LOCUS       NM_002390               4614 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ADAM metallopeptidase domain 11 (ADAM11), transcript
            variant 1, mRNA.
ACCESSION   NM_002390 NM_021612
VERSION     NM_002390.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4614)
  AUTHORS   Barallobre-Barreiro,J., Didangelos,A., Schoendube,F.A., Drozdov,I.,
            Yin,X., Fernandez-Caggiano,M., Willeit,P., Puntmann,V.O.,
            Aldama-Lopez,G., Shah,A.M., Domenech,N. and Mayr,M.
  TITLE     Proteomics analysis of cardiac extracellular matrix remodeling in a
            porcine model of ischemia/reperfusion injury
  JOURNAL   Circulation 125 (6), 789-802 (2012)
   PUBMED   22261194
REFERENCE   2  (bases 1 to 4614)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   3  (bases 1 to 4614)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   4  (bases 1 to 4614)
  AUTHORS   Shea,S.H., Wall,T.L., Carr,L.G. and Li,T.K.
  TITLE     ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American
            college students
  JOURNAL   Behav Genet 31 (2), 231-239 (2001)
   PUBMED   11545539
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4614)
  AUTHORS   Sagane,K., Ohya,Y., Hasegawa,Y. and Tanaka,I.
  TITLE     Metalloproteinase-like, disintegrin-like, cysteine-rich proteins
            MDC2 and MDC3: novel human cellular disintegrins highly expressed
            in the brain
  JOURNAL   Biochem J 334 (Pt 1) (Pt 1), 93-98 (1998)
   PUBMED   9693107
REFERENCE   6  (bases 1 to 4614)
  AUTHORS   Wolfsberg,T.G., Primakoff,P., Myles,D.G. and White,J.M.
  TITLE     ADAM, a novel family of membrane proteins containing A Disintegrin
            And Metalloprotease domain: multipotential functions in cell-cell
            and cell-matrix interactions
  JOURNAL   J Cell Biol 131 (2), 275-278 (1995)
   PUBMED   7593158
  REMARK    Review article
REFERENCE   7  (bases 1 to 4614)
  AUTHORS   Katagiri,T., Harada,Y., Emi,M. and Nakamura,Y.
  TITLE     Human metalloprotease/disintegrin-like (MDC) gene: exon-intron
            organization and alternative splicing
  JOURNAL   Cytogenet Cell Genet 68 (1-2), 39-44 (1995)
   PUBMED   7956356
REFERENCE   8  (bases 1 to 4614)
  AUTHORS   Emi,M., Katagiri,T., Harada,Y., Saito,H., Inazawa,J., Ito,I.,
            Kasumi,F. and Nakamura,Y.
  TITLE     A novel metalloprotease/disintegrin-like gene at 17q21.3 is
            somatically rearranged in two primary breast cancers
  JOURNAL   Nat Genet 5 (2), 151-157 (1993)
   PUBMED   8252040
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005180.3, BC144550.1,
            AB009675.1, CD630831.1, CD630842.1, CN418442.1, BM557705.1 and
            BM681070.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002390.5.
            
            Summary: This gene encodes a member of the ADAM (a disintegrin and
            metalloprotease) protein family. Members of this family are
            membrane-anchored proteins structurally related to snake venom
            disintegrins, and have been implicated in a variety of biological
            processes involving cell-cell and cell-matrix interactions,
            including fertilization, muscle development, and neurogenesis. The
            encoded preproprotein is proteolytically processed to generate the
            mature protease. This gene represents a candidate tumor suppressor
            gene for human breast cancer based on its location within a minimal
            region of chromosome 17q21 previously defined by tumor deletion
            mapping. Alternative splicing results in multiple transcript
            variants, at least one of which encodes an isoform that is
            proteolytically processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB009675.1, SRR1660803.156588.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000200557.11/ ENSP00000200557.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC005180.3         42631-42821
            192-212             BC144550.1         1-21
            213-1266            AB009675.1         1-1054
            1267-1279           CD630831.1         126-138             c
            1280-1454           AB009675.1         1068-1242
            1455-1465           CD630842.1         419-429             c
            1466-1966           AB009675.1         1254-1754
            1967-1974           CN418442.1         389-396
            1975-2429           AB009675.1         1763-2217
            2430-2434           AC005180.3         61827-61831
            2435-2828           AB009675.1         2223-2616
            2829-3375           BM557705.1         133-679
            3376-3714           BC144550.1         3182-3520
            3715-3715           AC005180.3         64590-64590
            3716-4415           BC144550.1         3522-4221
            4416-4614           BM681070.1         17-215              c
FEATURES             Location/Qualifiers
     source          1..4614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4614
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /note="ADAM metallopeptidase domain 11"
                     /db_xref="GeneID:4185"
                     /db_xref="HGNC:HGNC:189"
                     /db_xref="MIM:155120"
     exon            1..273
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..2522
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; disintegrin and metalloproteinase
                     domain-containing protein 11; ADAM 11;
                     metalloproteinase-like, disintegrin-like, and
                     cysteine-rich protein"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 11 isoform 1 preproprotein"
                     /protein_id="NP_002381.2"
                     /db_xref="CCDS:CCDS11486.1"
                     /db_xref="GeneID:4185"
                     /db_xref="HGNC:HGNC:189"
                     /db_xref="MIM:155120"
                     /translation="MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGA
                     PEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLE
                     LNHHLLSSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFS
                     DGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNR
                     PRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVI
                     YKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRT
                     FQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDC
                     KCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNG
                     FVEAGEECDCGSVQECSRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVN
                     ECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAAADRF
                     CYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTF
                     YHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGE
                     RRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSI
                     AGAVLVAAIVLGGTGWGFKNIRRGRSGGA"
     exon            274..449
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            450..526
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            527..593
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            594..679
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            680..755
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            756..822
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            823..890
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            891..965
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1037
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1204
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1289
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1380
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1432
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1532
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1604
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1697
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1778
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1829
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1893
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1993
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2113
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2282
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2397
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2488
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2506
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..4614
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4573..4578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /note="hexamer: ATTAAA"
     polyA_site      4614
                     /gene="ADAM11"
                     /gene_synonym="MDC"
                     /note="major polyA site"
ORIGIN      
        1 aacccggccc cgccgccccg ccgggatggc cgcggccgga gcgcgctgag ccccggcgcc
       61 gtccctgccg cccccacctc tccgcgaccc ccgcccggcc ccgcgccccc gccccggctc
      121 cgcagctggc gcctccccac ccccgtccct gctcccgccc tccccgcgcc gctggcagcc
      181 gcagcccccg gaccgggagg aatgagcgag ccatgaggct gctgcggcgc tgggcgttcg
      241 cggctctgct gctgtcgctg ctccccacgc ccggtcttgg gacccaaggt cctgctggag
      301 ctctgcgatg ggggggctta ccccagctgg gaggcccagg agcccctgag gtcacggaac
      361 ccagccgtct ggttagggag agctccgggg gagaggtccg aaagcagcag ctggacacaa
      421 gggtccgcca ggagccacca gggggcccgc ctgtccatct ggcccaggtg agtttcgtca
      481 tcccagcctt caactcaaac ttcaccctgg acctggagct gaaccaccac ctcctctcct
      541 cgcaatacgt ggagcgccac ttcagccggg aggggacaac ccagcacagc accggggctg
      601 gagaccactg ctactaccag gggaagctcc gggggaaccc gcactccttc gccgccctct
      661 ccacctgcca ggggctgcat ggggtcttct ctgatgggaa cttgacttac atcgtggagc
      721 cccaagaggt ggctggacct tggggagccc ctcagggacc ccttccccac ctcatttacc
      781 ggacccctct cctcccagat cccctcggat gcagggaacc aggctgcctg tttgctgtgc
      841 ctgcccagtc ggctcctcca aaccggccga ggctgagaag gaaaaggcag gtccgccggg
      901 gccaccctac agtgcacagt gaaaccaagt atgtggagct aattgtgatc aacgaccacc
      961 agctgttcga gcagatgcga cagtcggtgg tcctcaccag caactttgcc aagtccgtgg
     1021 tgaacctggc cgatgtgata tacaaggagc agctcaacac tcgcatcgtc ctggttgcca
     1081 tggaaacatg ggcagatggg gacaagatcc aggtgcagga tgacctcctg gagaccctgg
     1141 cccggctcat ggtctaccga cgggagggtc tgcctgagcc cagtgatgcc acccacctct
     1201 tctcgggcag gaccttccag agcacgagca gcggggcagc ctacgtgggg ggcatatgct
     1261 ccctgtccca cggcgggggt gtgaacgagt acggcaacat gggggcgatg gccgtgaccc
     1321 ttgcccagac gctgggacag aacctgggca tgatgtggaa caaacaccgg agctcggcag
     1381 gggactgcaa gtgtccagac atctggctgg gctgcatcat ggaggacact gggttctacc
     1441 tgccccgcaa gttctcgcgc tgtagcatcg acgagtacaa ccagtttctg caggagggtg
     1501 gtggcagctg cctcttcaac aagcccctca agctcctgga ccccccagag tgcgggaacg
     1561 gcttcgtgga ggcaggggag gagtgcgact gcggctcggt gcaggagtgc agccgcgcag
     1621 gtggcaactg ctgcaagaaa tgcaccctga ctcacgacgc catgtgcagc gacgggctct
     1681 gctgtcgccg ctgcaagtac gaaccacggg gtgtgtcctg ccgagaggcc gtgaacgagt
     1741 gcgacatcgc ggagacctgc accggggact ctagccagtg cccgcctaac ctgcacaagc
     1801 tggacggtta ctactgtgac catgagcagg gccgctgcta cggaggtcgc tgcaaaaccc
     1861 gggaccggca gtgccaggtt ctttggggcc atgcggctgc tgatcgcttc tgctacgaga
     1921 agctgaatgt ggaggggacg gagcgtggga gctgtgggcg caagggatct ggctgggtcc
     1981 agtgcagtaa gcaggacgtg ctgtgtggct tcctcctctg tgtcaacatc tctggagctc
     2041 ctcggctagg ggacctggtg ggagacatca gtagtgtcac cttctaccac cagggcaagg
     2101 agctggactg caggggaggc cacgtgcagc tggcggacgg ctctgacctg agctatgtgg
     2161 aggatggcac agcctgcggg cctaacatgt tgtgcctgga ccatcgctgc ctgccagctt
     2221 ctgccttcaa cttcagcacc tgccccggca gtggggagcg ccggatttgc tcccaccacg
     2281 gggtctgcag caatgaaggg aagtgcatct gtcagccaga ctggacaggc aaagactgca
     2341 gtatccataa ccccctgccc acgtccccac ccacggggga gacggagaga tataaaggtc
     2401 ccagcggcac caacatcatc attggctcca ttgctggggc tgtcctggtt gcagccatcg
     2461 tcctgggcgg cacgggctgg ggatttaaaa acattcgccg aggaaggtcc ggaggggcct
     2521 aagtgccacc ctcctccctc caagcctggc acccaccgtc tcggccctga accacgaggc
     2581 tgcccccatc cagccacgga gggaggcacc atgcaaatgt cttccaggtc caaacccttc
     2641 aactcctggc tccgcagggg tttgggtggg ggctgtggcc ctgcccttgg caccaccagg
     2701 gtggaccagg cctggagggc acttcctcca cagtccccca cccacctcct gcggctcagc
     2761 cttgcacacc cactgccccg tgtgaatgta gcttccacct catggattgc cacagctcaa
     2821 ctcgggggcg cctggaggga tgcccccagg cagccaccag tggacctagc ctggatggcc
     2881 cctccttgca accaggcagc tgagaccagg gtcttacctc tctgggacct agggggacgg
     2941 ggctgacatc tacatttttt aaaactgaat cttaatcgat gaatgtaaac tcgggggtgc
     3001 tggggccagg gcagatgtgg ggatgttttg acatttacag gagggcccgg agaaactgag
     3061 gtatggccat gccctagacc ctccccaagg atgaccacac ccgaagtcct gtcactgagc
     3121 acagtcaggg gctgggcatc ccagcttgcc cccgcttagc cccgctgagc ttggaggaag
     3181 tatgagtgct gattcaaacc aaagctgcct gtgccatgcc caaggcctag gttatgggta
     3241 cggcaaccac atgtcccaga tcgtctccaa ttcgaaaaca accgtcctgc tgtccctgtc
     3301 aggacacatg gattttggca gggcgggggg ggttctagaa aatatagttc ctataataaa
     3361 atggcacctt ccccctttca agaagggtga ttctggggcc gactcagggt ttaggtgccc
     3421 cctggtgtgg cctagatgtc cccacctggg ccatctttct ggggaggact ctcccaggta
     3481 gggaaggcca gaggtggccc agtgcctgga gggttagggt ctctgcctgg gatatgcaag
     3541 aggaagtagg aaagggaggt ctcatggatg atcctaggct gctagaagtc cttaaggccc
     3601 catctagtcc attccactcc ctacccccat tccagagccg agtagtaagt ttacagatgt
     3661 ttcccccatt acgtaccccc acccatccct gctgcagcga gcctgagagc caggtagagc
     3721 caggcacagc tcctcagtct tctcacacag tcctgccggt ggccttccct catgaccctt
     3781 gcttgggagg gtggagcact ggctccttga ccctaaaagg tagctggcag gggcaagatg
     3841 ggggccagct acctaatgga tgaaagccac aagtgaatac agttcttgtc accagggttg
     3901 ccctgccctc actcggcagg gagttctgac accccagggc ccgtgagcta cctgcttgag
     3961 cccctgtttc tggggcacct tcgaggaggc gttgtggagg gcatcgcccc ctgtttattc
     4021 acaacaccct caggggcaaa caggcctggg acccgctgac accattttgg gtagctggat
     4081 gcacccgaca gcagtggggt ccacacactg agctccagct ggcactgccc actcaagggc
     4141 tgagtggagg ggcccctccg gccagctctg ctccaccagc cctgcaagct gatgcagggc
     4201 gggggaaggg ctgggtgttg cactattgct gcgctgcctt aaggcatctg tcctctggtg
     4261 gtgcacccgt gcacacaggt acagtgcatc tgggcacagc ttttggatcc acacctctgc
     4321 acaagtgtga atacctctgc acatatgggc gtatctgtgt gtgctcgtgt atatggggtg
     4381 gggaacatga gacttcctgt gaccagtcca ccctggctcc cagctgtctg tatcctcctg
     4441 ccccgccctg gcgagtgcct accctggcag aacccaggga ggagtggagg ctgcctctgc
     4501 ctgggcctcc acacagcatc ctgtacatac gccacctggg ctgggggtgg ggaggcaggg
     4561 ccaggagcat cgattaaaga tcacatcctg gggcttccag ggagctcaca ccaa
//
