LOCUS       NM_080658               1371 bp    mRNA    linear   PRI 10-JUL-2024
DEFINITION  Homo sapiens aminoacylase 3 (ACY3), mRNA.
ACCESSION   NM_080658
VERSION     NM_080658.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1371)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 1371)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1371)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 1371)
  AUTHORS   Yu,B., Zheng,Y., Alexander,D., Morrison,A.C., Coresh,J. and
            Boerwinkle,E.
  TITLE     Genetic determinants influencing human serum metabolome among
            African Americans
  JOURNAL   PLoS Genet 10 (3), e1004212 (2014)
   PUBMED   24625756
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1371)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 1371)
  AUTHORS   Chen,Y.R., Chen,T.Y., Zhang,S.L., Lin,S.M., Zhao,Y.R., Ye,F.,
            Zhang,X., Shi,L., Dang,S.S. and Liu,M.
  TITLE     Identification of a novel protein binding to hepatitis C virus core
            protein
  JOURNAL   J Gastroenterol Hepatol 24 (7), 1300-1304 (2009)
   PUBMED   19486448
  REMARK    GeneRIF: Suggest that ACY3 is an HCV core binding protein, which
            may play a role in the development of HCV-associated diseases.
REFERENCE   9  (bases 1 to 1371)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (bases 1 to 1371)
  AUTHORS   Pushkin,A., Carpenito,G., Abuladze,N., Newman,D., Tsuprun,V.,
            Ryazantsev,S., Motemoturu,S., Sassani,P., Solovieva,N.,
            Dukkipati,R. and Kurtz,I.
  TITLE     Structural characterization, tissue distribution, and functional
            expression of murine aminoacylase III
  JOURNAL   Am J Physiol Cell Physiol 286 (4), C848-C856 (2004)
   PUBMED   14656720
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003385.2 and BC008689.1.
            
            On Nov 22, 2018 this sequence version replaced NM_080658.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008689.1, SRR5189664.85078.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255082.8/ ENSP00000255082.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AP003385.2         49054-49124         c
            72-1371             BC008689.1         1-1300
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1371
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /note="aminoacylase 3"
                     /db_xref="GeneID:91703"
                     /db_xref="HGNC:HGNC:24104"
                     /db_xref="MIM:614413"
     exon            1..148
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..222
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..478
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1202
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /EC_number="3.5.1.114"
                     /note="acylase III; aspartoacylase-2; hepatitis C virus
                     core-binding protein 1; aspartoacylase (aminocyclase) 3;
                     aspartoacylase (aminoacylase) 3; HCV core-binding protein
                     1"
                     /codon_start=1
                     /product="N-acyl-aromatic-L-amino acid amidohydrolase
                     (carboxylate-forming)"
                     /protein_id="NP_542389.1"
                     /db_xref="CCDS:CCDS8175.1"
                     /db_xref="GeneID:91703"
                     /db_xref="HGNC:HGNC:24104"
                     /db_xref="MIM:614413"
                     /translation="MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRA
                     SFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGP
                     KASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRS
                     GEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAF
                     EMEAYRPVGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGES
                     TVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS"
     exon            479..674
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..768
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..876
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..986
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1371
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1350..1355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /note="hexamer: TATAAA"
     polyA_site      1371
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /note="major polyA site"
ORIGIN      
        1 actttcttcc ctgaaggagc agcacagaac aaaagctcca ggcagctgct tccgctgttt
       61 cgggggtagg gcggagtgac agccccacgg gccacgcagc aagcagaaga tccccgggag
      121 tcaccctcaa ccctctgggg ccacgtgggc ccatgaatac cagcctgtct gcgagttaga
      181 cgccagtcct ggtggcccgg gaagcccaga tccgcatcag cggttctgca ccccacacca
      241 gcatgtgctc actgcctgtg ccccgggagc ccctgcgtcg cgtggctgtg actgggggca
      301 cgcatggcaa cgagatgtcg ggcgtctacc tggcccggca ctggctgcat gcccccgcag
      361 agctgcagag agccagcttc tccgctgtgc ctgtgctggc caacccggca gccacatccg
      421 gctgccgccg ctacgtggac catgacctca accgcacctt caccagcagc ttcctcaatt
      481 ccaggcccac cccggacgac ccatatgagg tgacaagagc ccgagagctg aaccagctgc
      541 tggggcccaa ggcctcgggc caggcctttg actttgtcct tgacctgcac aacaccacgg
      601 ccaacatggg cacctgctta atcgcgaagt cctcccacga agtctttgcc atgcacctgt
      661 gccgccatct gcagctgcag taccccgagc tgtcctgcca ggtcttcctg taccagcggt
      721 ctggggagga gagctacaac ctggactctg tggccaaaaa tggactgggt ctggagctgg
      781 gcccccagcc acagggtgtg ctgcgggctg acattttctc aaggatgagg accctggtgg
      841 ccacagttct ggacttcatc gaactcttca accagggtac ggcctttcct gcctttgaga
      901 tggaagccta tagacccgtg ggcgtcgtgg acttcccccg caccgaggcc gggcacctgg
      961 caggcactgt gcatcctcag ctgcaggacc gagacttcca gccactgcag cctggtgctc
     1021 ccatcttcca gatgttcagt ggggaggacc tgctctatga gggagagtcc acggtgtacc
     1081 ccgtgttcat taacgaggct gcctactatg agaagggcgt tgcctttgtc cagactgaga
     1141 agttcacatt caccgtgcct gccatgcccg cgctgacccc tgccccgagc ccagcttcct
     1201 aacccaagac acacctcccc aacctcagtc ttcccatctg aacgatgggt cctgaggcac
     1261 agctctgagc acagaggtcc cttctgccac ctaccatgca ccatgttcct tgccaggcct
     1321 ccccaacccc tggcctcaat ttccctttct ataaaatgga agatgtccag a
//
