LOCUS       NM_001106              11782 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens activin A receptor type 2B (ACVR2B), mRNA.
ACCESSION   NM_001106
VERSION     NM_001106.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11782)
  AUTHORS   Zhang,X., Ye,L., Li,X., Chen,Y., Jiang,Y., Li,W. and Wen,Y.
  TITLE     The association between sarcopenia susceptibility and polymorphisms
            of FTO, ACVR2B, and IRS1 in Tibetans
  JOURNAL   Mol Genet Genomic Med 9 (8), e1747 (2021)
   PUBMED   34302448
  REMARK    GeneRIF: The association between sarcopenia susceptibility and
            polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans.
REFERENCE   2  (bases 1 to 11782)
  AUTHORS   O'Sullivan,M.P., Denihan,N., Sikora,K., Finder,M., Ahearne,C.,
            Clarke,G., Hallberg,B., Boylan,G.B. and Murray,D.M.
  TITLE     Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not
            Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic
            Encephalopathy
  JOURNAL   Neuropediatrics 52 (4), 261-267 (2021)
   PUBMED   33706404
  REMARK    GeneRIF: Activin A and Acvr2b mRNA from Umbilical Cord Blood Are
            Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic
            Encephalopathy.
REFERENCE   3  (bases 1 to 11782)
  AUTHORS   Wallner,C., Drysch,M., Becerikli,M., Schmidt,S.V., Hahn,S.,
            Wagner,J.M., Reinkemeier,F., Dadras,M., Sogorski,A., von
            Glinski,M., Lehnhardt,M. and Behr,B.
  TITLE     Deficiency of myostatin protects skeletal muscle cells from
            ischemia reperfusion injury
  JOURNAL   Sci Rep 11 (1), 12572 (2021)
   PUBMED   34131275
  REMARK    GeneRIF: Deficiency of myostatin protects skeletal muscle cells
            from ischemia reperfusion injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11782)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 11782)
  AUTHORS   Pham,T.C.P., Bojsen-Moller,K.N., Madsbad,S., Wojtaszewski,J.F.P.,
            Richter,E.A. and Sylow,L.
  TITLE     Effects of Roux-en-Y gastric bypass on circulating follistatin,
            activin A, and peripheral ActRIIB signaling in humans with obesity
            and type 2 diabetes
  JOURNAL   Int J Obes (Lond) 45 (2), 316-325 (2021)
   PUBMED   32873911
  REMARK    GeneRIF: Effects of Roux-en-Y gastric bypass on circulating
            follistatin, activin A, and peripheral ActRIIB signaling in humans
            with obesity and type 2 diabetes.
REFERENCE   6  (bases 1 to 11782)
  AUTHORS   Nishitoh,H., Ichijo,H., Kimura,M., Matsumoto,T., Makishima,F.,
            Yamaguchi,A., Yamashita,H., Enomoto,S. and Miyazono,K.
  TITLE     Identification of type I and type II serine/threonine kinase
            receptors for growth/differentiation factor-5
  JOURNAL   J Biol Chem 271 (35), 21345-21352 (1996)
   PUBMED   8702914
REFERENCE   7  (bases 1 to 11782)
  AUTHORS   De Winter,J.P., De Vries,C.J., Van Achterberg,T.A., Ameerun,R.F.,
            Feijen,A., Sugino,H., De Waele,P., Huylebroeck,D., Verschueren,K.
            and Van Den Eijden-Van Raaij,A.J.
  TITLE     Truncated activin type II receptors inhibit bioactivity by the
            formation of heteromeric complexes with activin type I. receptors
  JOURNAL   Exp Cell Res 224 (2), 323-334 (1996)
   PUBMED   8612709
REFERENCE   8  (bases 1 to 11782)
  AUTHORS   Attisano,L., Wrana,J.L., Montalvo,E. and Massague,J.
  TITLE     Activation of signalling by the activin receptor complex
  JOURNAL   Mol Cell Biol 16 (3), 1066-1073 (1996)
   PUBMED   8622651
REFERENCE   9  (bases 1 to 11782)
  AUTHORS   Hilden,K., Tuuri,T., Eramaa,M. and Ritvos,O.
  TITLE     Expression of type II activin receptor genes during differentiation
            of human K562 cells and cDNA cloning of the human type IIB activin
            receptor
  JOURNAL   Blood 83 (8), 2163-2170 (1994)
   PUBMED   8161782
REFERENCE   10 (bases 1 to 11782)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Characterization of type II activin receptors. Binding, processing,
            and phosphorylation
  JOURNAL   J Biol Chem 268 (25), 19013-19018 (1993)
   PUBMED   8395525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP006191.1, BC099642.4 and
            BP352716.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001106.3.
            
            Summary: Activins are dimeric growth and differentiation factors
            which belong to the transforming growth factor-beta (TGF-beta)
            superfamily of structurally related signaling proteins. Activins
            signal through a heteromeric complex of receptor serine kinases
            which include at least two type I (I and IB) and two type II (II
            and IIB) receptors. These receptors are all transmembrane proteins,
            composed of a ligand-binding extracellular domain with
            cysteine-rich region, a transmembrane domain, and a cytoplasmic
            domain with predicted serine/threonine specificity. Type I
            receptors are essential for signaling; and type II receptors are
            required for binding ligands and for expression of type I
            receptors. Type I and II receptors form a stable complex after
            ligand binding, resulting in phosphorylation of type I receptors by
            type II receptors. Type II receptors are considered to be
            constitutively active kinases. This gene encodes activin A type IIB
            receptor, which displays a 3- to 4-fold higher affinity for the
            ligand than activin A type II receptor. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X77533.1, BC099642.4 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352511.5/ ENSP00000340361.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AP006191.1         57013-57421
            410-429             AP006191.1         57422-57441
            430-765             BC099642.4         1-336
            766-903             BP352716.1         320-457
            904-1991            BC099642.4         475-1562
            1992-11782          AP006191.1         86475-96265
FEATURES             Location/Qualifiers
     source          1..11782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..11782
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /note="activin A receptor type 2B"
                     /db_xref="GeneID:93"
                     /db_xref="HGNC:HGNC:174"
                     /db_xref="MIM:602730"
     exon            1..485
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            486..693
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            694..803
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            804..955
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1099
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1243
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1392
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1507
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1646
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1777
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..11782
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11762..11767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /note="hexamer: AATAAA"
     polyA_site      11782
                     /gene="ACVR2B"
                     /gene_synonym="ActR-IIB; ACTRIIB; HTX4"
                     /note="major polyA site"
ORIGIN      
        1 ggctcggctc cgtggccgcc gctcaggagc cattttggac tcggttcagc tcccctcccc
       61 cccacccctc cccccgttca tggcccctcc ggactcggcc cctgcgcccg gggcccgggc
      121 ccagccccgc cgcgctatgc ctgagtcggg cgcgccccgg cccgtgcccc gccgccgccc
      181 cccggccccc gcgtcgcccc ggagcccggg ccgcagcctg cgccgcccgc agcggccctg
      241 agcccggccc cgccgaccgg cccttggagc ccgaacgctg ctcggggacg aaggcgcagg
      301 aagcgcgcag ggaacgagac cgaaggaagg agcgggaagg agagcgcagc cgccgcctgg
      361 ccctgcgcgc cccgggagcg ccgtgcggcc ctgcccgcgg gctccgggtg tgcgcggggc
      421 ggcgccgcgg aacatgacgg cgccctgggt ggccctcgcc ctcctctggg gatcgctgtg
      481 cgccggctct gggcgtgggg aggctgagac acgggagtgc atctactaca acgccaactg
      541 ggagctggag cgcaccaacc agagcggcct ggagcgctgc gaaggcgagc aggacaagcg
      601 gctgcactgc tacgcctcct ggcgcaacag ctctggcacc atcgagctcg tgaagaaggg
      661 ctgctggcta gatgacttca actgctacga taggcaggag tgtgtggcca ctgaggagaa
      721 cccccaggtg tacttctgct gctgtgaagg caacttctgc aacgaacgct tcactcattt
      781 gccagaggct gggggcccgg aagtcacgta cgagccaccc ccgacagccc ccaccctgct
      841 cacggtgctg gcctactcac tgctgcccat cgggggcctt tccctcatcg tcctgctggc
      901 cttttggatg taccggcatc gcaagccccc ctacggtcat gtggacatcc atgaggaccc
      961 tgggcctcca ccaccatccc ctctggtggg cctgaagcca ctgcagctgc tggagatcaa
     1021 ggctcggggg cgctttggct gtgtctggaa ggcccagctc atgaatgact ttgtagctgt
     1081 caagatcttc ccactccagg acaagcagtc gtggcagagt gaacgggaga tcttcagcac
     1141 acctggcatg aagcacgaga acctgctaca gttcattgct gccgagaagc gaggctccaa
     1201 cctcgaagta gagctgtggc tcatcacggc cttccatgac aagggctccc tcacggatta
     1261 cctcaagggg aacatcatca catggaacga actgtgtcat gtagcagaga cgatgtcacg
     1321 aggcctctca tacctgcatg aggatgtgcc ctggtgccgt ggcgagggcc acaagccgtc
     1381 tattgcccac agggacttta aaagtaagaa tgtattgctg aagagcgacc tcacagccgt
     1441 gctggctgac tttggcttgg ctgttcgatt tgagccaggg aaacctccag gggacaccca
     1501 cggacaggta ggcacgagac ggtacatggc tcctgaggtg ctcgagggag ccatcaactt
     1561 ccagagagat gccttcctgc gcattgacat gtatgccatg gggttggtgc tgtgggagct
     1621 tgtgtctcgc tgcaaggctg cagacggacc cgtggatgag tacatgctgc cctttgagga
     1681 agagattggc cagcaccctt cgttggagga gctgcaggag gtggtggtgc acaagaagat
     1741 gaggcccacc attaaagatc actggttgaa acacccgggc ctggcccagc tttgtgtgac
     1801 catcgaggag tgctgggacc atgatgcaga ggctcgcttg tccgcgggct gtgtggagga
     1861 gcgggtgtcc ctgattcgga ggtcggtcaa cggcactacc tcggactgtc tcgtttccct
     1921 ggtgacctct gtcaccaatg tggacctgcc ccctaaagag tcaagcatct aagcccagga
     1981 catgagtgtc tgtccagact cagtggatct gaagaaaaaa ggaaaaaaag ttgtgttttg
     2041 ttttggaaat cccataaaac caacaaacac ataaaatgca gctgctattt taccttgact
     2101 ttttattatt attattataa ttattataat tattattatt aatattattt tttggattgg
     2161 atcagttttt accagcatat tgctctactg tatcacaaac agcggacacg tcagcaggcg
     2221 ttgaggtgct gagctgtgga tgcagaacca gcgccatgct gaagagcctc agccacctcc
     2281 tgtcctttgg gattcgtttt tcccgctttc tctttgtttg tcgtctcaga atctgtgaca
     2341 caaagaaacc catctcctgt cttaggaaac ctaatgctgc aaactctacc tagaggaacc
     2401 tttgaagact gttacataag aacatacctt cctcagaaga ggagtttcct ctgccctctg
     2461 cccttctccc ctgcctccct ccctcccctc cttttatttt gttttagtga gcttaagaaa
     2521 cagcagatgt gtctttcacg gatctaacgg gtgttgtcct gatcgagaaa aaaactggga
     2581 tgagaatggt ttggactgga gttggaaggg gaggacggta ctgggggtag ggtttggaac
     2641 agagctacac tggactcggg cacattcgga gcagcatcct ttagtatgga ggctacttct
     2701 caggtaacca ggaattgagg ggaaggacct tgtggaggcc gagcattaac agcaagagcg
     2761 gggtttggag aaagtctgag attgggtgca gccctgactt acctgctggc cctgaccagt
     2821 ttcttttcac taacttggcc ttgggcatag gatgaaacat tttttctgcc ctaattttaa
     2881 aactaggtga gggtagaatc atcacaggtt aggaatacat tcttcataag acacgatgct
     2941 gtaaataccc ttaatggacg aaaagttgaa atacttttgt ttcctcttgg agcagttcag
     3001 ggaaatgccc acaggggatt gtcctgcaca gatagggcaa gaggatttcc tgggtggagt
     3061 ctgccaaggc ctgcctcgct ggggacccca gagtcctgca cctctggttc cgccccaggt
     3121 ggtgacatta ctgtccccgt tctgtggctc gtggacaaga ctttctccag accccttaaa
     3181 gtggtacata ttctaaaaaa ctgtttttct attatgccat aaccttgctc tagtcagtga
     3241 atgttcctaa tgctgctgtt tcaacatttg aattcttttt aatttatgaa acatgctaaa
     3301 tttttttttt caaacaaaac acacacatcc acatatacac atgcttcgct atgtggcttc
     3361 caaggtttaa attttgaaaa gtaaaagaat taaaacttca cgaccacaga tcacctcaaa
     3421 ccagaaatac ctcagaattt tctacttatg taaggtttat tatatatttt gttagttgtg
     3481 ttgtcttgta gtaagtatat tttaatgtaa gttggctttt gtgacaagga agtttaaaag
     3541 aaatagagaa aaagaaaaaa gtttgcatct tctagggagt gctaccattt ttgtttgata
     3601 acgccccctt gtaaataatt gtcatcaact gtaggttggc tgtctgggcc aagtctgggc
     3661 atttatcagt cttgtttgtg aaggcttttc cttctggttt ctttagatca ttttatttaa
     3721 aaacagtgca tctcttcatc gtgagggtag gcaaggcggg ggccgtgggg agaggttgac
     3781 ctgggtgaga actgaagagg ccgcctcctc ttgggttgtt tggagcttca catgtaattc
     3841 acatgtaaca tgtaacttga tcggtcagtg ttcagaatga caagtaaccc cgcttaaact
     3901 tggtagaagg atggccctta gacctgaatg gggtgatttt acttgggatt taacttcttc
     3961 agcaaattaa cagcaacgtt ggaagagatc tgtggcgcct ctgtgaagca caccgtgact
     4021 caggccagtc ttttagtgca gcgtgtctgg gagtgaaggg ttttgccctt gctggtcttg
     4081 gagtccacag tgtgaggggc actgcacatg cctgggcatc tacctagtgt gctatgttca
     4141 gtgtctgggg cttactgccc cggggtcctt tcctctgggt gttggggcac agggtgctat
     4201 gggaggccca tttgcttccc tctcggagct cagtttttgc ttcatgggtc aaaatgtggg
     4261 ctggccaagt ggttacagga acagggtttc ggtaagctat gttgtctttt tttttttttt
     4321 tttttttttt tttaatggtt tgattttgtg ctgtggtatt ttttttccct tagaataatt
     4381 tttaatggca aaacaggcct tacagcagtt gcttttcttt accatttatt tctttaagaa
     4441 gctttaaaat atttattgaa aagtgccata tctaatttct ttagctttcg cctcaggcag
     4501 tgcaggcatc tttacttttc atcctcagaa gaaacaaacg actaacaaat gtagcaaatt
     4561 tactgcagga atagttaggt catgatacta cctgaacact aaaccccagc ctctttgttt
     4621 ggttttagtt cctctgggtg gtttttcttt tgtgtgctgg cttgattctt gtgagaagtt
     4681 ttgacctggc caagggaggg ttgagccatg gttctggtgt gggactttgc ggtcaagaca
     4741 cagtacagac aggtcaggcc tgcgtgcctt ttctctgggt ggcctccccg ttaggcccac
     4801 cgtacgctca gccactatag tgtccctgtg gggccttgcc atcagattgt gtgtcaggag
     4861 atggtacctt tttggtgtgg ctggggagga gtgtggtcca tgccagttct ttgggcttca
     4921 ggccactctt cccctcatgc tgtggtgtaa agtgcaccca tcaggtggta tatctggttc
     4981 tgatggcaag aagaaggtgg gggatctcct tatagggcat gggtctagga gcacagatgg
     5041 gccttttgcc ccgggtaaat gcttgtctgt ttgctgtcat gtgttctttg aggagtgagc
     5101 catctcgagc cctgctttga atttactggg tcatagagcc tctgcctgtg ctcttttcca
     5161 taatgacttc atgtgacatg cacttttggt gggctcagat aattggtttc tttttgtttt
     5221 tgacctcagg ctctgtggca gactggggaa aatggggcct ggcatcattt tccctgtcaa
     5281 tgggaggggc tgttccatgc agggtgggag gggaccaagt tagcagagag tagccaagga
     5341 tccttgcttc ttcctttcta gtgtgctgtc atccaagcag gctcctggct gtagggatgg
     5401 gccttgggga agaatcttct ttgaaagcat ctatgataac tgagaagtca tccctagttg
     5461 gagaaatcca gtaatgagca gaaggaggaa gcaagtgagg acagaggcca ttgtattaca
     5521 gtgtcacgca gagggccctc aatgatgggg cattggggaa ggctgtagac atagtcatca
     5581 gaacatcctg gcctggcata agctgggttt tctcctggga ccattggtcc tcagcaggag
     5641 ttctttgcat gagttgctca ggggcaaggg ctgcaagtgg gctgtgctta ggagaaagtg
     5701 acacctggca gtgagggaag atggtgagca ttattagcct ttgttgtcca gcatggcctt
     5761 cttgtcctgt ctgctctgga gaggagcctg tgggaccagt cctgcctggg gagggcatac
     5821 ccacacgtgc cagctgattc tgactctgaa tacatcatgt ccggacttgg gggtgtttct
     5881 gcagaaaaag gaggttgttt ttcagccttg aacatcttca ggaggataga gactcttgct
     5941 cacatattct tagcaaaggg aagggtctct catctccagg ccacagagat agttcttcca
     6001 ttgccctaag aggctaggct aaccctcttg acataactta gacagcaaag cacttcatcc
     6061 tgtagttggg ctctgtcacc tttctcttca gttggccaca ttctcgtttc ctccatcctg
     6121 ctatgctttg tgtgctcggg ctgtgtgtgg ggtttttccc tggtggaagg aagcccagct
     6181 gtgtattgaa tgtccttcat gtgttgtgtg tggctcagaa agcctgtcac ttggcccctg
     6241 tgctctgagc cgtgagggtg gggaggtggc tgttccatta aagtgggagt attggatggc
     6301 cctcttgaaa ctagaatttt gcctttttta gtatgcagta taaagtttcc agcatctatt
     6361 ggtaacacaa agatttgctg gtttttaaaa taatacagta agcataagta tgtaagtttt
     6421 tagaattggt actagaagtt ggacagctag ttattctcga gaactttatt tcactagaaa
     6481 aatatactaa ttggaaagca gtttccagga gttaactcag tttaattttc agtctcagtt
     6541 attttagcct gttgagtttt tgatggcaca cctttggaga gatggccacg cctgattccc
     6601 atttcagggg catcagacca taccttttta agaagctccg tgaatctagt catctaccct
     6661 tcatcctggg cgaacagcca aaaagagaag gggacaaggt gtctttttct ccttctcact
     6721 ggggtgacat gaattctttt agttaatggc tgtttgcaaa ttctaaacta atgaaatact
     6781 tagcagctaa catgttcaat ctagtaatga tgagtttaaa tctcaattga cagtaatgtt
     6841 ttagataaac aggcccagta attcagttga tgaactgtat atcttctcag tctagatttg
     6901 taaatgttta atgaattcag ggttataagc atagttcttt aagtaagatt ccagatagtt
     6961 gatttgcaac cagcagtcta cctatgaatg tatcccaaac ctttagaaga ttggaaaaga
     7021 tttttgaaat aatgatttag ttttgtagga aaaacacccc cttgaaaatt aattcggttg
     7081 acccagtaac attttttaaa acaattggtg gctccaaaag gcctgccaac aaagaaaagt
     7141 ccaaattatc tagtgggaca ttttgaatgt tttatgttta ttttgggtcc actgtaaact
     7201 ttggttcaaa aaagaatttg aatttaaaga atttaccatt atttaaatta ttaccaagtt
     7261 tttacatttt catgatggta ttttccaggt atgaatgaaa catgactttt tgattgtggt
     7321 acttcctgta tcccctgtag tgccaaaacc agtgatactt tatttgctcc tatggcagct
     7381 catagaggta accgaagtga tttttcctca gtaattgaaa cacatattct ctaaatgcca
     7441 atgtgtggtg atgggccctg cactgccttc atttctctag ggcagtgtct ttggattgtc
     7501 tagggcctag gtaattctga gaactactgt aaaccaacca cagggcacta aagcaatgta
     7561 cacaccactc tttgtgtgta tggaaggggt tatataaacc tgggctatgc tggacatcta
     7621 cagaagagta ttacattcac ttgcaaagtt tacatttttg agctcacagt tatgaaaaat
     7681 atgacccaca agtttttcag gcaggtgagg atgggtcttc ttgcaaatgc atgagttctg
     7741 tcttgagtcc tgggaacttc tctgttggtt gagtgtgggc tcattccctg actctcctaa
     7801 tcatgtttgc gtcagaatgt tagcattgta aataaaagaa taggttgtat aatagataca
     7861 caacacttga aactttactt taaaaaaatc gatagttcta catatatatt tagttatatc
     7921 acttgacaga tttcttctac acagtgtgga gattgtttta taccacagat tatttttata
     7981 aagttagtga atttgaatga ttttgtaatc agagctaatg agctttacct ttcaagagaa
     8041 acgtacactg gagcatgagt ggtgtggaac ttttacttag tgtttatatg gattcttgtg
     8101 atacactggc agactggagt caatttgcgg gtcttttttg gccaaaactc cacttgtggt
     8161 tgtgtaggac agtgatattc agctcagctt cttgtggatt gggaggagag agggcctgca
     8221 atgtgtttta cattggtgct tcctcctgag atttctgttg aacaaagggt tctgaggtca
     8281 aaaattagtt tgtaagcctt tgccatagga catagtcatg tgagagtgtt tgggggaaca
     8341 gaaattgtat aggggtgcct attggggtgg gatgggactc gaataagatt caggtacaaa
     8401 aactttgaaa tgagaatctg gtggtttgag taatccacca gactgaatta tctaagatca
     8461 cattatccag gttggggggc agaattaccc agttaagtaa ttgttcagaa aagtggggag
     8521 ggtggcatgt ggatgcagtg atccaattaa atggagagct gccaggcaca ttttgtcctc
     8581 tctggtcagt gagaatggtt gggttggctc gctgcttcaa tctgtggaat cagccaggag
     8641 cccagtgagg aagctcagaa ccccagtaac agcagagcat ctttcagata gctccagagt
     8701 tttcctgctt ttctgaggaa gctcagcatc actgccacaa tacggaaagt ggtcttcatt
     8761 ttagcctatt tatttttagg cagagagtgg atggttattt gtgtgggact tttggtggcg
     8821 atatataatg aataattaag ttaatttctg gtatgcataa tggccagtcc tgaggcccag
     8881 ctgaagacct gtcccccaga ccctgcccgc tggcttcagg ctgctgcttc tagacagagg
     8941 tgcactggac gggatagttt tatcaagaga atccctaatg tgtcatttta aaccagctgt
     9001 gctttttatt cattctggtt gagcgtatag gtttacactt tacccttttt atacttggaa
     9061 taaatttagt tccagcagat ctagtagcac tccagaaacc aaccccatct gttccccata
     9121 aaaagaacat tttctctgct ctccagccac gtgtcttgga atgtaattct gttgtgcctt
     9181 tgtttttatc actctcttcg ccccaaaagc aactgctgta agcttttttc tacttgtctt
     9241 ttctagtccc caacctctac ctttttcctt tttcccagcc ctaatttctg gatgcacttc
     9301 tgtgatccag gtattttaag aaccagttac ctcagacctc atgttgaaca gtgtcgccat
     9361 ctgggtcctc ttgatactgc agacttttaa cgtacacatg caggaaccct gctgagcgtg
     9421 ggcacttgtt ttaaagcaaa actcttccca aggactgaag aaagggcttc tggcaagctc
     9481 gtcatggcat tgtggtggga tgggtctaga gtgtcatctg aatggtgctt cctgtgttcc
     9541 tctttgaatt ctgccatttt cagtattctt gtgtgtctga ataggcaaag cgatttaatt
     9601 ggctggtctt gcacgcaaat tagttccaaa gataagctct ttgtaacaca tttccagtcg
     9661 ctaatgctca aatgtagaac attcctttaa atggcaggat aaaaaaccca ctatccacca
     9721 tagtgcattt tgggaagatg tctgtagcat atgttgctgt gaaattaggc cttgtgggat
     9781 atggctgttt gtcattttga tgtattttaa ataaatatat atatttttta aagagccttt
     9841 tttaccagtt caaaaagttt aattaaccag cagtcaccgc atctgaattt ttgtctctgg
     9901 ggcatagatg gcagaccaag attaaaagtg gtaactcagc tatacgagca tgggctacct
     9961 tcctgggctc tcctgcagtc ctgtagacct gctgttccgc agaccatggg acacaaggtc
    10021 agtgtgttcc cagtgagggt cccaagtcag tcatcttaag tgtttgttct ctgccccatt
    10081 cagtggactg ttgacttcag tccctgcaag tgctttagcc cgagtggggt tttctcagag
    10141 cactgccacg agttaagtgt gtgtttagcc aaataatttc tccgtaaggg aaaaatgcag
    10201 tcacccaaat tttaccaaca atgacagaga tgagagtaga aaagattagg caacatctga
    10261 gttttaactt gaaaagtgtc caagtcatca tgaaaggccg actgggagca agtgattatt
    10321 agagattctt caggagacct catctgaaaa tgttaagact gccagtgagg gaaggaattg
    10381 ttaaaatgcc agcggctttt ttttcctctt tttttctgta attctgtaaa aatgcagaga
    10441 aagttgagtg gtacttcaga attgagggag agggttaccg cagagtagaa atatatttct
    10501 agatttcagt tccacaccac aaatccacaa caatgccatt tttcaactgt acaaaaatct
    10561 gcttatgaac tggacatgat cttaatggta gtgtcaaagg ccaagttttt cacctgttaa
    10621 tatttttcca catttgtcct tgaatctgaa taactttata cagtactgta aatttaactt
    10681 acatcgagtt tgttgtcaat tcttatgaaa agagctttct gcatgtaaca catacggtta
    10741 aagaacacag caaaggacaa aatttgcagg aacagttttg gaaccaacag aaaatgtcac
    10801 cttttatttg ccatcttata tatatctatc agttttacca gctacttcta aatttgtaca
    10861 ttatttgtaa gggaaagaag gaaaacccta agacttgtct aacttagtgg agaatgtgtg
    10921 tgttgggctt aggatggata gctaagtctt attgagctgt gttacctaac ttgtatataa
    10981 aaattgtaat taaaagtttg ggttcacctg tttctcacag tttaaaatga tgagtaattg
    11041 caaactctgg aaatgtgact agtatatgat ttaaggctgt agaagcaagg aagctctttc
    11101 aagtgctaaa actaaagact tctagttttt ggctcaaata agtactgttt gtataccagg
    11161 atatgtgaga tgtaaatgta gtaggtcact tttcaccctt gtagctataa aataaaaatt
    11221 ttgtagaaca gaaatagctt gtactactga attaacaaaa gttatactaa agtatcatgt
    11281 ttaaaaaaaa tatatatata tatacagagt taagcttgtt gctgttaccc tgtctggatt
    11341 tgaaaagtgt gctgatttat atatatatat tacacacaca cacacacaca cacacacaca
    11401 cacacacaca cacacacaca cacacacaca cacacacaca cacatacacc taaaatggcc
    11461 taaagcagac atccatgtaa ttacagttgc aaaatgaaaa cattttggaa agaacattgt
    11521 atcatagttc attcatttgc agtggatctt tgttcctttt tactgtggta attttagaaa
    11581 tgagtgtcaa gtttgaaatt agatctgcta agttggggtt ttgctgcttg aactctgcac
    11641 tgggtcctca aataaaccga tgtgaatgta gttttttccc cctgtgtgaa gaagcagtta
    11701 caccccaaca ataggaggaa aaatctagaa ctatttcaag ttttatcttt ttgtatatga
    11761 aaataaaata ataataaaac aa
//
