LOCUS       NM_001288973            7941 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 12 (ADAM12), transcript
            variant 3, mRNA.
ACCESSION   NM_001288973 XM_005270188
VERSION     NM_001288973.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7941)
  AUTHORS   Mygind,K.J., Nikodemus,D., Gnosa,S., Kweder,R., Albrechtsen,N.J.W.,
            Kveiborg,M., Erler,J.T. and Albrechtsen,R.
  TITLE     ADAM12-Generated Basigin Ectodomain Binds beta1 Integrin and
            Enhances the Expression of Cancer-Related Extracellular Matrix
            Proteins
  JOURNAL   Int J Mol Sci 25 (11), 5871 (2024)
   PUBMED   38892056
  REMARK    GeneRIF: ADAM12-Generated Basigin Ectodomain Binds beta1 Integrin
            and Enhances the Expression of Cancer-Related Extracellular Matrix
            Proteins.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7941)
  AUTHORS   Ibrahim,H.M., Abdelrahman,A.E., Elwan,A., Bakry,A., Fahmy,M.M.,
            Abdelhamid,M.I., Abdelwanis,A.H. and Fouad,E.M.
  TITLE     Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon
            Cancer: Clinicopathologic Study
  JOURNAL   Appl Immunohistochem Mol Morphol 31 (10), 673-681 (2023)
   PUBMED   37751246
  REMARK    GeneRIF: Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients
            of Colon Cancer: Clinicopathologic Study.
REFERENCE   3  (bases 1 to 7941)
  AUTHORS   Sun,B., Jiang,T., Yong,J., Peng,J., Dong,S., Gu,Y., Ji,X., Luo,L.
            and Chang,W.L.
  TITLE     MiR-135b-5p targets ADAM12 to suppress invasion and accelerate
            trophoblast apoptosis in preeclampsia
  JOURNAL   Placenta 143, 69-79 (2023)
   PUBMED   37864886
  REMARK    GeneRIF: MiR-135b-5p targets ADAM12 to suppress invasion and
            accelerate trophoblast apoptosis in preeclampsia.
REFERENCE   4  (bases 1 to 7941)
  AUTHORS   Duhachek-Muggy,S., Li,H., Qi,Y. and Zolkiewska,A.
  TITLE     Alternative mRNA splicing generates two distinct ADAM12 prodomain
            variants
  JOURNAL   PLoS One 8 (10), e75730 (2013)
   PUBMED   24116070
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7941)
  AUTHORS   Nyren-Erickson,E.K., Jones,J.M., Srivastava,D.K. and Mallik,S.
  TITLE     A disintegrin and metalloproteinase-12 (ADAM12): function, roles in
            disease progression, and clinical implications
  JOURNAL   Biochim Biophys Acta 1830 (10), 4445-4455 (2013)
   PUBMED   23680494
  REMARK    GeneRIF: understanding of ADAM12 both as a biomarker and a
            potential drug target could help make significant inroads into both
            early diagnosis and treatment of disease
            Review article
REFERENCE   6  (bases 1 to 7941)
  AUTHORS   Galliano,M.F., Huet,C., Frygelius,J., Polgren,A., Wewer,U.M. and
            Engvall,E.
  TITLE     Binding of ADAM12, a marker of skeletal muscle regeneration, to the
            muscle-specific actin-binding protein, alpha -actinin-2, is
            required for myoblast fusion
  JOURNAL   J Biol Chem 275 (18), 13933-13939 (2000)
   PUBMED   10788519
REFERENCE   7  (bases 1 to 7941)
  AUTHORS   Iba,K., Albrechtsen,R., Gilpin,B.J., Loechel,F. and Wewer,U.M.
  TITLE     Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports
            tumor cell adhesion
  JOURNAL   Am J Pathol 154 (5), 1489-1501 (1999)
   PUBMED   10329602
REFERENCE   8  (bases 1 to 7941)
  AUTHORS   Loechel,F., Gilpin,B.J., Engvall,E., Albrechtsen,R. and Wewer,U.M.
  TITLE     Human ADAM 12 (meltrin alpha) is an active metalloprotease
  JOURNAL   J Biol Chem 273 (27), 16993-16997 (1998)
   PUBMED   9642263
REFERENCE   9  (bases 1 to 7941)
  AUTHORS   Gilpin,B.J., Loechel,F., Mattei,M.G., Engvall,E., Albrechtsen,R.
            and Wewer,U.M.
  TITLE     A novel, secreted form of human ADAM 12 (meltrin alpha) provokes
            myogenesis in vivo
  JOURNAL   J Biol Chem 273 (1), 157-166 (1998)
   PUBMED   9417060
REFERENCE   10 (bases 1 to 7941)
  AUTHORS   Yagami-Hiromasa,T., Sato,T., Kurisaki,T., Kamijo,K., Nabeshima,Y.
            and Fujisawa-Sehara,A.
  TITLE     A metalloprotease-disintegrin participating in myoblast fusion
  JOURNAL   Nature 377 (6550), 652-656 (1995)
   PUBMED   7566181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from KF444157.1, AC063963.11 and
            AK055628.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001288973.1.
            
            Summary: This gene encodes a member of a family of proteins that
            are structurally related to snake venom disintegrins and have been
            implicated in a variety of biological processes involving cell-cell
            and cell-matrix interactions, including fertilization, muscle
            development, and neurogenesis. Expression of this gene has been
            used as a maternal serum marker for pre-natal development.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. Shorter isoforms are secreted, while
            longer isoforms are membrane-bound form. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (3, also known as ADAM12-La) is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KF444157.1, SRR14038197.1739448.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448723.2/ ENSP00000391268.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6003              KF444157.1         82-6084
            6004-6019           AC063963.11        95284-95299         c
            6020-7941           AK055628.1         450-2371
FEATURES             Location/Qualifiers
     source          1..7941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     gene            1..7941
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /note="ADAM metallopeptidase domain 12"
                     /db_xref="GeneID:8038"
                     /db_xref="HGNC:HGNC:190"
                     /db_xref="MIM:602714"
     exon            1..420
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..3053
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /note="isoform 3 preproprotein is encoded by transcript
                     variant 3; disintegrin and metalloproteinase
                     domain-containing protein 12; meltrin-alpha;
                     metalloprotease-disintegrin 12 transmembrane"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 12 isoform 3 preproprotein"
                     /protein_id="NP_001275902.1"
                     /db_xref="CCDS:CCDS91373.1"
                     /db_xref="GeneID:8038"
                     /db_xref="HGNC:HGNC:190"
                     /db_xref="MIM:602714"
                     /translation="MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVS
                     ASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQD
                     GTDVSLARNYTGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR
                     YKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIV
                     ADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDP
                     FTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDH
                     SDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC
                     SRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNA
                     TTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG
                     HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSS
                     FAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMP
                     DPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPP
                     FCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKK
                     TTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDIS
                     RPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLP
                     ADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK"
     exon            421..518
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            519..592
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            593..671
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            672..748
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            749..935
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1001
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1073
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1243
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1328
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1477
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1655
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1745
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1941
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2050
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2249
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2327
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2436
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2572
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2681
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2861
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2992
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..7941
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7921..7926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /note="hexamer: AATAAA"
     polyA_site      7941
                     /gene="ADAM12"
                     /gene_synonym="ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN;
                     MLTNA"
                     /note="major polyA site"
ORIGIN      
        1 atttcacagg cctgccttct ctcactaacg ctcttcctag tccccgggcc aactcggaca
       61 gtttgctcat ttattgcaac ggtcaaggct ggcttgtgcc agaacggcgc gcgcgcgcgc
      121 acgcacgcac acacacgggg ggaaactttt ttaaaaatga aaggctagaa gagctcagcg
      181 gcggcgcggg cgctgcgcga gggctccgga gctgactcgc cgaggcagga aatccctccg
      241 gtcgcgacgc ccggccccgg ctcggcgccc gcgtgggatg gtgcagcgct cgccgccggg
      301 cccgagagct gctgcactga aggccggcga cgatggcagc gcgcccgctg cccgtgtccc
      361 ccgcccgcgc cctcctgctc gccctggccg gtgctctgct cgcgccctgc gaggcccgag
      421 gggtgagctt atggaaccaa ggaagagctg atgaagttgt cagtgcctct gttgggagtg
      481 gggacctctg gatcccagtg aagagcttcg actccaagaa tcatccagaa gtgctgaata
      541 ttcgactaca acgggaaagc aaagaactga tcataaatct ggaaagaaat gaaggtctca
      601 ttgccagcag tttcacggaa acccactatc tgcaagacgg tactgatgtc tccctcgctc
      661 gaaattacac gggtcactgt tactaccatg gacatgtacg gggatattct gattcagcag
      721 tcagtctcag cacgtgttct ggtctcaggg gacttattgt gtttgaaaat gaaagctatg
      781 tcttagaacc aatgaaaagt gcaaccaaca gatacaaact cttcccagcg aagaagctga
      841 aaagcgtccg gggatcatgt ggatcacatc acaacacacc aaacctcgct gcaaagaatg
      901 tgtttccacc accctctcag acatgggcaa gaaggcataa aagagagacc ctcaaggcaa
      961 ctaagtatgt ggagctggtg atcgtggcag acaaccgaga gtttcagagg caaggaaaag
     1021 atctggaaaa agttaagcag cgattaatag agattgctaa tcacgttgac aagttttaca
     1081 gaccactgaa cattcggatc gtgttggtag gcgtggaagt gtggaatgac atggacaaat
     1141 gctctgtaag tcaggaccca ttcaccagcc tccatgaatt tctggactgg aggaagatga
     1201 agcttctacc tcgcaaatcc catgacaatg cgcagcttgt cagtggggtt tatttccaag
     1261 ggaccaccat cggcatggcc ccaatcatga gcatgtgcac ggcagaccag tctgggggaa
     1321 ttgtcatgga ccattcagac aatccccttg gtgcagccgt gaccctggca catgagctgg
     1381 gccacaattt cgggatgaat catgacacac tggacagggg ctgtagctgt caaatggcgg
     1441 ttgagaaagg aggctgcatc atgaacgctt ccaccgggta cccatttccc atggtgttca
     1501 gcagttgcag caggaaggac ttggagacca gcctggagaa aggaatgggg gtgtgcctgt
     1561 ttaacctgcc ggaagtcagg gagtctttcg ggggccagaa gtgtgggaac agatttgtgg
     1621 aagaaggaga ggagtgtgac tgtggggagc cagaggaatg tatgaatcgc tgctgcaatg
     1681 ccaccacctg taccctgaag ccggacgctg tgtgcgcaca tgggctgtgc tgtgaagact
     1741 gccagctgaa gcctgcagga acagcgtgca gggactccag caactcctgt gacctcccag
     1801 agttctgcac aggggccagc cctcactgcc cagccaacgt gtacctgcac gatgggcact
     1861 catgtcagga tgtggacggc tactgctaca atggcatctg ccagactcac gagcagcagt
     1921 gtgtcacgct ctggggacca ggtgctaaac ctgcccctgg gatctgcttt gagagagtca
     1981 attctgcagg tgatccttat ggcaactgtg gcaaagtctc gaagagttcc tttgccaaat
     2041 gcgagatgag agatgctaaa tgtggaaaaa tccagtgtca aggaggtgcc agccggccag
     2101 tcattggtac caatgccgtt tccatagaaa caaacatccc cctgcagcaa ggaggccgga
     2161 ttctgtgccg ggggacccac gtgtacttgg gcgatgacat gccggaccca gggcttgtgc
     2221 ttgcaggcac aaagtgtgca gatggaaaaa tctgcctgaa tcgtcaatgt caaaatatta
     2281 gtgtctttgg ggttcacgag tgtgcaatgc agtgccacgg cagaggggtg tgcaacaaca
     2341 ggaagaactg ccactgcgag gcccactggg cacctccctt ctgtgacaag tttggctttg
     2401 gaggaagcac agacagcggc cccatccggc aagcagataa ccaaggttta accataggaa
     2461 ttctggtgac catcctgtgt cttcttgctg ccggatttgt ggtttatctc aaaaggaaga
     2521 ccttgatacg actgctgttt acaaataaga agaccaccat tgaaaaacta aggtgtgtgc
     2581 gcccttcccg gccaccccgt ggcttccaac cctgtcaggc tcacctcggc caccttggaa
     2641 aaggcctgat gaggaagccg ccagattcct acccaccgaa ggacaatccc aggagattgc
     2701 tgcagtgtca gaatgttgac atcagcagac ccctcaacgg cctgaatgtc cctcagcccc
     2761 agtcaactca gcgagtgctt cctcccctcc accgggctcc acgtgcacct agcgtccctg
     2821 ccagacccct gccagccaag cctgcactta ggcaggccca ggggacctgt aagccaaacc
     2881 cccctcagaa gcctctgcct gcagatcctc tggccagaac aactcggctc actcatgcct
     2941 tggccaggac cccaggacaa tgggagactg ggctccgcct ggcacccctc agacctgctc
     3001 cacaatatcc acaccaagtg cccagatcca cccacaccgc ctatattaag tgagaagccg
     3061 acaccttttt tcaacagtga agacagaagt ttgcactatc tttcagctcc agttggagtt
     3121 ttttgtacca acttttagga ttttttttaa tgtttaaaac atcattacta taagaacttt
     3181 gagctactgc cgtcagtgct gtgctgtgct atggtgctct gtctacttgc tcaggtactt
     3241 gtaaattatt aatttatgca gaatgttgat tacagtgcag tgcgctgtag taggcatttt
     3301 taccatcact gagttttcca tggcaggaag gcttgttgtg cttttagtat tttagtgaac
     3361 ttgaaatatc ctgcttgatg ggattctgga caggatgtgt ttgctttctg atcaaggcct
     3421 tattggaaag cagtccccca actaccccca gctgtgctta tggtaccaga tgcagctcaa
     3481 gagatcccaa gtagaatctc agttgatttt ctggattccc catctcaggc cagagccaag
     3541 gggcttcagg tccaggctgt gtttggcttt cagggaggcc ctgtgcccct tgacaactgg
     3601 caggcaggct cccagggaca cctgggagaa atctggcttc tggccaggaa gctttggtga
     3661 gaacctgggt tgcagacagg aatcttaagg tgtagccaca ccaggataga gactggaaca
     3721 ctagacaagc cagaacttga ccctgagctg accagccgtg agcatgtttg gaaggggtct
     3781 gtagtgtcac tcaaggcggt gcttgataga aatgccaagc acttcttttt ctcgctgtcc
     3841 tttctagagc actgccacca gtaggttatt tagcttggga aaggtggtgt ttctgtaaga
     3901 aacctactgc ccaggcactg caaaccgcca cctccctata ctgcttggag ctgagcaaat
     3961 caccacaaac tgtaatacaa tgatcctgta ttcagacaga tgaggctttc catgggacca
     4021 caactatttt cagatgtgaa ccattaacca gatctagtca atcaagtctg tttactgcaa
     4081 ggttcaactt attaacaatt aggcagactc tttatgcttg caaaaactac aaccaatgga
     4141 atgtgatgtt catgggtata gttcatgtct gctatcatta ttcgtagata ttggacaaag
     4201 aaccttctct atggggcatc ctctttttcc aacttggctg caggaatctt taaaagatgc
     4261 ttttaacaga gtctgaacct atttcttaaa cacttgcaac ctacctgttg agcatcacag
     4321 aatgtgataa ggaaatcaac ttgcttatca acttcctaaa tattatgaga tgctggcttg
     4381 ggcagcatcc ccttgaactc ttcactcttc aaatgcctga ctagggagcc atgtttcaca
     4441 aggtctttaa agtgactaat ggcatgagaa atacaaaaat actcagataa ggtaaaatgc
     4501 catgatgcct ctgtcttctg gactggtttt cacattagaa gacaattgac aacagttaca
     4561 taattcactc tgagtgtttt atgagaaagc cttcttttgg gggtcaacag ttttcctatg
     4621 ctttgaaaca gaaaaatatg taccaagaat cttggtttgc cttccagaaa acaaaactgc
     4681 atttcacttt cccggtgttc cccactgtat ctaggcaaca tagtattcat gactatggat
     4741 aaactaaaca cgtgacacaa acacacacaa aagggaaccc agctctaata cattccaact
     4801 cgtatagcat gcatctgttt attctatagt tattaagttc tttaaaatgt aaagccatgc
     4861 tggaaaataa tactgctgag atacatacag aattactgta actgattaca cttggtaatt
     4921 gtactaaagc caaacatata tatactatta aaaaggttta cagaatttta tggtgcatta
     4981 cgtgggcatt gtctttttag atgcccaaat ccttagatct ggcatgttag cccttcctcc
     5041 aattataaga ggatatgaac tgagtttttc ttttgttgtt tgttcttagc tgtaattcct
     5101 atgcttctat ttcagagagc caggagagtt tgatattaaa ggaggttaaa actgtgatct
     5161 tatgccatgt catcaatggc cacttagggg ccatggctga tgacacattc ttatctctac
     5221 agtactaatg tgttattata gagccatgca ttttatttct gaataagaac atatttaaac
     5281 taatattccc ttacaatatg gacagtatta atccttccaa gatgcagtat ttatcaagtg
     5341 aagcatattt agcagcaaat tccattttaa cataacttag gaaccaataa ccagggtgtt
     5401 ttgtggttgg gggaggcacg gggtggagta ttctttttta tatcctcaaa acaaaaaaaa
     5461 tcaatactta tatttcaatg gcaatctagt atttttttaa aagactgtat aggcatgaat
     5521 aatagaggtg gtttgagttt tgtagggcca tcacctggaa agtcaatgtg actagacaca
     5581 aagtagccca gaggctactt ttcttcctac agcttattat agttgtaggt tctatgacct
     5641 cacttcatgg gttccaggca attccgctga aaggtttgtc tcctgaaatt ttttaagttt
     5701 gttttcctga cacatgtaat cagatgtgta gcaaccgagg gaaacgaagc ctaacattct
     5761 ccattgtgga aatacacaca ggaggttaca tttcacagcg tggatttttc cagcttacac
     5821 atgtgggatg acatcacaga aaccacaaaa gcagcaaatt aaactgtagg agagtcaata
     5881 ctcctgacga gtctcggggg gggggcattt ttatgccttc ttaactttat gagaattctc
     5941 aggctgaact ataggccatt gttcccaggc aaatcaatac atcaatgcat cctcaaaaaa
     6001 aaaaaaaaaa aaaaaaaacc ggctaaaact gtgtcaaaat gttcttaagg agcctatggt
     6061 ctccacggtg ctaaaaagag cctggtgctg ggccgactgg cagggctgag catcctcctg
     6121 ccccctcgcc actgatgttt actaagcact ctgagccaat gagaccccca gcagcagaaa
     6181 gggcacaagg tggcgccagg gcagcagggc cagatctttc tcatgcacct cgacctcttg
     6241 cagactttct tcgtgagatg tactactcat ttcaaaactg ctttgcaggg ctcccctatg
     6301 tattcggggg gcccacggca cactcaggct ggagatcctt cctcactgcg ctcaagatgg
     6361 cctcagccag acaccagtta cccagctgaa agtcacaatc cctcccagaa gtctcccaac
     6421 actagtgctg accagaggtg gggctctcag gctaggagtt tcacacacaa tgacaggctg
     6481 ctgggggaca ttgcaggacc ccttttcctc tcctctccat gctagaagcc agccctaggc
     6541 agctgcagtt actccctgtg actcagcagc aggctgattc aacacagctg cccacacaaa
     6601 gccagtggct aatacatctg tttacctttc cctatcaccc agacacaagc ccctttccca
     6661 ggtcaaacca caggccgatg catctccagt ttgacagtca aatcactact tccattgcta
     6721 ctttagatca gccaaagtgg tgactgctgc agtgtgtggc tatccctaca aggcccaccc
     6781 aagggatgcc caaagcccaa ccttctccag ggctgcagcc cagagcaacc ccaccagcct
     6841 aagtccagca gaggacctcc cacccaatgt cttgttctaa ttagaagggg aagttagcca
     6901 cagaaaatca acttatctat aattacaaaa ttctcttgac tcaccttaaa gttcctattg
     6961 acatctactg cttttaaacc tatttgaaaa ctctgatact aaaacaaatg acactctaag
     7021 aaagtttggg agccccatgc tgagaaccat ttctgtgcag tgaggatgtt tccagaagct
     7081 acttacctac atgtgaatgt gccattttct ttccttttgt agagaaaatc ccctttactt
     7141 tttggaacag taatggcagc ttctagtaca gccattacag tttcatatga gaaaaattaa
     7201 gaataactat aaaattgtta aaatatccaa taatggataa tgatggccag aagatttaac
     7261 atacaaagta attctcaatg taaagctatt cagctcttcc aggttgaatg ccctgtaacc
     7321 caccctgacc ttccacatca tcttcaaaaa gcagtttctc tgttccccat gattctccta
     7381 taaggtaact ctttagtcct ccatttagca cattttaaat cctccaaaga ataagtatca
     7441 tgtgattatt ttagctttac aaaaaaaaag ttgaatggcg ttttattttc atggcctata
     7501 agcaggtacc ttagtagggc agatatagga aaaacaaatt agagcaaaac aaatcctcta
     7561 caaatccaag gcaggaaaag tggtggcaga gtgactcatt ctcctgtccc tcccatcagg
     7621 tcaaatcagg aggctgcagt gaatgcctgt tctttgaatg tgtagcagtt gttcctgtaa
     7681 ctctttaaaa cttggctata ggctgtttag cacagtacag attaaagata cagttacgta
     7741 aacagcaaag taattttata gtgcttcatc catttatcat gctttggttt gctaattttt
     7801 tcacatacct ttttctatca cagtctgttg cttttgtaca catttctcat attggggttc
     7861 gacaggtaaa cacaaactgc tatttcagta gaaaaagtta ttgttatgaa tattaaaccc
     7921 aataaattgt ataaaggtaa a
//
