagccc ttggagcccc
      241 aggtccttca ggacgatctc ccaattagcc tcaaaaaggt gcttcagacc agtctgcctg
      301 agcccctgag gatcaagttg gagctggacg gtgacagtca tatcctggag ctgctacaga
      361 atagggagtt ggtcccaggc cgcccaaccc tggtgtggta ccagcccgat ggcactcggg
      421 tggtcagtga gggacacact ttggagaact gctgctacca gggaagagtg cggggatatg
      481 caggctcctg ggtgtccatc tgcacctgct ctgggctcag aggcttggtg gtcctgaccc
      541 cagagagaag ctataccctg gagcaggggc ctggggacct tcagggtcct cccattattt
      601 cgcgaatcca agatctccac ctgccaggcc acacctgtgc cctgagctgg cgggaatctg
      661 tacacactca gaagccacca gagcaccccc tgggacagcg ccacattcgc cggaggcggg
      721 atgtggtaac agagaccaag actgtggagt tggtgattgt ggctgatcac tcggaggccc
      781 agaaataccg ggacttccag cacctgctaa accgcacact ggaagtggcc ctcttgctgg
      841 acacattctt ccggcccctg aatgtacgag tggcactagt gggcctggag gcctggaccc
      901 agcgtgacct ggtggagatc agcccaaacc cagctgtcac cctcgaaaac ttcctccact
      961 ggcgcagggc acatttgctg cctcgattgc cccatgacag tgcccagctg gtgactggta
     1021 cttcattctc tgggcctacg gtgggcatgg ccattcagaa ctccatctgt tctcctgact
     1081 tctcaggagg tgtgaacatg gaccactcca ccagcatcct gggagtcgcc tcctccatag
     1141 cccatgagtt gggccacagc ctgggcctgg accatgattt gcctgggaat agctgcccct
     1201 gtccaggtcc agccccagcc aagacctgca tcatggaggc ctccacagac ttcctaccag
     1261 gcctgaactt cagcaactgc agccgacggg ccctggagaa agccctcctg gatggaatgg
     1321 gcagctgcct cttcgaacgg ctgcctagcc taccccctat ggctgctttc tgcggaaata
     1381 tgtttgtgga gccgggcgag cagtgtgact gtggcttcct ggatgactgc gtcgatccct
     1441 gctgtgattc tttgacctgc cagctgaggc caggtgcaca gtgtgcatct gacggaccct
     1501 gttgtcaaaa ttgccagctg cgcccgtctg gctggcagtg tcgtcctacc agaggggatt
     1561 gtgacttgcc tgaattctgc ccaggagaca gctcccagtg tccccctgat gtcagcctag
     1621 gggatggcga gccctgcgct ggcgggcaag ctgtgtgcat gcacgggcgt tgtgcctcct
     1681 atgcccagca gtgccagtca ctttggggac ctggagccca gcccgctgcg ccactttgcc
     1741 tccagacagc taatactcgg ggaaatgctt ttgggagctg tgggcgcaac cccagtggca
     1801 gttatgtgtc ctgcacccct agagatgcca tttgtgggca gctccagtgc cagacaggta
     1861 ggacccagcc tctgctgggc tccatccggg atctactctg ggagacaata gatgtgaatg
     1921 ggactgagct gaactgcagc tgggtgcacc tggacctggg cagtgatgtg gcccagcccc
     1981 tcctgactct gcctggcaca gcctgtggcc ctggcctggt gtgtatagac catcgatgcc
     2041 agcgtgtgga tctcctgggg gcacaggaat gtcgaagcaa atgccatgga catggggtct
     2101 gtgacagcaa caggcactgc tactgtgagg agggctgggc accccctgac tgcaccactc
     2161 agctcaaagc aaccagctcc ctgaccacag ggctgctcct cagcctcctg gtcttattgg
     2221 tcctggtgat gcttggtgcc agctactggt accgtgcccg cctgcaccag cgactctgcc
     2281 agctcaaggg acccacctgc cagtacaggg cagcccaatc tggtccctct gaacggccag
     2341 gacctccgca gagggccctg ctggcacgag gcactaagtc tcaggggcca gccaagcccc
     2401 cacccccaag gaagccactg cctgccgacc cccagggccg gtgcccatcg ggtgacctgc
     2461 ccggcccagg ggctggaatc ccgcccctag tggtaccctc cagaccagcg ccaccgcctc
     2521 cgacagtgtc ctcgctctac ctctgacctc tccggaggtt ccgctgcctc caagccggac
     2581 ttagggcttc aagaggcggg cgtgccctct ggagtcccct accatgactg aaggcgccag
     2641 agactggcgg tgtcttaaga ctccgggcac cgccacgcgc tgtcaagcaa cactctgcgg
     2701 acctgccggc gtagttgcag cgggggcttg gggaggggct gggggttgga cgggattgag
     2761 gaaggtccgc acagcctgtc tctgctcagt tgcaataaac gtgacatctt gggagcgtt
//
