LOCUS       NM_001107                580 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens acylphosphatase 1 (ACYP1), transcript variant 1, mRNA.
ACCESSION   NM_001107
VERSION     NM_001107.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 580)
  AUTHORS   Sakano,Y., Noda,T., Kobayashi,S., Kitagawa,A., Iwagami,Y.,
            Yamada,D., Tomimaru,Y., Akita,H., Gotoh,K., Asaoka,T., Tanemura,M.,
            Umeshita,K., Mimori,K., Doki,Y. and Eguchi,H.
  TITLE     Clinical Significance of Acylphosphatase 1 Expression in Combined
            HCC-iCCA, HCC, and iCCA
  JOURNAL   Dig Dis Sci 67 (8), 3817-3830 (2022)
   PUBMED   34626299
  REMARK    GeneRIF: Clinical Significance of Acylphosphatase 1 Expression in
            Combined HCC-iCCA, HCC, and iCCA.
REFERENCE   2  (bases 1 to 580)
  AUTHORS   Degl'Innocenti,D., Marzocchini,R., Malentacchi,F., Ramazzotti,M.,
            Raugei,G. and Ramponi,G.
  TITLE     ACYP1 gene possesses two alternative splicing forms that induce
            apoptosis
  JOURNAL   IUBMB Life 56 (1), 29-33 (2004)
   PUBMED   14992377
  REMARK    GeneRIF: two products of the ACYP1 gene are characterized as the
            result of alternative splicing in which an extra 79 bp long exon is
            inserted between the two known exons
REFERENCE   3  (bases 1 to 580)
  AUTHORS   Paoli,P., Pazzagli,L., Giannoni,E., Caselli,A., Manao,G., Camici,G.
            and Ramponi,G.
  TITLE     A nucleophilic catalysis step is involved in the hydrolysis of aryl
            phosphate monoesters by human CT acylphosphatase
  JOURNAL   J Biol Chem 278 (1), 194-199 (2003)
   PUBMED   12409302
  REMARK    GeneRIF: Data show that CT acylphosphatase catalyzes the hydrolysis
            of aryl phosphates and acyl phosphates by two different mechanisms.
REFERENCE   4  (bases 1 to 580)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 580)
  AUTHORS   Fiaschi,T., Marzella,R., Veggi,D., Marzocchini,R., Raugei,G.,
            Rocchi,M. and Ramponi,G.
  TITLE     Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to
            chromosome band 14q24.3
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 235-236 (1998)
   PUBMED   9730610
REFERENCE   6  (bases 1 to 580)
  AUTHORS   Fiaschi,T., Raugei,G., Marzocchini,R., Chiarugi,P., Cirri,P. and
            Ramponi,G.
  TITLE     Cloning and expression of the cDNA coding for the erythrocyte
            isoenzyme of human acylphosphatase
  JOURNAL   FEBS Lett 367 (2), 145-148 (1995)
   PUBMED   7796909
REFERENCE   7  (bases 1 to 580)
  AUTHORS   Nassi,P., Nediani,C., Liguri,G., Taddei,N. and Ramponi,G.
  TITLE     Effects of acylphosphatase on the activity of erythrocyte membrane
            Ca2+ pump
  JOURNAL   J Biol Chem 266 (17), 10867-10871 (1991)
   PUBMED   1645713
REFERENCE   8  (bases 1 to 580)
  AUTHORS   Degl'Innocenti,D., Berti,A., Stefani,M., Liguri,G. and Ramponi,G.
  TITLE     Immunoaffinity purification and immunoassay determination of human
            erythrocyte acylphosphatase
  JOURNAL   Biotechnol Appl Biochem 12 (4), 450-459 (1990)
   PUBMED   2169259
REFERENCE   9  (bases 1 to 580)
  AUTHORS   Liguri,G., Camici,G., Manao,G., Cappugi,G., Nassi,P., Modesti,A.
            and Ramponi,G.
  TITLE     A new acylphosphatase isoenzyme from human erythrocytes:
            purification, characterization, and primary structure
  JOURNAL   Biochemistry 25 (24), 8089-8094 (1986)
   PUBMED   3026468
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312101.1, BC035568.1 and
            X84194.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001107.4.
            
            Summary: This gene is a member of the acylphosphatase family. The
            encoded protein is a small cytosolic enzyme that catalyzes the
            hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two
            isoenzymes have been isolated and described based on their tissue
            localization: erythrocyte (common) type acylphosphatase encoded by
            this gene, and muscle type acylphosphatase. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Oct
            2014].
            
            Transcript Variant: This variant (1) encodes isoform a. Both
            variants 1 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035568.1, SRR1163655.666173.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238618.8/ ENSP00000238618.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               AK312101.1         26-404
            380-460             BC035568.1         390-470
            461-509             X84194.1           450-498
            510-580             BC035568.1         520-590
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..580
                     /gene="ACYP1"
                     /gene_synonym="ACYPE"
                     /note="acylphosphatase 1"
                     /db_xref="GeneID:97"
                     /db_xref="HGNC:HGNC:179"
                     /db_xref="MIM:600875"
     exon            1..71
                     /gene="ACYP1"
                     /gene_synonym="ACYPE"
                     /inference="alignment:Splign:2.1.0"
     exon            72..163
                     /gene="ACYP1"
                     /gene_synonym="ACYPE"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..379
                     /gene="ACYP1"
                     /gene_synonym="ACYPE"
                     /EC_number="3.6.1.7"
                     /note="isoform a is encoded by transcript variant 1;
                     acylphosphate phosphohydrolase 1; acylphosphatase,
                     erythrocyte isozyme; acylphosphatase, organ-common type
                     isozyme; acylphosphatase 1, erythrocyte (common) type"
                     /codon_start=1
                     /product="acylphosphatase-1 isoform a"
                     /protein_id="NP_001098.1"
                     /db_xref="CCDS:CCDS9838.1"
                     /db_xref="GeneID:97"
                     /db_xref="HGNC:HGNC:179"
                     /db_xref="MIM:600875"
                     /translation="MAEGNTLISVDYEIFGKVQGVFFRKHTQAEGKKLGLVGWVQNTD
                     RGTVQGQLQGPISKVRHMQEWLETRGSPKSHIDKANFNNEKVILKLDYSDFQIVK"
     exon            164..580
                     /gene="ACYP1"
                     /gene_synonym="ACYPE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      560..565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACYP1"
                     /gene_synonym="ACYPE"
                     /note="hexamer: AATAAA"
     polyA_site      580
                     /gene="ACYP1"
                     /gene_synonym="ACYPE"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgccttg gtgagccgtt ggcgtggtgg tcccggagtg atcctggcag ccggtgggga
       61 agacaaggag ggtttgagca tggcagaagg aaacaccctg atatcagtgg attatgaaat
      121 ttttgggaag gtgcaagggg tgtttttccg taagcatact caggctgagg gtaaaaagct
      181 gggattggta ggctgggtcc agaacactga ccggggcaca gtgcaaggac aattgcaagg
      241 tcccatctcc aaggtgcgtc atatgcagga atggcttgaa acaagaggaa gtcctaaatc
      301 acacatcgac aaagcaaact tcaacaatga aaaagtcatc ttgaagttgg attactcaga
      361 cttccaaatt gtaaaataat ggcctgaatt taagttttct aagataaact cagtggtttg
      421 gtttttatta ttaatagaga tagaactatt gtgtgttaat attagcatta gtcaataagt
      481 tattttaatg tcagattttt gaatgttatt atatattacc tgtatgatgg aaggattacc
      541 actgtacaca aatctaatca ataaaaacgt tagaaccttc
//
